| None-DILI (N = 5,920) | DILI (n = 1,151) | P value | SMD | ||
---|---|---|---|---|---|---|
 | n | (%) | n | (%) |  |  |
Age at TB diagnosis, years | ||||||
 Mean (SD) | 47 | (19) | 48 | (18) | 0.695 | 0.013 |
  < 30 | 1407 | (23.8) | 243 | (21.1) | 0.001 | 0.167 |
 30–49 | 1843 | (31.1) | 359 | (31.2) | ||
 50–69 | 1773 | (29.9) | 414 | (35.9) | ||
 70 +  | 897 | (15.1) | 135 | (11.8) | ||
Gender | Â | Â | Â | Â | 0.105 | 0.053 |
 Male | 4051 | (68.4) | 759 | (65.9) |  |  |
 Female | 1869 | (31.6) | 392 | (34.1) |  |  |
Race | Â | Â | Â | Â | 0.668 | 0.018 |
 Han | 5792 | (97.8) | 1129 | (98.1) |  |  |
 Others | 128 | (2.2) | 22 | (1.9) |  |  |
Treatment status | Â | Â | Â | Â | 0.472 | 0.025 |
 Initial | 5464 | (92.3) | 1070 | (93.0) |  |  |
 Retreatment | 456 | (7.7) | 81 | (7.0) |  |  |
Diagnosis site | Â | Â | Â | Â | Â | 0.042 |
 Lung | 5509 | (93.1) | 1083 | (94.1) |  |  |
 Other sites | 411 | (6.9) | 68 | (5.9) |  |  |
Education | Â | Â | Â | Â | 0.006 | 0.112 |
 Illiteracy | 2248 | (38.0) | 488 | (42.4) |  |  |
 Semi-literate | 212 | (3.6) | 37 | (3.2) |  |  |
 Undergraduate | 3289 | (55.6) | 582 | (50.6) |  |  |
 Bachelor | 171 | (2.9) | 44 | (3.8) |  |  |
Profession | Â | Â | Â | Â | 0.381 | 0.072 |
 Industry | 3281 | (55.4) | 625 | (54.3) |  |  |
 Clothing | 1718 | (29.0) | 329 | (28.6) |  |  |
 Retirees | 416 | (7.0) | 85 | (7.4) |  |  |
 Government | 235 | (4.0) | 57 | (5.0) |  |  |
 Others | 139 | (2.3) | 22 | (1.9) |  |  |
 Student | 131 | (2.2) | 33 | (2.9) |  |  |
Ratio of ULN of serological markersa Median (IQR) | ||||||
 ALT | 0.44 | (0.27,0.66) | 0.52 | (0.30,0.66) |  < 0.001 | 0.104 |
 ALP | 0.68 | (0.56,0.82) | 0.68 | (0.55,0.82) | 0.871 | 0.047 |
 Tbil | 0.52 | (0.38,0.71) | 0.54 | (0.40,0.74) | 0.005 | 0.072 |
Serological markers status | ||||||
 Abnormal ALT | 273 | (4.6) | 91 | (7.9) |  < 0.001 | 0.136 |
 Abnormal ALP | 400 | (6.8) | 100 | (8.7) | 0.023 | 0.072 |
 Abnormal Tbil | 366 | (6.2) | 87 | (7.6) | 0.093 | 0.054 |
Comorbidities | ||||||
 Diabetes | 599 | (10.1) | 102 | (8.9) | 0.211 | 0.043 |
 Hypertension | 1108 | 18.7 | 216 | 18.8 | 1.000 | 0.001 |
 Liver-related diseasesb | 624 | 10.5 | 224 | 19.5 |  < 0.001 | 0.252 |
 HBV | 105 | 1.8 | 17 | 1.5 | 0.560 | 0.023 |
Medication | ||||||
 TCM | 1250 | (21.1) | 323 | (28.1) |  < 0.001 | 0.162 |
 Hepatoprotective agentsc | 1971 | (33.3) | 486 | (42.2) |  < 0.001 | 0.192 |
 PZA | 1105 | (18.7) | 304 | (26.4) |  < 0.001 | 0.186 |
 RIF | 590 | (10.0) | 121 | (10.5) | 0.610 | 0.018 |
 INH | 1000 | (16.9) | 267 | (23.2) |  < 0.001 | 0.158 |