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Validation of the Turkish version of the Centre for Epidemiologic Studies Depression Scale (CES-D) in patients with Type 2 diabetes mellitus
- Vicky Lehmann†1,
- Ceylan Makine†1,
- Çagatay Karşıdağ†2,
- Pinar Kadıoğlu†3,
- Kubilay Karşıdağ†4 and
- François Pouwer†1Email author
© Lehmann et al; licensee BioMed Central Ltd. 2011
Received: 17 March 2011
Accepted: 26 July 2011
Published: 26 July 2011
Depression is a common co-morbid health problem in patients with diabetes that is underrecognised. Current international guidelines recommend screening for depression in patients with diabetes. Yet, few depression screening instruments have been validated for use in this particular group of patients. Aim of the present study was to investigate the psychometric properties of the Turkish version of the Centre for Epidemiologic Studies Depression Scale (CES-D) in patients with type 2 diabetes.
A sample of 151 Turkish outpatients with type 2 diabetes completed the CES-D, the World Health Organization-Five Well-Being Index (WHO-5), and the Problem Areas in Diabetes scale (PAID). Explanatory factor analyses, various correlations and Cronbach's alpha were investigated to test the validity and reliability of the CES-D in Turkish diabetes outpatients.
The original four-factor structure proposed by Radloff was not confirmed. Explanatory factor analyses revealed a two-factor structure representing two subscales: (1) depressed mood combined with somatic symptoms of depression and (2) positive affect. However, one item showed insufficient factor loadings. Cronbach's alpha of the total score was high (0.88), as were split-half coefficients (0.77-0.90). The correlation of the CES-D with the WHO-5 was the strongest (r = -0.70), and supported concurrent validity.
The CES-D appears to be a valid measure for the assessment of depression in Turkish diabetes patients. Future studies should investigate its sensitivity and specificity as well as test-retest reliability.
Depression is a common complication of type 2 diabetes, affecting 10-20% of the patients, particularly those with cardiovascular complications [1, 2]. A recent multi-center study in three Dutch outpatient clinics showed that approximately 40% of outpatients with type 2 diabetes report depressive affect on the WHO-5 and/or the CES-D . Compared to non-diabetic controls, patients with diabetes have a 2 times higher risk being depressed . Depression is a burdensome co-morbid disease in diabetes that is associated with impaired quality of life [4, 5]. In patients with diabetes, depression is also associated with less optimal self-care behaviors , impaired glycaemic control and a higher risk for long term complications, higher use of medical services, and higher mortality rates [7–11]. However, recognition rates of depression in diabetes were found to be low, for example with medical staff recognizing 20-25% of cases [12, 13]. Recently, the prevalence of diabetes in Turkey was estimated at 2.9 million . This would mean that approximately 290.000 to 580.000 Turkish people suffer from both diabetes and co-morbid depression. Current guidelines from the International Diabetes Federation for the treatment of type 2 diabetes recommend the routine use of questionnaires to assess psychological wellbeing in clinical practice . One well-established questionnaire examining depressive symptoms is the Centre for Epidemiologic Studies Depression Scale (CES-D ) which could be used for this purpose. However, the psychometric properties of this questionnaire have not been examined yet in a Turkish sample of diabetic patients. The aim of this paper is therefore to investigate several aspects of the validity and reliability of the Turkish version of the CES-D in patients with diabetes, including its latent structure. We aimed to explore the latent structure of the CES-D (Turkish version) as earlier research has described different factor structures for this scale. As a result, it is unclear which factor structure should be used in Turkish participants (and specifically in diabetic Turkish patients).
This paper describes posterior analyses on data from a previous study concerning the associations between depression and appraisal of insulin therapy . The original study was conducted in two outpatient clinics in Istanbul, Turkey: the Istanbul Medical Faculty Hospital and the Cerrahpaşa Medical Faculty Hospital. Consecutive patients with Type 2 diabetes mellitus who were treated with a diet and/or oral agents were invited to participate in this study. Exclusion criteria for the original research were being illiterate or not being able to read due to vision problems. All subjects gave their written informed consent and the Ethical Review Committee of the Istanbul University Medical Faculty and Cerrahpaşa Medical Faculty approved the study.
Measures and Data
Demographic characteristics and data concerning treatment for diabetes or depression were acquired through self-report.
The Centre for Epidemiologic Studies Depression Scale (CES-D) is a self-report questionnaire that has been developed to measure depressive symptoms and to detect people at risk of having a depressive disorder . The Turkish version of the CES-D, developed by Spijker and colleagues , was used in the presented study. The CES-D contains 20 items that can be responded to on a four-point Likert scale, with response categories ranging from 'rarely or none of the time' (0 points) to 'most or all of the times' (3 points) which are summed up to a total score where higher score indicate more severe depressive symptoms. A cut-off score of ≥ 16 is generally accepted as indicator for clinical meaningful depressive symptoms.
Earlier studies yielded a four-factor-structure  that has been replicated in various studies [19–24]. However, studies in more specific populations or with diverse ethnical backgrounds have found inconsistent results. For example, Spijker et al.  reported a five-factor structure for Dutch elderly, a four-factor structure for Turkish elderly, and a three-factor structure for Moroccan elderly people living in the Netherlands while Fountoulakis et al.  reported a three-factor structure for a Greek sample. Furthermore, Tatar and Saltukoglu  conducted extensive analyses in a huge sample of 1143 Turkish students and healthy adults, supporting the initial four-factor structure, but also reporting problems concerning the dimension of somatic complaints and especially with item 7. Given these findings, we anticipated to find a four-factor structure in our dataset.
The World Health Organization-Five Well-Being Index (WHO-5, ) is a brief self-report measure that can be used to assess general emotional well-being over the past two weeks. It consists of five positively formulated items that can be answered on a six-point Likert scale, ranging from 'not present' (0) to 'constantly present' (5). These scores have to be summed up to acquire the total well-being index ranging from 0 (worst outcome) to 25 (best outcome). A sum score of ≤ 13 was introduced as cut-off indicating depression . The WHO  also suggested another way of handling the sum score. They suggested multiplying the sum score by 4, yielding possible total scores between 0 and 100 (best outcome) which could be treated as percentages and percentage scores lower than 28 indicate depression. The WHO-5 appeared to be applicable for diabetes patients [28, 30] and to be one of the most sensitive (93%) measures to detect depression, compared to other brief self-report measures . However, specificity tended to be relatively low, (64%) which indicates that the percentage of false-positive results is rather high. Since the WHO-5 measures a positively connoted construct as well-being, we suspect negative associations with the outcome of the CES-D.
The Problem Areas in Diabetes scale (PAID) is a 20 item self-report measurement that can be used to assess diabetes-specific emotional distress, such as worries about complications or concerns about food [17, 32, 33]. The items are rated on a six-point Likert-scale ranging from 'not a problem' (1) to 'a serious problem' (6). The raw scores are transformed into a scale ranging from 0 - 100 where higher scores indicate more emotional problems related to diabetes. If problems related to diabetes coincide with depressive symptoms, their association is consequently suspected to be positive.
Descriptive analyses were conducted in order to inspect sample characteristics and outcome on the three self-report measurements. Explanatory factor analyses were planned (using oblique rotation) to examine the underlying factor structure of the CES-D. The Scree plot and eigenvalues > 1 criterion were used to decide about the appropriateness of the number of retrieved factors. An oblique (instead of varimax) rotation was used, based on the assumption that a test measuring depression will have correlated factors. However, an explanatory factor analysis using an orthogonal varimax rotation was also performed to ensure comparability with previous validation studies. Reliability was examined inspecting the internal consistencies (Cronbach's alpha) of the total score and subscales indicated by the factor analysis. Correlations between the CES-D with the other self-report measures were calculated, using Pearson's correlation, to test its convergent validity.
Demographic, clinical and psychological characteristics of the whole sample of type 2 diabetes participants; as well as separated by gender and hospital where they have been treated
Istanbul University Hospital
Cerrahpaşa University Hospital
Age in years (SD);
28 - 81
28 - 75
36 - 79
30 - 81
40 - 73
BMI (SD); range
21 - 45
21 - 36
23 - 41
23 - 38
23 - 45
< 1 year
> 10 years
Level of education
CES-D; m (SD)
CES-D ≥ 16;
WHO-5; m (SD)
WHO ≤ 28,
PAID ≥ 40,
The Kaiser-Meyer-Olkin test (KMO) was found to be .891 (thus higher than .50) and Bartlett's test of sphericity showed a highly significant result (χ2 = 1409.1), thus both tests indicated the appropriateness of performing factor analyses in the presented sample .
Results from the factor analyses of the 5-factor and the 2-factor solution
too much effort
not get going
as good as others
others dislike me
In summary, these factor analyses showed that the latent structure of the Turkish version of the CES-D could best be described as a one-factor solution (given the high first eigenvalue) or a 2-factor solution (depression and positive affect). The two factors were moderately correlated with another r = .329 (p < .0001), but strongly associated to the total score with r = .918 (depression) and r = .676 (positive affect).
To also assure comparability with the original factor analysis performed by Radloff, we repeated the explanatory factor analysis using varimax rotation. The same unfeasible 5-factor solution has been found, only the ordering of the factors was different. Also, the subsequent factor analyses using forced entry showed the same problematic results finally suggesting the same 2-factor solution (data not shown).
Results of the reliability analyses using Cronbach's Alpha
Pearson's Correlations of the CES-D scores with the WHO-5 and PAID scores
CES-D Factor 1
CES-D Factor 2
diabetes-related emotional problems
social support problems
This study was the first to investigate the psychometric properties of the CES-D in a Turkish sample of diabetes mellitus type 2 patients. We aimed to focus on the factor structure, concurrent validity, and reliability of the Turkish version of the CES-D. The results of our factor analyses did neither confirm the initial 4-factor structure of the CES-D nor former findings in other countries which showed 3-, 4-, or 5-factor solutions. In contrast, our results showed a 2-factor solution separating depressed mood (combined with somatic complaints) and positive affect into two factors which were coherent in terms of item content. However, the very large eigenvalue for the first factor is in line with other findings supports the usage of the CES-D as a one-dimensional measure investigating depressed mood. The fact that we found a 2-factor structure with positively and negatively worded items is in line with results from several other self-report measures (e.g. the W-BQ12 or ITAS [35, 36]) since it is common that positively and negatively worded items load on different factors. Yet, they both contribute and form parts of the overall construct of depression as shown by their correlation with each other and with the total score. Their correlations with the other self-report measures suggest that the first factor (depression) is more strongly associated with the other measures yielding similar results as the total score. However, correlations of the second factor showed to be of significant importance as well. The usefulness of the combination of depressed and somatic complaints in our first factor may be questioned though. There is the well-known problem that people with chronic diseases show elevated levels of depression measured with self-report instrument due to somatic complaints that are actually caused by their disease and not depression. This is for example also the case in the Beck Depression Inventory and a general problem in chronically ill people and not specific to the CES-D.
Two items of the CES-D appeared to have less optimal scaling characteristics in the present study: item 13 (talk less) and item 19 (others dislike me). Item 13 formed a separate factor in our first factor analysis (resulting in a 5-factor solution) and also in the 4-factor solution, before elapsing into the first factor and showing satisfying factor loadings in the subsequent analysis. However, item 19 is of higher importance, because its factor loading is rather low. We hold the opinion that this may be due to cultural factors, as Turkey is more of a group culture, less individualized, where the family and family members play a relatively important role. It may also be that the scaling characteristics will become better in samples with more severe depression. For example, in the present study, over 80% of the participants denied that others disliked them, therefore the distribution of this item was rather skewed.
One could also argue that these rather unsuspected results of the factor analyses can be attributed to the fact that we used an oblique rotation in contrast to varimax which was used in former publications. However, we also checked this technique and the results were the same only showing a different order of the extracted factors. Thus, our expected four-factor structure was not supported by the data which was surprising, since especially the findings of Tatar and Saltukoglu  promised similar results due to the same cultural background of the sample. However, testing a chronically ill sample may means a higher association of depressed and somatic symptoms leading to their combined loading on one factor instead of in a healthy sample where depressed and somatic complaints may be more fine-grained and loose from another.
In general, different factoranalytic outcomes in different studies seem not too problematic for clinical practice, since the use of the CES-D total score is supported by the results of the present study.
The CES-D proved to be a highly reliable instrument within this sample with high Cronbach's alpha values for the total score and the two factors ranging from 0.82 - 0.90.
The correlations of the CES-D with the WHO-5 and the PAID were in line with expectations, we found a strong negative association between depressed mood and emotional well-being and less strong, but positive, associations between depressed aspects and diabetes related problems.
A major limitation of our study was the relatively small sample size. However, preliminary tests as KMO and Bartlett's test assured the appropriateness of our sample for trustworthy factor analyses. However, future research should also include more heterogeneous samples for example concerning the severity and treatment of diabetes. Another limitation of our study is the fact that the patients had no clinical diagnoses concerning depressed mood or major depressive disorder. This would have facilitated testing the sensitivity and specificity to challenge the screening capacity of the CES-D even more. Determining the percentage of diabetes patients with elevated levels of depressive symptoms within this sample yielded numbers of about one quarter and one tenth respectively, using the cut-offs of the CES-D and WHO-5. Our sample reported a mean CESD score of 11 (SD = 9.7) which imposes the question whether another cut-off for the CESD might be more appropriate in Turkish diabetic populations. A score higher than one standard deviation above the mean could indicate an appropriate cut-off which would yield a score of 21 in this sample. However, more studies also including verified diagnoses of depression, both types of diabetes, patients from primary care settings, and patients with more severe treatment (i.e. insulin) should be conducted to approach the possibility of a different cut-off more thoroughly.
In conclusion, we want to highlight the overall good performance of the CES-D concerning its psychometric properties. Considering the recommendation of the International Diabetes Federation to routinely use questionnaires assessing the psychological well-being in diabetes patients we assume that the CES-D can be used as a valid and reliable measure for the assessment of depression in Turkish diabetes patients. Nevertheless, we want to emphasize that screening only is not enough since a high amount of false positive results are produced by screening measures and they could never substitute a detailed clinical interview and diagnosis. Moreover, screening for depression should be embedded in a collaborative care approach for depression .
- Pouwer F, Beekman AT, Nijpels G, et al: Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study. Diabetologia. 2003, 46 (7): 892-8. 10.1007/s00125-003-1124-6.View ArticlePubMedGoogle Scholar
- Ali S, Stone MA, Peters JL, et al: The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2006, 23 (11): 1165-73. 10.1111/j.1464-5491.2006.01943.x.View ArticlePubMedGoogle Scholar
- Pouwer F, Geelhoed-Duijvestijn PHLM, Tack CJ, et al: Prevalence of comorbid depression is high in out-patients with Type 1 or Type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands. Diabetic Medicine. 2010, 27 (2): 217-224. 10.1111/j.1464-5491.2009.02903.x.View ArticlePubMedGoogle Scholar
- Ali S, Stone M, Skinner TC, et al: The association between depression and health-related quality of life in people with type 2 diabetes: a systematic literature review. Diabetes Metab Res Rev. 2010, 26 (2): 75-89. 10.1002/dmrr.1065.View ArticlePubMedGoogle Scholar
- Schram MT, Baan CA, Pouwer F: Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium. Curr Diabetes Rev. 2009, 5 (2): 112-9. 10.2174/157339909788166828.View ArticlePubMedPubMed CentralGoogle Scholar
- Egede LE, Ellis C, Grubaugh AL: The effect of depression on self-care behaviors and quality of care in a national sample of adults with diabetes. Gen Hosp Psychiatry. 2009, 31 (5): 422-7. 10.1016/j.genhosppsych.2009.06.007.View ArticlePubMedGoogle Scholar
- Pouwer F, Snoek FJ: Association between symptoms of depression and glycaemic control may be unstable across gender. Diabet Med. 2001, 18 (7): 595-8. 10.1046/j.1464-5491.2001.00499.x.View ArticlePubMedGoogle Scholar
- Subramaniam M, Sum CF, Pek E, et al: Comorbid depression and increased health care utilisation in individuals with diabetes. Gen Hosp Psychiatry. 2009, 31 (3): 220-4. 10.1016/j.genhosppsych.2009.01.001.View ArticlePubMedGoogle Scholar
- Lin EH, Heckbert SR, Rutter CM, et al: Depression and increased mortality in diabetes: unexpected causes of death. Ann Fam Med. 2009, 7 (5): 414-21. 10.1370/afm.998.View ArticlePubMedPubMed CentralGoogle Scholar
- Katon WJ, Fan MY, Unutzer J, et al: Depression and diabetes: a potentially lethal combination. J Gen Intern Med. 2008, 23 (10): 1571-5. 10.1007/s11606-008-0731-9.View ArticlePubMedPubMed CentralGoogle Scholar
- Lustman PJ, Anderson RJ, Freedland KE, et al: Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care. 2000, 23 (7): 934-42. 10.2337/diacare.23.7.934.View ArticlePubMedGoogle Scholar
- Pouwer F, Beekman AT, Lubach C, et al: Nurses' recognition and registration of depression, anxiety and diabetes-specific emotional problems in outpatients with diabetes mellitus. Patient Educ Couns. 2006, 60 (2): 235-40. 10.1016/j.pec.2005.01.009.View ArticlePubMedGoogle Scholar
- Rubin RR, Ciechanowski P, Egede LE, et al: Recognizing and treating depression in patients with diabetes. Curr Diab Rep. 2004, 4 (2): 119-25. 10.1007/s11892-004-0067-8.View ArticlePubMedGoogle Scholar
- Onat A, Hergenc G, Uyarel H, et al: Prevalence, incidence, predictors and outcome of type 2 diabetes in Turkey. Anadolu Kardiyol Derg. 2006, 6 (4): 314-21.PubMedGoogle Scholar
- Global Guideline for Type 2 Diabetes. 2005, [http://www.idf.org/webdata/docs/IDF%20GGT2D.pdf]
- Radloff LS: The CES-D Scale: A Self-Report Depression Scale for Research in the General Population. Appl Psychol Meas. 1977, 1: 385-401. 10.1177/014662167700100306.View ArticleGoogle Scholar
- Makine C, Karsidag C, Kadioglu P, et al: Symptoms of depression and diabetes-specific emotional distress are associated with a negative appraisal of insulin therapy in insulin-naive patients with Type 2 diabetes mellitus. A study from the European Depression in Diabetes [EDID] Research Consortium. Diabet Med. 2009, 26 (1): 28-33. 10.1111/j.1464-5491.2008.02606.x.View ArticlePubMedGoogle Scholar
- Spijker J, Van Der Wurff FB, Poort EC, et al: Depression in first generation labour migrants in Western Europe: the utility of the Center for Epidemiologic Studies Depression Scale (CES-D). Int J Geriatr Psychiatry. 2004, 19 (6): 538-44. 10.1002/gps.1122.View ArticlePubMedGoogle Scholar
- Makambi KH, Williams CD, Taylor TR, et al: An assessment of the CES-D scale factor structure in black women: The Black Women's Health Study. Psychiatry Res. 2009, 168 (2): 163-70. 10.1016/j.psychres.2008.04.022.View ArticlePubMedPubMed CentralGoogle Scholar
- Nguyen HT, Kitner-Triolo M, Evans MK, et al: Factorial invariance of the CES-D in low socioeconomic status African Americans compared with a nationally representative sample. Psychiatry Res. 2004, 126 (2): 177-87. 10.1016/j.psychres.2004.02.004.View ArticlePubMedGoogle Scholar
- Long Foley K, Reed PS, Mutran EJ, et al: Measurement adequacy of the CES-D among a sample of older African-Americans. Psychiatry Res. 2002, 109 (1): 61-9. 10.1016/S0165-1781(01)00360-2.View ArticlePubMedGoogle Scholar
- Mccallum J, Mackinnon A, Simons L, et al: Measurement properties of the Center for Epidemiological Studies Depression Scale: an Australian community study of aged persons. J Gerontol B Psychol Sci Soc Sci. 1995, 50 (3): S182-9.View ArticlePubMedGoogle Scholar
- Hertzog C, Van Alstine J, Usala P, et al: Measurement properties of the Center of Epidemiological Studies Depression Scale (CES-D) in older populations. Psychological Assessment. 1990, 2: 64-72.View ArticleGoogle Scholar
- Knight RG, Williams S, Mcgee R, et al: Psychometric properties of the Centre for Epidemiologic Studies Depression Scale (CES-D) in a sample of women in middle life. Behav Res Ther. 1997, 35 (4): 373-80. 10.1016/S0005-7967(96)00107-6.View ArticlePubMedGoogle Scholar
- Fountoulakis K, Iacovides A, Kleanthous S, et al: Reliability, validity and psychometric properties of the Greek translation of the Center for Epidemiological Studies-Depression (CES-D) Scale. BMC Psychiatry. 2001, 1: 3-10.1186/1471-244X-1-3.View ArticlePubMedPubMed CentralGoogle Scholar
- Tatar A, Saltukoglu G: The Adaptation of the CES-Depression Scale into Turkish through the use of Confirmatory Factor Analysis and Item Response Theory and the Examination of Psychometric Characteristics. Bulletein of Clinical Psychopharamcology. 2010, 20: 213-227.Google Scholar
- World Health Organization. [http://www.who-5.org]
- Awata S, Bech P, Yoshida S, et al: Reliability and validity of the Japanese version of the World Health Organization-Five Well-Being Index in the context of detecting depression in diabetic patients. Psychiatry Clin Neurosci. 2007, 61 (1): 112-9. 10.1111/j.1440-1819.2007.01619.x.View ArticlePubMedGoogle Scholar
- World Health Organization Info Package: Mastering Depression in Primary Care. Edited by: ROo Europe. 1998, Frederiksborg: World Health OrganizationGoogle Scholar
- Bech P, Gudex C, Johansen KS: The WHO (Ten) Well-Being Index: validation in diabetes. Psychother Psychosom. 1996, 65 (4): 183-90. 10.1159/000289073.View ArticlePubMedGoogle Scholar
- Primack BA: The WHO-5 Wellbeing Index performed the best in screening for depression in primary care. ACP J Club. 2003, 139 (2): 48-PubMedGoogle Scholar
- Snoek FJ, Pouwer F, Welch GW, et al: Diabetes-related emotional distress in Dutch and U.S. diabetic patients: cross-cultural validity of the problem areas in diabetes scale. Diabetes Care. 2000, 23 (9): 1305-9. 10.2337/diacare.23.9.1305.View ArticlePubMedGoogle Scholar
- Welch GW, Jacobson AM, Polonsky WH: The Problem Areas in Diabetes Scale. An evaluation of its clinical utility. Diabetes Care. 1997, 20 (5): 760-6. 10.2337/diacare.20.5.760.View ArticlePubMedGoogle Scholar
- Kaiser HF: An Index of Factorial Simplicity. Psychometrika. 1974, 39: 31-36. 10.1007/BF02291575.View ArticleGoogle Scholar
- Pouwer F, Snoek FJ, Van Der Ploeg HM, et al: The well-being questionnaire: evidence for a three-factor structure with 12 items (W-BQ12). Psychol Med. 2000, 30 (2): 455-62. 10.1017/S0033291700001719.View ArticlePubMedGoogle Scholar
- Snoek FJ, Skovlund SE, Pouwer F: Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes. Health Qual Life Outcomes. 2007, 5: 69-10.1186/1477-7525-5-69.View ArticlePubMedPubMed CentralGoogle Scholar
- Pouwer F: Should we screen for emotional distress in type 2 diabetes mellitus?. Nature Reviews Endocrinology. 2009, 5 (12): 665-671. 10.1038/nrendo.2009.214.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2288/11/109/prepub
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