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  1. Data-sharing policies in randomized clinical trials (RCTs) should have an evaluation component. The main objective of this case–control study was to assess the impact of published re-uses of RCT data in terms ...

    Authors: N. Anthony, C. Pellen, C. Ohmann, D. Moher and F. Naudet
    Citation: BMC Medical Research Methodology 2021 21:119
    Content type: Research Published on:

  2. Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the ...

    Authors: Aurélie Piedvache, Stef van Buuren, Henrique Barros, Ana Isabel Ribeiro, Elizabeth Draper and Jennifer Zeitlin
    Citation: BMC Medical Research Methodology 2021 21:118
    Content type: Research article Published on:

  3. In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and research...

    Authors: Lonni Besançon, Nathan Peiffer-Smadja, Corentin Segalas, Haiting Jiang, Paola Masuzzo, Cooper Smout, Eric Billy, Maxime Deforet and Clémence Leyrat
    Citation: BMC Medical Research Methodology 2021 21:117
    Content type: Commentary Published on:

  4. We hypothesized that monitoring the volume of activity and overall performance indicators is not sufficient to understand the underlying differences between emergency departments. We aimed to understand the un...

    Authors: Marine Demarquet, Laurie Fraticelli, Julie Freyssenge, Clément Claustre, Mikaël Martinez, Jonathan Duchenne, Carlos El Khoury, Abdesslam Redjaline and Karim Tazarourte
    Citation: BMC Medical Research Methodology 2021 21:116
    Content type: Research Published on:

  5. The monitoring and evaluation of public health programs based on traditional face-to-face interviews in hard-to-reach and unstable regions present many challenges. Mobile phone-based methods are considered to ...

    Authors: Xiaomeng Chen, Diwakar Mohan, Abdoulaye Maïga, Emily Frost, Djeneba Coulibaly, Luay Basil, Birahim Yaguemar Gueye, Mariam Traore Guindo, Assa Sidibé Keita, Haoua Dembelé Keita and Melissa A. Marx
    Citation: BMC Medical Research Methodology 2021 21:115
    Content type: Research article Published on:

  6. Use of real world data (RWD) from non-randomised studies (e.g. single-arm studies) is increasingly being explored to overcome issues associated with data from randomised controlled trials (RCTs). We aimed to c...

    Authors: Janharpreet Singh, Keith R. Abrams and Sylwia Bujkiewicz
    Citation: BMC Medical Research Methodology 2021 21:114
    Content type: Research Published on:

  7. In a star-shaped network, pairwise comparisons link treatments with a reference treatment (often placebo or standard care), but not with each other. Thus, comparisons between non-reference treatments rely on i...

    Authors: Jeong-Hwa Yoon, Sofia Dias and Seokyung Hahn
    Citation: BMC Medical Research Methodology 2021 21:113
    Content type: Technical advance Published on:

  8. Neighbourhood is a complex structure but of high relevance for health. Its operationalisation remains however a challenge.The aim of this work is to present a new application of the use of semi-variograms as a...

    Authors: Odile Sauzet, Janne H. Breiding, Kim A. Zolitschka, Jürgen Breckenkamp and Oliver Razum
    Citation: BMC Medical Research Methodology 2021 21:112
    Content type: Research Published on:

  10. Diagnostic accuracy studies aim to examine the diagnostic accuracy of a new experimental test, but do not address the actual merit of the resulting diagnostic information to a patient in clinical practice. In ...

    Authors: Amra Hot, Patrick M. Bossuyt, Oke Gerke, Simone Wahl, Werner Vach and Antonia Zapf
    Citation: BMC Medical Research Methodology 2021 21:110
    Content type: Research Published on:

  11. Cardinality matching (CM), a novel matching technique, finds the largest matched sample meeting prespecified balance criteria thereby overcoming limitations of propensity score matching (PSM) associated with l...

    Authors: Stephen P. Fortin, Stephen S Johnston and Martijn J Schuemie
    Citation: BMC Medical Research Methodology 2021 21:109
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2021 21:174

  12. PR loss in ER+/HER2- breast cancer indicates worse prognosis and insensitivity to anti-estrogen therapy, while the mechanisms of PR loss in ER+/HER2- breast cancer remain unrevealed.

    Authors: Taobo Hu, Yan Chen, Yiqiang Liu, Danhua Zhang, Jiankang Pan and Mengping Long
    Citation: BMC Medical Research Methodology 2021 21:108
    Content type: Research Published on:

  13. Sparse relative effectiveness evidence is a frequent problem in Health Technology Assessment (HTA). Where evidence directly pertaining to the decision problem is sparse, it may be feasible to expand the eviden...

    Authors: Georgios F. Nikolaidis, Beth Woods, Stephen Palmer and Marta O. Soares
    Citation: BMC Medical Research Methodology 2021 21:107
    Content type: Research article Published on:

  14. A debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the method...

    Authors: Adriaan Penson, Sylvia van Deuren, Ewald Bronkhorst, Ellen Keizer, Tom Heskes, Marieke J. H. Coenen, Judith G. M. Rosmalen, Wim J. E. Tissing, Helena J. H. van der Pal, Andrica C. H. de Vries, Marry M. van den Heuvel-Eibrink, Sebastian Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Margriet van der Heiden-van der Loo, Saskia M. F. Pluijm…
    Citation: BMC Medical Research Methodology 2021 21:106
    Content type: Research Published on:

  15. Previous research has shown that chronic disease case definitions constructed using population-based administrative health data may have low accuracy for ascertaining cases of episodic diseases such as rheumat...

    Authors: Allison Feely, Lily SH Lim, Depeng Jiang and Lisa M. Lix
    Citation: BMC Medical Research Methodology 2021 21:105
    Content type: Research article Published on:

  16. Tacrolimus is given post-kidney transplant to suppress the immune system, and the amount of drug in the body is measured frequently. Higher variability over time may be indicative of poor drug adherence, leadi...

    Authors: Kristen R. Campbell, Rui Martins, Scott Davis and Elizabeth Juarez-Colunga
    Citation: BMC Medical Research Methodology 2021 21:104
    Content type: Research Published on:

  17. Practical methods for facilitating process improvement are needed to support high quality, safe care. How best to specify (identify and define) process improvements – the changes that need to be made in a heal...

    Authors: Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern and Mary Dixon-Woods
    Citation: BMC Medical Research Methodology 2021 21:103
    Content type: Technical advance Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2021 21:156

  18. Ninety-day hometime, the number of days a patient is living in the community in the first 90 after stroke, exhibits a non-normal bucket-shaped distribution, with lower and upper constraints making its analysis...

    Authors: Jessalyn K. Holodinsky, Amy Y. X. Yu, Moira K. Kapral and Peter C. Austin
    Citation: BMC Medical Research Methodology 2021 21:102
    Content type: Research article Published on:

  19. Systematic reviews (SRs) and meta-analyses (MAs) are commonly conducted to evaluate and summarize medical literature. This is especially useful in assessing in vitro studies for consistency. Our study aims to ...

    Authors: Linh Tran, Dao Ngoc Hien Tam, Abdelrahman Elshafay, Thao Dang, Kenji Hirayama and Nguyen Tien Huy
    Citation: BMC Medical Research Methodology 2021 21:101
    Content type: Research article Published on:

  21. Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a compo...

    Authors: Jordi Cortés Martínez, Ronald B. Geskus, KyungMann Kim and Guadalupe Gómez Melis
    Citation: BMC Medical Research Methodology 2021 21:99
    Content type: Research Published on:

  22. Viral haemorrhagic fevers are characterized by irregular outbreaks with high mortality rate. Difficulties arise when implementing therapeutic trials in this context. The outbreak duration is hard to predict an...

    Authors: Pauline Manchon, Drifa Belhadi, France Mentré and Cédric Laouénan
    Citation: BMC Medical Research Methodology 2021 21:98
    Content type: Research article Published on:

  23. In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has ...

    Authors: Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande and Mayur B. Patel
    Citation: BMC Medical Research Methodology 2021 21:97
    Content type: Research article Published on:

  24. Advances in machine learning (ML) provide great opportunities in the prediction of hospital readmission. This review synthesizes the literature on ML methods and their performance for predicting hospital readm...

    Authors: Yinan Huang, Ashna Talwar, Satabdi Chatterjee and Rajender R. Aparasu
    Citation: BMC Medical Research Methodology 2021 21:96
    Content type: Research article Published on:

  25. Diagnosis performances of case-identifying algorithms developed in healthcare database are usually assessed by comparing identified cases with an external data source. When this is not feasible, intra-database...

    Authors: Nicolas H. Thurin, Pauline Bosco-Levy, Patrick Blin, Magali Rouyer, Jérémy Jové, Stéphanie Lamarque, Séverine Lignot, Régis Lassalle, Abdelilah Abouelfath, Emmanuelle Bignon, Pauline Diez, Marine Gross-Goupil, Michel Soulié, Mathieu Roumiguié, Sylvestre Le Moulec, Marc Debouverie…
    Citation: BMC Medical Research Methodology 2021 21:95
    Content type: Research article Published on:

  26. Systematic reviews (SRs) are considered one of the most reliable types of studies in evidence-based medicine. SRs rely on a comprehensive and systematic data gathering, including the search of academic literat...

    Authors: Tobias Justesen, Josefine Freyberg and Anders N. Ø. Schultz
    Citation: BMC Medical Research Methodology 2021 21:94
    Content type: Research article Published on:

  27. The availability of large epidemiological or clinical data storing biological samples allow to study the prognostic value of novel biomarkers, but efficient designs are needed to select a subsample on which to...

    Authors: Francesca Graziano, Maria Grazia Valsecchi and Paola Rebora
    Citation: BMC Medical Research Methodology 2021 21:93
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2022 22:158

  28. Clinical trials in home hospice settings are important to build the evidence base for practice, but balancing the burden and benefit of clinical trial conduct for clinicians, patients, and family caregivers is...

    Authors: Jennifer Tjia, Margaret Clayton, Germán Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport and Susan DeSanto-Madeya
    Citation: BMC Medical Research Methodology 2021 21:92
    Content type: Research article Published on:

  29. During the COVID-19 emergency, IRST IRCCS, an Italian cancer research institute and promoter of no profit clinical studies, adapted its activities and procedures as per European and national guidelines to main...

    Authors: Linda Valmorri, Bernadette Vertogen, Chiara Zingaretti, Anna Miserocchi, Roberta Volpi, Alberto Clemente, Isabella Bondi, Irene Valli, Britt Rudnas, Giovanni Martinelli and Oriana Nanni
    Citation: BMC Medical Research Methodology 2021 21:91
    Content type: Commentary Published on:

  30. Healthcare-associated infections (HAIs) represent a major Public Health issue. Hospital-based prevalence studies are a common tool of HAI surveillance, but data quality problems and non-representativeness can ...

    Authors: A. D’Ambrosio, J. Garlasco, F. Quattrocolo, C. Vicentini and C. M. Zotti
    Citation: BMC Medical Research Methodology 2021 21:90
    Content type: Technical advance Published on:

  31. Survival analyses methods (SAMs) are central to analysing time-to-event outcomes. Appropriate application and reporting of such methods are important to ensure correct interpretation of the data. In this study...

    Authors: Moses M. Ngari, Susanne Schmitz, Christopher Maronga, Lazarus K. Mramba and Michel Vaillant
    Citation: BMC Medical Research Methodology 2021 21:89
    Content type: Research article Published on:

  32. Crowdsourcing engages the help of large numbers of people in tasks, activities or projects, usually via the internet. One application of crowdsourcing is the screening of citations for inclusion in a systemati...

    Authors: Anna H. Noel-Storr, Patrick Redmond, Guillaume Lamé, Elisa Liberati, Sarah Kelly, Lucy Miller, Gordon Dooley, Andy Paterson and Jenni Burt
    Citation: BMC Medical Research Methodology 2021 21:88
    Content type: Research article Published on:

  33. Short-term associations between extreme heat events and adverse health outcomes are well-established in epidemiologic studies. However, the use of different exposure definitions across studies has limited our ...

    Authors: Shan Jiang, Joshua L. Warren, Noah Scovronick, Shannon E. Moss, Lyndsey A. Darrow, Matthew J. Strickland, Andrew J. Newman, Yong Chen, Stefanie T. Ebelt and Howard H. Chang
    Citation: BMC Medical Research Methodology 2021 21:87
    Content type: Research article Published on:

  34. Health-related quality of life (HRQoL) tools are limited by the indicators included in the construct and variation in interpretation by different researchers. Neutral Theory describes the ideal construct that ...

    Authors: Ravi Jandhyala
    Citation: BMC Medical Research Methodology 2021 21:86
    Content type: Research article Published on:

  35. Asset-based indices are widely-used proxy measures of wealth in low and middle-income countries (LMIC). The stability of these indices within households over time is not known.

    Authors: Jithin Sam Varghese, John A. Maluccio, Solveig A. Cunningham, Manuel Ramirez-Zea and Aryeh D. Stein
    Citation: BMC Medical Research Methodology 2021 21:85
    Content type: Research article Published on:

  36. When quantifying the probability of survival in cancer patients using cancer registration data, it is common to estimate marginal relative survival, which under assumptions can be interpreted as marginal net s...

    Authors: Paul C. Lambert, Elisavet Syriopoulou and Mark R. Rutherford
    Citation: BMC Medical Research Methodology 2021 21:84
    Content type: Research article Published on:

  37. Generalized linear mixed models (GLMMs), typically used for analyzing correlated data, can also be used for smoothing by considering the knot coefficients from a regression spline as random effects. The result...

    Authors: Muhammad Abu Shadeque Mullah, James A. Hanley and Andrea Benedetti
    Citation: BMC Medical Research Methodology 2021 21:83
    Content type: Research article Published on:

  38. The COVID-19 pandemic has become a source of fear across the world. Measuring the level or significance of fear in different populations may help identify populations and areas in need of public health and edu...

    Authors: Ashley Elizabeth Muller, Jan Peter William Himmels and Stijn Van de Velde
    Citation: BMC Medical Research Methodology 2021 21:82
    Content type: Research article Published on:

  39. Identifying how unwarranted variations in healthcare delivery arise is challenging. Experimental vignette studies can help, by isolating and manipulating potential drivers of differences in care. There is a la...

    Authors: Jessica Sheringham, Isla Kuhn and Jenni Burt
    Citation: BMC Medical Research Methodology 2021 21:81
    Content type: Research article Published on:

  40. Research participation is beneficial to patients, clinicians and healthcare services. There is currently poor alignment between UK clinical research activity and local prevalence of disease. The National Insti...

    Authors: Tanvi Rai, Sharon Dixon and Sue Ziebland
    Citation: BMC Medical Research Methodology 2021 21:80
    Content type: Research article Published on:

  41. An assumption in many analyses of longitudinal patient-reported outcome (PRO) data is that there is a single population following a single health trajectory. One approach that may help researchers move beyond ...

    Authors: Jae-Yung Kwon, Richard Sawatzky, Jennifer Baumbusch, Sandra Lauck and Pamela A. Ratner
    Citation: BMC Medical Research Methodology 2021 21:79
    Content type: Research article Published on:

  42. Missing data is a pervasive problem in clinical research. Generative adversarial imputation nets (GAIN), a novel machine learning data imputation approach, has the potential to substitute missing data accurate...

    Authors: Weinan Dong, Daniel Yee Tak Fong, Jin-sun Yoon, Eric Yuk Fai Wan, Laura Elizabeth Bedford, Eric Ho Man Tang and Cindy Lo Kuen Lam
    Citation: BMC Medical Research Methodology 2021 21:78
    Content type: Research article Published on:

  43. Patient-reported outcome measures (PROMs) are commonly-used surrogates for clinical outcomes in cancer research. When researching severe diseases such as cancer, it is difficult to avoid the problem of incompl...

    Authors: Pimrapat Gebert, Daniel Schindel, Johann Frick, Liane Schenk and Ulrike Grittner
    Citation: BMC Medical Research Methodology 2021 21:77
    Content type: Research article Published on:

  44. The expansion of access to antiretroviral therapy (ART) has been accompanied by an increase in pre-treatment drug resistance (PDR). While it is critical to monitor the increasing prevalence of PDR across count...

    Authors: Lawrence Mbuagbaw, Clémence Ongolo-Zogo, Olivia C. Mendoza, Babalwa Zani, Frederick Morfaw, Agatha Nyambi, Annie Wang, Michel Kiflen, Hussein El-Kechen, Alvin Leenus, Mark Youssef, Nadia Rehman, Lucas Hermans, Virginia MacDonald and Silvia Bertagnolio
    Citation: BMC Medical Research Methodology 2021 21:76
    Content type: Research article Published on:

  45. In non-inferiority trials, there is a concern that intention-to-treat (ITT) analysis, by including participants who did not receive the planned interventions, may bias towards making the treatment and control ...

    Authors: Anthony D. Bai, Adam S. Komorowski, Carson K. L. Lo, Pranav Tandon, Xena X. Li, Vaibhav Mokashi, Anna Cvetkovic, Aidan Findlater, Laurel Liang, George Tomlinson, Mark Loeb and Dominik Mertz
    Citation: BMC Medical Research Methodology 2021 21:75
    Content type: Research article Published on:

  46. Chest pain is among the most common presenting complaints in the emergency department (ED). Swift and accurate risk stratification of chest pain patients in the ED may improve patient outcomes and reduce unnec...

    Authors: Nan Liu, Marcel Lucas Chee, Zhi Xiong Koh, Su Li Leow, Andrew Fu Wah Ho, Dagang Guo and Marcus Eng Hock Ong
    Citation: BMC Medical Research Methodology 2021 21:74
    Content type: Research article Published on:

  47. Recommendations within guidelines are developed by synthesising the best available evidence; when limited evidence is identified recommendations are generally based on informal consensus. However, there are po...

    Authors: P. Carter, K. J. M. O’Donoghue, K. Dworzynski, L. O’Shea, V. Roberts, T. Reeves, A. Bastounis, M. A. Mugglestone, J. Fawke and S. Pilling
    Citation: BMC Medical Research Methodology 2021 21:73
    Content type: Research article Published on:

  48. Missing data are common in randomised controlled trials (RCTs) and can bias results if not handled appropriately. A statistically valid analysis under the primary missing-data assumptions should be conducted, ...

    Authors: Ping-Tee Tan, Suzie Cro, Eleanor Van Vogt, Matyas Szigeti and Victoria R. Cornelius
    Citation: BMC Medical Research Methodology 2021 21:72
    Content type: Research article Published on:

  49. Burn is a tragic event for an individual, the family, and community. It can cause irreparable physical, mental, economic, and social injury. Researches well documented that a quick visit to a healthcare center...

    Authors: Touraj Ahmadi-Jouybari, Somayeh Najafi-Ghobadi, Reza Karami-Matin, Saeid Najafian-Ghobadi and Khadijeh Najafi-Ghobadi,
    Citation: BMC Medical Research Methodology 2021 21:71
    Content type: Research article Published on:

  50. Conventional methods for phase I dose-escalation trials in oncology are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in the same trial.

    Authors: Burak Kürsad Günhan, Sebastian Weber, Abdelkader Seroutou and Tim Friede
    Citation: BMC Medical Research Methodology 2021 21:69
    Content type: Research article Published on:
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BMC Medical Research Methodology

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