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  1. Content type: Research article

    Adequate participant recruitment is vital to the conduct of a clinical trial. Projected recruitment rates are often over-estimated, and the time to recruit the target population (accrual period) is often under...

    Authors: Rickey E Carter, Susan C Sonne and Kathleen T Brady

    Citation: BMC Medical Research Methodology 2005 5:11

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  2. Content type: Research article

    Cluster randomised trials can be susceptible to a range of methodological problems. These problems are not commonly recognised by many researchers. In this paper we discuss the issues that can lead to bias in ...

    Authors: Seokyung Hahn, Suezann Puffer, David J Torgerson and Judith Watson

    Citation: BMC Medical Research Methodology 2005 5:10

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  3. Content type: Research article

    To adequately assess individual studies and synthesize quantitative research on weight loss studies, transparent reporting of data is required. The authors examined the reporting quality of randomized trials i...

    Authors: Cheryl A Gibson, Erik P Kirk, James D LeCheminant, Bruce W Bailey Jr, Guoyuan Huang and Joseph E Donnelly

    Citation: BMC Medical Research Methodology 2005 5:9

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  4. Content type: Research article

    To determine if the search technique that is used to sample randomized controlled trial (RCT) manuscripts from a field of medical science can influence the measurement of the change in quality over time in tha...

    Authors: Mark K Borsody and Chisa Yamada

    Citation: BMC Medical Research Methodology 2005 5:7

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  5. Content type: Research article

    Failure to be comprehensive can distort the results of a systematic review. Conversely, extensive searches may yield unmanageable number of citations of which only few may be relevant. Knowledge of usefulness ...

    Authors: Ana P Betrán, Lale Say, A Metin Gülmezoglu, Tomas Allen and Lynn Hampson

    Citation: BMC Medical Research Methodology 2005 5:6

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  6. Content type: Research article

    Epidemiological studies of exposures that vary with time require an additional level of methodological complexity to account for the time-dependence of exposure. This study compares a nested case-control appro...

    Authors: Vidal Essebag, Robert W Platt, Michal Abrahamowicz and Louise Pilote

    Citation: BMC Medical Research Methodology 2005 5:5

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  7. Content type: Research article

    There is analytical potential for multiple cause of death data collected from death certificates. This study examines relationships of multiple causes of death as a function of factors available on the death c...

    Authors: Melanie M Wall, Jinzhou Huang, John Oswald and Diane McCullen

    Citation: BMC Medical Research Methodology 2005 5:4

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  8. Content type: Debate

    In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based app...

    Authors: Rickey E Carter

    Citation: BMC Medical Research Methodology 2005 5:3

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  9. Content type: Research article

    Methodological research to support searching for those doing systematic reviews of epidemiological studies is a relatively neglected area. Our aim was to determine how many databases it is necessary to search ...

    Authors: Pamela Royle, Lynda Bain and Norman Waugh

    Citation: BMC Medical Research Methodology 2005 5:2

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  10. Content type: Research article

    Browne et al. [Browne, MacCallum, Kim, Andersen, Glaser: When fit indices and residuals are incompatible. Psychol Methods 2002] employed a structural equation model of measurements of target cell lysing by nat...

    Authors: Leslie A Hayduk, Hannah Pazderka-Robinson, Greta G Cummings, Merry-Jo D Levers and Melanie A Beres

    Citation: BMC Medical Research Methodology 2005 5:1

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  11. Content type: Research article

    Cluster sample study designs are cost effective, however cluster samples violate the simple random sample assumption of independence of observations. Failure to account for the intra-cluster correlation of obs...

    Authors: Stephanie A Knox and Patty Chondros

    Citation: BMC Medical Research Methodology 2004 4:30

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  12. Content type: Research article

    Many medical specialities have reviewed the statistical content of their journals. To our knowledge this has not been done in general practice. Given the main role of a general practitioner as a diagnostician ...

    Authors: Alan S Rigby, Gillian K Armstrong, Michael J Campbell and Nick Summerton

    Citation: BMC Medical Research Methodology 2004 4:28

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  13. Content type: Research article

    There is a common belief that most cancer prevention trials should be restricted to high-risk subjects in order to increase statistical power. This strategy is appropriate if the ultimate target population is ...

    Authors: Stuart G Baker, Barnett S Kramer and Donald Corle

    Citation: BMC Medical Research Methodology 2004 4:24

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  14. Content type: Research article

    In most recent large efficacy trials of barrier contraceptive methods, a high proportion of participants withdrew before the intended end of follow-up. The objective of this analysis was to explore characteris...

    Authors: Elizabeth G Raymond, Pai Lien Chen, Bosny Pierre-Louis, Joanne Luoto, Kurt T Barnhart, Lynn Bradley, Mitchell D Creinin, Alfred Poindexter, Livia Wan, Mark Martens, Robert Schenken, Cate F Nicholas and Richard Blackwell

    Citation: BMC Medical Research Methodology 2004 4:23

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  15. Content type: Research article

    Consumers of research (researchers, administrators, educators and clinicians) frequently use standard critical appraisal tools to evaluate the quality of published research reports. However, there is no consen...

    Authors: Persis Katrak, Andrea E Bialocerkowski, Nicola Massy-Westropp, VS Saravana Kumar and Karen A Grimmer

    Citation: BMC Medical Research Methodology 2004 4:22

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  16. Content type: Debate

    Publication bias, as typically defined, refers to the decreased likelihood of studies' results being published when they are near the null, not statistically significant, or otherwise "less interesting." But c...

    Authors: Carl V Phillips

    Citation: BMC Medical Research Methodology 2004 4:20

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  17. Content type: Research article

    Balanced decisions about health care interventions require reliable evidence on harms as well as benefits. Most systematic reviews focus on efficacy and randomised trials, for which the methodology is well est...

    Authors: Heather M McIntosh, Nerys F Woolacott and Anne-Marie Bagnall

    Citation: BMC Medical Research Methodology 2004 4:19

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  18. Content type: Research article

    Recently developed measures such as I 2 and H allow the evaluation of the impact of heterogeneity in conventional meta-analyses. There has been no examination of the development of heterogeneity in the context of...

    Authors: Elmer V Villanueva and Silva Zavarsek

    Citation: BMC Medical Research Methodology 2004 4:18

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  19. Content type: Research article

    Reducing maternal mortality and morbidity are among the key international development goals. A prerequisite for monitoring the progress towards attainment of these goals is accurate assessment of the levels of...

    Authors: A Metin Gülmezoglu, Lale Say, Ana P Betrán, Jose Villar and Gilda Piaggio

    Citation: BMC Medical Research Methodology 2004 4:16

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  20. Content type: Study protocol

    The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but informa...

    Authors: Ana MB Menezes, Cesar G Victora and Rogelio Perez-Padilla

    Citation: BMC Medical Research Methodology 2004 4:15

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  21. Content type: Research article

    Current methods of measuring the quality of journals assume that citations of articles within journals are normally distributed. Furthermore using journal impact factors to measure the quality of individual ar...

    Authors: Andy R Weale, Mick Bailey and Paul A Lear

    Citation: BMC Medical Research Methodology 2004 4:14

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  22. Content type: Research article

    Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in publish...

    Authors: Emili García-Berthou and Carles Alcaraz

    Citation: BMC Medical Research Methodology 2004 4:13

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  23. Content type: Research article

    In recent years there has been increased interest in evaluating breast cancer screening using data from before-and-after studies in multiple geographic regions. One approach, not previously mentioned, is the p...

    Authors: Stuart G Baker, Barrett S Kramer and Philip C Prorok

    Citation: BMC Medical Research Methodology 2004 4:12

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  24. Content type: Software

    Rating scales form an important means of gathering evaluation data. Since important decisions are often based on these evaluations, determining the reliability of rating data can be critical. Most commonly use...

    Authors: David J Solomon

    Citation: BMC Medical Research Methodology 2004 4:11

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  25. Content type: Research article

    The use of preference-based measures in the evaluation of health outcomes has extended considerably over the last decade. Their alleged advantage over other types of general instruments in the evaluation of he...

    Authors: Luis Prieto and José A Sacristán

    Citation: BMC Medical Research Methodology 2004 4:10

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  26. Content type: Research article

    Increasingly, researchers are recognizing that there are many situations where the use of a cluster randomized trial may be more appropriate than an individually randomized trial. Similarly, the need for appro...

    Authors: Marion K Campbell, Jeremy M Grimshaw and Diana R Elbourne

    Citation: BMC Medical Research Methodology 2004 4:9

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  27. Content type: Research article

    Patient recruitment is one of the most difficult aspects of clinical trials, especially for research involving elderly subjects. In this paper, we describe our experience with patient recruitment for the behav...

    Authors: Bei-Hung Chang, Ann M Hendricks, Mara T Slawsky and Joseph S Locastro

    Citation: BMC Medical Research Methodology 2004 4:8

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  28. Content type: Research article

    We sought to improve upon previously published statistical modeling strategies for binary classification of dyslipidemia for general population screening purposes based on the waist-to-hip circumference ratio ...

    Authors: Michael C Costanza and Fred Paccaud

    Citation: BMC Medical Research Methodology 2004 4:7

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  29. Content type: Research article

    The purpose of this study was to determine the standard tasks performed by clinical research coordinators (CRCs) in oncology clinical trials.

    Authors: Fernando Rico-Villademoros, Teresa Hernando, Juan-Luis Sanz, Antonio López-Alonso, Oscar Salamanca, Carlos Camps and Rafael Rosell

    Citation: BMC Medical Research Methodology 2004 4:6

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  30. Content type: Research article

    Qualitative research makes an important contribution to our understanding of health and healthcare. However, qualitative evidence can be difficult to search for and identify, and the effectiveness of different...

    Authors: Rachel L Shaw, Andrew Booth, Alex J Sutton, Tina Miller, Jonathan A Smith, Bridget Young, David R Jones and Mary Dixon-Woods

    Citation: BMC Medical Research Methodology 2004 4:5

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  31. Content type: Debate

    Two main pathways exist for the development of knowledge in clinical homeopathy. These comprise clinical trials conducted primarily by university-based researchers and cases reports and homeopathic "provings" ...

    Authors: Trevor DB Thompson

    Citation: BMC Medical Research Methodology 2004 4:4

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  32. Content type: Research article

    Effective strategies for implementing best practices in low and middle income countries are needed. RHL is an annually updated electronic publication containing Cochrane systematic reviews, commentaries and pr...

    Authors: A Metin Gülmezoglu, José Villar, Jeremy Grimshaw, Gilda Piaggio, Pisake Lumbiganon and Ana Langer

    Citation: BMC Medical Research Methodology 2004 4:2

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  33. Content type: Debate

    Controlled clinical trials of health care interventions are either explanatory or pragmatic. Explanatory trials test whether an intervention is efficacious; that is, whether it can have a beneficial effect in ...

    Authors: Marshall Godwin, Lucia Ruhland, Ian Casson, Susan MacDonald, Dianne Delva, Richard Birtwhistle, Miu Lam and Rachelle Seguin

    Citation: BMC Medical Research Methodology 2003 3:28

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  34. Content type: Research article

    In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated t...

    Authors: Penny Whiting, Anne WS Rutjes, Johannes B Reitsma, Patrick MM Bossuyt and Jos Kleijnen

    Citation: BMC Medical Research Methodology 2003 3:25

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  35. Content type: Study protocol

    Public health research involving social or kin groups (such as sexual partners or family members), rather than samples of unrelated individuals, has become more widespread in response to social ecological appr...

    Authors: James M McMahon, Stephanie Tortu, Leilani Torres, Enrique R Pouget and Rahul Hamid

    Citation: BMC Medical Research Methodology 2003 3:24

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  36. Content type: Research article

    Cross-sectional studies with binary outcomes analyzed by logistic regression are frequent in the epidemiological literature. However, the odds ratio can importantly overestimate the prevalence ratio, the measu...

    Authors: Aluísio JD Barros and Vânia N Hirakata

    Citation: BMC Medical Research Methodology 2003 3:21

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  37. Content type: Debate

    While the desirability of interdisciplinary inquiry has been widely acknowledged, indeed has become 'the mantra of science policy', the methods of interdisciplinary collaboration are opaque to outsiders and gener...

    Authors: David W Robertson, Douglas K Martin and Peter A Singer

    Citation: BMC Medical Research Methodology 2003 3:20

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