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Typically, randomization software should allow users to exert control over the different aspects of randomization including block design, provision of unique identifiers and control over the format and type of...
Citation: BMC Medical Research Methodology 2004 4:26
The habitual "any other comments" general open question at the end of structured questionnaires has the potential to increase response rates, elaborate responses to closed questions, and allow respondents to i...
Citation: BMC Medical Research Methodology 2004 4:25
There is a common belief that most cancer prevention trials should be restricted to high-risk subjects in order to increase statistical power. This strategy is appropriate if the ultimate target population is ...
Citation: BMC Medical Research Methodology 2004 4:24
In most recent large efficacy trials of barrier contraceptive methods, a high proportion of participants withdrew before the intended end of follow-up. The objective of this analysis was to explore characteris...
Citation: BMC Medical Research Methodology 2004 4:23
Consumers of research (researchers, administrators, educators and clinicians) frequently use standard critical appraisal tools to evaluate the quality of published research reports. However, there is no consen...
Citation: BMC Medical Research Methodology 2004 4:22
Several reviews of published cluster randomised trials have reported that about half did not take clustering into account in the analysis, which was thus incorrect and potentially misleading. In this paper I a...
Citation: BMC Medical Research Methodology 2004 4:21
Publication bias, as typically defined, refers to the decreased likelihood of studies' results being published when they are near the null, not statistically significant, or otherwise "less interesting." But c...
Citation: BMC Medical Research Methodology 2004 4:20
Balanced decisions about health care interventions require reliable evidence on harms as well as benefits. Most systematic reviews focus on efficacy and randomised trials, for which the methodology is well est...
Citation: BMC Medical Research Methodology 2004 4:19
Recently developed measures such as I 2 and H allow the evaluation of the impact of heterogeneity in conventional meta-analyses. There has been no examination of the development of heterogeneity in the context of...
Citation: BMC Medical Research Methodology 2004 4:18
Meta-analysis can be used to pool rate measures across studies, but challenges arise when follow-up duration varies. Our objective was to compare different statistical approaches for pooling count data of vary...
Citation: BMC Medical Research Methodology 2004 4:17
Reducing maternal mortality and morbidity are among the key international development goals. A prerequisite for monitoring the progress towards attainment of these goals is accurate assessment of the levels of...
Citation: BMC Medical Research Methodology 2004 4:16
The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but informa...
Citation: BMC Medical Research Methodology 2004 4:15
Current methods of measuring the quality of journals assume that citations of articles within journals are normally distributed. Furthermore using journal impact factors to measure the quality of individual ar...
Citation: BMC Medical Research Methodology 2004 4:14
Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in publish...
Citation: BMC Medical Research Methodology 2004 4:13
In recent years there has been increased interest in evaluating breast cancer screening using data from before-and-after studies in multiple geographic regions. One approach, not previously mentioned, is the p...
Citation: BMC Medical Research Methodology 2004 4:12
Rating scales form an important means of gathering evaluation data. Since important decisions are often based on these evaluations, determining the reliability of rating data can be critical. Most commonly use...
Citation: BMC Medical Research Methodology 2004 4:11
The use of preference-based measures in the evaluation of health outcomes has extended considerably over the last decade. Their alleged advantage over other types of general instruments in the evaluation of he...
Citation: BMC Medical Research Methodology 2004 4:10
Increasingly, researchers are recognizing that there are many situations where the use of a cluster randomized trial may be more appropriate than an individually randomized trial. Similarly, the need for appro...
Citation: BMC Medical Research Methodology 2004 4:9
Patient recruitment is one of the most difficult aspects of clinical trials, especially for research involving elderly subjects. In this paper, we describe our experience with patient recruitment for the behav...
Citation: BMC Medical Research Methodology 2004 4:8
We sought to improve upon previously published statistical modeling strategies for binary classification of dyslipidemia for general population screening purposes based on the waist-to-hip circumference ratio ...
Citation: BMC Medical Research Methodology 2004 4:7
The purpose of this study was to determine the standard tasks performed by clinical research coordinators (CRCs) in oncology clinical trials.
Citation: BMC Medical Research Methodology 2004 4:6
Qualitative research makes an important contribution to our understanding of health and healthcare. However, qualitative evidence can be difficult to search for and identify, and the effectiveness of different...
Citation: BMC Medical Research Methodology 2004 4:5
Two main pathways exist for the development of knowledge in clinical homeopathy. These comprise clinical trials conducted primarily by university-based researchers and cases reports and homeopathic "provings" ...
Citation: BMC Medical Research Methodology 2004 4:4
Researchers from the developing world contribute only a limited proportion to the total research output published in leading medical education journals. Some of them believe that there is a substantial editori...
Citation: BMC Medical Research Methodology 2004 4:3
Effective strategies for implementing best practices in low and middle income countries are needed. RHL is an annually updated electronic publication containing Cochrane systematic reviews, commentaries and pr...
Citation: BMC Medical Research Methodology 2004 4:2
Citation: BMC Medical Research Methodology 2004 4:1
The original article was published in BMC Medical Research Methodology 2003 3:8
Controlled clinical trials of health care interventions are either explanatory or pragmatic. Explanatory trials test whether an intervention is efficacious; that is, whether it can have a beneficial effect in ...
Citation: BMC Medical Research Methodology 2003 3:28
This paper demonstrates how structural equation modelling (SEM) can be used as a tool to aid in carrying out power analyses. For many complex multivariate designs that are increasingly being employed, power an...
Citation: BMC Medical Research Methodology 2003 3:27
The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especiall...
Citation: BMC Medical Research Methodology 2003 3:26
In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated t...
Citation: BMC Medical Research Methodology 2003 3:25
Public health research involving social or kin groups (such as sexual partners or family members), rather than samples of unrelated individuals, has become more widespread in response to social ecological appr...
Citation: BMC Medical Research Methodology 2003 3:24
Citation: BMC Medical Research Methodology 2003 3:23
The original article was published in BMC Medical Research Methodology 2002 2:13
In many randomized and non-randomized comparative trials, researchers measure a continuous endpoint repeatedly in order to decrease intra-patient variability and thus increase statistical power. There has been...
Citation: BMC Medical Research Methodology 2003 3:22
Cross-sectional studies with binary outcomes analyzed by logistic regression are frequent in the epidemiological literature. However, the odds ratio can importantly overestimate the prevalence ratio, the measu...
Citation: BMC Medical Research Methodology 2003 3:21
While the desirability of interdisciplinary inquiry has been widely acknowledged, indeed has become 'the mantra of science policy', the methods of interdisciplinary collaboration are opaque to outsiders and gener...
Citation: BMC Medical Research Methodology 2003 3:20
The aim of this article is to explore ways in which selection bias and ascertainment bias can be reduced and investigated in trials, by using the example of a drug trial carried out in both developed and devel...
Citation: BMC Medical Research Methodology 2003 3:19
Misconduct in medical research has been the subject of many papers in recent years. Among different types of misconduct, data fabrication might be considered as one of the most severe cases. There have been so...
Citation: BMC Medical Research Methodology 2003 3:18
The Anglia Menorrhagia Education Study (AMES) is a randomized controlled trial testing the effectiveness of an education package applied to general practices. Binary data are available from two sources; genera...
Citation: BMC Medical Research Methodology 2003 3:17
There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints...
Citation: BMC Medical Research Methodology 2003 3:16
Techniques for interim analysis, the statistical analysis of results while they are still accumulating, are highly-developed in the setting of clinical trials. But in the setting of laboratory experiments such...
Citation: BMC Medical Research Methodology 2003 3:15
The electronic version of the British Medical Journal (eBMJ) has a unique feature in that it provides an electronic record of the number of times an article has been viewed ("hits") in the week after its publi...
Citation: BMC Medical Research Methodology 2003 3:14
As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date.
Citation: BMC Medical Research Methodology 2003 3:13
It has been estimated that about 45% of abstracts that are accepted for presentation at biomedical meetings will subsequently be published in full. The acceptance of abstracts at meetings and their fate after ...
Citation: BMC Medical Research Methodology 2003 3:12
When evaluating cancer screening it is important to estimate the cumulative risk of false positives from periodic screening. Because the data typically come from studies in which the number of screenings varie...
Citation: BMC Medical Research Methodology 2003 3:11
Randomized trials stochastically answer the question. "What would be the effect of treatment on outcome if one turned back the clock and switched treatments in the given population?" Generalizations to other s...
Citation: BMC Medical Research Methodology 2003 3:10
All quantifications of mortality, morbidity, and other health measures involve numerous sources of error. The routine quantification of random sampling error makes it easy to forget that other sources of error...
Citation: BMC Medical Research Methodology 2003 3:9
Many randomized trials involve missing binary outcomes. Although many previous adjustments for missing binary outcomes have been proposed, none of these makes explicit use of randomization to bound the bias wh...
Citation: BMC Medical Research Methodology 2003 3:8
The Erratum to this article has been published in BMC Medical Research Methodology 2004 4:1
Randomised controlled clinical trials are performed to resolve uncertainty concerning comparator interventions. Appropriate acknowledgment of uncertainty enables the concurrent achievement of two goals : the a...
Citation: BMC Medical Research Methodology 2003 3:7
Phase II cancer studies are undertaken to assess the activity of a new drug or a new treatment regimen. Activity is sometimes defined in terms of a survival probability, a binary outcome such as one-year survi...
Citation: BMC Medical Research Methodology 2003 3:6
The Bayesian approach is one alternative for estimating correlation coefficients in which knowledge from previous studies is incorporated to improve estimation. The purpose of this paper is to illustrate the u...
Citation: BMC Medical Research Methodology 2003 3:5
Speed
79 days to first decision for reviewed manuscripts only
57 days to first decision for all manuscripts
196 days from submission to acceptance
19 days from acceptance to publication
Citation Impact
4.615- 2-year Impact Factor
5.260 - 5-year Impact Factor
2.262 - Source Normalized Impact per Paper (SNIP)
1.820 - SCImago Journal Rank (SJR)
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3,218,958 Downloads
3,897 Altmetric mentions