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  1. Administrative healthcare claims databases are used in drug safety research but are limited for investigating the impacts of prenatal exposures on neonatal and pediatric outcomes without mother-infant pair ide...

    Authors: James Weaver, Jill H. Hardin, Clair Blacketer, Alexis A. Krumme, Melanie H. Jacobson and Patrick B. Ryan
    Citation: BMC Medical Research Methodology 2023 23:246
    Content type: Research Published on:

  2. Systematic reviews of randomized controlled trials are the best evidence for informing on intervention effectiveness. Their results, however, can be biased due to omitted evidence in the quantitative analyses....

    Authors: Stefano Giuseppe Lazzarini, Marzia Stella Yousif, Silvia Bargeri, Greta Castellini and Silvia Gianola
    Citation: BMC Medical Research Methodology 2023 23:245
    Content type: Research Published on:

  3. The COVID-19 pandemic required that our research team change our mail-only (MO) strategy for a research survey to a strategy more manageable by staff working remotely. We used a modified web-push approach (MWP...

    Authors: Varsha G. Vimalananda, Jolie B. Wormwood, Kailyn E. Sitter, B. Graeme Fincke, Shirley Qian, Maya N. Tait and Mark Meterko
    Citation: BMC Medical Research Methodology 2023 23:244
    Content type: Research Published on:

  5. Plasmode simulations are a type of simulations that use real data to determine the synthetic data-generating equations. Such simulations thus allow evaluating statistical methods under realistic conditions. As...

    Authors: Youssra Souli, Xavier Trudel, Awa Diop, Chantal Brisson and Denis Talbot
    Citation: BMC Medical Research Methodology 2023 23:242
    Content type: Research Published on:

  6. Near-real time surveillance of excess mortality has been an essential tool during the COVID-19 pandemic. It remains critical for monitoring mortality as the pandemic wanes, to detect fluctuations in the death ...

    Authors: Richard James Holleyman, Sharmani Barnard, Clarissa Bauer-Staeb, Andrew Hughes, Samantha Dunn, Sebastian Fox, John N. Newton, Justine Fitzpatrick, Zachary Waller, David John Deehan, Andre Charlett, Celia L. Gregson, Rebecca Wilson, Paul Fryers, Peter Goldblatt and Paul Burton
    Citation: BMC Medical Research Methodology 2023 23:241
    Content type: Research Published on:

  7. Data harmonisation is essential in real-world data (RWD) research projects based on hospital information systems databases, as coding systems differ between countries. The Hungarian hospital information system...

    Authors: Ágota Mészáros, Sándor Kovács, Tibor Héja, Zsolt Bagyura and Antal Zemplényi
    Citation: BMC Medical Research Methodology 2023 23:240
    Content type: Research Published on:

  9. Cancer surveillance researchers analyze incidence or mortality rates jointly indexed by age group and calendar period using age-period-cohort models. Many studies consider age- and period-specific rates in two...

    Authors: Philip S. Rosenberg, Adalberto Miranda-Filho and David C. Whiteman
    Citation: BMC Medical Research Methodology 2023 23:238
    Content type: Research Published on:

  11. Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVI...

    Authors: W. Li, V. Cornelius, S. Finfer, B. Venkatesh and L. Billot
    Citation: BMC Medical Research Methodology 2023 23:236
    Content type: Research Published on:

  12. Public health surveillance serves a crucial function within health systems, enabling the monitoring, early detection, and warning of infectious diseases. Recently, outbreak detection algorithms have gained sig...

    Authors: Bushra Zareie, Jalal Poorolajal, Amin Roshani and Manoochehr Karami
    Citation: BMC Medical Research Methodology 2023 23:235
    Content type: Review Published on:

  13. The COVID-19 pandemic resulted in major disruption to healthcare delivery worldwide causing medical services to adapt their standard practices. Learning how these adaptations result in unintended patient harm ...

    Authors: Thomas Purchase, Alison Cooper, Delyth Price, Emma Dorgeat, Huw Williams, Paul Bowie, Jean-Pascal Fournier, Peter Hibbert, Adrian Edwards, Rhiannon Phillips, Natalie Joseph-Williams and Andrew Carson-Stevens
    Citation: BMC Medical Research Methodology 2023 23:234
    Content type: Research Published on:

  14. When data is distributed across multiple sites, sharing information at the individual level among sites may be difficult. In these multi-site studies, propensity score model can be fitted with data within each...

    Authors: Chen Huang, Kecheng Wei, Ce Wang, Yongfu Yu and Guoyou Qin
    Citation: BMC Medical Research Methodology 2023 23:233
    Content type: Research Published on:

  15. Growth studies rely on longitudinal measurements, typically represented as trajectories. However, anthropometry is prone to errors that can generate outliers. While various methods are available for detecting ...

    Authors: Paraskevi Massara, Arooj Asrar, Celine Bourdon, Moses Ngari, Charles D. G. Keown-Stoneman, Jonathon L. Maguire, Catherine S. Birken, James A. Berkley, Robert H. J. Bandsma and Elena M. Comelli
    Citation: BMC Medical Research Methodology 2023 23:232
    Content type: Research article Published on:

  16. In observational studies, double robust or multiply robust (MR) approaches provide more protection from model misspecification than the inverse probability weighting and g-computation for estimating the avera...

    Authors: Ce Wang, Kecheng Wei, Chen Huang, Yongfu Yu and Guoyou Qin
    Citation: BMC Medical Research Methodology 2023 23:231
    Content type: Research Published on:

  17. This study investigated the associations between the number of authors and collective self-citations versus citations by others.

    Authors: Cyril Jaksic, Angèle Gayet-Ageron and Thomas Perneger
    Citation: BMC Medical Research Methodology 2023 23:230
    Content type: Research Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2023 23:260

  18. Selecting and collecting data to support appropriate primary and secondary outcomes is a critical step in designing trials that can change clinical practice. In this study, we aimed to investigate who contribu...

    Authors: Heidi R. Green, Annabel Dawson, Adel Elfeky, David Pickles, Shaun Treweek and Katie Gillies
    Citation: BMC Medical Research Methodology 2023 23:229
    Content type: Research Published on:

  19. Participants in epidemiological cohorts may not be representative of the full invited population, limiting the generalizability of prevalence and incidence estimates. We propose that this problem can be remedi...

    Authors: Anton Nilsson, Jonas Björk, Ulf Strömberg and Carl Bonander
    Citation: BMC Medical Research Methodology 2023 23:228
    Content type: Research Published on:

  20. Observational studies using causal inference frameworks can provide a feasible alternative to randomized controlled trials. Advances in statistics, machine learning, and access to big data facilitate unravelin...

    Authors: Ivan Olier, Yiqiang Zhan, Xiaoyu Liang and Victor Volovici
    Citation: BMC Medical Research Methodology 2023 23:227
    Content type: Editorial Published on:

  21. Systematic reviews answer research questions through a defined methodology. It is a complex task and multiple articles need to be referred to acquire wide range of required knowledge to conduct a systematic re...

    Authors: Mayura Thilanka Iddagoda and Leon Flicker
    Citation: BMC Medical Research Methodology 2023 23:226
    Content type: Review Published on:

  22. INTEROCC is a seven-country cohort study of occupational exposures and brain cancer risk, including occupational exposure to electromagnetic fields (EMF). In the absence of data on individual exposures, a Job ...

    Authors: Tamer Oraby, Santanu Chakraborty, Siva Sivaganesan, Laurel Kincl, Lesley Richardson, Mary McBride, Jack Siemiatycki, Elisabeth Cardis and Daniel Krewski
    Citation: BMC Medical Research Methodology 2023 23:225
    Content type: Research article Published on:

  23. Currently, there are no guidelines for the treatment of rheumatoid arthritis (RA) tailored to the context of the Kingdom of Saudi Arabia (KSA). Adaptation of guidelines accounts for contextual factors and beco...

    Authors: Joanne Khabsa, Sally Yaacoub, Mohammed A. Omair, Hanan Al Rayes and Elie A. Akl
    Citation: BMC Medical Research Methodology 2023 23:224
    Content type: Research Published on:

  24. Network meta-analysis compares multiple interventions and estimates the relative treatment effects between all interventions, combining both direct and indirect evidence. Recently, a framework was developed to...

    Authors: Virginia Chiocchia, Alexander Holloway and Georgia Salanti
    Citation: BMC Medical Research Methodology 2023 23:223
    Content type: Software Published on:

  25. People with amyotrophic lateral sclerosis (ALS) face disability- and travel-related barriers to research participation. We investigate the usefulness and acceptability of asynchronous, online focus groups (AOF...

    Authors: Shelagh K. Genuis, Westerly Luth, Garnette Weber, Tania Bubela and Wendy S. Johnston
    Citation: BMC Medical Research Methodology 2023 23:222
    Content type: Research Published on:

  26. Determining risk factors of single-vehicle run-off-road (SV-ROR) crashes, as a significant number of all the single-vehicle crashes and all the fatalities, may provide infrastructure for quicker and more effec...

    Authors: Fatemeh Jahanjoo, Mohammad Asghari-Jafarabadi and Homayoun Sadeghi-Bazargani
    Citation: BMC Medical Research Methodology 2023 23:221
    Content type: Research Published on:

  27. In medical, social, and behavioral research we often encounter datasets with a multilevel structure and multiple correlated dependent variables. These data are frequently collected from a study population that...

    Authors: Xynthia Kavelaars, Joris Mulder and Maurits Kaptein
    Citation: BMC Medical Research Methodology 2023 23:220
    Content type: Research Published on:

  28. Cross-sectional studies are useful for the estimation of prevalence of a particular event with concerns in specific populations, as in the case of diseases or other public health interests. Most of these studi...

    Authors: Milcíades Ibáñez-Pinilla, Sara Villalba-Niño and Nury N. Olaya-Galán
    Citation: BMC Medical Research Methodology 2023 23:219
    Content type: Research Published on:

  29. The advent of clinical trial data sharing platforms has created opportunities for making new discoveries and answering important questions using already collected data. However, existing methods for meta-analy...

    Authors: Vivek A. Rudrapatna, Vignesh G. Ravindranath, Douglas V. Arneson, Arman Mosenia, Atul J. Butte and Shan Wang
    Citation: BMC Medical Research Methodology 2023 23:218
    Content type: Research Published on:

  30. Respondent-driven sampling (RDS) is a peer chain-recruitment method for populations without a sampling frame or that are hard-to-reach. Although RDS is usually done face-to-face, the online version (WebRDS) ha...

    Authors: Pedro Ferrer-Rosende, María Feijoo-Cid, María Isabel Fernández-Cano, Sergio Salas-Nicás, Valeria Stuardo-Ávila and Albert Navarro-Giné
    Citation: BMC Medical Research Methodology 2023 23:217
    Content type: Research Published on:

  31. Fractures are rare events and can occur because of a fall. Fracture counts are distinct from other count data in that these data are positively skewed, inflated by excess zero counts, and events can recur over...

    Authors: Anower Hossain, Ranjit Lall, Chen Ji, Julie Bruce, Martin Underwood and Sarah E. Lamb
    Citation: BMC Medical Research Methodology 2023 23:216
    Content type: Research Published on:

  32. Gravity models are often hard to apply in practice due to their data-hungry nature. Standard implementations of gravity models require that data on each variable is available for each supply node. Since these ...

    Authors: Timo Latruwe, Marlies Van der Wee, Pieter Vanleenhove, Kwinten Michielsen, Sofie Verbrugge and Didier Colle
    Citation: BMC Medical Research Methodology 2023 23:215
    Content type: Research Published on:

  33. Patient-Reported Outcomes or Experience Measures (PROMS / PREMS) are routinely used in clinical studies to assess participants’ views and experiences of trial interventions and related quality of life. Purely ...

    Authors: Andrew Symon, Kate Lightly, Rachel Howard, Shuchita Mundle, Brian Faragher, Molly Hanley, Jill Durocher, Beverly Winikoff and Andrew Weeks
    Citation: BMC Medical Research Methodology 2023 23:214
    Content type: Research Published on:

  34. Configural, metric, and scalar measurement invariance have been indicators of bias-free statistical cross-group comparisons, although they are difficult to verify in the data. Low comparability of translated q...

    Authors: Natalja Menold, Louise Biddle, Hagen von Hermanni, Jasmin Kadel and Kayvan Bozorgmehr
    Citation: BMC Medical Research Methodology 2023 23:213
    Content type: Research Published on:

  35. Healthcare, as with other sectors, has undergone progressive digitalization, generating an ever-increasing wealth of data that enables research and the analysis of patient movement. This can help to evaluate t...

    Authors: Amelie Flothow, Anna Novelli and Leonie Sundmacher
    Citation: BMC Medical Research Methodology 2023 23:212
    Content type: Research article Published on:

  36. Barriers to mental health research participation are well documented including distrust of services and research; and stigma surrounding mental health. They can contribute to a lack of diversity amongst partic...

    Authors: Mais Iflaifel, Charlotte L Hall, Heidi R Green, Andrew Willis, Stefan Rennick-Egglestone, Edmund Juszczak, Mark Townsend, Jennifer Martin and Kirsty Sprange
    Citation: BMC Medical Research Methodology 2023 23:211
    Content type: Research Published on:

  37. Epidemiological surveys offer essential data on adolescent substance use. Nevertheless, the precision of these self-report-based surveys often faces mistrust from researchers and the public. We evaluate the ef...

    Authors: Janaka V. Kosgolla, Douglas C. Smith, Shahana Begum and Crystal A. Reinhart
    Citation: BMC Medical Research Methodology 2023 23:210
    Content type: Research Published on:

  38. Random Forests are a powerful and frequently applied Machine Learning tool. The permutation variable importance (VIMP) has been proposed to improve the explainability of such a pure prediction model. It descri...

    Authors: Christoph Wies, Robert Miltenberger, Gunter Grieser and Antje Jahn-Eimermacher
    Citation: BMC Medical Research Methodology 2023 23:209
    Content type: Research Published on:

  39. Health and social care interventions are often complex and can be decomposed into multiple components. Multicomponent interventions are often evaluated in randomised controlled trials. Across trials, intervent...

    Authors: Suzanne C. Freeman, Elnaz Saeedi, José M. Ordóñez-Mena, Clareece R. Nevill, Jamie Hartmann-Boyce, Deborah M. Caldwell, Nicky J. Welton, Nicola J. Cooper and Alex J. Sutton
    Citation: BMC Medical Research Methodology 2023 23:208
    Content type: Research Published on:

  40. Intensive care unit (ICU) length of stay (LOS) and the risk adjusted equivalent (RALOS) have been used as quality metrics. The latter measures entail either ratio or difference formulations or ICU random effec...

    Authors: John L. Moran, Graeme J. Duke, John D. Santamaria and Ariel Linden
    Citation: BMC Medical Research Methodology 2023 23:207
    Content type: Research Published on:

  41. Stepped-wedge cluster randomized trials (SWCRTs) are a type of cluster-randomized trial in which clusters are randomized to cross-over to the active intervention sequentially at regular intervals during the st...

    Authors: Clement Ma, Alina Lee, Darren Courtney, David Castle and Wei Wang
    Citation: BMC Medical Research Methodology 2023 23:206
    Content type: Research Published on:

  42. Patterns of survey response and the characteristics associated with response over time in longitudinal studies are important to discern for the development of tailored retention efforts aimed at minimizing res...

    Authors: Claire A. Kolaja, Jennifer N. Belding, Satbir K. Boparai, Sheila F. Castañeda, Toni Rose Geronimo-Hara, Teresa M. Powell, Xin M. Tu, Jennifer L. Walstrom, Beverly D. Sheppard and Rudolph P. Rull
    Citation: BMC Medical Research Methodology 2023 23:205
    Content type: Research Published on:

  43. Non-experimental studies (also known as observational studies) are valuable for estimating the effects of various medical interventions, but are notoriously difficult to evaluate because the methods used in no...

    Authors: Ethan Steinberg, Nikolaos Ignatiadis, Steve Yadlowsky, Yizhe Xu and Nigam Shah
    Citation: BMC Medical Research Methodology 2023 23:204
    Content type: Research Published on:

  46. Studies have suggested that agreement between administrative health data and self-report for asthma status ranges from fair to good, but few studies benefited from administrative health data over a long period...

    Authors: Marie-Claude Rousseau, Florence Conus, Mariam El-Zein, Andrea Benedetti and Marie-Elise Parent
    Citation: BMC Medical Research Methodology 2023 23:201
    Content type: Research Published on:

  47. Trial design plays a key role in clinical trials. Traditional group sequential design has been used in cardiovascular clinical trials over decades as the trials can potentially be stopped early, therefore, it ...

    Authors: Jufen Zhang and Christy Saju
    Citation: BMC Medical Research Methodology 2023 23:200
    Content type: Research Published on:

  48. Alzheimer’s disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins in the brain, brain atrophy and severe cogniti...

    Authors: Jérémie Lespinasse, Carole Dufouil and Cécile Proust-Lima
    Citation: BMC Medical Research Methodology 2023 23:199
    Content type: Research Published on:

  49. Symptoms reported following the administration of investigational drugs play an important role in decisions for registration and treatment guidelines. However, symptoms are subjective, and interview methods to...

    Authors: Kamala Thriemer, Robert James Commons, Megha Rajasekhar, Tamiru Shibiru Degaga, Krisin Chand, Nguyen Hoang Chau, Ashenafi Assefa, Mohammad Nader Naddim, Ayodhia Pitaloka Pasaribu, Awab Ghulam Rahim, Inge Sutanto, Tran Tinh Hien, Asrat Hailu, Mohammad Anwar Hasanzai, Lenny L. Ekawati, Adugna Woyessa…
    Citation: BMC Medical Research Methodology 2023 23:198
    Content type: Research Published on:

  50. Real-world observational data are an important source of evidence on the treatment effectiveness for patients hospitalized with coronavirus disease 2019 (COVID-19). However, observational studies evaluating tr...

    Authors: Oksana Martinuka, Derek Hazard, Hamid Reza Marateb, Camille Maringe, Marjan Mansourian, Manuel Rubio-Rivas and Martin Wolkewitz
    Citation: BMC Medical Research Methodology 2023 23:197
    Content type: Research Published on:
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BMC Medical Research Methodology

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