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  1. The COVID-19 pandemic continues to rage on, and clinical research has been promoted worldwide. We aimed to assess the clinical and methodological characteristics of treatment clinical trials that have been set...

    Authors: Beatrice Mainoli, Tiago Machado, Gonçalo S. Duarte, Luísa Prada, Nilza Gonçalves, Joaquim J. Ferreira and João Costa

    Citation: BMC Medical Research Methodology 2021 21:42

    Content type: Research article

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  2. Clinical interpretation of changes measured on a scale is dependent on knowing the minimum clinically important difference (MCID) for that scale: the threshold above which clinicians, patients, and researchers...

    Authors: Jennifer A. Watt, Areti Angeliki Veroniki, Andrea C. Tricco and Sharon E. Straus

    Citation: BMC Medical Research Methodology 2021 21:41

    Content type: Research article

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  4. Dynamic treatment regimens (DTRs) formalise the multi-stage and dynamic decision problems that clinicians often face when treating chronic or progressive medical conditions. Compared to randomised controlled t...

    Authors: Robert K. Mahar, Myra B. McGuinness, Bibhas Chakraborty, John B. Carlin, Maarten J. IJzerman and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2021 21:39

    Content type: Research article

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  5. Data collection is the most critical stage in any population health study and correctly implementing fieldwork enhances the quality of collected information. However, even the most carefully planned large-scal...

    Authors: Mir Baz Khan, Sidrah Nausheen, Imtiaz Hussain, Kristy Hackett, Kaneez Zehra, Khalid Feroze, David Canning, Iqbal Shah and Sajid Bashir Soofi

    Citation: BMC Medical Research Methodology 2021 21:38

    Content type: Research article

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  6. Most health surveys have experienced a decline in response rates. A structured approach to evaluate whether a decreasing - and potentially more selective - response over time biased estimated trends in health ...

    Authors: Famke J. M. Mölenberg, Chris de Vries, Alex Burdorf and Frank J. van Lenthe

    Citation: BMC Medical Research Methodology 2021 21:37

    Content type: Research article

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  7. Time-to-event data that is subject to interval censoring is common in the practice of medical research and versatile statistical methods for estimating associations in such settings have been limited. For righ...

    Authors: Martin Nygård Johansen, Søren Lundbye-Christensen, Jacob Moesgaard Larsen and Erik Thorlund Parner

    Citation: BMC Medical Research Methodology 2021 21:36

    Content type: Technical advance

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  8. Randomized controlled trials are considered the gold standard to evaluate causal associations, whereas assessing causality in observational studies is challenging.

    Authors: Emilia Gvozdenović, Lucio Malvisi, Elisa Cinconze, Stijn Vansteelandt, Phoebe Nakanwagi, Emmanuel Aris and Dominique Rosillon

    Citation: BMC Medical Research Methodology 2021 21:35

    Content type: Research article

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  9. Ensemble modeling aims to boost the forecasting performance by systematically integrating the predictive accuracy across individual models. Here we introduce a simple-yet-powerful ensemble methodology for fore...

    Authors: Gerardo Chowell and Ruiyan Luo

    Citation: BMC Medical Research Methodology 2021 21:34

    Content type: Research article

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  10. To evaluate the completeness of reporting abstracts of systematic reviews (SRs) before and after the publication of the PRISMA-A checklist in 2013 and to assess if an association exists between abstract charac...

    Authors: Milagros Adobes Martin, Sala Santamans Faustino, Inmaculada Llario Almiñana, Riccardo Aiuto, Roberto Rotundo and Daniele Garcovich

    Citation: BMC Medical Research Methodology 2021 21:33

    Content type: Research article

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  11. Natural or quasi experiments are appealing for public health research because they enable the evaluation of events or interventions that are difficult or impossible to manipulate experimentally, such as many p...

    Authors: Frank de Vocht, Srinivasa Vittal Katikireddi, Cheryl McQuire, Kate Tilling, Matthew Hickman and Peter Craig

    Citation: BMC Medical Research Methodology 2021 21:32

    Content type: Technical advance

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  12. Scale-up BP was a quasi-experimental implementation study, following a successful randomised controlled trial of the roll-out of telemonitoring in primary care across Lothian, Scotland. Our primary objective w...

    Authors: Richard A. Parker, Paul Padfield, Janet Hanley, Hilary Pinnock, John Kennedy, Andrew Stoddart, Vicky Hammersley, Aziz Sheikh and Brian McKinstry

    Citation: BMC Medical Research Methodology 2021 21:31

    Content type: Research article

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  13. In infectious disease transmission dynamics, the high heterogeneity in individual infectiousness indicates that few index cases generate large numbers of secondary cases, which is commonly known as superspread...

    Authors: Shi Zhao, Mingwang Shen, Salihu S. Musa, Zihao Guo, Jinjun Ran, Zhihang Peng, Yu Zhao, Marc K. C. Chong, Daihai He and Maggie H. Wang

    Citation: BMC Medical Research Methodology 2021 21:30

    Content type: Research article

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  14. Statistical methods for modeling longitudinal and time-to-event data has received much attention in medical research and is becoming increasingly useful. In clinical studies, such as cancer and AIDS, longitudi...

    Authors: Julius S. Ngwa, Howard J. Cabral, Debbie M. Cheng, David R. Gagnon, Michael P. LaValley and L. Adrienne Cupples

    Citation: BMC Medical Research Methodology 2021 21:29

    Content type: Research article

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  15. COVID-19 has led to the adoption of unprecedented mitigation measures which could trigger many unintended consequences. These unintended consequences can be far-reaching and just as important as the intended o...

    Authors: Anne-Marie Turcotte-Tremblay, Idriss Ali Gali Gali and Valéry Ridde

    Citation: BMC Medical Research Methodology 2021 21:28

    Content type: Commentary

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  16. Ethnographic approaches offer a method and a way of thinking about implementation. This manuscript applies a specific case study method to describe the impact of the longitudinal interplay between implementati...

    Authors: Jennifer M. Van Tiem, Heather Schacht Reisinger, Julia E. Friberg, Jaime R. Wilson, Lynn Fitzwater, Ralph J. Panos and Jane Moeckli

    Citation: BMC Medical Research Methodology 2021 21:27

    Content type: Research article

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  17. Over 2 billion people suffer from vision impairment or blindness globally, and access to validated visual measurement tools in imperative in accurately describing and managing the burden of eye disease. The pr...

    Authors: William Mitchell, Srinivas Marmamula, Nazlee Zebardast, Weiwen Ng, Joseph J. Locascio, Thirupathi Kumbam, Satya Brahmanandam and Navya Rekha Barrenkala

    Citation: BMC Medical Research Methodology 2021 21:26

    Content type: Research article

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  18. Many respondent-driven sampling (RDS) methodologies have been employed to investigate hard-to-reach populations; however, these methodologies present some limits. We describe a minimally investigated RDS metho...

    Authors: Maxime Inghels, Arsène Kra Kouassi, Serge Niangoran, Anne Bekelynck, Séverine Carillon, Lazare Sika, Mariatou Koné, Christine Danel, Annabel Desgrées du Loû and Joseph Larmarange

    Citation: BMC Medical Research Methodology 2021 21:25

    Content type: Research article

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  19. Early pregnancy weights are needed to quantify gestational weight gain accurately. Different methods have been used in previous studies to impute early-pregnancy weights. However, no studies have systematicall...

    Authors: Jiaxi Yang, Dongqing Wang, Anne Marie Darling, Enju Liu, Nandita Perumal, Wafaie W. Fawzi and Molin Wang

    Citation: BMC Medical Research Methodology 2021 21:24

    Content type: Research article

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  20. The U.S. lacks a stroke surveillance system. This study develops a method to transform an existing registry into a nationally representative database to evaluate acute ischemic stroke care quality.

    Authors: Boback Ziaeian, Haolin Xu, Roland A. Matsouaka, Ying Xian, Yosef Khan, Lee S. Schwamm, Eric E. Smith and Gregg C. Fonarow

    Citation: BMC Medical Research Methodology 2021 21:23

    Content type: Research article

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  21. Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size ...

    Authors: M. S. M. Persson, K. E. Harman, K. S. Thomas, J. R. Chalmers, Y. Vinogradova, S. M. Langan, J. Hippisley-Cox and S. Gran

    Citation: BMC Medical Research Methodology 2021 21:22

    Content type: Research article

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  22. The use of individual patient data (IPD) in network meta-analyses (NMA) is rapidly growing. This study aimed to determine, through simulations, the impact of select factors on the validity and precision of NMA...

    Authors: Steve Kanters, Mohammad Ehsanul Karim, Kristian Thorlund, Aslam Anis and Nick Bansback

    Citation: BMC Medical Research Methodology 2021 21:21

    Content type: Research article

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  23. Audit and feedback (A&F) interventions are one of the most common approaches for implementing evidence-based practices. A key barrier to more effective A&F interventions is the lack of a theory-guided approach...

    Authors: Heather L. Colquhoun, Kelly Carroll, Kevin W. Eva, Jeremy M. Grimshaw, Noah Ivers, Susan Michie and Jamie C. Brehaut

    Citation: BMC Medical Research Methodology 2021 21:20

    Content type: Research article

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  24. Retention of participants in cohort studies is a major challenge. A better understanding of all elements involved in participation and attrition phenomena in particular settings is needed to develop effective ...

    Authors: Sandra C. S. Marques, Julia Doetsch, Georgia Abate, Anne Brødsgaard, Grazia Colombo, Marina Cuttini, Pernille Pedersen and Henrique Barros

    Citation: BMC Medical Research Methodology 2021 21:19

    Content type: Research article

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  25. Semi-competing risks arise when interest lies in the time-to-event for some non-terminal event, the observation of which is subject to some terminal event. One approach to assessing the impact of covariates on...

    Authors: Catherine Lee, Paola Gilsanz and Sebastien Haneuse

    Citation: BMC Medical Research Methodology 2021 21:18

    Content type: Research article

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  26. Recurrent episodes of pneumonia are frequently modeled using extensions of the Cox proportional hazards model with the underlying assumption of time-constant relative risks measured by the hazard ratio. We aim...

    Authors: Jordache Ramjith, Kit C.B. Roes, Heather J. Zar and Marianne A. Jonker

    Citation: BMC Medical Research Methodology 2021 21:17

    Content type: Research article

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  27. Multi-state models are being increasingly used to capture complex disease pathways. The convenient formula of the exponential multi-state model can facilitate a quick and accessible understanding of the data. ...

    Authors: Micki Hill, Paul C. Lambert and Michael J. Crowther

    Citation: BMC Medical Research Methodology 2021 21:16

    Content type: Research article

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  28. The rising burden of the ongoing COVID-19 epidemic in South Africa has motivated the application of modeling strategies to predict the COVID-19 cases and deaths. Reliable and accurate short and long-term forec...

    Authors: Tarylee Reddy, Ziv Shkedy, Charl Janse van Rensburg, Henry Mwambi, Pravesh Debba, Khangelani Zuma and Samuel Manda

    Citation: BMC Medical Research Methodology 2021 21:15

    Content type: Research article

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  29. As cancer treatment, biotherapies can be as effective as chemotherapy while reducing the risk of secondary effects, so that they can be taken over longer periods than conventional chemotherapy. Thus, some tria...

    Authors: Adrien Guilloteau, Michal Abrahamowicz, Olayide Boussari, Valérie Jooste, Thomas Aparicio, Catherine Quantin, Karine Le Malicot and Christine Binquet

    Citation: BMC Medical Research Methodology 2021 21:14

    Content type: Research article

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  30. Missing data are common in end-of-life care studies, but there is still relatively little exploration of which is the best method to deal with them, and, in particular, if the missing at random (MAR) assumptio...

    Authors: Giulia Carreras, Guido Miccinesi, Andrew Wilcock, Nancy Preston, Daan Nieboer, Luc Deliens, Mogensm Groenvold, Urska Lunder, Agnes van der Heide and Michela Baccini

    Citation: BMC Medical Research Methodology 2021 21:13

    Content type: Research article

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  31. Trials with binary outcomes can be synthesised using within-trial exact likelihood or approximate normal likelihood in one-stage or two-stage approaches, respectively. The performance of the one-stage and the ...

    Authors: Loukia M. Spineli, Katerina Papadimitropoulou and Chrysostomos Kalyvas

    Citation: BMC Medical Research Methodology 2021 21:12

    Content type: Research article

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  33. As the development of core outcome sets (COS) increases, guidance for developing and reporting high-quality COS continues to evolve; however, a number of methodological uncertainties still remain. The objectiv...

    Authors: Alexandria Remus, Valerie Smith and Francesca Wuytack

    Citation: BMC Medical Research Methodology 2021 21:10

    Content type: Research article

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  34. Multivariable prediction models are important statistical tools for providing synthetic diagnosis and prognostic algorithms based on patients’ multiple characteristics. Their apparent measures for predictive a...

    Authors: Katsuhiro Iba, Tomohiro Shinozaki, Kazushi Maruo and Hisashi Noma

    Citation: BMC Medical Research Methodology 2021 21:9

    Content type: Research article

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  35. In increasingly ageing populations, there is an emergent need to develop a robust prediction model for estimating an individual absolute risk for all-cause mortality, so that relevant assessments and intervent...

    Authors: Olesya Ajnakina, Deborah Agbedjro, Ryan McCammon, Jessica Faul, Robin M. Murray, Daniel Stahl and Andrew Steptoe

    Citation: BMC Medical Research Methodology 2021 21:8

    Content type: Research article

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  36. Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited success is the selection o...

    Authors: Mar Rodríguez-Girondo, Niels van den Berg, Michel H. Hof, Marian Beekman and Eline Slagboom

    Citation: BMC Medical Research Methodology 2021 21:7

    Content type: Research article

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  37. Genital warts are a common and highly contagious sexually transmitted disease. They have a large economic burden and affect several aspects of quality of life. Incidence data underestimate the real occurrence ...

    Authors: David Moriña, Amanda Fernández-Fontelo, Alejandra Cabaña, Pedro Puig, Laura Monfil, Maria Brotons and Mireia Diaz

    Citation: BMC Medical Research Methodology 2021 21:6

    Content type: Research article

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  38. Questionnaires used in longitudinal studies may have questions added or removed over time for numerous reasons. Data missing completely at a follow-up survey is a unique issue for longitudinal studies. While s...

    Authors: Claire A. Kolaja, Ben Porter, Teresa M. Powell and Rudolph P. Rull

    Citation: BMC Medical Research Methodology 2021 21:5

    Content type: Research article

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  39. There is a growing interest in assessment of the quality of hospital care, based on outcome measures. Many quality of care comparisons rely on binary outcomes, for example mortality rates. Due to low numbers, ...

    Authors: I. E. Ceyisakar, N. van Leeuwen, Diederik W. J. Dippel, Ewout W. Steyerberg and H. F. Lingsma

    Citation: BMC Medical Research Methodology 2021 21:4

    Content type: Research article

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  41. Time-series analysis with case-only data is a prominent method for the effect of environmental determinants on disease events in environmental epidemiology. In this analysis, adjustment for seasonality and lon...

    Authors: Honghyok Kim, Jong-Tae Lee, Kelvin C. Fong and Michelle L. Bell

    Citation: BMC Medical Research Methodology 2021 21:2

    Content type: Research article

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  42. Since the start of the COVID-19 outbreak, a large number of COVID-19-related papers have been published. However, concerns about the risk of expedited science have been raised. We aimed at reviewing and catego...

    Authors: Marc Raynaud, Huanxi Zhang, Kevin Louis, Valentin Goutaudier, Jiali Wang, Quentin Dubourg, Yongcheng Wei, Zeynep Demir, Charlotte Debiais, Olivier Aubert, Yassine Bouatou, Carmen Lefaucheur, Patricia Jabre, Longshan Liu, Changxi Wang, Xavier Jouven…

    Citation: BMC Medical Research Methodology 2021 21:1

    Content type: Research article

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  43. Long-term effectiveness of asthma control medication has been shown in clinical trials but results from observational studies with children and adolescents are lacking. Marginal structural models estimated usi...

    Authors: Carolin Veit, Ronald Herrera, Gudrun Weinmayr, Jon Genuneit, Doris Windstetter, Christian Vogelberg, Erika von Mutius, Dennis Nowak, Katja Radon, Jessica Gerlich and Tobias Weinmann

    Citation: BMC Medical Research Methodology 2020 20:307

    Content type: Research article

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  44. Although a variety of instruments are available that capture stress experience, the assessment of chronic stress has been hindered by the lack of economical screening instruments. Recently, an English-language...

    Authors: K. Petrowski, E. Braehler, B. Schmalbach, A. Hinz, C. Bastianon and T. Ritz

    Citation: BMC Medical Research Methodology 2020 20:306

    Content type: Research article

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  45. In most countries, the official statistics for the coronavirus disease 2019 (COVID-19) take account of in-hospital deaths but not those that occur at home. The study’s objective was to introduce a methodology ...

    Authors: Hervé Hubert, Valentine Baert, Jean-Baptiste Beuscart and Emmanuel Chazard

    Citation: BMC Medical Research Methodology 2020 20:305

    Content type: Research article

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  46. To assess the agreement of continuous measurements between a number of observers, Jones et al. introduced limits of agreement with the mean (LOAM) for multiple observers, representing how much an individual ob...

    Authors: Heidi S. Christensen, Jens Borgbjerg, Lars Børty and Martin Bøgsted

    Citation: BMC Medical Research Methodology 2020 20:304

    Content type: Technical advance

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  47. Records of medication prescriptions can be used in conjunction with pharmacy dispensing records to investigate the incidence of adherence, which is defined as observing the treatment plans agreed between a patien...

    Authors: Holly Tibble, James Lay-Flurrie, Aziz Sheikh, Rob Horne, Mehrdad A. Mizani and Athanasios Tsanas

    Citation: BMC Medical Research Methodology 2020 20:303

    Content type: Research article

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  48. Social-environmental data obtained from the US Census is an important resource for understanding health disparities, but rarely is the full dataset utilized for analysis. A barrier to incorporating the full da...

    Authors: Elizabeth Handorf, Yinuo Yin, Michael Slifker and Shannon Lynch

    Citation: BMC Medical Research Methodology 2020 20:302

    Content type: Research article

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  49. Qualitative methods offer a unique contribution to health research. Academic dissertations in the medical field provide an opportunity to explore research practice. Our aim was to assess the use of qualitative...

    Authors: Charlotte Ullrich, Anna Stürmlinger, Michel Wensing and Katja Krug

    Citation: BMC Medical Research Methodology 2020 20:301

    Content type: Research article

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  50. Typically, subgroup analyses in clinical trials are conducted by comparing the intervention effect in each subgroup by means of an interaction test. However, trials are rarely, if ever, adequately powered for ...

    Authors: Russell Thirard, Raimondo Ascione, Jane M. Blazeby and Chris A. Rogers

    Citation: BMC Medical Research Methodology 2020 20:300

    Content type: Technical advance

    Published on:

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