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BMC Medical Research Methodology

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  1. Content type: Research article

    The bias caused by drop-out is an important factor in large population-based epidemiological studies. Many studies account for it by weighting their longitudinal data, but to date there is no detailed final ap...

    Authors: Steffen C. E. Schmidt and Alexander Woll

    Citation: BMC Medical Research Methodology 2017 17:164

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  2. Content type: Research article

    As implementation science advances, the number of interventions to promote the translation of evidence into healthcare, health systems, or health policy is growing. Accordingly, classification schemes for thes...

    Authors: Susan E. Slaughter, Gabrielle L. Zimmermann, Megan Nuspl, Heather M. Hanson, Lauren Albrecht, Rosmin Esmail, Khara Sauro, Amanda S. Newton, Maoliosa Donald, Michele P. Dyson, Denise Thomson and Lisa Hartling

    Citation: BMC Medical Research Methodology 2017 17:161

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  3. Content type: Research article

    Missing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causi...

    Authors: Janus Christian Jakobsen, Christian Gluud, Jørn Wetterslev and Per Winkel

    Citation: BMC Medical Research Methodology 2017 17:162

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  4. Content type: Research article

    The Marginal Structural Cox Model (Cox-MSM), an alternative approach to handle time-dependent confounder, was introduced for survival analysis and applied to estimate the joint causal effect of two time-depend...

    Authors: Clovis Lusivika-Nzinga, Hana Selinger-Leneman, Sophie Grabar, Dominique Costagliola and Fabrice Carrat

    Citation: BMC Medical Research Methodology 2017 17:160

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  5. Content type: Technical advance

    Randomization is considered to be a key feature to protect against bias in randomized clinical trials. Randomization induces comparability with respect to known and unknown covariates, mitigates selection bias...

    Authors: Ralf-Dieter Hilgers, Diane Uschner, William F. Rosenberger and Nicole Heussen

    Citation: BMC Medical Research Methodology 2017 17:159

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  6. Content type: Research article

    In healthcare research, outcomes with skewed probability distributions are common. Sample size calculations for such outcomes are typically based on estimates on a transformed scale (e.g. log) which may someti...

    Authors: Aidan G. O’Keeffe, Gareth Ambler and Julie A. Barber

    Citation: BMC Medical Research Methodology 2017 17:157

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  7. Content type: Research article

    The Alcohol Use Disorders Identification Test (AUDIT) is a commonly used scale to measure severity of alcohol consumption that contains an item asking if anyone has expressed concern about your drinking or sug...

    Authors: John A. Cunningham, Alexandra Godinho, Vladyslav Kushnir and Nicolas Bertholet

    Citation: BMC Medical Research Methodology 2017 17:158

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  8. Content type: Research article

    The follow-up rate, a standard index of the completeness of follow-up, is important for assessing the validity of a cohort study. A common method for estimating the follow-up rate, the “Percentage Method”, def...

    Authors: Xiaonan Xue, Ilir Agalliu, Mimi Y. Kim, Tao Wang, Juan Lin, Reza Ghavamian and Howard D. Strickler

    Citation: BMC Medical Research Methodology 2017 17:155

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  9. Content type: Research article

    Regulations, study design complexity and amounts of collected and shared data in clinical trials render efficient data handling procedures inevitable. Recent research suggests that electronic data capture can ...

    Authors: Robert Fleischmann, Anne-Marie Decker, Antje Kraft, Knut Mai and Sein Schmidt

    Citation: BMC Medical Research Methodology 2017 17:153

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  10. Content type: Research article

    Exploratory preclinical, as well as clinical trials, may involve a small number of patients, making it difficult to calculate and analyze the pharmacokinetic (PK) parameters, especially if the PK parameters sh...

    Authors: Sudeep Pradhan, Byungjeong Song, Jaeyeon Lee, Jung-woo Chae, Kyung Im Kim, Hyun-moon Back, Nayoung Han, Kwang-il Kwon and Hwi-yeol Yun

    Citation: BMC Medical Research Methodology 2017 17:154

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  11. Content type: Research article

    Mechanical Turk (MTurk) is an online portal operated by Amazon where ‘requesters’ (individuals or businesses) can submit jobs for ‘workers.’ MTurk is used extensively by academics as a quick and cheap means of...

    Authors: John A. Cunningham, Alexandra Godinho and Vladyslav Kushnir

    Citation: BMC Medical Research Methodology 2017 17:156

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  12. Content type: Research article

    Our objective was to assess the frequency of data extraction errors and its potential impact on results in systematic reviews. Furthermore, we evaluated the effect of different extraction methods, reviewer cha...

    Authors: Tim Mathes, Pauline Klaßen and Dawid Pieper

    Citation: BMC Medical Research Methodology 2017 17:152

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  13. Content type: Research article

    An up-to-date systematic review is important for researchers to decide whether to embark on new research or continue supporting ongoing studies. The aim of this study is to examine the time taken between the l...

    Authors: Wilson W. S. Tam, Kenneth K. H. Lo, Parames Khalechelvam, Joey Seah and Shawn Y. S. Goh

    Citation: BMC Medical Research Methodology 2017 17:151

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  14. Content type: Research article

    There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different ...

    Authors: S. R. Zeissig, V. Weyer-Elberich, K. Emrich, H. Binder, S. Fischbeck, B. H. Imruck, P. Friedrich-Mai, M. E. Beutel and M. Blettner

    Citation: BMC Medical Research Methodology 2017 17:150

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  15. Content type: Research article

    It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug be...

    Authors: Feng Liu, Stephen J. Walters and Steven A. Julious

    Citation: BMC Medical Research Methodology 2017 17:149

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  16. Content type: Research Article

    The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance,...

    Authors: Antoine Barbieri, Jean Peyhardi, Thierry Conroy, Sophie Gourgou, Christian Lavergne and Caroline Mollevi

    Citation: BMC Medical Research Methodology 2017 17:148

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  17. Content type: Research article

    It is challenging for current statistical models to predict clinical progression of Parkinson’s disease (PD) because of the involvement of multi-domains and longitudinal data.

    Authors: Ming Wang, Zheng Li, Eun Young Lee, Mechelle M. Lewis, Lijun Zhang, Nicholas W. Sterling, Daymond Wagner, Paul Eslinger, Guangwei Du and Xuemei Huang

    Citation: BMC Medical Research Methodology 2017 17:147

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  18. Content type: Research article

    Several statistical approaches have been proposed to assess and correct for exposure measurement error. We aimed to provide a critical overview of the most common approaches used in nutritional epidemiology.

    Authors: Derrick A. Bennett, Denise Landry, Julian Little and Cosetta Minelli

    Citation: BMC Medical Research Methodology 2017 17:146

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  19. Content type: Research article

    The reproducibility of research is essential to rigorous science, yet significant concerns of the reliability and verifiability of biomedical research have been recently highlighted. Ongoing efforts across sev...

    Authors: Leslie D. McIntosh, Anthony Juehne, Cynthia R. H. Vitale, Xiaoyan Liu, Rosalia Alcoser, J. Christian Lukas and Bradley Evanoff

    Citation: BMC Medical Research Methodology 2017 17:143

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  20. Content type: Research article

    The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that ...

    Authors: Kevin P. Weinfurt, Adrian F. Hernandez, Gloria D. Coronado, Lynn L. DeBar, Laura M. Dember, Beverly B. Green, Patrick J. Heagerty, Susan S. Huang, Kathryn T. James, Jeffrey G. Jarvik, Eric B. Larson, Vincent Mor, Richard Platt, Gary E. Rosenthal, Edward J. Septimus, Gregory E. Simon…

    Citation: BMC Medical Research Methodology 2017 17:144

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  21. Content type: Research article

    The requirement to obtain written informed consent may undermine the potential of pragmatic randomized clinical trials (pRCTs) to improve evidence-based care. This requirement could compromise trials statistic...

    Authors: Rafael Dal-Ré, Antonio J. Carcas, Xavier Carné and David Wendler

    Citation: BMC Medical Research Methodology 2017 17:145

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  22. Content type: Research article

    We sought to understand the main ethical considerations when conducting clinical trials in the prehospital ambulance based setting.

    Authors: Stephanie Armstrong, Adele Langlois, Despina Laparidou, Mark Dixon, Jason P. Appleton, Philip M. Bath, Helen Snooks and A. Niroshan Siriwardena

    Citation: BMC Medical Research Methodology 2017 17:142

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  23. Content type: Research article

    The ACE-III, a gold standard for screening cognitive impairment, is restricted by language and culture, with no uniform set of guidelines for its adaptation. To develop guidelines a compilation of all the adap...

    Authors: Nadine Mirza, Maria Panagioti, Muhammad Wali Waheed and Waquas Waheed

    Citation: BMC Medical Research Methodology 2017 17:141

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  24. Content type: Correspondence

    Focused ethnography is an applied and pragmatic form of ethnography that explores a specific social phenomenon as it occurs in everyday life. Based on the literature a problem-focused research question is form...

    Authors: A.P. Bikker, H. Atherton, H. Brant, T. Porqueddu, J.L. Campbell, A. Gibson, B. McKinstry, C. Salisbury and S. Ziebland

    Citation: BMC Medical Research Methodology 2017 17:139

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  25. Content type: Research article

    Although there has been growing research on the burden of treatment, the current state of evidence on measuring this concept is unknown. This scoping review aimed to provide an overview of the current state of...

    Authors: Adem Sav, Asiyeh Salehi, Frances S. Mair and Sara S. McMillan

    Citation: BMC Medical Research Methodology 2017 17:140

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BMC Medical Research Methodology

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