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  1. We aimed at assessing the degree of measurement error in essential fatty acid intakes from a food frequency questionnaire and the impact of correcting for such an error on precision and bias of odds ratios in ...

    Authors: May A Beydoun, Jay S Kaufman, Joseph Ibrahim, Jessie A Satia and Gerardo Heiss

    Citation: BMC Medical Research Methodology 2007 7:41

    Content type: Research article

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  2. This study compares the Bayesian and frequentist (non-Bayesian) approaches in the modelling of the association between the risk of preterm birth and maternal proximity to hazardous waste and pollution from the...

    Authors: Afisi S Ismaila, Angelo Canty and Lehana Thabane

    Citation: BMC Medical Research Methodology 2007 7:39

    Content type: Research article

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  3. The Bayesian approach is now widely recognised as a proper framework for analysing risk in health care. However, the traditional text-book Bayesian approach is in many cases difficult to implement, as it is ba...

    Authors: Terje Aven and Karianne Eidesen

    Citation: BMC Medical Research Methodology 2007 7:38

    Content type: Research article

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  4. The widespread international use of the 26-item WHO Quality of Life Instrument (WHOQOL-Bref) necessitates the assessment of its factor structure across cultures. For, alternative factor models may provide a be...

    Authors: Jude U Ohaeri, Abdel W Awadalla, Abdul-Hamid M El-Abassi and Anila Jacob

    Citation: BMC Medical Research Methodology 2007 7:37

    Content type: Research article

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  5. The purpose of this study was to validate the accuracy of an alternative cervical cancer test – visual inspection with acetic acid (VIA) – by addressing possible imperfections in the gold standard through late...

    Authors: Lynne Gaffikin, John A McGrath, Marc Arbyn and Paul D Blumenthal

    Citation: BMC Medical Research Methodology 2007 7:36

    Content type: Research article

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  6. Missing data is a challenging problem in many prognostic studies. Multiple imputation (MI) accounts for imputation uncertainty that allows for adequate statistical testing. We developed and tested a methodolog...

    Authors: Martijn W Heymans, Stef van Buuren, Dirk L Knol, Willem van Mechelen and Henrica CW de Vet

    Citation: BMC Medical Research Methodology 2007 7:33

    Content type: Research article

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  7. With the advent of high throughput genotyping technology and the information available via projects such as the human genome sequencing and the HapMap project, more and more data relevant to the study of genet...

    Authors: Angela J Frodsham and Julian PT Higgins

    Citation: BMC Medical Research Methodology 2007 7:31

    Content type: Research article

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  8. The 'Hawthorne Effect' may be an important factor affecting the generalisability of clinical research to routine practice, but has been little studied. Hawthorne Effects have been reported in previous clinical...

    Authors: Rob McCarney, James Warner, Steve Iliffe, Robbert van Haselen, Mark Griffin and Peter Fisher

    Citation: BMC Medical Research Methodology 2007 7:30

    Content type: Research article

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  9. Hierarchical modelling represents a statistical method used to analyze nested data, as those concerning patients afferent to different hospitals. Aim of this paper is to build a hierarchical regression model u...

    Authors: Paola D'Errigo, Maria E Tosti, Danilo Fusco, Carlo A Perucci and Fulvia Seccareccia

    Citation: BMC Medical Research Methodology 2007 7:29

    Content type: Research article

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  10. Information overload, increasing time constraints, and inappropriate search strategies complicate the detection of clinical practice guidelines (CPGs). The aim of this study was to provide clinicians with reco...

    Authors: Andrea Haase, Markus Follmann, Guido Skipka and Hanna Kirchner

    Citation: BMC Medical Research Methodology 2007 7:28

    Content type: Research article

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  11. Data for health surveys are often collected using either mailed questionnaires, telephone interviews or a combination. Mode of data collection can affect the propensity to refuse to respond and result in diffe...

    Authors: Helene Feveile, Ole Olsen and Annie Hogh

    Citation: BMC Medical Research Methodology 2007 7:27

    Content type: Research article

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  12. Understanding the relationships between physical activity (PA) and disease has become a major area of research interest. Activity monitors, devices that quantify free-living PA for prolonged periods of time (d...

    Authors: David R Paul, Matthew Kramer, Alanna J Moshfegh, David J Baer and William V Rumpler

    Citation: BMC Medical Research Methodology 2007 7:26

    Content type: Research article

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  13. There is much evidence to suggest that risk for common clinical disorders begins in foetal life. Exposure to environmental risk factors however is often not random. Many commonly used indices of prenatal adver...

    Authors: Anita Thapar, Gordon Harold, Frances Rice, XiaoJia Ge, Jacky Boivin, Dale Hay, Marianne van den Bree and Allyson Lewis

    Citation: BMC Medical Research Methodology 2007 7:25

    Content type: Research article

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  14. To investigate the interchangeability of measures of disability and health-related quality of life (HRQL) by comparing their associations patterns with disease-related impairment measures in patients with a va...

    Authors: Nadine Weisscher, Rob J de Haan and Marinus Vermeulen

    Citation: BMC Medical Research Methodology 2007 7:24

    Content type: Research article

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  15. The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencie...

    Authors: Soe Soe Thwin, Kerri M Clough-Gorr, Maribet C McCarty, Timothy L Lash, Sharon H Alford, Diana SM Buist, Shelley M Enger, Terry S Field, Floyd Frost, Feifei Wei and Rebecca A Silliman

    Citation: BMC Medical Research Methodology 2007 7:23

    Content type: Technical advance

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  16. The ability to locate those sampled has important implications for response rates and thus the success of survey research. The purpose of this study was to examine predictors of locating women requiring tracin...

    Authors: Suzanne M Cadarette, Leigh Dickson, Monique AM Gignac, Dorcas E Beaton, Susan B Jaglal and Gillian A Hawker

    Citation: BMC Medical Research Methodology 2007 7:22

    Content type: Research article

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  17. Claims data provide rapid indicators of SSIs for coronary artery bypass surgery and have been shown to successfully rank hospitals by SSI rates. We now operationalize this method for use by payers without tran...

    Authors: Susan S Huang, James M Livingston, Nigel SB Rawson, Steven Schmaltz and Richard Platt

    Citation: BMC Medical Research Methodology 2007 7:20

    Content type: Software

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  18. Questionnaires are used routinely in clinical research to measure health status and quality of life. Questionnaire measurements are traditionally formally assessed by indices of reliability (the degree of meas...

    Authors: Matthew Hankins

    Citation: BMC Medical Research Methodology 2007 7:19

    Content type: Research article

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  19. Analyzing drop out rates and when they occur may give important information about the patient characteristics and trial characteristics that affect the overall uptake of an intervention.

    Authors: Carl Heneghan, Rafael Perera, Alison Ward A, David Fitzmaurice, Emma Meats and Paul Glasziou

    Citation: BMC Medical Research Methodology 2007 7:18

    Content type: Research article

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  20. Pragmatic randomised controlled trials are often used in primary care to evaluate the effect of a treatment strategy. In these trials it is difficult to achieve both high internal validity and high generalisab...

    Authors: Gerdine AJ Fransen, Corine J van Marrewijk, Suhreta Mujakovic, Jean WM Muris, Robert JF Laheij, Mattijs E Numans, Niek J de Wit, Melvin Samsom, Jan BMJ Jansen and J André Knottnerus

    Citation: BMC Medical Research Methodology 2007 7:16

    Content type: Debate

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  21. It is notoriously difficult to recruit patients to randomised controlled trials in primary care. This is particularly true when the disease process under investigation occurs relatively infrequently and must b...

    Authors: Brian McKinstry, Victoria Hammersley, Fergus Daly and Frank Sullivan

    Citation: BMC Medical Research Methodology 2007 7:15

    Content type: Research article

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  22. Health surveys provide important information on the burden and secular trends of risk factors and disease. Several factors including survey and item non-response can affect data quality. There are few reports ...

    Authors: Rainford Wilks, Novie Younger, Jasneth Mullings, Namvar Zohoori, Peter Figueroa, Marshall Tulloch-Reid, Trevor Ferguson, Christine Walters, Franklyn Bennett, Terrence Forrester, Elizabeth Ward and Deanna Ashley

    Citation: BMC Medical Research Methodology 2007 7:13

    Content type: Research article

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  23. Poor response rates to postal questionnaires can introduce bias and reduce the statistical power of a study. To improve response rates in our trial in primary care we tested the effect of introducing an uncond...

    Authors: Stephen D Brealey, Christine Atwell, Stirling Bryan, Simon Coulton, Helen Cox, Ben Cross, Fiona Fylan, Andrew Garratt, Fiona J Gilbert, Maureen GC Gillan, Maggie Hendry, Kerenza Hood, Helen Houston, David King, Veronica Morton, Jo Orchard…

    Citation: BMC Medical Research Methodology 2007 7:12

    Content type: Research article

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  24. In most case control studies the hardest decision is the choice of the control group, as in the ideal control group the proportion exposed is the same as in the population that produced the cases.

    Authors: Odimariles MS Dantas, Ricardo AA Ximenes, Maria de Fatima PM de Albuquerque, Ulisses R Montarroyos, Wayner V de Souza, Patrícia Varejão and Laura C Rodrigues

    Citation: BMC Medical Research Methodology 2007 7:11

    Content type: Research article

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  25. Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus.

    Authors: Beverley J Shea, Jeremy M Grimshaw, George A Wells, Maarten Boers, Neil Andersson, Candyce Hamel, Ashley C Porter, Peter Tugwell, David Moher and Lex M Bouter

    Citation: BMC Medical Research Methodology 2007 7:10

    Content type: Research article

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  26. Little is known about the response mechanisms among survivors of disasters. We studied the selective attrition and possible bias in a longitudinal study among survivors of a fireworks disaster.

    Authors: Bellis van den Berg, Peter van der Velden, Rebecca Stellato and Linda Grievink

    Citation: BMC Medical Research Methodology 2007 7:8

    Content type: Research article

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  27. To explore the strengths and weaknesses of conventional biomedical research strategies and methods as applied to complementary and alternative medicine (CAM), and to suggest a new research framework for assess...

    Authors: Vinjar Fønnebø, Sameline Grimsgaard, Harald Walach, Cheryl Ritenbaugh, Arne Johan Norheim, Hugh MacPherson, George Lewith, Laila Launsø, Mary Koithan, Torkel Falkenberg, Heather Boon and Mikel Aickin

    Citation: BMC Medical Research Methodology 2007 7:7

    Content type: Debate

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  28. Often in survey research, subsets of the population invited to complete the survey do not respond in a timely manner and valuable resources are expended in recontact efforts. Various methods of improving respo...

    Authors: Jean-Paul Chretien, Laura K Chu, Tyler C Smith, Besa Smith and Margaret AK Ryan

    Citation: BMC Medical Research Methodology 2007 7:6

    Content type: Research article

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  29. Meta-analysis handles randomized trials with no outcome events in both treatment and control arms inconsistently, including them when risk difference (RD) is the effect measure but excluding them when relative...

    Authors: Jan O Friedrich, Neill KJ Adhikari and Joseph Beyene

    Citation: BMC Medical Research Methodology 2007 7:5

    Content type: Research article

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  30. The inclusion of qualitative studies in systematic reviews poses methodological challenges. This paper presents worked examples of two methods of data synthesis (textual narrative and thematic), used in relati...

    Authors: Patricia J Lucas, Janis Baird, Lisa Arai, Catherine Law and Helen M Roberts

    Citation: BMC Medical Research Methodology 2007 7:4

    Content type: Research article

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  31. When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation. A multivariate random-effects meta-analysis mus...

    Authors: Richard D Riley, Keith R Abrams, Alexander J Sutton, Paul C Lambert and John R Thompson

    Citation: BMC Medical Research Methodology 2007 7:3

    Content type: Research article

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  32. This paper describes the study protocol, the recruitment, and base-line data for evaluating the success of randomisation of the PRO-AGE (PRevention in Older people – Assessment in GEneralists' practices) project.

    Authors: Andreas E Stuck, Kalpa Kharicha, Ulrike Dapp, Jennifer Anders, Wolfgang von Renteln-Kruse, Hans Peter Meier-Baumgartner, Steve Iliffe, Danielle Harari, Martin D Bachmann, Matthias Egger, Gerhard Gillmann, John C Beck and Cameron G Swift

    Citation: BMC Medical Research Methodology 2007 7:2

    Content type: Study protocol

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  33. Health risk appraisal is a promising method for health promotion and prevention in older persons. The Health Risk Appraisal for the Elderly (HRA-E) developed in the U.S. has unique features but has not been te...

    Authors: Andreas E Stuck, Kalpa Kharicha, Ulrike Dapp, Jennifer Anders, Wolfgang von Renteln-Kruse, Hans Peter Meier-Baumgartner, Danielle Harari, Cameron G Swift, Katja Ivanova, Matthias Egger, Gerhard Gillmann, Jerilyn Higa, John C Beck and Steve Iliffe

    Citation: BMC Medical Research Methodology 2007 7:1

    Content type: Research article

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  34. Reasons for attrition in studies vary, but may be a major concern in long-term studies if those who drop out differ systematically from those who continue to participate. Factors associated with dropout were e...

    Authors: Naomi M Gades, Debra J Jacobson, Michaela E McGree, Michael M Lieber, Rosebud O Roberts, Cynthia J Girman and Steven J Jacobsen

    Citation: BMC Medical Research Methodology 2006 6:58

    Content type: Research article

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  35. Missing data present a challenge to many research projects. The problem is often pronounced in studies utilizing self-report scales, and literature addressing different strategies for dealing with missing data...

    Authors: Fiona M Shrive, Heather Stuart, Hude Quan and William A Ghali

    Citation: BMC Medical Research Methodology 2006 6:57

    Content type: Research article

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  36. It is often stated that external validity is not sufficiently considered in the assessment of clinical studies. Although tools for its evaluation have been established, there is a lack of awareness of their si...

    Authors: Gudrun Bornhöft, Stefanie Maxion-Bergemann, Ursula Wolf, Gunver S Kienle, Andreas Michalsen, Horst C Vollmar, Simon Gilbertson and Peter F Matthiessen

    Citation: BMC Medical Research Methodology 2006 6:56

    Content type: Correspondence

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  37. Provision of evidence on costs alongside evidence on the effects of interventions can enhance the relevance of systematic reviews to decision-making. However, patterns of use of economics methods alongside sys...

    Authors: Ian Shemilt, Miranda Mugford, Michael Drummond, Eric Eisenstein, Jacqueline Mallender, David McDaid, Luke Vale and Damian Walker

    Citation: BMC Medical Research Methodology 2006 6:55

    Content type: Research article

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  38. Stepped wedge randomised trial designs involve sequential roll-out of an intervention to participants (individuals or clusters) over a number of time periods. By the end of the study, all participants will hav...

    Authors: Celia A Brown and Richard J Lilford

    Citation: BMC Medical Research Methodology 2006 6:54

    Content type: Research article

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  39. Providers use risk-adjustment systems to help manage healthcare costs. Typically, ordinary least squares (OLS) models on either untransformed or log-transformed cost are used. We examine the predictive ability...

    Authors: Maria Montez-Rath, Cindy L Christiansen, Susan L Ettner, Susan Loveland and Amy K Rosen

    Citation: BMC Medical Research Methodology 2006 6:53

    Content type: Research article

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  40. Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magni...

    Authors: Jonathan R Treadwell, Stephen J Tregear, James T Reston and Charles M Turkelson

    Citation: BMC Medical Research Methodology 2006 6:52

    Content type: Debate

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  41. Meta-analysis has become a well-known method for synthesis of quantitative data from previously conducted research in applied health sciences. So far, meta-analysis has been particularly useful in evaluating a...

    Authors: Leon Bax, Ly-Mee Yu, Noriaki Ikeda, Harukazu Tsuruta and Karel GM Moons

    Citation: BMC Medical Research Methodology 2006 6:50

    Content type: Software

    Published on: