van Teijlingen ER, Hundley V: The Importance of Pilot Studies. Social Research Update. 2001, 35: [http://sru.soc.surrey.ac.uk/SRU35.html]
Google Scholar
Lancaster GA, Dodd S, Williamson PR: Design and analysis of pilot studies: recommendations for good practice. Journal of Evaluation in Clinical Practice. 2004, 10: 307-312. 10.1111/j..2002.384.doc.x.
Article
PubMed
Google Scholar
Arnold DM, Burns KE, Adhikari NKH, Kho ME, Meade MO, Cook DJ: The design and interpretation of pilot trials in clinical research in critical care. Critical Care Medicine. 2009, 37: S69-S74. 10.1097/CCM.0b013e3181920e33.
Article
PubMed
Google Scholar
Arain M, Campbell MJ, Cooper CL, Lancaster GA: What is a pilot or feasibility study? A review of current practice and editorial policy. BMC Medical Research Methodology. 2010, 10: 67-10.1186/1471-2288-10-67.
Article
PubMed
PubMed Central
Google Scholar
Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, Robson R, Thabane M, Giangregorio L, Goldsmituh CH: A tutorial on pilot studies: the what, why and how. BMC Medical Research Methodology. 2010, 10: 1-10.1186/1471-2288-10-1.
Article
PubMed
PubMed Central
Google Scholar
NIHR Health Technology Assessment Programme (NETSCC): Feasibility and Pilot studies. 2011, Last accessed June 27, [http://www.netscc.ac.uk/glossary/index.asp#glos7]
Google Scholar
Loscalzo J: Pilot trials in clinical research: Of what value are they?. Circulation. 2009, 119: 1694-1696. 10.1161/CIRCULATIONAHA.109.861625.
Article
PubMed
Google Scholar
Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, Tyrer P: Framework for design and evaluation of complex interventions to improve health. BMJ. 2000, 321: 694-6. 10.1136/bmj.321.7262.694.
Article
CAS
PubMed
PubMed Central
Google Scholar
Craig P, Dieppe P, Macintyre , Mitchie , Nazareth I, Petticrew M: Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ. 2008, 337: 979-983. 10.1136/bmj.a979.
Article
Google Scholar
Aisen PS Schmeidler J, Pasinetti GM: Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology. 2002, 58: 1050-4.
Article
PubMed
Google Scholar
Andreatini R, Sartori VA, Seabra MLV, Leite JR: Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytotherapy Research. 2002, 16: 650-4. 10.1002/ptr.1027.
Article
CAS
PubMed
Google Scholar
Barrett JA, Watkins C, Plant R, Dickinson H, Clayton L, Sharma AK, Reston A, Gratton J, Fall S, Flynn A, Smith T, Leathley M, Smith S, Barer DH: The COSTAR wheelchair study: a two-centre pilot study of self-propulsion in a wheelchair in early stroke rehabilitation. Clinical Rehabilitation. 2001, 15: 32-41. 10.1191/026921501672264719.
Article
CAS
PubMed
Google Scholar
Bean J, Herman S, Kiely DK, Callahan D, Mizer K, Frontera WR, Fielding RA: Weighted stair climbing in mobility-limited older people: a pilot study. Journal of the American Geriatrics Society. 2002, 50: 663-70. 10.1046/j.1532-5415.2002.50160.x.
Article
PubMed
Google Scholar
Beatty G, Hunt P, Smith A, Hoh R, Huang W, Martin J, Deeks SG: A randomized pilot study comparing combination therapy plus enfuvirtide versus a treatment interruption followed by combination therapy plus enfuvirtide. Antiviral Therapy. 2006, 11: 315-9.
CAS
PubMed
Google Scholar
Bernstein DI, Spruance SL, Arora SS, Schroeder JL, Meng T-C: Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study. Clinical Infectious Diseases. 2005, 41: 808-14. 10.1086/432802.
Article
CAS
PubMed
Google Scholar
Beysen C, Murphy EJ, Nagaraja H, Decaris M, Riiff T, Fong A, Hellerstein MK, Boyle PJ: A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes. Journal of Lipid Research. 2008, 49: 2657-63. 10.1194/jlr.M800165-JLR200.
Article
CAS
PubMed
Google Scholar
Blake H, Batson M: Exercise intervention in brain injury: a pilot randomized study of Tai Qigong. Clinical Rehabilitation. 2009, 23: 589-98. 10.1177/0269215508101736.
Article
CAS
PubMed
Google Scholar
Buckley T, Schalzberg AF: The acute and post-discontinuation effects of a glucocorticoid receptor (GR) antagonist probe on sleep and the HPA axis in chronic insomnia: a pilot study. Journal of Clinical Sleep Medicine. 2008, 4: 235-241.
PubMed
PubMed Central
Google Scholar
Callaghan MJ, Oldham JA, Winstanley J: A comparison of two types of electrical stimulation of the quadriceps in the treatment of patellofemoral pain syndrome. a pilot study. Clinical Rehabilitation. 2001, 15: 637-46. 10.1191/0269215501cr457oa.
Article
CAS
PubMed
Google Scholar
Carling C, Kristoffersen DT, Herrin J, Treweek S, Oxman AD, Schünemann H, Aki EA, Montori V: How should the impact of different presentations of treatment effects on patient choice be evaluated? A pilot randomized trial. PLoS ONE. 2008, 11: e3693-
Article
Google Scholar
Chandra P, Binongo JNG, Ziegler TR, Schlanger LE, Wang W, Someren JT, Tangpricha V: Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study. Endocrine Practice. 2008, 14: 10-7.
Article
PubMed
PubMed Central
Google Scholar
Christensen ER, Stegger M, Jensen-Fangel S, Laursen AL, Ostergaard L: Mitochondrial DNA levels in fat and blood cells from patients with lipodystrophy or peripheral neuropathy and the effect of 90 days of high-dose coenzyme Q treatment: a randomized, double-blind, placebo-controlled pilot study. Clinical Infectious Diseases. 2004, 39: 1371-9. 10.1086/424881.
Article
CAS
Google Scholar
Cortesi F, Giannotti F, Sebastiani T, Bruni O, Ottaviano S: Knowledge of sleep in Italian high school students: pilot-test of a school-based sleep educational program. Journal of Adolescent Health. 2004, 34: 344-351.
Article
PubMed
Google Scholar
Crogan NL, Evans BC, Bendel R: Storytelling intervention for patients with cancer: part 2-pilot testing. Oncology Nursing Forum. 2008, 35: 265-72. 10.1188/08.ONF.265-272.
Article
PubMed
Google Scholar
Dass S, Bowman SJ, Vital EM, Ikeda K, Pease CT, Hamburger J, Richards A, Rauz S, Emery P: Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study. Annals of the Rheumatic Diseases. 2008, 67: 1541-4.
Article
CAS
PubMed
Google Scholar
de Geest S, Schafer-Keller P, Denhaerynck K, Thannberger N, Kofer S, Bock A, Surber C, Steiger J: Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens. Clinical Transplantation. 2006, 20: 359-68. 10.1111/j.1399-0012.2006.00493.x.
Article
PubMed
Google Scholar
de Lusignan S, Wells S, Johnson P, Meredith K, Leatham E: Compliance and effectiveness of 1 year's home telemonitoring. The report of a pilot study of patients with chronic heart failure. European Journal of Heart Failure. 2001, 3: 723-30. 10.1016/S1388-9842(01)00190-8.
Article
CAS
PubMed
Google Scholar
diZerega GS, Verco SJS, Young P, Kettel M, Kobak W, Martin D, Sanfilippo J, Peers EM, Scrimgeour A, Brown CB: A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Human Reproduction. 2002, 17: 1031-8. 10.1093/humrep/17.4.1031.
Article
CAS
PubMed
Google Scholar
Farbu E, Rekand T, Vik-Mo E, Lygren , Gilhus NE, Aarli JA: Post-polio syndrome patients treated with intravenous immunoglobin: a double-blinded randomized controlled pilot study. European Journal of Neurology. 2007, 14: 60-65. 10.1111/j.1468-1331.2006.01552.x.
Article
CAS
PubMed
Google Scholar
Fuchs S, Dib N, Cohen BM, Okubagzi P, Diethrich EB, Campbell A, Macko J, Kessler PD, Rasmussen HS, Epstein SE, Kornowski R: A randomized, double-blind, placebo-controlled, multicenter, pilot study of the safety and feasibility of catheter-based intramyocardial injection of AdVEGF121 in patients with refractory advanced coronary artery disease. Catheterization and Cardiovascular Interventions. 2006, 68: 372-8. 10.1002/ccd.20859.
Article
PubMed
Google Scholar
Fürst A, Stuttner A, Agha A, Behan A, Jauch K-W: Colonic J-pouch vs. coloplasty following resection of distal rectal cancer Early results of a prospective, randomized, pilot study. Diseases or the Colon & Rectum. 2003, 46: 1161-1166. 10.1007/s10350-004-6707-x.
Article
Google Scholar
Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P: Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph: the Lung Screening Study of the National Cancer Institute. Chest. 2004, 126: 114-21. 10.1378/chest.126.1.114.
Article
PubMed
Google Scholar
Grenander A, Bredbacka S, Rydvall A, Aroch R, Edner G, Koskinen LOD, Olivecrona M: Antithrombin treatment in patients with traumatic brain injury: a pilot study. Journal of Neurosurgical Anesthesiology. 2001, 13: 49-56. 10.1097/00008506-200101000-00010.
Article
CAS
PubMed
Google Scholar
Hayton MJ, Santing AJA, Hughes PJ, Frostock SP, Trail IA, Stanley JK: Botulinum toxininjection in the treatment of tennis elbow. A double-blind, randomized, controlled, pilot study. Journal of Bone and Joint Surgery. 2005, 87-A: 502-507.
Google Scholar
Jain S, Dawson J, Quinn NP, Playford ED: Occupational therapy in multiple system atrophy: a pilot randomized controlled trial. Movement Disorders. 2004, 19: 1360-4. 10.1002/mds.20211.
Article
PubMed
Google Scholar
Janelli LM, Kanski GW, Wu YW: The influence of individualized music on patients in physical restraints: a pilot study. The Journal of the New York State Nurses' Association. 2005, 35: 22-7.
Google Scholar
Karleen Su T-I, Khanna D, Furst DE, Danovitch G, Burger C, Maranian P, Clements PJ: Rapamycin versus methrotrexate in early diffuse systematic sclerosis: results from a randomized, single-blind pilot study. Arthritis and Rheumatism. 2009, 60: 3821-30. 10.1002/art.24986.
Article
Google Scholar
Khodabux CM, von Lindern JS, van Hilten JA, Scherjon S, Walther FJ, Brand A: A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. Transfusion. 2008, 48: 1634-43. 10.1111/j.1537-2995.2008.01747.x.
Article
PubMed
Google Scholar
Klais CM, Eandi CM, Ober MD, Sorenson JA, Sadeghi SN, Freund KB, Spaide RF, Slakter JS, Yannuzzi LA: Anecortave acetate treatment for retinal angiomatous proliferation: a pilot study. Retina. 2006, 26: 773-9. 10.1097/01.iae.0000244261.52901.67.
Article
PubMed
Google Scholar
Klarin B, Molin G, Jeppsson B, Larsson A: Use of probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomized controlled open pilot study. Critical Care. 2008, 12: R136-10.1186/cc7109.
Article
PubMed
PubMed Central
Google Scholar
Lannin NA, Clemson L, McCluskey A, Lin CW, Cameron ID, Barras S: Feasibility and results of a randomised pilot-study of pre-discharge occupational therapy home visits. BMC Health Sservices Research. 2007, 7: 42-10.1186/1472-6963-7-42.
Article
Google Scholar
Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW: Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. Journal of Neurooncology. 2009, 93: 349-54. 10.1007/s11060-008-9781-4.
Article
CAS
Google Scholar
Luiten RM, Kueter EW, Mooi W, Gallee MP, Rankin EM, Gerritsen WR, Clift SM, Nooijen WJ, Weder P, van de Kasteele WF, Sein J, van den Berk PC, Nieweg OE, Berns AM, Spits H, de Gast GC: Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. Journal of Clinical Oncology. 2005, 23: 8978-91. 10.1200/JCO.2005.01.6816.
Article
CAS
PubMed
Google Scholar
Madden JAJ, Plummer SF, Tang J, Garaiova I, Plummer NT, Herbison M, Hunter JO, Shimada T, Cheng L, Shirakawa T: Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study. International Immunopharmacology. 2005, 5: 1091-7. 10.1016/j.intimp.2005.02.006.
Article
CAS
PubMed
Google Scholar
McCrossan B, Morgan G, Grant B, Sands A, Craig B, Casey F: Assisting the transition from hospital to home for children with major congenital heart disease by telemedicine: a feasibility study and initial results. Medical informatics and the Internet in Medicine. 2007, 32: 297-304. 10.1080/14639230701791611.
Article
CAS
PubMed
Google Scholar
Morriss R, Dowrick C, Salmon P, Peters S, Rogers A, Dunn G, Lewis B, Charles-Jones H, Hogg J, Clifforda R, Iredale W, Towey M, Gask L: Turning theory into practice: rationale, feasibility and external validity of an exploratory randomized controlled trial of training family practitioners in reattribution to manage patients with medically unexplained symptoms (the MUST). General Hospital Psychiatry. 2006, 28: 343-51. 10.1016/j.genhosppsych.2006.03.012.
Article
PubMed
Google Scholar
Mustian KM, Katula JA, Zhao H: A pilot study to assess the influence of Tai Chi Chuan on functional capacity among breast cancer survivors. Journal of Supportive Oncology. 2006, 4: 139-145.
PubMed
Google Scholar
Rasmussen NA, Schroder P, Olsen LR, Brodsgaard M, Unden M, Bech P: Modafinil augmentation in depressed patients with partial response to antidepressants: a pilot study on self-reported symptoms covered by the Major Depression Inventory (MDI) and the Symptom Checklist (SCL-92). Nordic Journal of Psychiatry. 2005, 59: 173-8. 10.1080/08039480510023025.
Article
PubMed
Google Scholar
Rowe DE, Feise RJ, Crowther ER, Grod JP, Menke JM, Goldsmith CH, Stoline MR, Souza TA, Kambach B: Chiropractice manipulation in adolescent idiopathic scoliosis: a pilot study. BMC Chiropractic & Osteopathy. 2006, 14: 15-10.1186/1746-1340-14-15.
Article
Google Scholar
Sheehan JL, Winzeler-Mercay U, Mudie MH: A randomized controlled pilot study to obtain the best estimate of the size of the effect of a thermoplastic resting splint on spasticity in the stroke-affected wrist and fingers. Clinical Rehabilitation. 2006, 20: 1032-7. 10.1177/0269215506071267.
Article
CAS
PubMed
Google Scholar
Shoptaw S, Watson DW, Reiber C, Rawson RA, Montgomery MA, Majewska MD, Ling W: Randomized controlled pilot trial of cabergoline, hydergine and levodopa/carbidopa: Los Angeles Cocaine Rapid Efficacy Screening Trial (CREST). Addiction. 2005, 100 (SUPPL 1): 78-90.
Article
PubMed
Google Scholar
Simpson TL, Saxon AJ, Meredith CW, Malte CA, McBride B, Ferguson LC, Gross CA, Hart KL, Raskind M: A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcoholism: Clinical and Experimental Research. 2009, 33: 255-63. 10.1111/j.1530-0277.2008.00807.x.
Article
CAS
Google Scholar
Stiasny-Kolster K, Kohnen R, Schollmayer E, Moller JC, Oertel WH, the Rotigotine SP 666 Study Group: Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot study. Movement Disorders. 2004, 19: 1432-8. 10.1002/mds.20251.
Article
PubMed
Google Scholar
Stoel MG, Marques KMJ, de Cook CC, Bronzwaer JGF, von Birgelen C, Zijlstra F: High dose adenosine for suboptimal myocardial reperfusion after primary PCI: a randomized placebo-controlled pilot study. Catheterization and Cardiovascular Interventions. 2008, 71: 283-289.
Article
PubMed
Google Scholar
Todd MK, Reis-Bergan MJ, Sidman CL, Flohr JA, Jameson-Walker K, Spicer-Bartolau T, Wildeman K: Effect of a family-based intervention on electronic media use and body composition among boys aged 8--11 years: a pilot study. Journal of Child Health Care. 2008, 12: 344-58. 10.1177/1367493508097404.
Article
PubMed
Google Scholar
Tsai H-J, Hung H-C, Yang J-L, Huang C-S, Tsauo J-Y: Could kinesio tape replace the bandage in decongestive lymphatic therapy for breast-cancer-related lymphedema? A pilot study. Supportive Care in Cancer. 2009, 17: 1353-60. 10.1007/s00520-009-0592-8.
Article
PubMed
Google Scholar
van Royen N, Schirmer SH, Atasever B, Behrens CY, Ubbink D, Buschmann EE, Voskuil M, Bot P, Hoefer I, Schlingemann RO, Biemond BJ, Tijssen JG, Bode C, Schaper W, Oskam J, Legemate DA, Piek JJ, Buschmann I: START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease. Circulation. 2005, 112: 1040-6. 10.1161/CIRCULATIONAHA.104.529552.
Article
CAS
PubMed
Google Scholar
Werk M, Langner S, Reinkensmeier B, Boettcher H-F, Tepe G, Dietz U, Hosten N, Hamm B, Speck U, Ricke J: Inhibition of restenosis in femoropopliteal arteries. Paclitaxel-coated versus uncoated balloon: Femoral paclitaxel randomized pilot trial. Circulation. 2008, 118: 1358-65. 10.1161/CIRCULATIONAHA.107.735985.
Article
CAS
PubMed
Google Scholar
Yadav V, Marracci G, Lovera J, Woodward W, Bogardus K, Marquardt W, Shinto L, Morris C, Bourdette DN: Lipoic acid in multiple sclerosis: a pilot study. Multiple Sclerosis. 2005, 11: 159-65. 10.1191/1352458505ms1143oa.
Article
CAS
PubMed
Google Scholar
Schulz KF, Altman DG, Moher D: CONSORT 2010 Statement; updated guidelines for reporting parallel group randomised trials. BMJ. 2010, 340: 698-702.
Article
Google Scholar
Cytel Software Corporation: StatXact: Version 8. 2007, Cambridge, MA 02139
Google Scholar
Cook DJ, Rocker G, Meade M, Guyatt G, Geerts W, Anderson D, Skrobik Y, Hebert P, Albert M, Cooper J, Bates S, Caco C, Finfer S, Fowler R, Freitag A, Granton J, Jones G, Langevin S, Mehta S, Pagliarello G, Poirier G, Rabbat C, Schiff D, Griffith L, Crowther M, the Canadian Critical Care Trials Group: Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study. Journal of Critical Care. 2005, 20: 364-372. 10.1016/j.jcrc.2005.09.010.
Article
PubMed
Google Scholar
Gardner G, Gardner A, MacLellan L, Osborne S: Reconceptualising the objectives of a pilot study for clinical research. International Journal of Nursing Studies. 2003, 40: 719-724. 10.1016/S0020-7489(03)00011-7.
Article
PubMed
Google Scholar