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  1. National mortality statistics are based on a single underlying cause of death. This practice does not adequately represent the impact of the range of conditions experienced in an ageing population in which mul...

    Authors: Annette Dobson, Paul McElwee, Mohammad Reza Baneshi, James Eynstone-Hinkins, Lauren Moran and Michael Waller
    Citation: BMC Medical Research Methodology 2023 23:83
  2. Failure time data frequently occur in many medical studies and often accompany with various types of censoring. In some applications, left truncation may occur and can induce biased sampling, which makes the p...

    Authors: Li Shao, Hongxi Li, Shuwei Li and Jianguo Sun
    Citation: BMC Medical Research Methodology 2023 23:82
  3. Understanding how SARS-CoV-2 infection impacts long-term patient outcomes requires identification of comparable persons with and without infection. We report the design and implementation of a matching strateg...

    Authors: Valerie A. Smith, Theodore S. Z. Berkowitz, Paul Hebert, Edwin S. Wong, Meike Niederhausen, John A. Pura, Kristin Berry, Pamela Green, Anna Korpak, Alexandra Fox, Aaron Baraff, Alex Hickok, Troy A Shahoumian, Amy S.B. Bohnert, Denise M. Hynes, Edward J. Boyko…
    Citation: BMC Medical Research Methodology 2023 23:81
  4. Only rigorously prepared analyses can provide the highest level of evidence to inform decision-making. Several recent systematic reviews (SRs) examined the hypothesis that the early introduction of specific al...

    Authors: Uwe Matterne, Melissa A. Theurich, Simone Pröbstl, Dawid Pieper, Jiancong Wang, Anna Xu and Christian Apfelbacher
    Citation: BMC Medical Research Methodology 2023 23:80
  5. In network meta-analysis, estimation of a comparative effect can be performed for treatments that are connected either directly or indirectly. However, disconnected trial networks may arise, which poses a chal...

    Authors: Lauren McKeen, Paul Morris, Chong Wang, Max D. Morris and Annette M. O’Connor
    Citation: BMC Medical Research Methodology 2023 23:79
  6. Pre-trial acceptability studies may boost recruitment, especially in trials comparing distinctly different interventions. We evaluated the impact of an acceptability study on recruitment to a randomised trial ...

    Authors: Georgina Ramsay, Zoë Haime, Nadia E Crellin, Jacki L Stansfeld, Stefan Priebe, Maria Long and Joanna Moncrieff
    Citation: BMC Medical Research Methodology 2023 23:78
  7. COVID-19 is a new multi-organ disease causing considerable worldwide morbidity and mortality. While many recognized pathophysiological mechanisms are involved, their exact causal relationships remain opaque. B...

    Authors: Steven Mascaro, Yue Wu, Owen Woodberry, Erik P. Nyberg, Ross Pearson, Jessica A. Ramsay, Ariel O. Mace, David A. Foley, Thomas L. Snelling and Ann E. Nicholson
    Citation: BMC Medical Research Methodology 2023 23:76
  8. The problem of dealing with misreported data is very common in a wide range of contexts for different reasons. The current situation caused by the Covid-19 worldwide pandemic is a clear example, where the data...

    Authors: David Moriña, Amanda Fernández-Fontelo, Alejandra Cabaña, Argimiro Arratia and Pedro Puig
    Citation: BMC Medical Research Methodology 2023 23:75
  9. Baseline outcome risk can be an important determinant of absolute treatment benefit and has been used in guidelines for “personalizing” medical decisions. We compared easily applicable risk-based methods for o...

    Authors: Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg and David van Klaveren
    Citation: BMC Medical Research Methodology 2023 23:74
  10. Subjective “ladder” measurements of socio-economic status (SES) are easy-to-administer tools that ask respondents to rate their own SES, allowing them to evaluate their own material resources and determine whe...

    Authors: Maryann Zhao, Chuan-Chin Huang, Milagros Mendoza, Ximena Tovar, Leonid Lecca and Megan Murray
    Citation: BMC Medical Research Methodology 2023 23:73
  11. In pre-post designs, analysis of covariance (ANCOVA) is a standard technique to detect the treatment effect with a continuous variable measured at baseline and follow-up. For measurements subject to a high deg...

    Authors: Shiyang Ma and Tianying Wang
    Citation: BMC Medical Research Methodology 2023 23:72
  12. Drug toxicity does not affect patients equally; the toxicity may only exert in patients who possess certain attributes of susceptibility to specific drug properties (i.e., drug-host interaction). This concept ...

    Authors: Zhiyuan Lu, Ayako Suzuki and Dong Wang
    Citation: BMC Medical Research Methodology 2023 23:71
  13. Non-cancer mortality in cancer patients may be higher than overall mortality in the general population due to a combination of factors, such as long-term adverse effects of treatments, and genetic, environment...

    Authors: Laura Botta, Juste Goungounga, Riccardo Capocaccia, Gaelle Romain, Marc Colonna, Gemma Gatta, Olayidé Boussari and Valérie Jooste
    Citation: BMC Medical Research Methodology 2023 23:70
  14. In many countries, the prevalence of non-communicable diseases risk factors is commonly assessed through self-reported information from health interview surveys. It has been shown, however, that self-reported ...

    Authors: Ingrid Pelgrims, Brecht Devleesschauwer, Stefanie Vandevijvere, Eva M. De Clercq, Stijn Vansteelandt, Vanessa Gorasso and Johan Van der Heyden
    Citation: BMC Medical Research Methodology 2023 23:69
  15. Clinical guidelines should be based on a thorough evaluation of the evidence and generally include a rating of the quality of evidence and assign a strength to recommendations. Grading of Recommendations Asses...

    Authors: Ming Chuen Chong, Melissa K. Sharp, Susan M. Smith, Michelle O’Neill, Máirín Ryan, Rosarie Lynch, Kamal R. Mahtani and Barbara Clyne
    Citation: BMC Medical Research Methodology 2023 23:68
  16. Getting access to administrative health data for research purposes is a difficult and time-consuming process due to increasingly demanding privacy regulations. An alternative method for sharing administrative ...

    Authors: Lucy Mosquera, Khaled El Emam, Lei Ding, Vishal Sharma, Xue Hua Zhang, Samer El Kababji, Chris Carvalho, Brian Hamilton, Dan Palfrey, Linglong Kong, Bei Jiang and Dean T. Eurich
    Citation: BMC Medical Research Methodology 2023 23:67
  17. Combination therapies directed at multiple targets have potentially improved treatment effects for cancer patients. Compared to monotherapy, targeted combination therapy leads to an increasing number of subgro...

    Authors: Xin Chen, Jingyi Zhang, Liyun Jiang and Fangrong Yan
    Citation: BMC Medical Research Methodology 2023 23:66
  18. Overweight and obesity are severe public health problems worldwide. Obesity can lead to chronic diseases such as type 2 diabetes mellitus. Environmental factors may affect lifestyle aspects and are therefore e...

    Authors: Maximilian Präger, Christoph Kurz, Rolf Holle, Werner Maier and Michael Laxy
    Citation: BMC Medical Research Methodology 2023 23:65
  19. The effectiveness of malaria vector control interventions is often evaluated using cluster randomized trials (CRT) with outcomes assessed using repeated cross-sectional surveys. A key requirement for appropria...

    Authors: Yongdong Ouyang, Manisha A. Kulkarni, Natacha Protopopoff, Fan Li and Monica Taljaard
    Citation: BMC Medical Research Methodology 2023 23:64
  20. ‘A Measurement Tool to Assess Systematic Reviews, version 2’ (AMSTAR 2) is a validated 16-item scale designed to appraise systematic reviews (SRs) of healthcare interventions and to rate the overall confidence...

    Authors: Karina Karolina De Santis, Dawid Pieper, Robert C. Lorenz, Uta Wegewitz, Waldemar Siemens and Katja Matthias
    Citation: BMC Medical Research Methodology 2023 23:63
  21. To control emerging diseases, governments often have to make decisions based on limited evidence. The effective or temporal reproductive number is used to estimate the expected number of new cases caused by an...

    Authors: Chawarat Rotejanaprasert, Andrew B. Lawson and Richard J. Maude
    Citation: BMC Medical Research Methodology 2023 23:62
  22. In evidence synthesis practice, dealing with studies with no cases in both arms has been a tough problem, for which there is no consensus in the research community. In this study, we propose a method to measur...

    Authors: Chang Xu, Luis Furuya-Kanamori, Lifeng Lin, Liliane Zorzela, Tianqi Yu and Sunita Vohra
    Citation: BMC Medical Research Methodology 2023 23:61
  23. Latent class models are increasingly used to estimate the sensitivity and specificity of diagnostic tests in the absence of a gold standard, and are commonly fitted using Bayesian methods. These models allow u...

    Authors: Suzanne H. Keddie, Oliver Baerenbold, Ruth H. Keogh and John Bradley
    Citation: BMC Medical Research Methodology 2023 23:58
  24. Combinations of drugs are becoming increasingly common in oncology treatment. In some cases, patients can benefit from the interaction between two drugs, although there is usually a higher risk of developing t...

    Authors: Zhaohang Li, Ze Xu, Aijun Zhang, Guanpeng Qi and Zuojing Li
    Citation: BMC Medical Research Methodology 2023 23:57
  25. Science is becoming increasingly data intensive as digital innovations bring new capacity for continuous data generation and storage. This progress also brings challenges, as many scientific initiatives are ch...

    Authors: Mingkai Peng, Danielle A. Southern, Wrechelle Ocampo, Jaime Kaufman, David B. Hogan, John Conly, Barry W. Baylis, Henry T. Stelfox, Chester Ho and William A. Ghali
    Citation: BMC Medical Research Methodology 2023 23:56
  26. Safe and effective vaccines are crucial for the control of Covid-19 and to protect individuals at higher risk of severe disease. The test-negative design is a popular option for evaluating the effectiveness of...

    Authors: Paolo Eusebi, Niko Speybroeck, Sonja Hartnack, Jacob Stærk-Østergaard, Matthew J. Denwood and Polychronis Kostoulas
    Citation: BMC Medical Research Methodology 2023 23:55
  27. Longitudinal studies are critical to informing evolving responses to COVID-19 but can be hampered by attrition bias, which undermines their reliability for guiding policy and practice. We describe recruitment ...

    Authors: Thi Nguyen, Alexander J. Thomas, Phoebe Kerr, Ashleigh C. Stewart, Anna Lee Wilkinson, Long Nguyen, Aimée Altermatt, Kathryn Young, Katherine Heath, Anna Bowring, Stephanie Fletcher-Lartey, Dean Lusher, Sophie Hill, Alisa Pedrana, Mark Stoové, Katherine Gibney…
    Citation: BMC Medical Research Methodology 2023 23:54
  28. The study aimed to explore reporting characteristics of scoping reviews in dental public health and the impact of some factors on the reporting quality.

    Authors: Lara Dotto, Mateus Bertolini Fernandes dos Santos and Rafael Sarkis-Onofre
    Citation: BMC Medical Research Methodology 2023 23:53
  29. In health research, several chronic diseases are susceptible to competing risks (CRs). Initially, statistical models (SM) were developed to estimate the cumulative incidence of an event in the presence of CRs....

    Authors: Georgios Kantidakis, Hein Putter, Saskia Litière and Marta Fiocco
    Citation: BMC Medical Research Methodology 2023 23:51
  30. Commercial activity trackers are increasingly used in research and compared with research-based accelerometers are often less intrusive, cheaper, with improved storage and battery capacity, although typically ...

    Authors: Emilia Kristiansson, Jonatan Fridolfsson, Daniel Arvidsson, Agneta Holmäng, Mats Börjesson and Ulrika Andersson-Hall
    Citation: BMC Medical Research Methodology 2023 23:50
  31. Treatment switching, also called crossover, is common in clinical trials because of ethical concerns or other reasons. When it occurs and the primary objective is to identify treatment effects, the most widely...

    Authors: Lejun Deng, Chih-Yuan Hsu and Yu Shyr
    Citation: BMC Medical Research Methodology 2023 23:49
  32. Limited information is available about neonates’ critical conditions data quality. The study aim was to measure the agreement regarding presence of neonatal critical conditions between Medicaid Analytic eXtrac...

    Authors: Yasser Albogami, Yanmin Zhu, Xi Wang and Almut G Winterstein
    Citation: BMC Medical Research Methodology 2023 23:47
  33. Multi-institution electronic health records (EHR) are a rich source of real world data (RWD) for generating real world evidence (RWE) regarding the utilization, benefits and harms of medical interventions. The...

    Authors: Hythem Sidky, Jessica C. Young, Andrew T. Girvin, Eileen Lee, Yu Raymond Shao, Nathan Hotaling, Sam Michael, Kenneth J. Wilkins, Soko Setoguchi and Michele Jonsson Funk
    Citation: BMC Medical Research Methodology 2023 23:46
  34. Systematic reviews of studies of clinical prediction models are becoming increasingly abundant in the literature. Data extraction and risk of bias assessment are critical steps in any systematic review. CHARMS...

    Authors: Borja M. Fernandez-Felix, Jesus López-Alcalde, Marta Roqué, Alfonso Muriel and Javier Zamora
    Citation: BMC Medical Research Methodology 2023 23:44
  35. Researchers are cautioned against misinterpreting the conventional P value, especially while implementing the popular t test. Therefore, this study evaluated the agreement between the P value and Bayes factor (BF

    Authors: Natchalee Srimaneekarn, Pattamon Leelachaikul, Sasipa Thiradilok and Somchai Manopatanakul
    Citation: BMC Medical Research Methodology 2023 23:43
  36. Despite recent advances in causal inference methods, outcome regression remains the most widely used approach for estimating causal effects in epidemiological studies with a single-point exposure and outcome. ...

    Authors: Jiaxin Zhang, S Ghazaleh Dashti, John B. Carlin, Katherine J. Lee and Margarita Moreno-Betancur
    Citation: BMC Medical Research Methodology 2023 23:42
  37. Propensity score analysis is increasingly used to control for confounding factors in observational studies. Unfortunately, unavoidable missing values make estimating propensity scores extremely challenging. We...

    Authors: Shu Yang, Peipei Du, Xixi Feng, Daihai He, Yaolong Chen, Linda L. D. Zhong, Xiaodong Yan and Jiawei Luo
    Citation: BMC Medical Research Methodology 2023 23:41
  38. Multi-state models are complex stochastic models which focus on pathways defined by the temporal and sequential occurrence of numerous events of interest. In particular, the so-called illness-death models are ...

    Authors: Fran Llopis-Cardona, Carmen Armero and Gabriel Sanfélix-Gimeno
    Citation: BMC Medical Research Methodology 2023 23:40
  39. Incidence is one of the most important epidemiologic indices in surveillance. However, determining incidence is complex and requires time-consuming cohort studies or registries with date of diagnosis. Estimati...

    Authors: Annika Hoyer, Ralph Brinks, Thaddäus Tönnies, Sharon H. Saydah, Ralph B. D’Agostino Jr., Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan and Giuseppina Imperatore
    Citation: BMC Medical Research Methodology 2023 23:39
  40. Patient-reported outcomes such as health-related quality of life (HRQoL) are increasingly used as endpoints in randomized cancer clinical trials. However, the patients often drop out so that observation of the...

    Authors: Célia Touraine, Benjamin Cuer, Thierry Conroy, Beata Juzyna, Sophie Gourgou and Caroline Mollevi
    Citation: BMC Medical Research Methodology 2023 23:36
  41. Composite endpoints for estimating treatment efficacy are routinely used in several therapeutic areas and have become complex in the number and types of component outcomes included. It is assumed that its comp...

    Authors: Majid Nabipoor, Cynthia M. Westerhout, Sarah Rathwell and Jeffrey A. Bakal
    Citation: BMC Medical Research Methodology 2023 23:35
  42. This analysis addresses the characteristics of two emergency department (ED) patient populations defined by three model diseases (hip fractures, respiratory, and cardiac symptoms) making use of survey (primary...

    Authors: Anna Schneider, Andreas Wagenknecht, Hanna Sydow, Dorothee Riedlinger, Felix Holzinger, Andrea Figura, Johannes Deutschbein, Thomas Reinhold, Mareen Pigorsch, Ulrike Stasun, Liane Schenk and Martin Möckel
    Citation: BMC Medical Research Methodology 2023 23:34

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