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Table 4 Result of cut-point selection with different methods by ESR and their diagnostic properties

From: Methods of determining optimal cut-point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review

Methods

Cut-point (mm/h)

Se

(95%CI)

Sp

(95%CI)

PPV

(95%CI)

NPV

(95%CI)

LR + 

(95%CI)

LR-

(95%CI)

DOR

(95%CI)

Youden

39

0.40

(0.22,0.59)

0.87

(0.69,0.96)

0.75

(0.47,0.92)

0.59

(0.43,0.73)

3

(0.85,11.08)

0.69

(0.19,2.48)

4.33

(1.20,15.60)

Euclidian

22

0.63

(0.43,0.80)

0.60

(0.40,0.77)

0.61

(0.42,0.78)

0.62

(0.42,0.79)

1.58

(0.55,4.46)

0.61

(0.21,1.74)

2.59

(0.91,7.34)

Product

22

0.63

(0.43,0.80)

0.60

(0.40,0.77)

0.61

(0.42,0.78)

0.62

(0.42,0.79)

1.58

(0.55,4.46)

0.61

(0.21,1.74)

2.59

(0.91,7.34)

DOR

60

0.20

(0.07,0.38)

0.97

(0.82,0.99)

0.86

(0.42,0.99)

0.55

(0.40,0.68)

6

(0.74,59.27)

0.83

(0.09,7.33)

7.25

(0.81,64.45)

IU

22

0.63

(0.43,0.80)

0.60

(0,40,0.77)

0.61

(0.42,0.78)

0.62

(0.42,0.79)

1.58

(0.55,4.46)

0.61

(0.21,1.74)

2.59

(0.91,7.34)