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  1. Conducting a systematic review requires a comprehensive bibliographic search. Comparing different search strategies is essential for choosing those that cover all useful data sources. Our aim was to develop se...

    Authors: Boris Bikbov, Norberto Perico and Giuseppe Remuzzi
    Citation: BMC Medical Research Methodology 2018 18:110
    Content type: Research article Published on:

  2. Sexual desire is one of the domains of sexual function with multiple dimensions, which commonly affects men and women around the world. Classically, its assessment has been applied through self-report tools; h...

    Authors: Denisse Cartagena-Ramos, Miguel Fuentealba-Torres, Flávio Rebustini, Ana Carolina Andrade Biaggi Leite, Willyane de Andrade Alvarenga, Ricardo Alexandre Arcêncio, Rosana Aparecida Spadoti Dantas and Lucila Castanheira Nascimento
    Citation: BMC Medical Research Methodology 2018 18:109
    Content type: Research article Published on:

  4. Following publication of the original article [1], the authors reported that the following notation wasn’t used consistently.

    Authors: Ines Rombach, Alastair M Gray, Crispin Jenkinson, David W Murray and Oliver Rivero-Arias
    Citation: BMC Medical Research Methodology 2018 18:107
    Content type: Correction Published on:

    The original article was published in BMC Medical Research Methodology 2018 18:87

  5. Health inequalities, worse health associated with social and economic disadvantage, are reported by a minority of research articles. Locating these studies when conducting an equity-focused systematic review i...

    Authors: Stephanie L Prady, Eleonora P Uphoff, Madeleine Power and Su Golder
    Citation: BMC Medical Research Methodology 2018 18:106
    Content type: Research article Published on:

  6. In individually randomised trials we might expect interventions delivered in groups or by care providers to result in clustering of outcomes for participants treated in the same group or by the same care provi...

    Authors: Jane Candlish, M. Dawn Teare, Munyaradzi Dimairo, Laura Flight, Laura Mandefield and Stephen J. Walters
    Citation: BMC Medical Research Methodology 2018 18:105
    Content type: Research article Published on:

  7. Survey researchers use monetary incentives as a strategy to motivate physicians’ survey participation. Experiments from general population surveys demonstrate that prepaid incentives increase response rates an...

    Authors: Kristine Wiant, Emily Geisen, Darryl Creel, Gordon Willis, Andrew Freedman, Janet de Moor and Carrie Klabunde
    Citation: BMC Medical Research Methodology 2018 18:104
    Content type: Research article Published on:

  8. Research waste is estimated to be very common, but assessments of its prevalence and scope are rare. As an example, we assessed research waste in clinical research on calcium intake (assessing study design and...

    Authors: Mark J. Bolland, Alison Avenell and Andrew Grey
    Citation: BMC Medical Research Methodology 2018 18:103
    Content type: Research article Published on:

  9. Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this ma...

    Authors: Paul M Bakaki, Jennifer Staley, Rujia Liu, Neal Dawson, Negar Golchin, Alexis Horace, Hannah Johnson, Jennifer Waldron, Almut Winterstein, Lawrence C Kleinman and Shari D Bolen
    Citation: BMC Medical Research Methodology 2018 18:102
    Content type: Research article Published on:

  10. Research waste can occur when trials are conducted in the wrong populations. Vitamin D deficient populations are most likely to benefit from vitamin D supplementation. We investigated waste attributable to ran...

    Authors: Mark J. Bolland, Andrew Grey and Alison Avenell
    Citation: BMC Medical Research Methodology 2018 18:101
    Content type: Research article Published on:

  11. The aim of this study was to quantify and compare the diagnostic value of The Western Electric (WE) statistical process control (SPC) chart rules and the Anhoej rules for detection of non-random variation in t...

    Authors: Jacob Anhøj and Tore Wentzel-Larsen
    Citation: BMC Medical Research Methodology 2018 18:100
    Content type: Research article Published on:

  12. Consumers, clinicians, policymakers and researchers require high quality evidence to guide decision-making in child health. Though Cochrane systematic reviews (SRs) are a well-established source of evidence, l...

    Authors: Michelle Gates, Sarah A Elliott, Cydney Johnson, Denise Thomson, Katrina Williams, Ricardo M Fernandes and Lisa Hartling
    Citation: BMC Medical Research Methodology 2018 18:99
    Content type: Research article Published on:

  13. In the presence of an intermediate clinical event, the analysis of time-to-event survival data by conventional approaches, such as the log-rank test, can result in biased results due to the length-biased chara...

    Authors: Sohee Kim, Jinheum Kim and Chung Mo Nam
    Citation: BMC Medical Research Methodology 2018 18:98
    Content type: Research article Published on:

  14. The data from individual observational studies included in meta-analyses of drug effects are collected either from ad hoc methods (i.e. “primary data”) or databases that were established for non-research purpo...

    Authors: Guillermo Prada-Ramallal, Fatima Roque, Maria Teresa Herdeiro, Bahi Takkouche and Adolfo Figueiras
    Citation: BMC Medical Research Methodology 2018 18:97
    Content type: Research article Published on:

  15. We are witnessing an exponential increase in the number of randomized controlled trials (RCTs) reported from mainland China. The increase is particularly notable in the field of new generation antidepressants ...

    Authors: Zheng Tong, Fangzhou Li, Yusuke Ogawa, Norio Watanabe and Toshi A. Furukawa
    Citation: BMC Medical Research Methodology 2018 18:96
    Content type: Research article Published on:

  16. The objective of this study was to compare three data collection methods for the measurement of parent experiences with hospital outpatient care for child and adolescent diabetes, based on a randomised nationa...

    Authors: Oyvind Bjertnaes, Hilde Hestad Iversen and Torild Skrivarhaug
    Citation: BMC Medical Research Methodology 2018 18:95
    Content type: Research article Published on:

  17. Conducting prospective epidemiological studies of hospitalized patients with rare diseases like primary subarachnoid hemorrhage (pSAH) are difficult due to time and budgetary constraints. Routinely collected a...

    Authors: S. W. English, L. McIntyre, V. Saigle, M. Chassé, D. A. Fergusson, A. F. Turgeon, F. Lauzier, D. Griesdale, A. Garland, R. Zarychanski, A. Algird and C. van Walraven
    Citation: BMC Medical Research Methodology 2018 18:94
    Content type: Study protocol Published on:

  18. Intraclass correlation coefficients (ICC) are recommended for the assessment of the reliability of measurement scales. However, the ICC is subject to a variety of statistical assumptions such as normality and ...

    Authors: Carly A. Bobak, Paul J. Barr and A. James O’Malley
    Citation: BMC Medical Research Methodology 2018 18:93
    Content type: Research article Published on:

  19. This study aimed to describe the level of agreement of three commonly used delirium instruments: the Delirium Rating Scale-Revised-98 (DRS-R-98), Memorial Delirium Assessment Scale (MDAS), and Confusion Assess...

    Authors: Alden L. Gross, Doug Tommet, Madeline D’Aquila, Eva Schmitt, Edward R. Marcantonio, Benjamin Helfand, Sharon K. Inouye and Richard N. Jones
    Citation: BMC Medical Research Methodology 2018 18:92
    Content type: Research article Published on:

  21. Multiple imputation by chained equations (MICE) requires specifying a suitable conditional imputation model for each incomplete variable and then iteratively imputes the missing values. In the presence of miss...

    Authors: Jacques-Emmanuel Galimard, Sylvie Chevret, Emmanuel Curis and Matthieu Resche-Rigon
    Citation: BMC Medical Research Methodology 2018 18:90
    Content type: Research article Published on:

  22. Informative attrition occurs when the reason participants drop out from a study is associated with the study outcome. Analysing data with informative attrition can bias longitudinal study inferences. Approache...

    Authors: Catherine A. Welch, Séverine Sabia, Eric Brunner, Mika Kivimäki and Martin J. Shipley
    Citation: BMC Medical Research Methodology 2018 18:89
    Content type: Research article Published on:

  23. Research participant recruitment is often fraught with obstacles. Poor response rates can reduce statistical power, threaten both internal and external validity, and increase study costs and duration. Military...

    Authors: Alyson J. Littman, Gala True, Emily Ashmore, Tracy Wellens and Nicholas L. Smith
    Citation: BMC Medical Research Methodology 2018 18:88
    Content type: Research article Published on:

  24. Missing data can introduce bias in the results of randomised controlled trials (RCTs), but are typically unavoidable in pragmatic clinical research, especially when patient reported outcome measures (PROMs) ar...

    Authors: Ines Rombach, Alastair M. Gray, Crispin Jenkinson, David W. Murray and Oliver Rivero-Arias
    Citation: BMC Medical Research Methodology 2018 18:87
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2018 18:107

  25. Financial rewards have been shown to be an important motivator to include normal healthy volunteers in trials. Less emphasis has been put on non-healthy volunteers. No previous study has investigated the impac...

    Authors: Dawid Pieper, Nina Kotte and Peggy Ober
    Citation: BMC Medical Research Methodology 2018 18:86
    Content type: Research article Published on:

  26. Systematic literature searching is recognised as a critical component of the systematic review process. It involves a systematic search for studies and aims for a transparent report of study identification, le...

    Authors: Chris Cooper, Andrew Booth, Jo Varley-Campbell, Nicky Britten and Ruth Garside
    Citation: BMC Medical Research Methodology 2018 18:85
    Content type: Debate Published on:

  27. In contrast to aetiological associations, there is little empirical evidence for generalising health service use associations from cohort studies. We compared the health service use of cohort study participant...

    Authors: Nicola Creighton, Stuart Purdie, Matthew Soeberg, Richard Walton, Deborah Baker and Jane Young
    Citation: BMC Medical Research Methodology 2018 18:84
    Content type: Research article Published on:

  28. Random effects modelling is routinely used in clustered data, but for prediction models, random effects are commonly substituted with the mean zero after model development. In this study, we proposed a novel a...

    Authors: Haifang Ni, Rolf H. H. Groenwold, Mirjam Nielen and Irene Klugkist
    Citation: BMC Medical Research Methodology 2018 18:83
    Content type: Research article Published on:

  29. Health economic evaluations of interventions in infectious disease are commonly based on the predictions of ordinary differential equation (ODE) systems or Markov models (MMs). Standard MMs are static, whereas...

    Authors: Katrin Haeussler, Ardo van den Hout and Gianluca Baio
    Citation: BMC Medical Research Methodology 2018 18:82
    Content type: Research article Published on:

  30. Statistical methodology is a powerful tool in the health research; however, there is wide accord that statistical methodologies are not usually used properly. In particular when multiple comparisons are needed...

    Authors: Massimiliano Giacalone, Zirilli Agata, Paolo Carmelo Cozzucoli and Angela Alibrandi
    Citation: BMC Medical Research Methodology 2018 18:81
    Content type: Research article Published on:

  31. The lack of suitable and reliable scales to measure self-reported health and health behaviour among people with intellectual disabilities (ID) is an important methodological challenge in health research. This ...

    Authors: Kristel Vlot-van Anrooij, Hilde Tobi, Thessa I. M. Hilgenkamp, Geraline L. Leusink and Jenneken Naaldenberg
    Citation: BMC Medical Research Methodology 2018 18:80
    Content type: Research article Published on:

  35. Records pertaining to individuals whose identity cannot be verified with legal documentation may contain errors, or be incorrect by intention of the individual. Probabilistic data linkage, especially in vulner...

    Authors: Holly Tibble, Hsei Di Law, Matthew J. Spittal, Rosemary Karmel, Rohan Borschmann, Katie Hail-Jares, Laura A. Thomas and Stuart A. Kinner
    Citation: BMC Medical Research Methodology 2018 18:76
    Content type: Research article Published on:

  36. Phase III randomized controlled trials (RCT) typically exclude certain patient subgroups, thereby potentially jeopardizing estimation of a drug’s effects when prescribed to wider populations and under routine ...

    Authors: Helene Karcher, Shuai Fu, Jie Meng, Mikkel Zöllner Ankarfeldt, Orestis Efthimiou, Mark Belger, Josep Maria Haro, Lucien Abenhaim and Clementine Nordon
    Citation: BMC Medical Research Methodology 2018 18:75
    Content type: Technical advance Published on:

  37. Multilevel models for non-normal outcomes are widely used in medical and health sciences research. While methods for interpreting fixed effects are well-developed, methods to quantify and interpret random clus...

    Authors: Thomas J. Glorioso, Gary K. Grunwald, P. Michael Ho and Thomas M. Maddox
    Citation: BMC Medical Research Methodology 2018 18:74
    Content type: Research article Published on:

  38. Degenerative cervical myelopathy (DCM) is a common condition with many unmet clinical needs. Pooled analysis of studies is an important tool for advancing medical understanding. This process starts with a syst...

    Authors: Benjamin M. Davies, Samuel Goh, Keonwoo Yi, Isla Kuhn and Mark R. N. Kotter
    Citation: BMC Medical Research Methodology 2018 18:73
    Content type: Research article Published on:

  39. There are an increasing number of geo-coded information streams available which could improve public health surveillance accuracy and efficiency when properly integrated. Specifically, for zoonotic diseases, k...

    Authors: C. Rotejanaprasert, A. Lawson, H. Rossow, J. Sane, O. Huitu, H. Henttonen and V. J. Del Rio Vilas
    Citation: BMC Medical Research Methodology 2018 18:72
    Content type: Research article Published on:

  40. Limited translational success in critical care medicine is thought to be in part due to inadequate methodology, study design, and reporting in preclinical studies. The purpose of this study was to compare repo...

    Authors: Justin S. Merkow, Janine M. Hoerauf, Angela F. Moss, Jason Brainard, Lena M. Mayes, Ana Fernandez-Bustamante, Susan K. Mikulich-Gilbertson and Karsten Bartels
    Citation: BMC Medical Research Methodology 2018 18:71
    Content type: Research article Published on:

  42. Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery. Our goal in this study was to evalu...

    Authors: Annie M. Racine, Yun Gou, Tamara G. Fong, Edward R. Marcantonio, Eva M. Schmitt, Thomas G. Travison, Sharon K. Inouye and Richard N. Jones
    Citation: BMC Medical Research Methodology 2018 18:69
    Content type: Research article Published on:

  43. A thorough evaluation of the adequacy of clinical practice in a designated health care setting and temporal context is key for clinical care improvement. This study aimed to perform a clinical audit of primary...

    Authors: María Abad-Arranz, Ana Moran-Rodríguez, Enrique Mascarós Balaguer, Carmen Quintana Velasco, Laura Abad Polo, Sara Núñez Palomo, Jaime Gonzálvez Rey, Ana María Fernández Vargas, Antonio Hidalgo Requena, Jose Manuel Helguera Quevedo, Marina García Pardo and Jose Luis Lopez-Campos
    Citation: BMC Medical Research Methodology 2018 18:68
    Content type: Research article Published on:

  44. Recently, the intervention calculus when the DAG is absent (IDA) method was developed to estimate lower bounds of causal effects from observational high-dimensional data. Originally it was introduced to assess...

    Authors: Vahé Asvatourian, Clélia Coutzac, Nathalie Chaput, Caroline Robert, Stefan Michiels and Emilie Lanoy
    Citation: BMC Medical Research Methodology 2018 18:67
    Content type: Research article Published on:

  45. Network meta-analysis (NMA) allows for the estimation of comparative effectiveness of treatments that have not been studied in head-to-head trials; however, relative treatment effects for all interventions can...

    Authors: Susanne Schmitz, Áine Maguire, James Morris, Kai Ruggeri, Elisa Haller, Isla Kuhn, Joy Leahy, Natalia Homer, Ayesha Khan, Jack Bowden, Vanessa Buchanan, Michael O’Dwyer, Gordon Cook and Cathal Walsh
    Citation: BMC Medical Research Methodology 2018 18:66
    Content type: Research article Published on:

  48. Log-binomial and robust (modified) Poisson regression models are popular approaches to estimate risk ratios for binary response variables. Previous studies have shown that comparatively they produce similar po...

    Authors: Wansu Chen, Lei Qian, Jiaxiao Shi and Meredith Franklin
    Citation: BMC Medical Research Methodology 2018 18:63
    Content type: Research article Published on:

  49. A new patient-reported health measurement model has been developed to quantify descriptions of health states. Known as the multi-attribute preference response (MAPR) model, it is based on item response theory....

    Authors: Catharina G. M. Groothuis-Oudshoorn, Edwin R. van den Heuvel and Paul F. M. Krabbe
    Citation: BMC Medical Research Methodology 2018 18:62
    Content type: Research article Published on:

  50. In pharmacoepidemiology, the prescription preference-based instrumental variables (IV) are often used with linear models to solve the endogeneity due to unobserved confounders even when the outcome and the end...

    Authors: Babagnidé François Koladjo, Sylvie Escolano and Pascale Tubert-Bitter
    Citation: BMC Medical Research Methodology 2018 18:61
    Content type: Research article Published on:
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BMC Medical Research Methodology

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