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  1. The primary treatment for patients with myocardial infarction (MI) is percutaneous coronary intervention (PCI). Despite this, the incidence of major adverse cardiovascular events (MACEs) remains a significant ...

    Authors: Xiang Zhu, Pin Zhang, Han Jiang, Jie Kuang and Lei Wu
    Citation: BMC Medical Research Methodology 2024 24:59
    Content type: Research Published on:

  2. There is divergence in the rate at which people age. The concept of biological age is postulated to capture this variability, and hence to better represent an individual’s true global physiological state than ...

    Authors: Marije H. Sluiskes, Jelle J. Goeman, Marian Beekman, P. Eline Slagboom, Hein Putter and Mar Rodríguez-Girondo
    Citation: BMC Medical Research Methodology 2024 24:58
    Content type: Research Published on:

  3. The stepped-wedge cluster randomized trial (SW-CRT) design has become popular in healthcare research. It is an appealing alternative to traditional cluster randomized trials (CRTs) since the burden of logistic...

    Authors: Chen Yang, Asem Berkalieva, Madhu Mazumdar and Deukwoo Kwon
    Citation: BMC Medical Research Methodology 2024 24:57
    Content type: Research Published on:

  4. In clinical trials and epidemiological research, mixed-effects models are commonly used to examine population-level and subject-specific trajectories of biomarkers over time. Despite their increasing popularit...

    Authors: Melkamu M. Ferede, Getachew A. Dagne, Samuel M. Mwalili, Workagegnehu H. Bilchut, Habtamu A. Engida and Simon M. Karanja
    Citation: BMC Medical Research Methodology 2024 24:56
    Content type: Research Published on:

  5. Research Electronic Data CAPture (REDCap) is a web application for creating and managing online surveys and databases. Clinical data management is an essential process before performing any statistical analysi...

    Authors: João Carmezim, Pau Satorra, Judith Peñafiel, Esther García-Lerma, Natàlia Pallarès, Naiara Santos and Cristian Tebé
    Citation: BMC Medical Research Methodology 2024 24:55
    Content type: Software Published on:

  6. A variety of methods exist for the analysis of longitudinal data, many of which are characterized with the assumption of fixed visit time points for study individuals. This, however is not always a tenable ass...

    Authors: Michael Safo Oduro
    Citation: BMC Medical Research Methodology 2024 24:54
    Content type: Research Published on:

  7. Public health initiatives, including human biomonitoring, have been impacted by unique challenges since the onset of the COVID-19 pandemic, compounding a decades-long trend of declining public participation. T...

    Authors: Alyssa J. Mattson, Jiali Yu, Elizabeth M. Miller, Michael Schueller, Michael Pentella and Susie Y. Dai
    Citation: BMC Medical Research Methodology 2024 24:53
    Content type: Research Published on:

  8. The design of a multi-center randomized controlled trial (RCT) involves multiple considerations, such as the choice of the sample size, the number of centers and their geographic location, the strategy for rec...

    Authors: Oleksandr Sverdlov, Yevgen Ryeznik, Volodymyr Anisimov, Olga M. Kuznetsova, Ruth Knight, Kerstine Carter, Sonja Drescher and Wenle Zhao
    Citation: BMC Medical Research Methodology 2024 24:52
    Content type: Research Published on:

  9. Eurotransplant liver transplant candidates are prioritized by Model for End-stage Liver Disease (MELD), a 90-day waitlist survival risk score based on the INR, creatinine and bilirubin. Several studies revised...

    Authors: H. C. de Ferrante, M. van Rosmalen, B. M. L. Smeulders, S. Vogelaar and F. C. R. Spieksma
    Citation: BMC Medical Research Methodology 2024 24:51
    Content type: Research Published on:

  10. The determination of identity factors such as age and sex has gained significance in both criminal and civil cases. Paranasal sinuses like frontal and maxillary sinuses, are resistant to trauma and can aid pro...

    Authors: Omid Hamidi, Mahlagha Afrasiabi and Marjan Namaki
    Citation: BMC Medical Research Methodology 2024 24:50
    Content type: Research Published on:

  11. Several approaches are commonly used to estimate the effect of diet on changes of various intermediate disease markers in prospective studies, including “change-score analysis”, “concurrent change-change analy...

    Authors: Dan Tang, Yifan Hu, Ning Zhang, Xiong Xiao and Xing Zhao
    Citation: BMC Medical Research Methodology 2024 24:49
    Content type: Research Published on:

  12. In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, an...

    Authors: Dina Voeltz, Annika Hoyer, Amelie Forkel, Anke Schwandt and Oliver Kuß
    Citation: BMC Medical Research Methodology 2024 24:48
    Content type: Research Published on:

  14. Successfully recruiting male participants to complete a healthcare related study is important for healthcare study completion and to advance our clinical knowledgebase. To date, most research studies have exam...

    Authors: Danielle J. Borg, Melina Haritopoulou-Sinanidou, Pam Gabrovska, Hsu-Wen Tseng, David Honeyman, Daniel Schweitzer and Kym M. Rae
    Citation: BMC Medical Research Methodology 2024 24:46
    Content type: Research Published on:

  15. Scoping reviews have emerged as a valuable method for synthesizing emerging evidence, providing a comprehensive contextual overview, and influencing policy and practice developments. The objective of this stud...

    Authors: Xinyu Xue, Xintong Tang, Shanshan Liu, Ting Yu, Zhonglan Chen, Ningsu Chen and Jiajie Yu
    Citation: BMC Medical Research Methodology 2024 24:45
    Content type: Research Published on:

  16. The residual life of a patient with human immunodeficiency virus (HIV) is of major interest to patients and their physicians. While existing analyses of HIV patient survival focus mostly on data collected at b...

    Authors: Soo Min Kim, Yunsu Choi, Sangwook Kang and Korea HIV/AIDS cohort study
    Citation: BMC Medical Research Methodology 2024 24:44
    Content type: Research Published on:

  17. People with dementia are routinely included as research participants in trials and other quantitative studies in which they are invited to respond to standardised measures. This paper reviews the reporting of ...

    Authors: Kate Gridley, Kate Baxter and Yvonne Birks
    Citation: BMC Medical Research Methodology 2024 24:43
    Content type: Research Published on:

  18. Group sequential designs are one of the most widely used methodologies for adaptive design in randomized clinical trials. In settings where early outcomes are available, they offer large gains in efficiency co...

    Authors: Nick R. Parsons, Joydeep Basu and Nigel Stallard
    Citation: BMC Medical Research Methodology 2024 24:42
    Content type: Research Published on:

  19. Missing data is frequently an inevitable issue in cohort studies and it can adversely affect the study's findings. We assess the effectiveness of eight frequently utilized statistical and machine learning (ML)...

    Authors: JiaHang Li, ShuXia Guo, RuLin Ma, Jia He, XiangHui Zhang, DongSheng Rui, YuSong Ding, Yu Li, LeYao Jian, Jing Cheng and Heng Guo
    Citation: BMC Medical Research Methodology 2024 24:41
    Content type: Research Published on:

  20. Data mining has been used to help discover Frequent patterns in health data. it is widely used to diagnose and prevent various diseases and to obtain the causes and factors affecting diseases. Therefore, the a...

    Authors: Zahra Kohzadi, Ali Mohammad Nickfarjam, Leila Shokrizadeh Arani, Zeinab Kohzadi and Mehrdad Mahdian
    Citation: BMC Medical Research Methodology 2024 24:40
    Content type: Research Published on:

  21. Surrogate endpoints, such as those of interest in chronic kidney disease (CKD), are often evaluated using Bayesian meta-regression. Trials used for the analysis can evaluate a variety of interventions for diff...

    Authors: Willem Collier, Benjamin Haaland, Lesley A. Inker, Hiddo J.L. Heerspink and Tom Greene
    Citation: BMC Medical Research Methodology 2024 24:39
    Content type: Research Published on:

  22. Several strategies for identifying biologically implausible values in longitudinal anthropometric data have recently been proposed, but the suitability of these strategies for large population datasets needs t...

    Authors: Juliana Freitas de Mello e Silva, Natanael de Jesus Silva, Thaís Rangel Bousquet Carrilho, Elizabete de Jesus Pinto, Aline Santos Rocha, Jéssica Pedroso, Sara Araújo Silva, Ana Maria Spaniol, Rafaella da Costa Santin de Andrade, Gisele Ane Bortolini, Enny Paixão, Gilberto Kac, Rita de Cássia Ribeiro-Silva and Maurício L. Barreto
    Citation: BMC Medical Research Methodology 2024 24:38
    Content type: Research Published on:

  23. Despite the fact that team manual handling is common in different working environments, the previous studies in this regard, particularly those with a physiological approach are quite limited. The present stud...

    Authors: Mohammad Hamed Hosseini, Rashid Heidarimoghaddam, Mehrdad Anbarian, Saeed Ilbeigi and Leili Tapak
    Citation: BMC Medical Research Methodology 2024 24:37
    Content type: Research Published on:

  24. Surveys have been used worldwide to provide information on the COVID-19 pandemic impact so as to prepare and deliver an effective Public Health response. Overlapping panel surveys allow longitudinal estimates ...

    Authors: Luis Castro, María del Mar Rueda, Carmen Sánchez-Cantalejo, Ramón Ferri and Andrés Cabrera-León
    Citation: BMC Medical Research Methodology 2024 24:36
    Content type: Research Published on:

  25. The importance of contextual effects and their roles in clinical care controversial. A Cochrane review published in 2010 concluded that placebo interventions lack important clinical effects overall, but that p...

    Authors: Tobias Saueressig, Hugo Pedder, Patrick J Owen and Daniel L Belavy
    Citation: BMC Medical Research Methodology 2024 24:35
    Content type: Review Published on:

  26. Mendelian randomization is a popular method for causal inference with observational data that uses genetic variants as instrumental variables. Similarly to a randomized trial, a standard Mendelian randomizatio...

    Authors: Haodong Tian, Brian D. M. Tom and Stephen Burgess
    Citation: BMC Medical Research Methodology 2024 24:34
    Content type: Research Published on:

  27. The purpose of this paper is to evaluate the impact of modifying the published scoring system to address identified potential weaknesses in the published scoring system for the Evaluation of Activity Surveys i...

    Authors: Julie Agel, Umesh Ghimire, Nicholas M. Edwards, Bradley Nelson and Todd Rockwood
    Citation: BMC Medical Research Methodology 2024 24:33
    Content type: Research Published on:

  28. When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient...

    Authors: Antonio Remiro-Azócar, Anna Heath and Gianluca Baio
    Citation: BMC Medical Research Methodology 2024 24:32
    Content type: Research Published on:

  29. The Interrupted Time Series (ITS) is a robust design for evaluating public health and policy interventions or exposures when randomisation may be infeasible. Several statistical methods are available for the a...

    Authors: Elizabeth Korevaar, Simon L. Turner, Andrew B. Forbes, Amalia Karahalios, Monica Taljaard and Joanne E. McKenzie
    Citation: BMC Medical Research Methodology 2024 24:31
    Content type: Research Published on:

  30. Rapidly developing tests for emerging diseases is critical for early disease monitoring. In the early stages of an epidemic, when low prevalences are expected, high specificity tests are desired to avoid numer...

    Authors: Sierra Pugh, Bailey K. Fosdick, Mary Nehring, Emily N. Gallichotte, Sue VandeWoude and Ander Wilson
    Citation: BMC Medical Research Methodology 2024 24:30
    Content type: Research Published on:

  31. Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage. We aimed to develop a com...

    Authors: Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan and Lotty Hooft
    Citation: BMC Medical Research Methodology 2024 24:29
    Content type: Research Published on:

  32. Selective reporting of results from only well-performing cut-offs leads to biased estimates of accuracy in primary studies of questionnaire-based screening tools and in meta-analyses that synthesize results. I...

    Authors: Zelalem F. Negeri, Brooke Levis, John P. A. Ioannidis, Brett D. Thombs and Andrea Benedetti
    Citation: BMC Medical Research Methodology 2024 24:28
    Content type: Research Published on:

  33. Standard pediatric growth curves cannot be used to impute missing height or weight measurements in individual children. The Michaelis–Menten equation, used for characterizing substrate-enzyme saturation curves...

    Authors: William A. Walters, Catherine Ley, Trevor Hastie, Ruth E. Ley and Julie Parsonnet
    Citation: BMC Medical Research Methodology 2024 24:27
    Content type: Research Published on:

  34. The rapidly growing burden of non-communicable diseases (NCDs) among people living with HIV in sub-Saharan Africa (SSA) has expanded the number of multidisease models predicting future care needs and health sy...

    Authors: Sharon Jepkorir Sawe, Richard Mugo, Marta Wilson-Barthes, Brianna Osetinsky, Stavroula A. Chrysanthopoulou, Faith Yego, Ann Mwangi and Omar Galárraga
    Citation: BMC Medical Research Methodology 2024 24:26
    Content type: Research Published on:

  35. We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86–101, 2018) by allowing for interval null causal hypotheses, where values of the causal effect parameter...

    Authors: Linyi Zou, Teresa Fazia, Hui Guo and Carlo Berzuini
    Citation: BMC Medical Research Methodology 2024 24:25
    Content type: Research Published on:

  38. When multiple influential covariates need to be balanced during a clinical trial, stratified blocked randomization and covariate-adaptive randomization procedures are frequently used in trials to prevent bias ...

    Authors: Guogen Shan, Yulin Li, Xinlin Lu, Yahui Zhang and Samuel S. Wu
    Citation: BMC Medical Research Methodology 2024 24:22
    Content type: Research Published on:

  39. The relationships between place (e.g., neighborhood) and HIV are commonly investigated. As measurements of place are multivariate, most studies apply some dimension reduction, resulting in one variable (or a s...

    Authors: Trang Quynh Nguyen, Laken C. Roberts Lavigne, Carly Lupton Brantner, Gregory D. Kirk, Shruti H. Mehta and Sabriya L. Linton
    Citation: BMC Medical Research Methodology 2024 24:21
    Content type: Research Published on:

  40. Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic meth...

    Authors: Alexandra Bannach-Brown, Torsten Rackoll, Nurcennet Kaynak, Natascha Drude, René Aquarius, Sofija Vojvodić, Mariana Abreu, Julia M. L. Menon and Kimberley E. Wever
    Citation: BMC Medical Research Methodology 2024 24:20
    Content type: Review Published on:

  41. The global research response to the COVID-19 pandemic was impressive, but also led to an infodemic and considerable research waste. Registered, but unpublished trials added to this noise. We aimed to determine...

    Authors: Lisa Fincham, Ameer Hohlfeld, Mike Clarke, Tamara Kredo and Michael McCaul
    Citation: BMC Medical Research Methodology 2024 24:19
    Content type: Research Published on:

  42. An inability to successfully recruit participants into clinical research has consequences that negatively affect the conduct and reliability of research studies. Understanding facilitators of research particip...

    Authors: Charles Start, Meagan McBride, Guohao Zhu, Sana Shaikh and Jennifer Pierce
    Citation: BMC Medical Research Methodology 2024 24:18
    Content type: Research Published on:

  43. Treatment switching in randomised controlled trials (RCTs) is a problem for health technology assessment when substantial proportions of patients switch onto effective treatments that would not be available in...

    Authors: Nicholas R Latimer, Alice Dewdney and Marco Campioni
    Citation: BMC Medical Research Methodology 2024 24:17
    Content type: Research Published on:

  44. Lung cancer is a leading cause of cancer deaths and imposes an enormous economic burden on patients. It is important to develop an accurate risk assessment model to determine the appropriate treatment for pati...

    Authors: Lu Zhong, Fan Yang, Shanshan Sun, Lijie Wang, Hong Yu, Xiushan Nie, Ailing Liu, Ning Xu, Lanfang Zhang, Mingjuan Zhang, Yue Qi, Huaijun Ji, Guiyuan Liu, Huan Zhao, Yinan Jiang, Jingyi Li…
    Citation: BMC Medical Research Methodology 2024 24:16
    Content type: Research article Published on:

  45. Sample size calculation is a central aspect in planning of clinical trials. The sample size is calculated based on parameter assumptions, like the treatment effect and the endpoint’s variance. A fundamental pr...

    Authors: Björn Bokelmann, Geraldine Rauch, Jan Meis, Meinhard Kieser and Carolin Herrmann
    Citation: BMC Medical Research Methodology 2024 24:15
    Content type: Research Published on:

  46. Dengue is a mosquito-borne disease that causes over 300 million infections worldwide each year with no specific treatment available. Effective surveillance systems are needed for outbreak detection and resourc...

    Authors: Chawarat Rotejanaprasert, Kawin Chinpong, Andrew B. Lawson, Peerut Chienwichai and Richard J. Maude
    Citation: BMC Medical Research Methodology 2024 24:14
    Content type: Research Published on:

  47. Community optometrists in Scotland have performed regular free-at-point-of-care eye examinations for all, for over 15 years. Eye examinations include retinal imaging but image storage is fragmented and they ar...

    Authors: Claire Tochel, Emma Pead, Alice McTrusty, Fiona Buckmaster, Tom MacGillivray, Andrew J. Tatham, Niall C. Strang, Baljean Dhillon and Miguel O. Bernabeu
    Citation: BMC Medical Research Methodology 2024 24:13
    Content type: Research Published on:

  48. Seamless phase 2/3 design has become increasingly popular in clinical trials with a single endpoint. Trials that define success based on the achievement of all co-primary endpoints (CPEs) encounter the challen...

    Authors: Jiaying Yang, Guochun Li, Dongqing Yang, Juan Wu, Junqin Wang, Xingsu Gao and Pei Liu
    Citation: BMC Medical Research Methodology 2024 24:12
    Content type: Research Published on:

  49. In this article we describe the methodology of the time-to-event continual reassessment method in the presence of partial orders (PO-TITE-CRM) and the process of implementing this trial design into a phase I t...

    Authors: Amit Patel, Kristian Brock, Daniel Slade, Claire Gaunt, Anthony Kong, Hisham Mehanna, Lucinda Billingham and Piers Gaunt
    Citation: BMC Medical Research Methodology 2024 24:11
    Content type: Research Published on:

  50. Dengue infection ranges from asymptomatic to severe and life-threatening, with no specific treatment available. Vector control is crucial for interrupting its transmission cycle. Accurate estimation of outbrea...

    Authors: Chawarat Rotejanaprasert, Darin Areechokchai and Richard J. Maude
    Citation: BMC Medical Research Methodology 2024 24:10
    Content type: Research Published on:
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BMC Medical Research Methodology

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