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  1. To evaluate the performance of the automated abstract screening tool Rayyan.

    Authors: Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Seyed Hossein Hosseini Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani and Shahriar Faghani
    Citation: BMC Medical Research Methodology 2022 22:160
  2. Accurate and reliable estimates of violence against women form the backbone of global and regional monitoring efforts to eliminate this human right violation and public health problem. Estimating the prevalenc...

    Authors: Mathieu Maheu-Giroux, Lynnmarie Sardinha, Heidi Stöckl, Sarah R. Meyer, Arnaud Godin, Monica Alexander and Claudia García-Moreno
    Citation: BMC Medical Research Methodology 2022 22:159
  3. Preconception pregnancy risk profiles—characterizing the likelihood that a pregnancy attempt results in a full-term birth, preterm birth, clinical pregnancy loss, or failure to conceive—can provide critical in...

    Authors: Kaitlyn Cook, Neil J. Perkins, Enrique Schisterman and Sebastien Haneuse
    Citation: BMC Medical Research Methodology 2022 22:156
  4. Natalizumab and fingolimod are used as high-efficacy treatments in relapsing–remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different m...

    Authors: M. Lefort, S. Sharmin, J. B. Andersen, S. Vukusic, R. Casey, M. Debouverie, G. Edan, J. Ciron, A. Ruet, J. De Sèze, E. Maillart, H. Zephir, P. Labauge, G. Defer, C. Lebrun-Frenay, T. Moreau…
    Citation: BMC Medical Research Methodology 2022 22:155
  5. This study evaluated the adequacy of randomization in randomized controlled trials by investigating baseline differences in the primary outcome when a meta-analysis employed an outcome whose baseline level was...

    Authors: Eun-Gee Park and Seokyung Hahn
    Citation: BMC Medical Research Methodology 2022 22:154
  6. As the cost of RNA-sequencing decreases, complex study designs, including paired, longitudinal, and other correlated designs, become increasingly feasible. These studies often include multiple hypotheses and t...

    Authors: Elizabeth A. Wynn, Brian E. Vestal, Tasha E. Fingerlin and Camille M. Moore
    Citation: BMC Medical Research Methodology 2022 22:153
  7. Observational data are increasingly being used to conduct external comparisons to clinical trials. In this study, we empirically examined whether different methodological approaches to longitudinal missing dat...

    Authors: Vibeke Norvang, Espen A. Haavardsholm, Sara K. Tedeschi, Houchen Lyu, Joseph Sexton, Maria D. Mjaavatten, Tore K. Kvien, Daniel H. Solomon and Kazuki Yoshida
    Citation: BMC Medical Research Methodology 2022 22:152
  8. Middle-aged and older adults are more likely to suffer from chronic diseases because of their particular health characteristics, which lead to a high incidence of catastrophic health expenditure (CHE). This st...

    Authors: Wenqing Miao, Xiyu Zhang, Baoguo Shi, Wanxin Tian, Bing Wu, Yongqiang Lai, Yuze Li, Zhipeng Huang, Qi Xia, Huiqi Yang, Fan Ding, Linghan Shan, Ling Xin, Jingying Miao, Chenxi Zhang, Ye Li…
    Citation: BMC Medical Research Methodology 2022 22:151
  9. The major drivers of cost-effectiveness for chronic obstructive pulmonary disease (COPD) therapies are the occurrence of exacerbations and deaths. Exacerbations, including acute and long-term events, can cause...

    Authors: Kirsty Rhodes, Martin Jenkins, Enrico de Nigris, Magnus Aurivillius and Mario Ouwens
    Citation: BMC Medical Research Methodology 2022 22:150
  10. We examine the concept of Bayesian Additional Evidence (BAE) recently proposed by Sondhi et al. We derive simple closed-form expressions for BAE and compare its properties with other methods for assessing find...

    Authors: Samuel Pawel, Leonhard Held and Robert Matthews
    Citation: BMC Medical Research Methodology 2022 22:149
  11. Missing data prove troublesome in data analysis; at best they reduce a study’s statistical power and at worst they induce bias in parameter estimates. Multiple imputation via chained equations is a popular tec...

    Authors: Matthew A. Bolt, Samantha MaWhinney, Jack W. Pattee, Kristine M. Erlandson, David B. Badesch and Ryan A. Peterson
    Citation: BMC Medical Research Methodology 2022 22:148
  12. Accelerometery is commonly used to estimate physical activity, sleep, and sedentary behavior. In free-living conditions, periods of device removal (non-wear) can lead to misclassification of behavior with cons...

    Authors: Adam Vert, Kyle S. Weber, Vanessa Thai, Erin Turner, Kit B. Beyer, Benjamin F Cornish, F. Elizabeth Godkin, Christopher Wong, William E. McIlroy and Karen Van Ooteghem
    Citation: BMC Medical Research Methodology 2022 22:147
  13. Regression models are often used to explain the relative risk of infectious diseases among groups. For example, overrepresentation of immigrants among COVID-19 cases has been found in multiple countries. Sever...

    Authors: Solveig Engebretsen, Gunnar Rø and Birgitte Freiesleben de Blasio
    Citation: BMC Medical Research Methodology 2022 22:146
  14. Epidemiological studies of incidence play an essential role in quantifying disease burden, resource planning, and informing public health policies. A variety of measures for estimating cancer incidence have be...

    Authors: Norah Alsadhan, Alaa Almaiman, Mar Pujades-Rodriguez, Cathy Brennan, Farag Shuweihdi, Sultana A. Alhurishi and Robert M. West
    Citation: BMC Medical Research Methodology 2022 22:144
  15. Cohort collaborations often require meta-analysis of exposure-outcome association estimates across cohorts as an alternative to pooling individual-level data that requires a laborious process of data harmoniza...

    Authors: Debashree Ray, Alvaro Muñoz, Mingyu Zhang, Xiuhong Li, Nilanjan Chatterjee, Lisa P. Jacobson and Bryan Lau
    Citation: BMC Medical Research Methodology 2022 22:143
  16. Whether there is sufficient capacity and capability for the successful conduct and delivery of a clinical trial should be assessed by several stakeholders according to transparent and evidence-based criteria d...

    Authors: Viktoria Gloy, Benjamin Speich, Alexandra Griessbach, Ala Taji Heravi, Alexandra Schulz, Thomas Fabbro, Christiane Pauli Magnus, Stuart McLennan, Wendy Bertram and Matthias Briel
    Citation: BMC Medical Research Methodology 2022 22:142
  17. Screening for eligible patients continues to pose a great challenge for many clinical trials. This has led to a rapidly growing interest in standardizing computable representations of eligibility criteria (EC)...

    Authors: Ahmed Rafee, Sarah Riepenhausen, Philipp Neuhaus, Alexandra Meidt, Martin Dugas and Julian Varghese
    Citation: BMC Medical Research Methodology 2022 22:141
  18. Health surveys are commonly somewhat non-representative of their target population, potentially limiting the generalisability of prevalence estimates for health/behaviour characteristics and disease to the pop...

    Authors: Sarsha Yap, Qingwei Luo, Stephen Wade, Marianne Weber, Emily Banks, Karen Canfell, Dianne L. O’Connell and Julia Steinberg
    Citation: BMC Medical Research Methodology 2022 22:140
  19. Social media has led to fundamental changes in the way that people look for and share health related information. There is increasing interest in using this spontaneously generated patient experience data as a...

    Authors: Julia Walsh, Christine Dwumfour, Jonathan Cave and Frances Griffiths
    Citation: BMC Medical Research Methodology 2022 22:139
  20. Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, li...

    Authors: David Tappin, Daniel Mackay, Lucy Reynolds and Niamh Fitzgerald
    Citation: BMC Medical Research Methodology 2022 22:138
  21. With the spread of COVID-19, the time-series prediction of COVID-19 has become a research hotspot. Unlike previous epidemics, COVID-19 has a new pattern of long-time series, large fluctuations, and multiple pe...

    Authors: Haoran Dai, Wen Cao, Xiaochong Tong, Yunxing Yao, Feilin Peng, Jingwen Zhu and Yuzhen Tian
    Citation: BMC Medical Research Methodology 2022 22:137
  22. Manually extracted data points from health records are collated on an institutional, provincial, and national level to facilitate clinical research. However, the labour-intensive clinical chart review process ...

    Authors: Yifu Chen, Lucy Hao, Vito Z. Zou, Zsuzsanna Hollander, Raymond T. Ng and Kathryn V. Isaac
    Citation: BMC Medical Research Methodology 2022 22:136
  23. Valid and reliable research tools to assess children’s and adolescent’s health-related behaviour are highly needed across the globe. Rapid economic development, globalization, and associated lifestyle challeng...

    Authors: Jaroslav Kohoutek, Marek Maráček, Kwok Ng and Zdenek Hamrik
    Citation: BMC Medical Research Methodology 2022 22:135
  24. Guideline adaptation provides an important alternative to de novo guideline development by making the process more efficient and reducing unnecessary duplication. The quality evaluation of international guidel...

    Authors: Daniela D’angelo, Daniela Coclite, Antonello Napoletano, Silvia Gianola, Greta Castellini, Roberto Latina, Laura Iacorossi, Alice Josephine Fauci and Primiano Iannone
    Citation: BMC Medical Research Methodology 2022 22:134
  25. Prior work has shown that combining bootstrap imputation with tree-based machine learning variable selection methods can provide good performances achievable on fully observed data when covariate and outcome d...

    Authors: Jung-Yi Joyce Lin, Liangyuan Hu, Chuyue Huang, Ji Jiayi, Steven Lawrence and Usha Govindarajulu
    Citation: BMC Medical Research Methodology 2022 22:132
  26. A relative survival approach is often used in population-based cancer studies, where other cause (or expected) mortality is assumed to be the same as the mortality in the general population, given a specific c...

    Authors: Yuliya Leontyeva, Hannah Bower, Oskar Gauffin, Paul C Lambert and Therese M.-L. Andersson
    Citation: BMC Medical Research Methodology 2022 22:130
  27. Many clinical trial procedures were often undertaken in-person prior to the COVID-19 pandemic, which has resulted in adaptations to these procedures to enable trials to continue. The aim of this study was to u...

    Authors: Robin Chatters, Cindy L. Cooper, Alicia O’Cathain, Caroline Murphy, Athene Lane, Katie Sutherland, Christopher Burton, Angela Cape and Louis Tunnicliffe
    Citation: BMC Medical Research Methodology 2022 22:128
  28. The Numerical Rating Scale (NRS) and Patient-rated wrist/hand evaluation (PRWHE) are patient-reported outcomes frequently used for evaluating pain and function of the wrist and hand. The aim of this study was ...

    Authors: Susanna Stjernberg-Salmela, Teemu Karjalainen, Joona Juurakko, Pirjo Toivonen, Eero Waris, Simo Taimela, Clare L. Ardern, Teppo L. N. Järvinen and Jarkko Jokihaara
    Citation: BMC Medical Research Methodology 2022 22:127
  29. Prediction and classification algorithms are commonly used in clinical research for identifying patients susceptible to clinical conditions such as diabetes, colon cancer, and Alzheimer’s disease. Developing a...

    Authors: Arinjita Bhattacharyya, Subhadip Pal, Riten Mitra and Shesh Rai
    Citation: BMC Medical Research Methodology 2022 22:126
  30. The health crisis resulting from the global COVID-19 pandemic highlighted more than ever the need for rapid, reliable and safe methods of diagnosis and monitoring of respiratory diseases. To study pulmonary in...

    Authors: Lorena Álvarez-Rodríguez, Joaquim de Moura, Jorge Novo and Marcos Ortega
    Citation: BMC Medical Research Methodology 2022 22:125
  31. The growing volume of health data provides new opportunities for medical research. By using existing registries, large populations can be studied over a long period of time. Patient-level linkage of registries...

    Authors: Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling and Joke C. Korevaar
    Citation: BMC Medical Research Methodology 2022 22:124
  32. There are currently no methodological studies on the performance of the statistical models for estimating intervention effects based on the time-to-recurrent-event (TTRE) in stepped wedge cluster randomised tr...

    Authors: Shunsuke Oyamada, Shih-Wei Chiu and Takuhiro Yamaguchi
    Citation: BMC Medical Research Methodology 2022 22:123
  33. Missing data are common in longitudinal studies, and more so, in studies of older adults, who are susceptible to health and functional decline that limit completion of assessments. We assessed the extent, curr...

    Authors: Chinenye Okpara, Chidozie Edokwe, George Ioannidis, Alexandra Papaioannou, Jonathan D. Adachi and Lehana Thabane
    Citation: BMC Medical Research Methodology 2022 22:122
  34. Instrumental variable (IV) analysis holds the potential to estimate treatment effects from observational data. IV analysis potentially circumvents unmeasured confounding but makes a number of assumptions, such...

    Authors: I. E. Ceyisakar, N. van Leeuwen, E. W. Steyerberg and H. F. Lingsma
    Citation: BMC Medical Research Methodology 2022 22:121
  35. It is often challenging to determine which variables need to be included in the g-computation algorithm under the time-varying setting. Conditioning on instrumental variables (IVs) is known to introduce greate...

    Authors: Kosuke Inoue, Atsushi Goto, Naoki Kondo and Tomohiro Shinozaki
    Citation: BMC Medical Research Methodology 2022 22:120
  36. With the increasing use of mobile technology, ecological momentary assessments (EMAs) may enable routine monitoring of patient health outcomes and patient experiences of care by health agencies. This rapid rev...

    Authors: Rebecca J. Mitchell, Rory Goggins and Reidar P. Lystad
    Citation: BMC Medical Research Methodology 2022 22:119
  37. The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects and implications of the virus outbreak. Model results represent an important part of the in...

    Authors: Lukas Refisch, Fabian Lorenz, Torsten Riedlinger, Hannes Taubenböck, Martina Fischer, Linus Grabenhenrich, Martin Wolkewitz, Harald Binder and Clemens Kreutz
    Citation: BMC Medical Research Methodology 2022 22:116
  38. Cluster randomised trials often randomise a small number of units, putting them at risk of poor balance of covariates across treatment arms. Covariate constrained randomisation aims to reduce this risk by remo...

    Authors: Caroline Kristunas, Michael Grayling, Laura J. Gray and Karla Hemming
    Citation: BMC Medical Research Methodology 2022 22:111
  39. Systematic reviews of in-vitro studies, like any other study, can be of heterogeneous quality. The present study aimed to evaluate the methodological quality of systematic reviews of in-vitro dental studies.

    Authors: Christopher Hammel, Nikolaos Pandis, Dawid Pieper and Clovis Mariano Faggion Jr
    Citation: BMC Medical Research Methodology 2022 22:110

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