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Power estimation of tests in log-linear non-uniform association models for ordinal agreement
- Fabien Valet^{1}Email author and
- Jean-Yves Mary^{2}
https://doi.org/10.1186/1471-2288-11-70
© Valet and Mary; licensee BioMed Central Ltd. 2011
Received: 12 August 2010
Accepted: 17 May 2011
Published: 17 May 2011
Abstract
Background
Log-linear association models have been extensively used to investigate the pattern of agreement between ordinal ratings. In 2007, log-linear non-uniform association models were introduced to estimate, from a cross-classification of two independent raters using an ordinal scale, varying degrees of distinguishability between distant and adjacent categories of the scale.
Methods
In this paper, a simple method based on simulations was proposed to estimate the power of non-uniform association models to detect heterogeneities across distinguishabilities between adjacent categories of an ordinal scale, illustrating some possible scale defects.
Results
Different scenarios of distinguishability patterns were investigated, as well as different scenarios of marginal heterogeneity within rater. For sample size of N = 50, the probabilities of detecting heterogeneities within the tables are lower than .80, whatever the number of categories. In additition, even for large samples, marginal heterogeneities within raters led to a decrease in power estimates.
Conclusion
This paper provided some issues about how many objects had to be classified by two independent observers (or by the same observer at two different times) to be able to detect a given scale structure defect. Our results also highlighted the importance of marginal homogeneity within raters, to ensure optimal power when using non-uniform association models.
Background
Initially developped in psychometrics to assess the severity of behavioral troubles or disturbances [1–3], ordinal rating scales (ORS) are now essential tools in health research and health care: for example to measure clinical outcomes such as symptom grading [4], pathologists finding [5], disease severity [6], treatment response [7–9], as well as health-related quality of life [10, 11]. When the same objects are classified twice on a scale, differences in perception of one observer to another, or of the same observer at two successive times, lead to inter-rater and intra-rater variability. For patients, reproducibility of ratings made using an ORS is a major issue because their classification into one of the different categories may have important consequences on their therapeutic follow-up and possibly on their quality of life. There are two main components of reproducibility. The first component is marginal homogeneity between raters, which corresponds to the differences in raters marginal distributions and refers to the tendencies of a rater to make classifications higher or lower than those of the other rater. The second component is category distinguishability, that is to say the ability for observers to distinguish between categories. Recently, non-uniform association models (NUA) were proposed by Valet et al. [12] to estimate degrees of distinguishability between adjacent categories of an ORS. These models allowed to test different patterns of distinguishability and then to give information of the scale structure quality.
When designing a reproducibility study with two observers (or one observer at two different times) assessing the same objects on an ORS, two major questions have to be solved: How many objects has to be classified by the two observers to be able to detect a given heterogeneous pattern of distinguishability between adjacent categories? Is it important to select these objects in an attempt to approximate some marginal distributions? In this study, simulations were used to estimate the power of non-uniform association models to detect heterogeneities across distinguishabilities between adjacent categories as a function of typical distinguishability patterns and total number of objects classified, assuming homogeneous marginal distribution within reader and between readers. Then, for the same numbers of objects classified twice, the influence of different patterns of marginal heterogeneity within reader on power estimate was studied.
Methods
Log-linear non-uniform association models
Log-linear modelling and parameters interpretation
where μ is the overall effect and and are A and B effects on category i and j, respectively. For this model, agreement between raters is expected to be due to chance only.
When analyzing agreement in ordered contingency table, we can usually expect an association between ratings due to the natural ordering of the scale. As described by several authors [12–15], this association between rating is expected to increase as the distance between categories increases. For instance on a five-level severity scale, if an object is rated "1" by A, the probability for this object to be rated "5" by B is very low [16]. This association can be expressed through odds ratio τ _{ ij } = m _{ ii } m _{ jj } /m _{ ij } m _{ ji } . An odds ratio value equal to 1 indicates that the two ratings are independent. From odds ratio τ _{ ij }, Darroch and McCloud defined as the degree of distinguishability (DD) between two categories of an ORS, that is to say the readers' ability to distinguish between these two categories [17]. A DD value close to 1 indicates an almost perfect distinguishability between the two corresponding categories whereas a DD value close to 0 indicates that these two categories are very hard to distinguish.
Uniform Association (UA) and Non-Uniform Association (NUA) models
illustrating the possible DDs variations between categories, even between adjacent ones. NUA models are a generalization of UA models. Indeed, UA model is a particular case of a NUA model where parameters β _{ k } , _{ k+1}are all equal (do not depend on k). Comparison of log-likelihood of data when using UA and NUA models allows us to test DDs homogeneity between adjacent categories and can provide useful information on scale structure. See Valet et al. [12, 16] for a complete description of the NUA models and the possible patterns of distinguishability that can be tested.
Power estimation of tests in NUA models
To investigate the ability of NUA models to detect heterogeneities within the DDs between adjacent categories, a simple method was proposed to simulate ordered contingency tables resulting from the use of ORS having different patterns of distinguishability between their adjacent categories. Hereafter, tests were defined for a null hypothesis H _{0} corresponding to the UA model defined by equation (2), and alternative hypotheses H _{1} corresponding to NUA models defined by equation (3). Different scenarios of DDs heterogeneity were proposed to illustrate different typical scale structures. In all situations, marginal homogeneity between readers was assumed, which can be expressed as: .
Simulation of I × I contingency tables from the NUA models
The first set of equations of the system defined by (6) allows us to control the marginal probabilities distribution during simulations, i.e. to control marginal probabilities . (upperscript "S" stands for simulations). The second condition of the system ensures that μ remains the overall effect [18]. As the number of equation is equal to the number of unknown parameters, the system can be easily solved using classical algorithm that can find roots of nonlinear systems, as the well-known Newton-Krylov method for example [19, 20]. However, in this paper, a new method proposed by Lacruz et al. [21] was used. This "non-monotone spectral residual" method can find roots of nonlinear systems, by working without gradient information and it was shown to be competitive and frequently better than usual algorithms.
Many different scenarios of distinguishability patterns can be simulated, using different sets of {β _{ k,k+1}; k = 1,..., I - 1} in the NUA model. Suppose we aim to test all possible patterns of distinguishability, we will have to compare the null UA model (all β _{ k, k+1}are equal) and NUA models with all possible combinations of association parameters, i.e. to test all possible equalities between association parameters. For example, testing equality of exactly B (B = 2,..., I - 1) association parameters in a NUA model with I - 1 association parameters would already yield to comparisons. However, our aim was not to simulate exhaustively all possible patterns of distinguishability but credible patterns corresponding to typical scale structures in inter or intra-observer variation study. Therefore, as defined in Valet et al. [12] only combinations of "symmetric" and "close" association parameters were considered, that is to say NUA models where equality of some symmetric and close association parameters was assumed, respectively.
Definition of alternative hypotheses
Examples of association parameters and distinguishability patterns between adjacent categories from NUA models in a 5 × 5 contingency table
Hypothesis | Association parameters | Distinguishability patterns |
---|---|---|
H _{0} | All association parameters are equal | |
β _{1,2} = β _{2,3} = β _{3,4} = β _{4,5} = log(3) | 1 ---- 2 ---- 3 ---- 4 ---- 5 | |
1 association parameter is different | ||
β _{1,2} ≠ β _{2,3} = β _{3,4} = β _{4,5} = log(3) | 1 - 2 ---- 3 ---- 4 ---- 5 1-------- 2 - 3 - 4 ---- 5 | |
β _{2,3} ≠ β _{1,2} = β _{3,4} = β _{4,5} = log(3) | 1 ---- 2 - 3 ---- 4 ---- 5 1 -- 2-------- 3 - 4 -- 5 | |
Β _{3,4} ≠ β _{1,2} = β _{2,3} = β _{4,5} = log(3) | 1------ 2 -- 3 - 4 -- 5 1 -- 2 - 3 ------ 4 - 5 | |
Β _{4,5} ≠ β _{1,2} = β _{2,3} = β _{3,4} = log(3) | 1 ---- 2 ---- 3 ---- 4 - 5 1 - 2 -- 3 - 4 ---------- 5 | |
2 association parameters are different | ||
β _{1,2} = β _{2,3} ≠ β _{3,4} = β _{4,5} = log(3) | 1-2 - 3------4------5 1------2------ 3-4-5 | |
β _{1,2} = β _{4,3} ≠ β _{2,3} = β _{3,4} = log(3) | 1--2---- 3---- 4--5 1 ---- 2 - 3 - 4 ---- 5 | |
All association parameters are different | ||
β _{1,2} ≠ β _{2,3} ≠ β _{3,4} ≠ β _{4,5} | 1 - 2 ---- 3 -- 4 ------ 5 |
From the UA model where all association parameters are equal (H _{0} hypothesis), a different value just for one association parameter ( hypotheses) can be used, to account for a scale defect between two categories only (categories are regularly spaced along the scale in terms of distinguishabilities, except two). Equal values for symmetric (for instance it is easier to distinguish extreme categories than to distinguish intermediate categories) or close (for instance it is easier to distinguish lower categories on the scale than upper categories) association parameters can also be used as described by hypotheses . Finally, taking different values for all association parameters ( hypothesis) illustrates an ORS where all categories are irregularly spaced in terms of distinguishabilities.
Distribution of marginal probabilities
Sets of marginal theoretical probabilities in a 5 × 5 contingency table used in our simulations
Description | |||||
---|---|---|---|---|---|
.20 | .20 | .20 | .20 | .20 | Homogeneous distribution |
.05 | .24 | .24 | .24 | .23 | Few counts in first category |
.24 | .05 | .24 | .24 | .23 | Few counts in intermediate category |
.24 | .24 | .05 | .24 | .23 | Few counts in central category |
.05 | .30 | .30 | .30 | .05 | Few counts in extreme categories |
.05 | .05 | .30 | .30 | .30 | Few counts in the first two adjacent categories |
.05 | .15 | .40 | .30 | .10 | Heterogeneous distribution |
Power and Type I error estimation
For each specific set of {β _{ k, k+1}; k = 1,..., 4} and , parameters μ and λ _{ i } were calculated using the non-linear system defined by (6). Probabilities π _{ ij } of the multinomial distribution were calculated from equation (5), using the specific set of {β _{ k, k+1}; k = 1,..., 4} and the previously calculated values of μ and λ _{ i } . Then, 10000 simulations of 5 × 5 contingency tables summarizing classifications of N objects were drawn. The same null hypothesis of equal DDs between all adjacent categories was used. For this null hypothesis, a common value β _{1,2} = β _{2,3} = β _{3,4} = β _{4,5} = log(3) was chosen, corresponding to similar association between adjacent ratings (τ _{1,2} = τ _{2,3} = τ _{3,4} = τ _{4,5} = 3) and hence similar DDs between all adjacent categories. To account for different null hypotheses, we also proposed a common value of β _{1,2} = β _{2,3} = β _{3,4} = β _{4,5} log(2) and β _{1,2} = β _{2,3} = β _{3,4} = β _{4,5} = log(4). For each simulation, the log-likelihood of UA model (H _{0}) and NUA models defined by H _{1} were calculated. As proposed by several authors [12, 18], the G ^{2} likelihood ratio-statistic was used to compare these two models. Indeed, we used the difference statistics , which are chi-squared distributed, with Δdf = df _{ UA } - df _{ NUA } degrees of freedom. For the different tests corresponding to hypotheses , and , differences Δdf were equal to 1, 1 and 3, respectively. For each scenario, power was estimated as the proportion of significant NUA models when applied on contincency tables simulated under the same alternative hypothesis. Type one error α was estimated as the proportion of significant NUA models when applied on contingency tables simulated under the null hypothesis.
Results
N= | 50 | 100 | 150 | 200 | 250 | 50 | 100 | 150 | 200 | 250 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β _{12} | OR | DD | a. | d. | ||||||||||
.00 | 1 | .00 | .34 | .57 | .74 | .85 | .92 | .21 | .30 | .43 | .54 | .63 | ||
.69 | 2 | .50 | .10 | .12 | .16 | .19 | .21 | .10 | .10 | .10 | .11 | .13 | ||
1.10 | 3 | .67 | .07 | .06 | .06 | .05 | .05 | .09 | .10 | .07 | .06 | .06 | ||
1.39 | 4 | .75 | .08 | .08 | .10 | .11 | .12 | .11 | .13 | .11 | .10 | .10 | ||
1.61 | 5 | .80 | .11 | .14 | .17 | .21 | .26 | .14 | .17 | .16 | .16 | .18 | ||
1.79 | 6 | .83 | .15 | .20 | .27 | .35 | .42 | .15 | .21 | .21 | .23 | .25 | ||
1.95 | 7 | .86 | .18 | .27 | .38 | .46 | .55 | .17 | .25 | .26 | .29 | .33 | ||
2.08 | 8 | .87 | .22 | .34 | .45 | .56 | .67 | .18 | .29 | .31 | .34 | .40 | ||
2.20 | 9 | .88 | .24 | .39 | .54 | .66 | .76 | .20 | .30 | .35 | .40 | .48 | ||
2.30 | 10 | .90 | .28 | .43 | .60 | .73 | .82 | .21 | .35 | .40 | .44 | .52 | ||
2.48 | 12 | .92 | .33 | .53 | .70 | .83 | .89 | .23 | .39 | .45 | .52 | .61 | ||
2.64 | 14 | .93 | .38 | .61 | .78 | .89 | .95 | .26 | .43 | .52 | .58 | .67 | ||
2.77 | 16 | .94 | .42 | .67 | .83 | .92 | .97 | .26 | .47 | .56 | .63 | .73 | ||
β _{12}, β _{23} | OR | DD | b. | e. | ||||||||||
.00 | 1 | .00 | .73 | .95 | .99 | 1 | 1 | .59 | .84 | .96 | .99 | 1 | ||
.69 | 2 | .50 | .14 | .21 | .28 | .35 | .42 | .13 | .17 | .24 | .29 | .37 | ||
1.10 | 3 | .67 | .06 | .06 | .05 | .05 | .05 | .09 | .07 | .06 | .06 | .06 | ||
1.39 | 4 | .75 | .09 | .10 | .13 | .15 | .18 | .12 | .13 | .14 | .15 | .17 | ||
1.61 | 5 | .80 | .13 | .19 | .26 | .33 | .39 | .17 | .20 | .26 | .31 | .36 | ||
1.79 | 6 | .83 | .19 | .29 | .40 | .50 | .59 | .21 | .27 | .36 | .43 | .51 | ||
1.95 | 7 | .86 | .22 | .37 | .51 | .64 | .74 | .26 | .34 | .46 | .55 | .66 | ||
2.08 | 8 | .87 | .27 | .47 | .62 | .74 | .82 | .28 | .39 | .54 | .64 | .74 | ||
2.20 | 9 | .88 | .32 | .53 | .69 | .81 | .89 | .32 | .45 | .61 | .71 | .81 | ||
2.30 | 10 | .90 | .35 | .57 | .76 | .87 | .92 | .35 | .49 | .66 | .77 | .85 | ||
2.48 | 12 | .92 | .41 | .67 | .84 | .92 | .97 | .40 | .56 | .74 | .84 | .92 | ||
2.64 | 14 | .93 | .46 | .74 | .89 | .96 | .99 | .44 | .61 | .79 | .88 | .95 | ||
2.77 | 16 | .94 | .50 | .79 | .93 | .97 | .99 | .46 | .66 | .84 | .92 | .97 | ||
β _{12}, β _{45} | OR | DD | c. | f. | ||||||||||
.00 | 1 | .00 | .37 | .64 | .80 | .90 | .95 | .18 | .32 | .45 | .57 | .67 | ||
.69 | 2 | .50 | .10 | .13 | .17 | .21 | .25 | .09 | .10 | .11 | .13 | .15 | ||
1.10 | 3 | .67 | .06 | .06 | .05 | .05 | .05 | .08 | .06 | .06 | .05 | .05 | ||
1.39 | 4 | .75 | .08 | .08 | .10 | .12 | .14 | .09 | .09 | .09 | .09 | .10 | ||
1.61 | 5 | .80 | .11 | .16 | .21 | .27 | .31 | .12 | .13 | .16 | .18 | .22 | ||
1.79 | 6 | .83 | .15 | .24 | .33 | .42 | .49 | .15 | .19 | .24 | .30 | .35 | ||
1.95 | 7 | .86 | .20 | .32 | .44 | .55 | .66 | .18 | .25 | .32 | .41 | .47 | ||
2.08 | 8 | .87 | .25 | .41 | .55 | .67 | .77 | .21 | .30 | .40 | .50 | .59 | ||
2.20 | 9 | .88 | .28 | .47 | .63 | .76 | .84 | .23 | .35 | .47 | .58 | .67 | ||
2.30 | 10 | .90 | .32 | .53 | .71 | .82 | .90 | .27 | .40 | .53 | .65 | .74 | ||
2.48 | 12 | .92 | .38 | .64 | .81 | .90 | .95 | .32 | .18 | .64 | .76 | .84 | ||
2.64 | 14 | .93 | .45 | .71 | .87 | .95 | .98 | .37 | .56 | .73 | .84 | .90 | ||
2.77 | 16 | .94 | .49 | .77 | .91 | .97 | .99 | .40 | .61 | .78 | .89 | .94 |
N= | 50 | 100 | 150 | 200 | 250 | H _{1} ^{11} | 50 | 100 | 150 | 200 | 250 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β _{12} | OR | DD | a. | d. | ||||||||||
.00 | 1 | .00 | .22 | .38 | .51 | .59 | .72 | .14 | .16 | .21 | .26 | .32 | ||
.69 | 2 | .50 | .06 | .05 | .05 | .05 | .06 | .07 | .07 | .07 | .06 | .06 | ||
1.10 | 3 | .67 | .11 | .13 | .17 | .22 | .26 | .10 | .10 | .10 | .10 | .14 | ||
1.39 | 4 | .75 | .16 | .25 | .41 | .48 | .57 | .13 | .15 | .21 | .25 | .28 | ||
1.61 | 5 | .80 | .26 | .41 | .56 | .67 | .79 | .17 | .22 | .29 | .36 | .43 | ||
1.79 | 6 | .83 | .33 | .52 | .70 | .82 | .88 | .22 | .30 | .39 | .47 | .55 | ||
1.95 | 7 | .86 | .38 | .63 | .78 | .92 | .94 | .25 | .34 | .46 | .57 | .66 | ||
2.08 | 8 | .87 | .43 | .72 | .85 | .94 | .98 | .30 | .41 | .56 | .62 | .74 | ||
2.20 | 9 | .88 | .47 | .76 | .90 | .97 | .99 | .34 | .43 | .58 | .70 | .78 | ||
2.30 | 10 | .90 | .52 | .79 | .94 | .98 | .99 | .38 | .51 | .67 | .74 | .86 | ||
2.48 | 12 | .92 | .58 | .85 | .96 | .99 | 1 | .39 | .55 | .71 | .81 | .91 | ||
2.64 | 14 | .93 | .64 | .90 | .97 | 1 | 1 | .41 | .58 | .78 | .86 | .93 | ||
2.77 | 16 | .94 | .69 | .95 | .99 | 1 | 1 | .46 | .62 | .84 | .88 | .97 | ||
β _{12}, β _{23} | OR | DD | b. | e. | ||||||||||
.00 | 1 | .00 | .43 | .74 | .87 | .96 | .97 | .34 | .52 | .73 | .86 | .92 | ||
.69 | 2 | .50 | .06 | .06 | .05 | .05 | .06 | .08 | .07 | .06 | .06 | .05 | ||
1.10 | 3 | .67 | .12 | .20 | .28 | .37 | .44 | .16 | .19 | .28 | .35 | .40 | ||
1.39 | 4 | .75 | .24 | .41 | .57 | .66 | .78 | .28 | .41 | .54 | .62 | .74 | ||
1.61 | 5 | .80 | .34 | .57 | .78 | .86 | .93 | .36 | .52 | .71 | .81 | .89 | ||
1.79 | 6 | .83 | .42 | .69 | .86 | .95 | .97 | .40 | .62 | .81 | .89 | .94 | ||
1.95 | 7 | .86 | .51 | .78 | .90 | .97 | .98 | .48 | .71 | .89 | .94 | .98 | ||
2.08 | 8 | .87 | .53 | .85 | .95 | .98 | 1 | .54 | .76 | .93 | .96 | .99 | ||
2.20 | 9 | .88 | .62 | .88 | .97 | 1 | 1 | .55 | .80 | .94 | .97 | .99 | ||
2.30 | 10 | .90 | .64 | .90 | .97 | 1 | 1 | .57 | .85 | .96 | .98 | 1 | ||
2.48 | 12 | .92 | .69 | .93 | .99 | 1 | 1 | .65 | .86 | .98 | .99 | 1 | ||
2.64 | 14 | .93 | .73 | .96 | .99 | 1 | 1 | .67 | .87 | .97 | 1 | 1 | ||
2.77 | 16 | .94 | .77 | .98 | .99 | 1 | 1 | .71 | .93 | .99 | 1 | 1 | ||
β _{12}, β _{45} | OR | DD | c. | f. | ||||||||||
.00 | 1 | .00 | .20 | .37 | .52 | .63 | .74 | .10 | .16 | .27 | .32 | .37 | ||
.69 | 2 | .50 | .07 | .05 | .05 | .05 | .04 | .06 | .07 | .05 | .05 | .05 | ||
1.10 | 3 | .67 | .11 | .12 | .16 | .23 | .26 | .10 | .10 | .13 | .14 | .18 | ||
1.39 | 4 | .75 | .19 | .32 | .44 | .52 | .61 | .15 | .21 | .28 | .34 | .38 | ||
1.61 | 5 | .80 | .26 | .46 | .62 | .74 | .82 | .21 | .32 | .42 | .52 | .60 | ||
1.79 | 6 | .83 | .35 | .58 | .75 | .88 | .94 | .25 | .42 | .54 | .71 | .77 | ||
1.95 | 7 | .86 | .45 | .68 | .85 | .93 | .97 | .31 | .49 | .65 | .79 | .84 | ||
2.08 | 8 | .87 | .44 | .74 | .92 | .96 | 1 | .36 | .55 | .73 | .86 | .91 | ||
2.20 | 9 | .88 | .55 | .84 | .94 | .98 | .99 | .41 | .61 | .78 | .89 | .94 | ||
2.30 | 10 | .90 | .58 | .87 | .96 | .99 | 1 | .47 | .67 | .85 | .92 | .96 | ||
2.48 | 12 | .92 | .66 | .91 | .99 | .99 | 1 | .52 | .77 | .91 | .97 | .98 | ||
2.64 | 14 | .93 | .70 | .94 | .98 | 1 | 1 | .53 | .82 | .93 | .98 | 1 | ||
2.77 | 16 | .94 | .74 | .95 | .99 | 1 | 1 | .58 | .85 | .96 | .98 | 1 |
N= | 50 | 100 | 150 | 200 | 250 | H _{1} ^{21} | 50 | 100 | 150 | 200 | 250 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β _{12} | OR | DD | a. | d. | ||||||||||
.00 | 1 | .00 | .40 | .66 | .82 | .92 | .97 | .21 | .31 | .43 | .50 | .65 | ||
.69 | 2 | .50 | .16 | .22 | .31 | .35 | .45 | .11 | .12 | .16 | .18 | .24 | ||
1.10 | 3 | .67 | .07 | .09 | .08 | .12 | .12 | .09 | .08 | .07 | .08 | .08 | ||
1.39 | 4 | .75 | .06 | .05 | .05 | .04 | .06 | .08 | .07 | .07 | .06 | .05 | ||
1.61 | 5 | .80 | .08 | .06 | .06 | .08 | .08 | .08 | .08 | .08 | .07 | .06 | ||
1.79 | 6 | .83 | .09 | .10 | .12 | .14 | .16 | .07 | .09 | .10 | .10 | .11 | ||
1.95 | 7 | .86 | .11 | .11 | .17 | .22 | .25 | .12 | .12 | .12 | .13 | .15 | ||
2.08 | 8 | .87 | .13 | .17 | .24 | .31 | .36 | .11 | .14 | .15 | .18 | .23 | ||
2.20 | 9 | .88 | .15 | .21 | .30 | .37 | .45 | .13 | .17 | .20 | .23 | .27 | ||
2.30 | 10 | .90 | .18 | .24 | .34 | .43 | .52 | .14 | .19 | .25 | .24 | .30 | ||
2.48 | 12 | .92 | .21 | .35 | .45 | .58 | .67 | .19 | .21 | .31 | .32 | .40 | ||
2.64 | 14 | .93 | .24 | .38 | .53 | .66 | .77 | .19 | .26 | .33 | .42 | .49 | ||
2.77 | 16 | .94 | .29 | .46 | .61 | .76 | .84 | .20 | .28 | .39 | .45 | .55 | ||
β _{12}, β _{23} | OR | DD | b. | e. | ||||||||||
.00 | 1 | .00 | .85 | .99 | 1 | 1 | 1 | .71 | .92 | .99 | 1 | 1 | ||
.69 | 2 | .50 | .23 | .43 | .60 | .67 | .76 | .22 | .34 | .50 | .61 | .72 | ||
1.10 | 3 | .67 | .09 | .12 | .13 | .15 | .18 | .11 | .10 | .11 | .11 | .15 | ||
1.39 | 4 | .75 | .05 | .05 | .05 | .06 | .05 | .07 | .06 | .08 | .06 | .05 | ||
1.61 | 5 | .80 | .07 | .08 | .11 | .10 | .10 | .11 | .08 | .10 | .10 | .11 | ||
1.79 | 6 | .83 | .11 | .11 | .15 | .21 | .22 | .16 | .13 | .17 | .17 | .20 | ||
1.95 | 7 | .86 | .14 | .18 | .25 | .28 | .35 | .16 | .19 | .21 | .29 | .30 | ||
2.08 | 8 | .87 | .14 | .22 | .31 | .40 | .45 | .18 | .23 | .27 | .30 | .42 | ||
2.20 | 9 | .88 | .17 | .29 | .41 | .50 | .57 | .23 | .26 | .36 | .39 | .49 | ||
2.30 | 10 | .90 | .23 | .33 | .49 | .56 | .69 | .23 | .30 | .40 | .46 | .53 | ||
2.48 | 12 | .92 | .25 | .41 | .59 | .73 | .81 | .28 | .33 | .49 | .57 | .67 | ||
2.64 | 14 | .93 | .29 | .51 | .67 | .79 | .86 | .32 | .42 | .55 | .65 | .76 | ||
2.77 | 16 | .94 | .30 | .56 | .75 | .86 | .92 | .35 | .47 | .60 | .71 | .81 | ||
β _{12}, β _{45} | OR | DD | c. | f. | ||||||||||
.00 | 1 | .00 | .45 | .77 | .90 | .97 | .99 | .26 | .47 | .60 | .71 | .82 | ||
.69 | 2 | .50 | .14 | .26 | .36 | .44 | .50 | .11 | .15 | .21 | .25 | .32 | ||
1.10 | 3 | .67 | .08 | .09 | .10 | .13 | .12 | .08 | .09 | .08 | .09 | .10 | ||
1.39 | 4 | .75 | .05 | .06 | .05 | .05 | .06 | .08 | .06 | .06 | .06 | .06 | ||
1.61 | 5 | .80 | .06 | .07 | .08 | .07 | .09 | .10 | .08 | .09 | .08 | .07 | ||
1.79 | 6 | .83 | .08 | .12 | .14 | .16 | .21 | .12 | .11 | .12 | .14 | .14 | ||
1.95 | 7 | .86 | .12 | .15 | .20 | .24 | .33 | .14 | .14 | .17 | .19 | .23 | ||
2.08 | 8 | .87 | .13 | .22 | .28 | .38 | .44 | .14 | .17 | .22 | .28 | .33 | ||
2.20 | 9 | .88 | .20 | .25 | .36 | .47 | .56 | .17 | .20 | .27 | .35 | .41 | ||
2.30 | 10 | .90 | .20 | .31 | .46 | .55 | .66 | .17 | .22 | .33 | .41 | .49 | ||
2.48 | 12 | .92 | .26 | .38 | .54 | .67 | .80 | .23 | .31 | .43 | .50 | .60 | ||
2.64 | 14 | .93 | .28 | .50 | .64 | .77 | .87 | .26 | .42 | .51 | .63 | .73 | ||
2.77 | 16 | .94 | .35 | .55 | .75 | .87 | .90 | .29 | .45 | .61 | .70 | .79 |
Discussion
Results given by Figure 1 andtables 3 to 5 highlighted the strong influence that marginal heterogeneity within reader may have on power estimates of tests in NUA models. Conversely, when assuming marginal homogeneity within reader, NUA models are able to detect, from a null hypothesis of a DD equal to 2/3 between all adjacent categories and for a reasonable value of N = 200, null DD (between two or three categories with a probability greater than 80%. For a five-level scale, with an equal DD of 2/3 between its adjacent categories, NUA models are hence able to detect two or more confusing categories with a satisfying power. In the same way, for N = 200, NUA models are able to detect with a good power two or more adjacent categories (close or symmetric) for which the DDs are greater or equal to .92.
In our simulations of contingency tables resulting from cross-classifications of the same objects twice on an ordinal rating scale, the assumption of marginal homogeneity between readers was assumed, which can be seen as a limiting constraint. However, as described by the authors [12, 16], NUA models are based on the assumption that in agreement studies, high values of counts are expected on the diagonal of the contingency table, and on the parallels immediately over and below this diagonal, whereas low values of counts are expected in others parts of this contingency table. Thus defined, NUA models are suitable for contingency tables with marginal homogeneities and may not be adapted for contingency tables showing others patterns of marginal distribution. In addition, it should be noticed that such patterns of contingency tables usually show a baseline non null association between adjacent ratings, what may consolidate the choice of OR = 3 under the null hypothesis.
For each simulations, the algorithm of Lacruz et al. [21] was used to estimate parameters μ and λ _{ i } . Like many others systems, this system of non-linear equations appeared to be very sensitive to initial values. In order to handle this problem and to avoid local maximums, solutions μ and λ _{ i } of each system associated to a specific value K of the tested OR were used as initial parameters of the following system with the next tested K value.
In this simulation study we presented three alternative hypotheses illustrating different patterns of distinguishability between adjacent categories. The first tested hypothesis (DD between categories 1 and 2 different from the others), the corresponding symmetric hypothesis (DD between categories 4 and 5 different from the others), and the last hypothesis (DDs between extreme adjacent categories different from the others) allow to detect significant differences between extreme adjacent categories (1 and 2, 4 and 5 or both) and others intermediate ones. This is a usual pattern in ordinal rating scales, as the first category often corresponds to "no intensity" and the last one often corresponds to the "highest intensity" of the measured phenomenon. These two extreme adjacent categories are more likely to be distinguishable than the others because they correspond to extreme situations. Finally, the second hypothesis (DDs between close adjacent categories from 1 to 3 different then the others) and the corresponding symmetric one (DDs between close adjacent categories from 3 to 5 different from the others) allow to detect higher or lower DDs between some close adjacent categories of the scale. This can also be a typical pattern corresponding for example to ordinal scale where some consecutive grades shows many similarities and may be hard to distinguish.
Conclusions
In this paper we proposed a new simple method based on simulations, to estimate power of tests in log-linear non-uniform association models. To this aim, we first presented a method to simulate contingency tables resulting from cross-classifications of the same objects, using ordinal rating scales having different patterns of distinguishability between their adjacent categories. Then, taking typical situations of scale structures, we proposed a table summarizing the main effects of sample size, alternative hypotheses and marginal distributions on power estimates for the detection of DDs heterogeneities within the scale structure. Results were given for three typical alternative hypotheses, and in the case of an 5 × 5 contingency tables.
In health-research assessment of disease severity or patients' well being are more and more performed using ordinal rating scales. One of the major component of an ordinal scale is category distinguishability between its adjacent categories. Using a simple method based on simulations, this paper provided some issues about how many objects has to be classified by two observers to be able to detect a given scale structure defect, what may be of prime interest to improve ordinal scale quality and then others assessments made using this scale.
Declarations
Acknowledgements
The authors would like to thank Pr. Sylvie Chevret for her great interest and support of this work.
Authors’ Affiliations
References
- Biggs JT, Wylie LT, Ziegler VE: Validity of the Zung Self-rating Depression Scale. British Journal of Psychiatry. 1978, 132: 381-385. 10.1192/bjp.132.4.381.View ArticlePubMedGoogle Scholar
- Goga JA, Hambacher WO: Psychologic and behavioral assessment of geriatric patients: a review. Journal of the American Geriatrics Society. 1977, 25: 232-237.View ArticlePubMedGoogle Scholar
- Endicott J, Spitzer RL, Fleis JL, Cohen J: The global assessment scale. A procedure for measuring overall severity of psychiatry disturbance. Archives of General Psychiatry. 1976, 33: 766-771.View ArticlePubMedGoogle Scholar
- Mortimer AM: Symptom rating scales and outcome in schizophrenia. British Journal of Psychiatry. 2007, Suppl 50: 7-14.View ArticleGoogle Scholar
- Le T, Williams K, Senterman M, Hopkins L, Faught W, Fung-Kee-Fung M: Histopathologic assessment of chemotherapy effects in epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and delayed primary surgical debulking. Gynecologic Oncology. 2007, 106: 160-163. 10.1016/j.ygyno.2007.03.029.View ArticlePubMedGoogle Scholar
- Mahler DA, Ward J, Waterman LA, McCusker C, Zuwallack R, Baird JC: Patient-reported dyspnea in COPD reliability and association with stage of disease. Chest. 2009, 136: 1473-9. 10.1378/chest.09-0934.View ArticlePubMedPubMed CentralGoogle Scholar
- Chevallier B, Roche H, Olivier JP, Chollet P, Hurteloup P: Inammatory breast cancer. Pilot study of intensive induction chemotherapy (FEC-HD) results in a high histologic response rate. Journal of Clinical Oncology. 1993, 16: 223-228. 10.1097/00000421-199306000-00006.View ArticleGoogle Scholar
- Nurnberg HG, Hensley PL, Heiman JR, Croft HA, Debattista C, Paine S: Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. Journal of the American Medical Association. 2008, 300: 395-404. 10.1001/jama.300.4.395.View ArticlePubMedGoogle Scholar
- Kappos L, Freedman MS, Polman CH, Edan G, Hartung H, Miller DH, Montalban X, Barkhof F, Radu EW, Metzig C, Bauer L, Lanius V, Sandbrink R, Pohl C: Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. Lancet Neurology. 2009,Google Scholar
- Bowling A: Measuring Health: A review of Quality of Life Measurement Scales. 1991, Philadelphia: Open University Press, IncGoogle Scholar
- McDowell I, Newell C: Measuring Health: A guide to Rating Scales and Questionnaires. 1996, New York: Open University Press, IncGoogle Scholar
- Valet F, Guinot C, Mary JY: Log-linear non-uniform association models for agreement between two ratings on an ordinal scale. Statistics in Medicine. 2007, 300: 647-662.View ArticleGoogle Scholar
- Goodman LA: Simple models for the analysis of association in cross-classifications having ordered categories. Journal of the American Statistical Association. 1979, 74: 537-552. 10.2307/2286971.View ArticleGoogle Scholar
- Becker MP: Using association models to analyze agreement data: two examples. Statistics in Medicine. 1989, 8: 1199-1207. 10.1002/sim.4780081004.View ArticlePubMedGoogle Scholar
- Agresti A: A model for agreement between ratings on an ordinal scale. Biometrics. 1988, 44: 539-548. 10.2307/2531866.View ArticleGoogle Scholar
- Valet F, Guinot C, Ezzedine K, Mary JY: Quality assessment of ordinal scale reproducibility: log-linear models provided useful information on scale structure. Journal of Clinicel Epidemiology. 2008, 61: 983-990. 10.1016/j.jclinepi.2007.11.004.View ArticleGoogle Scholar
- Darroch JN, McCloud PI: Category distinguishability and obersver agreement. Australian Journal of Statistics. 1986, 28: 371-388. 10.1111/j.1467-842X.1986.tb00709.x.View ArticleGoogle Scholar
- Agresti A: Categorical Data analysis. Wiley series in probability and methematical statistics. 2002, New York: John Wiley and SonsGoogle Scholar
- Brown PN, Saas Y: Hybrid Krylov methods for non-linear systems of equations. SIAM Journal of Scientific Computing. 1990, 11: 450-481. 10.1137/0911026.View ArticleGoogle Scholar
- Brown PN, Saas Y: Convergence theory of nonlinear Newton-Hybrid Krylov algorithms. SIAM Journal of Scientific Computing. 1994, 4: 297-330.Google Scholar
- Lacruz W, Martinez JM, Raydan M: Spectral residual method without gradient information for solving large-scale nonlinear systems of equations. Mathematics of Computation. 2006, 75: 1429-1448. 10.1090/S0025-5718-06-01840-0.View ArticleGoogle Scholar
- R Development Core Team: R: A language and environment for statistical computing. 2009, R Foundation for Statistical Computing, Vienna, Austria, [ISBN 3-900051-00-3], [http://www.R-project.org]Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2288/11/70/prepub
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