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BMC Medical Research Methodology


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  1. Content type: Research article

    Rich literature has reported that there exists a nonlinear association between temperature and mortality. One important feature in the temperature-mortality association is the minimum mortality temperature (MM...

    Authors: Whanhee Lee, Ho Kim, Sunghee Hwang, Antonella Zanobetti, Joel D. Schwartz and Yeonseung Chung

    Citation: BMC Medical Research Methodology 2017 17:137

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  2. Content type: Research article

    Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this resea...

    Authors: Mónica Ballesteros, Nadia Montero, Antonio López-Pousa, Gerard Urrútia, Ivan Solà, Gabriel Rada, Hector Pardo-Hernandez and Xavier Bonfill

    Citation: BMC Medical Research Methodology 2017 17:135

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  3. Content type: Research article

    Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available b...

    Authors: Delaram Farzanfar, Asmaa Abumuamar, Jayoon Kim, Emily Sirotich, Yue Wang and Eleanor Pullenayegum

    Citation: BMC Medical Research Methodology 2017 17:133

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  4. Content type: Research article

    Multiple imputation is a popular approach to handling missing data in medical research, yet little is known about its applicability for estimating the relative risk. Standard methods for imputing incomplete bi...

    Authors: Thomas R. Sullivan, Katherine J. Lee, Philip Ryan and Amy B. Salter

    Citation: BMC Medical Research Methodology 2017 17:134

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  5. Content type: Research article

    Knowing about predictors of attrition in a panel is important to initiate early measures against loss of participants. We investigated attrition in both early and late phase of an online panel with special foc...

    Authors: Nicole Rübsamen, Manas K. Akmatov, Stefanie Castell, André Karch and Rafael T. Mikolajczyk

    Citation: BMC Medical Research Methodology 2017 17:132

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  6. Content type: Research article

    The Barthel Index (BI) is a measure of independence in activities of daily living (ADL). In the modified Barthel Index (MBI), a five-point system replaced the original two or three or four point rating system....

    Authors: Tomoko Ohura, Kimitaka Hase, Yoshie Nakajima and Takeo Nakayama

    Citation: BMC Medical Research Methodology 2017 17:131

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  7. Content type: Research article

    There is a great need for high quality clinical research for children. The European Pediatric Regulation aimed to improve the quality of clinical trials in order to increase the availability of treatments for ...

    Authors: Isabelle Gautier, Perrine Janiaud, Nelly Rollet, Nicolas André, Michel Tsimaratos, Catherine Cornu, Salma Malik, Stéphanie Gentile and Behrouz Kassaï

    Citation: BMC Medical Research Methodology 2017 17:130

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  8. Content type: Research article

    The common frequentist approach is limited in providing investigators with appropriate measures for conducting a new trial. To answer such important questions and one has to look at Bayesian statistics.

    Authors: David J. Biau, Samuel Boulezaz, Laurent Casabianca, Moussa Hamadouche, Philippe Anract and Sylvie Chevret

    Citation: BMC Medical Research Methodology 2017 17:128

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  9. Content type: Technical advance

    Multiple imputation is a recommended method to handle missing data. For significance testing after multiple imputation, Rubin’s Rules (RR) are easily applied to pool parameter estimates. In a logistic regressi...

    Authors: Iris Eekhout, Mark A. van de Wiel and Martijn W. Heymans

    Citation: BMC Medical Research Methodology 2017 17:129

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  10. Content type: Research article

    Aspirin has been considered to be beneficial in preventing cardiovascular diseases and cancer. Several pharmaco-epidemiology cohort studies have shown protective effects of aspirin on diseases using various st...

    Authors: In Sung Cho, Ye Rin Chae, Ji Hyeon Kim, Hae Rin Yoo, Suk Yong Jang, Gyu Ri Kim and Chung Mo Nam

    Citation: BMC Medical Research Methodology 2017 17:126

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  11. Content type: Research article

    Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique oppor...

    Authors: Feng Gao, J. Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A. Beiser, Ling Chen and Mae O. Gordon

    Citation: BMC Medical Research Methodology 2017 17:124

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  12. Content type: Research article

    Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Compute...

    Authors: Guy Harling, Dumile Gumede, Tinofa Mutevedzi, Nuala McGrath, Janet Seeley, Deenan Pillay, Till W. Bärnighausen and Abraham J. Herbst

    Citation: BMC Medical Research Methodology 2017 17:125

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  13. Content type: Research article

    The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an ...

    Authors: Cédric M. Panje, Markus Glatzer, Joscha von Rappard, Christian Rothermundt, Thomas Hundsberger, Valentin Zumstein, Ludwig Plasswilm and Paul Martin Putora

    Citation: BMC Medical Research Methodology 2017 17:123

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  14. Content type: Research article

    This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...

    Authors: Jonas Czwikla, Kathrin Jobski and Tania Schink

    Citation: BMC Medical Research Methodology 2017 17:122

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  15. Content type: Research article

    Dentine hypersensitivity (DH) affects people’s quality of life (QoL). However changes in the internal meaning of QoL, known as Response shift (RS) may undermine longitudinal assessment of QoL. This study aimed...

    Authors: Carolina Machuca, Mario V. Vettore, Marta Krasuska, Sarah R. Baker and Peter G. Robinson

    Citation: BMC Medical Research Methodology 2017 17:120

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  16. Content type: Research article

    Decisionmakers and guideline developers demand rapid syntheses of the evidence when time sensitive evidence-informed decisions are required. A potential trade-off of such rapid reviews is that their results ca...

    Authors: Gernot Wagner, Barbara Nussbaumer-Streit, Judith Greimel, Agustín Ciapponi and Gerald Gartlehner

    Citation: BMC Medical Research Methodology 2017 17:121

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  17. Content type: Research article

    Illness perceptions involve the personal beliefs that patients have about their illness and may influence health behaviours considerably. Since an instrument to measure these perceptions for Malay population i...

    Authors: Boon-How Chew, Rimke C. Vos, Monique Heijmans, Sazlina Shariff-Ghazali, Aaron Fernandez and Guy E. H. M. Rutten

    Citation: BMC Medical Research Methodology 2017 17:118

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  18. Content type: Research article

    Information about design, implementation, monitoring and evaluation is central to understand the impact of programmes within the field of sexual, reproductive, maternal, newborn, child and adolescent health (S...

    Authors: Anna E. Kågesten, Özge Tunçalp, Anayda Portela, Moazzam Ali, Nhan Tran and A. Metin Gülmezoglu

    Citation: BMC Medical Research Methodology 2017 17:117

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  19. Content type: Research article

    Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses...

    Authors: Fran Toye, Kate Seers, Erin Hannink and Karen Barker

    Citation: BMC Medical Research Methodology 2017 17:116

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  20. Content type: Research Article

    Random survival forest (RSF) models have been identified as alternative methods to the Cox proportional hazards model in analysing time-to-event data. These methods, however, have been criticised for the bias ...

    Authors: Justine B. Nasejje, Henry Mwambi, Keertan Dheda and Maia Lesosky

    Citation: BMC Medical Research Methodology 2017 17:115

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  21. Content type: Research article

    Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which involve multiple waves of data collection. Traditional multiple imputation (MI) methods (f...

    Authors: Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee and Julie Anne Simpson

    Citation: BMC Medical Research Methodology 2017 17:114

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  22. Content type: Research Article

    The analysis of perinatal outcomes often involves datasets with some multiple births. These are datasets mostly formed of independent observations and a limited number of clusters of size two (twins) and maybe...

    Authors: Odile Sauzet and Janet L. Peacock

    Citation: BMC Medical Research Methodology 2017 17:110

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  23. Content type: Research Article

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Authors: Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    Citation: BMC Medical Research Methodology 2017 17:112

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