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BMC Medical Research Methodology

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  1. Content type: Research Article

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Authors: Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:90

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  2. Content type: Research article

    Administrative data is a useful tool for research and quality improvement; however, validity of research findings based on these data depends on their reliability. Diagnoses assigned by physicians are subseque...

    Authors: Kristin Burles, Grant Innes, Kevin Senior, Eddy Lang and Andrew McRae

    Citation: BMC Medical Research Methodology 2017 17:89

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  3. Content type: Research article

    Bayesian hierarchical piecewise regression (BHPR) modeling has not been previously formulated to detect and characterise the mechanism of trajectory divergence between groups of participants that have longitud...

    Authors: Marie-jeanne Buscot, Simon S. Wotherspoon, Costan G. Magnussen, Markus Juonala, Matthew A. Sabin, David P. Burgner, Terho Lehtimäki, Jorma S. A. Viikari, Nina Hutri-Kähönen, Olli T. Raitakari and Russell J. Thomson

    Citation: BMC Medical Research Methodology 2017 17:86

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  5. Content type: Research article

    The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...

    Authors: Long H. Ngo, Sharon K. Inouye, Richard N. Jones, Thomas G. Travison, Towia A. Libermann, Simon T. Dillon, George A. Kuchel, Sarinnapha M. Vasunilashorn, David C. Alsop and Edward R. Marcantonio

    Citation: BMC Medical Research Methodology 2017 17:88

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  6. Content type: Research article

    Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, t...

    Authors: Lewis Cooney, Yoon K. Loke, Su Golder, Jamie Kirkham, Andrea Jorgensen, Ian Sinha and Daniel Hawcutt

    Citation: BMC Medical Research Methodology 2017 17:84

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  7. Content type: Research article

    Self-reported weight and height are commonly used in lieu of direct measurements of weight and height in large epidemiological surveys due to inevitable constraints such as budget and human resource. However, ...

    Authors: C. C. Kee, K. H. Lim, M. G. Sumarni, C. H. Teh, Y. Y. Chan, M. I. Nuur Hafizah, Y. K. Cheah, E. O. Tee, Y. Ahmad Faudzi and M. Amal Nasir

    Citation: BMC Medical Research Methodology 2017 17:85

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  8. Content type: Research article

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Authors: Nils Ternès, Federico Rotolo and Stefan Michiels

    Citation: BMC Medical Research Methodology 2017 17:83

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  9. Content type: Research article

    The relative scale has been used for decades in analysing binary data in epidemiology. In contrast, there has been a long tradition of carrying out meta-analyses of continuous outcomes on the absolute, origina...

    Authors: Harri Hemilä

    Citation: BMC Medical Research Methodology 2017 17:82

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  10. Content type: Research article

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Authors: Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    Citation: BMC Medical Research Methodology 2017 17:81

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  12. Content type: Research Article

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Authors: Klemen Pavlič and Maja Pohar Perme

    Citation: BMC Medical Research Methodology 2017 17:79

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  13. Content type: Research article

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Authors: Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    Citation: BMC Medical Research Methodology 2017 17:78

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  14. Content type: Research article

    The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and ...

    Authors: Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Anders Helles Carlsen and Peter Vedsted

    Citation: BMC Medical Research Methodology 2017 17:74

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  15. Content type: Technical advance

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Authors: Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    Citation: BMC Medical Research Methodology 2017 17:76

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  16. Content type: Research article

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Authors: Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    Citation: BMC Medical Research Methodology 2017 17:73

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  17. Content type: Research article

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Authors: Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    Citation: BMC Medical Research Methodology 2017 17:77

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  18. Content type: Research article

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Authors: Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    Citation: BMC Medical Research Methodology 2017 17:75

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  19. Content type: Research article

    Evaluation of the potential effectiveness of a programme’s objectives (health or otherwise) is important in demonstrating how programmes work. However, evaluations are expensive and can focus on unrealistic ou...

    Authors: Melissa Belford, Tony Robertson and Ruth Jepson

    Citation: BMC Medical Research Methodology 2017 17:70

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  20. Content type: Research article

    In studies of recurrent events, it is common to consider a person who has suffered a disease episode and received curative treatment to be not at risk of suffering a new episode for a duration of time. It is a...

    Authors: Yin-Bun Cheung, Ying Xu, Matthew Cairns and Paul Milligan

    Citation: BMC Medical Research Methodology 2017 17:72

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  22. Content type: Research article

    Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to i...

    Authors: Navjot Kaur, Ben Porter, Cynthia A. LeardMann, Laura E. Tobin, Hector Lemus and David D. Luxton

    Citation: BMC Medical Research Methodology 2017 17:69

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  23. Content type: Research article

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Authors: Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    Citation: BMC Medical Research Methodology 2017 17:66

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  24. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  25. Content type: Research article

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Authors: Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    Citation: BMC Medical Research Methodology 2017 17:68

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BMC Medical Research Methodology

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