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  1. To report our recommended methodology for extracting and then confirming research uncertainties – areas where research has failed to answer a research question – derived from previously published literature du...

    Authors: D. J. C. Grindlay, T. R. C. Davis, D. Kennedy, D. Larson, D. Furniss, K. Cowan, G. Giddins, A. Jain, R. W. Trickett and A. Karantana
    Citation: BMC Medical Research Methodology 2022 22:292
    Content type: Research Published on:

  2. Two common ways of assessing the clinical relevance of treatment outcomes are the minimal important difference (MID) and the patient acceptable symptom state (PASS). The former represents the smallest change i...

    Authors: Thomas Ibounig, Joona Juurakko, Tuomas Lähdeoja, Bakir O. Sumrein, Teppo L. N. Järvinen, Mika Paavola, Clare L. Ardern, Teemu Karjalainen, Simo Taimela and Lasse Rämö
    Citation: BMC Medical Research Methodology 2022 22:291
    Content type: Research Published on:

  3. There are situations when we need to model multiple time-scales in survival analysis. A usual approach in this setting would involve fitting Cox or Poisson models to a time-split dataset. However, this leads t...

    Authors: Nurgul Batyrbekova, Hannah Bower, Paul W. Dickman, Anna Ravn Landtblom, Malin Hultcrantz, Robert Szulkin, Paul C. Lambert and Therese M-L. Andersson
    Citation: BMC Medical Research Methodology 2022 22:290
    Content type: Research Published on:

  4. A short instrument would enhance the viability of a study. Therefore, we aimed to shorten the specific module (SPD-10) of the Quality of Life Instrument for Chronic Diseases - Chronic Renal Failure (QLICD-CRF)...

    Authors: Zhengqin Xiao, Yuxi Liu, Daniel Yee-Tak Fong, Xinping Huang, Min Weng and Chonghua Wan
    Citation: BMC Medical Research Methodology 2022 22:289
    Content type: Research Published on:

  5. Investigations of participant retention in longitudinal health and medical research, document  strategies that work best but overlook social marketing’s capacity to influence participant retention. After apply...

    Authors: Leesa Costello, Julie Dare, Manon Dontje, Claire Lambert and Leon Straker
    Citation: BMC Medical Research Methodology 2022 22:288
    Content type: Research article Published on:

  6. The increased adoption of the internet, social media, wearable devices, e-health services, and other technology-driven services in medicine and healthcare has led to the rapid generation of various types of di...

    Authors: Fang Liu and Demosthenes Panagiotakos
    Citation: BMC Medical Research Methodology 2022 22:287
    Content type: Review Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2023 23:109

  7. Risk prediction models are useful tools in clinical decision-making which help with risk stratification and resource allocations and may lead to a better health care for patients. AutoScore is a machine learni...

    Authors: Seyed Ehsan Saffari, Yilin Ning, Feng Xie, Bibhas Chakraborty, Victor Volovici, Roger Vaughan, Marcus Eng Hock Ong and Nan Liu
    Citation: BMC Medical Research Methodology 2022 22:286
    Content type: Research Published on:

  8. Meta-analyses of analgesic medicines for low back pain often rescale measures of pain intensity to use mean difference (MD) instead of standardised mean difference for pooled estimates. Although this improves ...

    Authors: Michael A. Wewege, Matthew D. Jones, Sam A. Williams, Steven J. Kamper and James H. McAuley
    Citation: BMC Medical Research Methodology 2022 22:285
    Content type: Research Published on:

  9. Cox proportional hazards regression models and machine learning models are widely used for predicting the risk of dementia. Existing comparisons of these models have mostly been based on empirical datasets and...

    Authors: Meng Wang, Matthew Greenberg, Nils D. Forkert, Thierry Chekouo, Gabriel Afriyie, Zahinoor Ismail, Eric E. Smith and Tolulope T. Sajobi
    Citation: BMC Medical Research Methodology 2022 22:284
    Content type: Research Published on:

  10. Semi-continuous data characterized by an excessive proportion of zeros and right-skewed continuous positive values appear frequently in medical research. One example would be the pharmaceutical expenditure (PE...

    Authors: Naser Kamyari, Ali Reza Soltanian, Hossein Mahjub, Abbas Moghimbeigi and Maryam Seyedtabib
    Citation: BMC Medical Research Methodology 2022 22:283
    Content type: Research Published on:

  11. There is growing enthusiasm for the application of machine learning (ML) and artificial intelligence (AI) techniques to clinical research and practice. However, instructions on how to develop robust high-quali...

    Authors: André Pfob, Sheng-Chieh Lu and Chris Sidey-Gibbons
    Citation: BMC Medical Research Methodology 2022 22:282
    Content type: Research Published on:

  12. The aim of this study was to evaluate the most effective combination of autoregressive integrated moving average (ARIMA), a time series model, and association rule mining (ARM) techniques to identify meaningfu...

    Authors: Rachasak Somyanonthanakul, Kritsasith Warin, Watchara Amasiri, Karicha Mairiang, Chatchai Mingmalairak, Wararit Panichkitkosolkul, Krittin Silanun, Thanaruk Theeramunkong, Surapon Nitikraipot and Siriwan Suebnukarn
    Citation: BMC Medical Research Methodology 2022 22:281
    Content type: Research Published on:

  14. Temporally harmonized asset indices allow the study of changes in relative wealth (mean, variance, social mobility) over time and its association with adult health and human capital in cohort studies. Conditio...

    Authors: Jithin Sam Varghese, Clive Osmond and Aryeh D. Stein
    Citation: BMC Medical Research Methodology 2022 22:279
    Content type: Research Published on:

  15. Given the inherent challenges of conducting randomized phase III trials in older cancer patients, single-arm phase II trials which assess the feasibility of a treatment that has already been shown to be effect...

    Authors: Bastien Cabarrou, Eve Leconte, Patrick Sfumato, Jean-Marie Boher and Thomas Filleron
    Citation: BMC Medical Research Methodology 2022 22:278
    Content type: Research Published on:

  16. The Headache Impact Test (HIT-6) and the Chronic Headache Questionnaire (CH-QLQ) measure headache-related quality of life but are not preference-based and therefore cannot be used to generate health utilities ...

    Authors: Kamran Khan, Hema Mistry, Manjit Matharu, Chloe Norman, Stavros Petrou, Kimberley Stewart, Martin Underwood and Felix Achana
    Citation: BMC Medical Research Methodology 2022 22:277
    Content type: Research Published on:

  17. The exponential growth of published systematic reviews (SRs) presents challenges for decision makers seeking to answer clinical, public health or policy questions. In 1997, an algorithm was created by Jadad et...

    Authors: C Lunny, Sai Surabi Thirugnanasampanthar, S Kanji, N Ferri, D Pieper, S Whitelaw, S Tasnim, H Nelson, EK Reid, Jia He (Janet) Zhang, Banveer Kalkat, Yuan Chi, Reema Abdoulrezzak, Di Wen Zheng, Lindy R.S. Pangka, Dian (Xin Ran) Wang…
    Citation: BMC Medical Research Methodology 2022 22:276
    Content type: Research Published on:

  18. Currently, the direct method is the main approach for establishment of reference interval (RI). However, only a handful of studies have described the effects of sample size on establishment of RI and estimatio...

    Authors: Chaochao Ma, Li’an Hou, Yutong Zou, Xiaoli Ma, Danchen Wang, Yingying Hu, Ailing Song, Xinqi Cheng and Ling Qiu
    Citation: BMC Medical Research Methodology 2022 22:275
    Content type: Research Published on:

  19. Reliable evidence on the effectiveness of interventions to prevent diabetes-related foot ulceration is essential to inform clinical practice. Well-conducted systematic reviews that synthesise evidence from all...

    Authors: Fay Crawford, Donald J. Nicolson, Aparna E. Amanna and Marie Smith
    Citation: BMC Medical Research Methodology 2022 22:274
    Content type: Research Published on:

  20. Functional connectivity (FC) studies are often performed to discern different patterns of brain connectivity networks between healthy and patient groups. Since many neuropsychiatric disorders are related to th...

    Authors: Fatemeh Pourmotahari, Hassan Doosti, Nasrin Borumandnia, Seyyed Mohammad Tabatabaei and Hamid Alavi Majd
    Citation: BMC Medical Research Methodology 2022 22:273
    Content type: Research Published on:

  21. Our aim was to extend traditional parametric models used to extrapolate survival in cost-effectiveness analyses (CEAs) by integrating individual-level patient data (IPD) from a clinical trial with estimates fr...

    Authors: Dieter Ayers, Shannon Cope, Kevin Towle, Ali Mojebi, Thomas Marshall and Devender Dhanda
    Citation: BMC Medical Research Methodology 2022 22:272
    Content type: Research Published on:

  22. Healthcare provider profiling involves the comparison of outcomes between patients cared for by different healthcare providers. An important component of provider profiling is risk-adjustment so that providers...

    Authors: Peter C. Austin
    Citation: BMC Medical Research Methodology 2022 22:271
    Content type: Research Published on:

  23. Mapping spacetime disease rates can provide a more in-depth understanding of their distribution and trends. Traditional spatiotemporal kriging methods can break the constraints of geopolitical boundaries and t...

    Authors: Dai-Rong Tsai, Jing-Rong Jhuang, Shih-Yung Su, Chun-Ju Chiang, Ya-Wen Yang and Wen-Chung Lee
    Citation: BMC Medical Research Methodology 2022 22:270
    Content type: Research Published on:

  24. This study aimed at utilizing a Bayesian approach semi-competing risks technique to model the underlying predictors of early recurrence and postoperative Death in patients with colorectal cancer (CRC).

    Authors: Leila Mahmoudi, Ramezan Fallah, Ghodratollah Roshanaei and Mohammad Asghari-Jafarabadi
    Citation: BMC Medical Research Methodology 2022 22:269
    Content type: Research Published on:

  25. The Nine-Questions Depression-Rating Scale (9Q) has been developed as an alternative assessment tool for assessing the severity of depressive symptoms in Thai adults. The traditional unweighted sum scoring app...

    Authors: Suttipong Kawilapat, Benchalak Maneeton, Narong Maneeton, Sukon Prasitwattanaseree, Thoranin Kongsuk, Suwanna Arunpongpaisal, Jintana Leejongpermpoon, Supattra Sukhawaha and Patrinee Traisathit
    Citation: BMC Medical Research Methodology 2022 22:268
    Content type: Research Published on:

  26. This paper is part of a broader investigation into the ways in which health and social care guideline producers are using qualitative evidence syntheses (QESs) alongside more established methods of guideline d...

    Authors: Chris Carmona, Susan Baxter and Christopher Carroll
    Citation: BMC Medical Research Methodology 2022 22:267
    Content type: Research Published on:

  27. Lymphoma is a malignancy of lymphocytes and lymphoid tissues comprising a heterogeneous group of diseases, with up to 80 entities now described. Lymphoma is the 6th most common cancer in Australia, affecting pati...

    Authors:
    Citation: BMC Medical Research Methodology 2022 22:266
    Content type: Research Published on:

  28. The failure of randomised controlled trials to adequately reflect areas of highest health need have been repeatedly highlighted. This has implications for the validity and generalisability of findings, for equ...

    Authors: Jennifer MacLellan, Joanne Turnbull and Catherine Pope
    Citation: BMC Medical Research Methodology 2022 22:265
    Content type: Research Published on:

  29. Biological products, whether they are innovator products or biosimilars, can incite an immunogenic response ensuing in the development of anti-drug antibodies (ADA). The presence of ADA’s often affects the dru...

    Authors: Halimu N. Haliduola, Fausto Berti, Heimo Stroissnig, Eric Guenzi, Hendrik Otto, Abid Sattar and Ulrich Mansmann
    Citation: BMC Medical Research Methodology 2022 22:264
    Content type: Research Published on:

  31. Incomplete and inconsistent reporting of adverse events (AEs) through multiple sources can distort impressions of the overall safety of the medical interventions examined as well as the benefit-risk relationsh...

    Authors: Ivan Paladin and Shelly Melissa Pranić
    Citation: BMC Medical Research Methodology 2022 22:262
    Content type: Research Published on:

  32. Count data from the national survey captures healthcare utilisation within a specific reference period, resulting in excess zeros and skewed positive tails. Often, it is modelled using count data models. This ...

    Authors: Nurul Salwana Abu Bakar, Jabrullah Ab Hamid, Mohd Shaiful Jefri Mohd Nor Sham, Mohd Nor Sham and Anis Syakira Jailani
    Citation: BMC Medical Research Methodology 2022 22:261
    Content type: Research Published on:

  33. Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials. Al...

    Authors: Corinne Jamoul, Laurence Collette, Elisabeth Coart, Koenraad D’Hollander, Tomasz Burzykowski, Everardo D. Saad and Marc Buyse
    Citation: BMC Medical Research Methodology 2022 22:260
    Content type: Research Published on:

  34. Although there are discussions regarding standards of the analysis of patient-reported outcomes and quality of life (QOL) in oncology clinical trials, that of QOL with death events is not within their scope. F...

    Authors: Kentaro Sakamaki and Takuya Kawahara
    Citation: BMC Medical Research Methodology 2022 22:259
    Content type: Research Published on:

  36. To describe the temporal trend of the number of new congenital heart disease (CHD) cases among newborns in Jinhua from 2019 to 2020 and explored an appropriate model to fit and forecast the tendency of CHD.

    Authors: Weize Xu, Zehua Shao, Hongliang Lou, Jianchuan Qi, Jihua Zhu, Die Li and Qiang Shu
    Citation: BMC Medical Research Methodology 2022 22:257
    Content type: Research Published on:

  37. Assessing the long term effects of many surgical interventions tested in pragmatic RCTs may require extended periods of participant follow-up to assess effectiveness and use patient-reported outcomes that requ...

    Authors: Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson and Andrew Metcalfe
    Citation: BMC Medical Research Methodology 2022 22:256
    Content type: Research Published on:

  38. Qualitative longitudinal research (QLR) comprises qualitative studies, with repeated data collection, that focus on the temporality (e.g., time and change) of a phenomenon. The use of QLR is increasing in heal...

    Authors: Åsa Audulv, Elisabeth O. C. Hall, Åsa Kneck, Thomas Westergren, Liv Fegran, Mona Kyndi Pedersen, Hanne Aagaard, Kristianna Lund Dam and Mette Spliid Ludvigsen
    Citation: BMC Medical Research Methodology 2022 22:255
    Content type: Research Published on:

  39. By substituting the general ‘susceptibility factor’ concept for the conventional ‘gene’ concept in the case-only approach for gene-environment interaction, the case-only approach can also be used in environmen...

    Authors: Jinyoung Moon and Hwan-Cheol Kim
    Citation: BMC Medical Research Methodology 2022 22:254
    Content type: Research Published on:

  40. The Symptom Checklist (SCL) developed by the Health Behaviour in School-aged Children (HBSC) study is a non-clinical measure of psychosomatic complaints (e.g., headache and feeling low) that has been used in n...

    Authors: Andreas Heinz, Philipp E. Sischka, Carolina Catunda, Alina Cosma, Irene García-Moya, Nelli Lyyra, Anne Kaman, Ulrike Ravens-Sieberer and William Pickett
    Citation: BMC Medical Research Methodology 2022 22:253
    Content type: Research Published on:

  41. Men are often viewed as a difficult group to recruit for psychological research, including in psycho-oncology. Whilst research has demonstrated the effectiveness of small monetary incentives for encouraging re...

    Authors: Megan McIntosh, Melissa J. Opozda, Michael O’Callaghan, Andrew D. Vincent, Daniel A. Galvão and Camille E. Short
    Citation: BMC Medical Research Methodology 2022 22:252
    Content type: Research Published on:

  42. In the context of the COVID-19 pandemic, social science research has required recruiting many prospective participants. Many researchers have explicitly taken advantage of widespread public interest in COVID-1...

    Authors: Eric B. Kennedy, Mia Charifson, Megan Jehn, Eric A. Jensen and Jenna Vikse
    Citation: BMC Medical Research Methodology 2022 22:251
    Content type: Research Published on:

  43. Missing data are ubiquitous in randomised controlled trials. Although sensitivity analyses for different missing data mechanisms (missing at random vs. missing not at random) are widely recommended, they are r...

    Authors: Andreas Staudt, Jennis Freyer-Adam, Till Ittermann, Christian Meyer, Gallus Bischof, Ulrich John and Sophie Baumann
    Citation: BMC Medical Research Methodology 2022 22:250
    Content type: Research Published on:

  44. Participant recruitment is one of the main challenges in research. It is suggested that including researcher photographs might increase participation rates, but empirical evidence is lacking. This study within...

    Authors: Barbara Prediger, Nadja Könsgen, Ana-Mihaela Bora, Anna Schlimbach and Dawid Pieper
    Citation: BMC Medical Research Methodology 2022 22:249
    Content type: Research Published on:

  45. Previous studies support cultural tailoring of recruitment materials as a strategy to promote the enrollment of minoritized groups in clinical trials. However, there is a lack of guidance for research teams to...

    Authors: Jennifer Cunningham-Erves, Sheila V. Kusnoor, Victoria Villalta-Gil, Sarah C. Stallings, Jabari S. Ichimura, Tiffany L. Israel, Paul A. Harris and Consuelo H. Wilkins
    Citation: BMC Medical Research Methodology 2022 22:248
    Content type: Research Published on:

  47. The Posttraumatic growth inventory (PTGI) aims to assess the positive psychological changes that individuals can perceive after a traumatic life event such as a cancer diagnosis. Several French translations of...

    Authors: Yseulys Dubuy, Véronique Sébille, Marianne Bourdon, Jean-Benoit Hardouin and Myriam Blanchin
    Citation: BMC Medical Research Methodology 2022 22:246
    Content type: Research Published on:

  49. A sample size justification is required for all studies and should give the minimum number of subjects to be recruited for the study to achieve its primary objective. The aim of this review is to describe samp...

    Authors: Oscar Han, Hao Wei Tan, Steven Julious, Laura Sutton, Richard Jacques, Ellen Lee, Jen Lewis and Stephen Walters
    Citation: BMC Medical Research Methodology 2022 22:242
    Content type: Research Published on:

  50. Many studies rely on self-reported height and weight. While a substantial body of literature exists on misreporting of height and weight, little exists on improving accuracy. The aim of this study was to deter...

    Authors: Nina Van Dyke, Eric J. Drinkwater and Jerome N. Rachele
    Citation: BMC Medical Research Methodology 2022 22:241
    Content type: Research Published on:
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BMC Medical Research Methodology

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