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  1. There is much evidence to suggest that risk for common clinical disorders begins in foetal life. Exposure to environmental risk factors however is often not random. Many commonly used indices of prenatal adver...

    Authors: Anita Thapar, Gordon Harold, Frances Rice, XiaoJia Ge, Jacky Boivin, Dale Hay, Marianne van den Bree and Allyson Lewis
    Citation: BMC Medical Research Methodology 2007 7:25
  2. To investigate the interchangeability of measures of disability and health-related quality of life (HRQL) by comparing their associations patterns with disease-related impairment measures in patients with a va...

    Authors: Nadine Weisscher, Rob J de Haan and Marinus Vermeulen
    Citation: BMC Medical Research Methodology 2007 7:24
  3. The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencie...

    Authors: Soe Soe Thwin, Kerri M Clough-Gorr, Maribet C McCarty, Timothy L Lash, Sharon H Alford, Diana SM Buist, Shelley M Enger, Terry S Field, Floyd Frost, Feifei Wei and Rebecca A Silliman
    Citation: BMC Medical Research Methodology 2007 7:23
  4. The ability to locate those sampled has important implications for response rates and thus the success of survey research. The purpose of this study was to examine predictors of locating women requiring tracin...

    Authors: Suzanne M Cadarette, Leigh Dickson, Monique AM Gignac, Dorcas E Beaton, Susan B Jaglal and Gillian A Hawker
    Citation: BMC Medical Research Methodology 2007 7:22
  5. Claims data provide rapid indicators of SSIs for coronary artery bypass surgery and have been shown to successfully rank hospitals by SSI rates. We now operationalize this method for use by payers without tran...

    Authors: Susan S Huang, James M Livingston, Nigel SB Rawson, Steven Schmaltz and Richard Platt
    Citation: BMC Medical Research Methodology 2007 7:20
  6. Questionnaires are used routinely in clinical research to measure health status and quality of life. Questionnaire measurements are traditionally formally assessed by indices of reliability (the degree of meas...

    Authors: Matthew Hankins
    Citation: BMC Medical Research Methodology 2007 7:19
  7. Analyzing drop out rates and when they occur may give important information about the patient characteristics and trial characteristics that affect the overall uptake of an intervention.

    Authors: Carl Heneghan, Rafael Perera, Alison Ward A, David Fitzmaurice, Emma Meats and Paul Glasziou
    Citation: BMC Medical Research Methodology 2007 7:18
  8. Pragmatic randomised controlled trials are often used in primary care to evaluate the effect of a treatment strategy. In these trials it is difficult to achieve both high internal validity and high generalisab...

    Authors: Gerdine AJ Fransen, Corine J van Marrewijk, Suhreta Mujakovic, Jean WM Muris, Robert JF Laheij, Mattijs E Numans, Niek J de Wit, Melvin Samsom, Jan BMJ Jansen and J André Knottnerus
    Citation: BMC Medical Research Methodology 2007 7:16
  9. It is notoriously difficult to recruit patients to randomised controlled trials in primary care. This is particularly true when the disease process under investigation occurs relatively infrequently and must b...

    Authors: Brian McKinstry, Victoria Hammersley, Fergus Daly and Frank Sullivan
    Citation: BMC Medical Research Methodology 2007 7:15
  10. Health surveys provide important information on the burden and secular trends of risk factors and disease. Several factors including survey and item non-response can affect data quality. There are few reports ...

    Authors: Rainford Wilks, Novie Younger, Jasneth Mullings, Namvar Zohoori, Peter Figueroa, Marshall Tulloch-Reid, Trevor Ferguson, Christine Walters, Franklyn Bennett, Terrence Forrester, Elizabeth Ward and Deanna Ashley
    Citation: BMC Medical Research Methodology 2007 7:13
  11. Poor response rates to postal questionnaires can introduce bias and reduce the statistical power of a study. To improve response rates in our trial in primary care we tested the effect of introducing an uncond...

    Authors: Stephen D Brealey, Christine Atwell, Stirling Bryan, Simon Coulton, Helen Cox, Ben Cross, Fiona Fylan, Andrew Garratt, Fiona J Gilbert, Maureen GC Gillan, Maggie Hendry, Kerenza Hood, Helen Houston, David King, Veronica Morton, Jo Orchard…
    Citation: BMC Medical Research Methodology 2007 7:12
  12. In most case control studies the hardest decision is the choice of the control group, as in the ideal control group the proportion exposed is the same as in the population that produced the cases.

    Authors: Odimariles MS Dantas, Ricardo AA Ximenes, Maria de Fatima PM de Albuquerque, Ulisses R Montarroyos, Wayner V de Souza, Patrícia Varejão and Laura C Rodrigues
    Citation: BMC Medical Research Methodology 2007 7:11
  13. Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus.

    Authors: Beverley J Shea, Jeremy M Grimshaw, George A Wells, Maarten Boers, Neil Andersson, Candyce Hamel, Ashley C Porter, Peter Tugwell, David Moher and Lex M Bouter
    Citation: BMC Medical Research Methodology 2007 7:10
  14. Little is known about the response mechanisms among survivors of disasters. We studied the selective attrition and possible bias in a longitudinal study among survivors of a fireworks disaster.

    Authors: Bellis van den Berg, Peter van der Velden, Rebecca Stellato and Linda Grievink
    Citation: BMC Medical Research Methodology 2007 7:8
  15. To explore the strengths and weaknesses of conventional biomedical research strategies and methods as applied to complementary and alternative medicine (CAM), and to suggest a new research framework for assess...

    Authors: Vinjar Fønnebø, Sameline Grimsgaard, Harald Walach, Cheryl Ritenbaugh, Arne Johan Norheim, Hugh MacPherson, George Lewith, Laila Launsø, Mary Koithan, Torkel Falkenberg, Heather Boon and Mikel Aickin
    Citation: BMC Medical Research Methodology 2007 7:7
  16. Often in survey research, subsets of the population invited to complete the survey do not respond in a timely manner and valuable resources are expended in recontact efforts. Various methods of improving respo...

    Authors: Jean-Paul Chretien, Laura K Chu, Tyler C Smith, Besa Smith and Margaret AK Ryan
    Citation: BMC Medical Research Methodology 2007 7:6
  17. Meta-analysis handles randomized trials with no outcome events in both treatment and control arms inconsistently, including them when risk difference (RD) is the effect measure but excluding them when relative...

    Authors: Jan O Friedrich, Neill KJ Adhikari and Joseph Beyene
    Citation: BMC Medical Research Methodology 2007 7:5
  18. The inclusion of qualitative studies in systematic reviews poses methodological challenges. This paper presents worked examples of two methods of data synthesis (textual narrative and thematic), used in relati...

    Authors: Patricia J Lucas, Janis Baird, Lisa Arai, Catherine Law and Helen M Roberts
    Citation: BMC Medical Research Methodology 2007 7:4
  19. When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation. A multivariate random-effects meta-analysis mus...

    Authors: Richard D Riley, Keith R Abrams, Alexander J Sutton, Paul C Lambert and John R Thompson
    Citation: BMC Medical Research Methodology 2007 7:3
  20. This paper describes the study protocol, the recruitment, and base-line data for evaluating the success of randomisation of the PRO-AGE (PRevention in Older people – Assessment in GEneralists' practices) project.

    Authors: Andreas E Stuck, Kalpa Kharicha, Ulrike Dapp, Jennifer Anders, Wolfgang von Renteln-Kruse, Hans Peter Meier-Baumgartner, Steve Iliffe, Danielle Harari, Martin D Bachmann, Matthias Egger, Gerhard Gillmann, John C Beck and Cameron G Swift
    Citation: BMC Medical Research Methodology 2007 7:2
  21. Health risk appraisal is a promising method for health promotion and prevention in older persons. The Health Risk Appraisal for the Elderly (HRA-E) developed in the U.S. has unique features but has not been te...

    Authors: Andreas E Stuck, Kalpa Kharicha, Ulrike Dapp, Jennifer Anders, Wolfgang von Renteln-Kruse, Hans Peter Meier-Baumgartner, Danielle Harari, Cameron G Swift, Katja Ivanova, Matthias Egger, Gerhard Gillmann, Jerilyn Higa, John C Beck and Steve Iliffe
    Citation: BMC Medical Research Methodology 2007 7:1
  22. Reasons for attrition in studies vary, but may be a major concern in long-term studies if those who drop out differ systematically from those who continue to participate. Factors associated with dropout were e...

    Authors: Naomi M Gades, Debra J Jacobson, Michaela E McGree, Michael M Lieber, Rosebud O Roberts, Cynthia J Girman and Steven J Jacobsen
    Citation: BMC Medical Research Methodology 2006 6:58
  23. Missing data present a challenge to many research projects. The problem is often pronounced in studies utilizing self-report scales, and literature addressing different strategies for dealing with missing data...

    Authors: Fiona M Shrive, Heather Stuart, Hude Quan and William A Ghali
    Citation: BMC Medical Research Methodology 2006 6:57
  24. It is often stated that external validity is not sufficiently considered in the assessment of clinical studies. Although tools for its evaluation have been established, there is a lack of awareness of their si...

    Authors: Gudrun Bornhöft, Stefanie Maxion-Bergemann, Ursula Wolf, Gunver S Kienle, Andreas Michalsen, Horst C Vollmar, Simon Gilbertson and Peter F Matthiessen
    Citation: BMC Medical Research Methodology 2006 6:56
  25. Provision of evidence on costs alongside evidence on the effects of interventions can enhance the relevance of systematic reviews to decision-making. However, patterns of use of economics methods alongside sys...

    Authors: Ian Shemilt, Miranda Mugford, Michael Drummond, Eric Eisenstein, Jacqueline Mallender, David McDaid, Luke Vale and Damian Walker
    Citation: BMC Medical Research Methodology 2006 6:55
  26. Stepped wedge randomised trial designs involve sequential roll-out of an intervention to participants (individuals or clusters) over a number of time periods. By the end of the study, all participants will hav...

    Authors: Celia A Brown and Richard J Lilford
    Citation: BMC Medical Research Methodology 2006 6:54
  27. Providers use risk-adjustment systems to help manage healthcare costs. Typically, ordinary least squares (OLS) models on either untransformed or log-transformed cost are used. We examine the predictive ability...

    Authors: Maria Montez-Rath, Cindy L Christiansen, Susan L Ettner, Susan Loveland and Amy K Rosen
    Citation: BMC Medical Research Methodology 2006 6:53
  28. Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magni...

    Authors: Jonathan R Treadwell, Stephen J Tregear, James T Reston and Charles M Turkelson
    Citation: BMC Medical Research Methodology 2006 6:52
  29. Meta-analysis has become a well-known method for synthesis of quantitative data from previously conducted research in applied health sciences. So far, meta-analysis has been particularly useful in evaluating a...

    Authors: Leon Bax, Ly-Mee Yu, Noriaki Ikeda, Harukazu Tsuruta and Karel GM Moons
    Citation: BMC Medical Research Methodology 2006 6:50
  30. In this paper we compare the results in an analysis of determinants of caregivers' health derived from two approaches, a structural equation model and a log-linear model, using the same data set.

    Authors: Bin Zhu, Stephen D Walter, Peter L Rosenbaum, Dianne J Russell and Parminder Raina
    Citation: BMC Medical Research Methodology 2006 6:49
  31. The interpretation of the results of active-control trials regarding the efficacy and safety of a new drug is important for drug registration and following clinical use. It has been suggested that non-inferior...

    Authors: Jean-Jacques Parienti, Renaud Verdon and Véronique Massari
    Citation: BMC Medical Research Methodology 2006 6:46
  32. A recent paper found that terminal digits of statistical values in Nature deviated significantly from an equiprobable distribution, indicating errors or inconsistencies in rounding. This finding, as well as th...

    Authors: Monwhea Jeng
    Citation: BMC Medical Research Methodology 2006 6:45
  33. The Levels of Evidence Rating System is widely believed to categorize studies by quality, with Level I studies representing the highest quality evidence. We aimed to determine the reporting quality of Randomis...

    Authors: Rudolf W Poolman, Peter AA Struijs, Rover Krips, Inger N Sierevelt, Kristina H Lutz and Mohit Bhandari
    Citation: BMC Medical Research Methodology 2006 6:44
  34. A trial was commissioned to evaluate the effectiveness of larval therapy to debride and heal sloughy and necrotic venous leg ulcers. Larval therapy in the trial was to be delivered in either loose or bagged fo...

    Authors: ES Petherick, S O'Meara, K Spilsbury, CP Iglesias, EA Nelson and DJ Torgerson
    Citation: BMC Medical Research Methodology 2006 6:43
  35. Citation counts are often regarded as a measure of the utilization and contribution of published articles. The objective of this study is to assess whether statistical reporting and statistical errors in the a...

    Authors: Pentti Nieminen, James Carpenter, Gerta Rucker and Martin Schumacher
    Citation: BMC Medical Research Methodology 2006 6:42
  36. Disease specific mortality is often used as outcome rather than total mortality in clinical trials. This approach assumes that the classification of cause of death is unbiased. We explored whether use of funga...

    Authors: Anne K Due, Helle K Johansen and Peter C Gøtzsche
    Citation: BMC Medical Research Methodology 2006 6:40
  37. Home ultraviolet B (UVB) treatment is a much-debated treatment, especially with regard to effectiveness, safety and side effects. However, it is increasingly being prescribed, especially in the Netherlands. De...

    Authors: Mayke BG Koek, Erik Buskens, Paul HA Steegmans, Huib van Weelden, Carla AFM Bruijnzeel-Koomen and Vigfús Sigurdsson
    Citation: BMC Medical Research Methodology 2006 6:39
  38. Mathematical models are widely used for studying the dynamic of infectious agents such as hepatitis C virus (HCV). Most often, model parameters are estimated using standard least-square procedures for each ind...

    Authors: Rodolphe Thiébaut, Jérémie Guedj, Hélène Jacqmin-Gadda, Geneviève Chêne, Pascale Trimoulet, Didier Neau and Daniel Commenges
    Citation: BMC Medical Research Methodology 2006 6:38
  39. The International Classification of Functioning, Disability and Health (ICF) is the framework developed by WHO to describe functioning and disability at both the individual and population levels.

    Authors: Alarcos Cieza, Szilvia Geyh, Somnath Chatterji, Nenad Kostanjsek, Bedirhan T Üstün and Gerold Stucki
    Citation: BMC Medical Research Methodology 2006 6:36
  40. Conventional systematic review techniques have limitations when the aim of a review is to construct a critical analysis of a complex body of literature. This article offers a reflexive account of an attempt to...

    Authors: Mary Dixon-Woods, Debbie Cavers, Shona Agarwal, Ellen Annandale, Antony Arthur, Janet Harvey, Ron Hsu, Savita Katbamna, Richard Olsen, Lucy Smith, Richard Riley and Alex J Sutton
    Citation: BMC Medical Research Methodology 2006 6:35

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