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  1. Content type: Research article

    A new patient-reported health measurement model has been developed to quantify descriptions of health states. Known as the multi-attribute preference response (MAPR) model, it is based on item response theory....

    Authors: Catharina G. M. Groothuis-Oudshoorn, Edwin R. van den Heuvel and Paul F. M. Krabbe

    Citation: BMC Medical Research Methodology 2018 18:62

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  2. Content type: Research article

    Attrition occurs when a participant fails to respond to one or more study waves. The accumulation of attrition over several waves can lower the sample size and power and create a final sample that could differ...

    Authors: Samantha Spiers, Evrim Oral, Elizabeth T. H. Fontham, Edward S. Peters, James L. Mohler, Jeannette T. Bensen and Christine S. Brennan

    Citation: BMC Medical Research Methodology 2018 18:60

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  3. Content type: Research article

    Web-based surveys have become increasingly popular but response rates are low and may be prone to selection bias. How people are invited to participate may impact response rates and needs further study as prev...

    Authors: Xiaochen Tai, Alanna M. Smith, Allison J. McGeer, Eve Dubé, Dorothy Linn Holness, Kevin Katz, Linda McGillis Hall, Shelly A. McNeil, Jeff Powis and Brenda L. Coleman

    Citation: BMC Medical Research Methodology 2018 18:59

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  4. Content type: Research article

    Realist approaches seek to answer questions such as ‘how?’, ‘why?’, ‘for whom?’, ‘in what circumstances?’ and ‘to what extent?’ interventions ‘work’ using context-mechanism-outcome (CMO) configurations. Quanti...

    Authors: John A. Ford, Andy Jones, Geoff Wong, Allan Clark, Tom Porter and Nick Steel

    Citation: BMC Medical Research Methodology 2018 18:57

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  5. Content type: Research article

    The assessment of multiple systematic reviews (AMSTAR) tool is widely used for investigating the methodological quality of systematic reviews (SR). Originally, AMSTAR was developed for SRs of randomized contro...

    Authors: Dawid Pieper, Nadja Koensgen, Jessica Breuing, Long Ge and Uta Wegewitz

    Citation: BMC Medical Research Methodology 2018 18:56

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  6. Content type: Research article

    When profiling multiple health care providers, adjustment for case-mix is essential to accurately classify the quality of providers. Unfortunately, misclassification of provider performance is not uncommon and...

    Authors: Timo B. Brakenhoff, Kit C. B. Roes, Karel G. M. Moons and Rolf H. H. Groenwold

    Citation: BMC Medical Research Methodology 2018 18:54

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  7. Content type: Research article

    To evaluate participant-related variables associated with missing assessment(s) at follow-up visits during a longitudinal research study.

    Authors: Sara E. Heins, Amy W. Wozniak, Elizabeth Colantuoni, Kristin A. Sepulveda, Pedro A. Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M. Needham and Victor D. Dinglas

    Citation: BMC Medical Research Methodology 2018 18:55

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  8. Content type: Research article

    Decisions about which subgroup of chronic hepatitis C (CHC) patients should be treated with direct acting anti-viral agents (DAAs) have economic importance due to high drug prices. Treat-all DAA strategies for...

    Authors: Rodolfo Castro, Louise Crathorne, Hugo Perazzo, Julio Silva, Chris Cooper, Jo Varley-Campbell, Daniel Savignon Marinho, Marcela Haasova, Valdilea G. Veloso, Rob Anderson and Chris Hyde

    Citation: BMC Medical Research Methodology 2018 18:53

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  9. Content type: Research article

    Motivational Interviewing (MI), Brief Advice (BA) and Health Education (HE) are established smoking cessation induction methods for smokers with low desire to quit. Although randomized controlled trials (RCT’s...

    Authors: Majid Bani-Yaghoub, Abdellatif Elhomani and Delwyn Catley

    Citation: BMC Medical Research Methodology 2018 18:52

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  10. Content type: Research article

    Rapid response in health technology assessment is a synthesis of the best available evidence prepared in a timely manner to meet specific demands. We build a consensus among Brazilian specialists in health tec...

    Authors: Marcus Tolentino Silva, Everton Nunes da Silva and Jorge Otávio Maia Barreto

    Citation: BMC Medical Research Methodology 2018 18:51

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  11. Content type: Software

    Joint modelling of longitudinal and time-to-event outcomes has received considerable attention over recent years. Commensurate with this has been a rise in statistical software options for fitting these models...

    Authors: Graeme L. Hickey, Pete Philipson, Andrea Jorgensen and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2018 18:50

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  12. Content type: Research article

    In many studies the information of patients who are dying in the hospital is censored when examining the change in length of hospital stay (cLOS) due to hospital-acquired infections (HIs). While appropriate es...

    Authors: Shahina Rahman, Maja von Cube, Martin Schumacher and Martin Wolkewitz

    Citation: BMC Medical Research Methodology 2018 18:49

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  13. Content type: Debate

    Randomised trials with long-term follow-up can provide estimates of the long-term effects of health interventions. However, analysis of long-term outcomes in randomised trials may be complicated by problems wi...

    Authors: Robert D. Herbert, Jessica Kasza and Kari Bø

    Citation: BMC Medical Research Methodology 2018 18:48

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  14. Content type: Research article

    The successful initiation of people living with HIV/AIDS on antiretroviral therapy (ART) in South Africa has engendered challenges of poor retention in care and suboptimal adherence to medication. The adherenc...

    Authors: Ferdinand C. Mukumbang, Bruno Marchal, Sara Van Belle and Brian van Wyk

    Citation: BMC Medical Research Methodology 2018 18:47

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  15. Content type: Research article

    List randomization (LR), a survey method intended to mitigate biases related to sensitive true/false questions, has received recent attention from researchers. However, tests of its validity are limited, with ...

    Authors: Noah Haber, Guy Harling, Jessica Cohen, Tinofa Mutevedzi, Frank Tanser, Dickman Gareta, Kobus Herbst, Deenan Pillay, Till Bärnighausen and Günther Fink

    Citation: BMC Medical Research Methodology 2018 18:46

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  16. Content type: Research article

    Systematic reviews and meta-analyses of observational studies are frequently performed, but no widely accepted guidance is available at present. We performed a systematic scoping review of published methodolog...

    Authors: Monika Mueller, Maddalena D’Addario, Matthias Egger, Myriam Cevallos, Olaf Dekkers, Catrina Mugglin and Pippa Scott

    Citation: BMC Medical Research Methodology 2018 18:44

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  17. Content type: Research article

    Researchers and funders should consider the statistical power of planned Individual Participant Data (IPD) meta-analysis projects, as they are often time-consuming and costly. We propose simulation-based power...

    Authors: Joie Ensor, Danielle L. Burke, Kym I. E. Snell, Karla Hemming and Richard D. Riley

    Citation: BMC Medical Research Methodology 2018 18:41

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  18. Content type: Research article

    Information on causes of death (COD) is crucial for measuring the health outcomes of populations and progress towards the Sustainable Development Goals. In many countries such as Vietnam where the civil regist...

    Authors: Hong Thi Tran, Hoa Phuong Nguyen, Sue M. Walker, Peter S. Hill and Chalapati Rao

    Citation: BMC Medical Research Methodology 2018 18:43

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  19. Content type: Research article

    Recent methodologic evidence suggests that lack of blinding in randomized trials can result in under- or overestimation of the treatment effect size. The objective of this study is to quantify the extent of bi...

    Authors: Humam Saltaji, Susan Armijo-Olivo, Greta G. Cummings, Maryam Amin, Bruno R. da Costa and Carlos Flores-Mir

    Citation: BMC Medical Research Methodology 2018 18:42

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  20. Content type: Research article

    Accurate smoking status is key for research purposes, but can be costly and difficult to measure. Within the Veteran’s Health Administration (VA), smoking status is recorded as part of routine care as “health ...

    Authors: Anne C. Melzer, Erika A. Pinsker, Barbara Clothier, Siamak Noorbaloochi, Diana J. Burgess, Elisheva R. Danan and Steven S. Fu

    Citation: BMC Medical Research Methodology 2018 18:39

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  21. Content type: Research article

    For an intervention to be considered evidence-based, findings need to be replicated. When this is done in new contexts (e.g., a new country), adaptations may be needed. Yet, we know little about how researcher...

    Authors: Ulrica von Thiele Schwarz, Ulrika Förberg, Knut Sundell and Henna Hasson

    Citation: BMC Medical Research Methodology 2018 18:36

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  22. Content type: Research article

    Systematic reviews (SRs) in the field of neuropathic pain (NeuP) are increasingly important for decision-making. However, methodological flaws in SRs can reduce the validity of conclusions. Hence, it is import...

    Authors: Svjetlana Dosenovic, Antonia Jelicic Kadic, Katarina Vucic, Nikolina Markovina, Dawid Pieper and Livia Puljak

    Citation: BMC Medical Research Methodology 2018 18:37

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  23. Content type: Research article

    Certain cancer case ascertainment methods used in Quebec and elsewhere are known to underestimate the burden of cancer, particularly for some subgroups. Algorithms using claims data are a low-cost option to im...

    Authors: Mamadou Diop, Erin C. Strumpf and Geetanjali D. Datta

    Citation: BMC Medical Research Methodology 2018 18:38

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  24. Content type: Debate

    When discussing results medical research articles often tear substantive and statistical (methodical) contributions apart, just as if both were independent. Consequently, reasoning on bias tends to be vague, u...

    Authors: Michael Höfler, John Venz, Sebastian Trautmann and Robert Miller

    Citation: BMC Medical Research Methodology 2018 18:34

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  25. Content type: Correction

    Following publication of the original article [1] the authors reported that reference 15 (Cella et al.) had been incorrectly replaced with a duplicate of Brombin et al. during publication.

    Authors: Maria Sudell, Ruwanthi Kolamunnage-Dona and Catrin Tudur-Smith

    Citation: BMC Medical Research Methodology 2018 18:33

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    The original article was published in BMC Medical Research Methodology 2016 16:168

  26. Content type: Research article

    Sample size planning for longitudinal data is crucial when designing mediation studies because sufficient statistical power is not only required in grant applications and peer-reviewed publications, but is ess...

    Authors: Haitao Pan, Suyu Liu, Danmin Miao and Ying Yuan

    Citation: BMC Medical Research Methodology 2018 18:32

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  27. Content type: Research article

    Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear...

    Authors: Roelof B. Toonen, Klaas J. Wardenaar, Elisabeth H. Bos, Sonja L. van Ockenburg and Peter de Jonge

    Citation: BMC Medical Research Methodology 2018 18:31

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  28. Content type: Research article

    Increasing numbers of systematic reviews (SRs) on total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been published in recent years, but their quality has been unclear. The purpose of this stu...

    Authors: Xinyu Wu, Huan Sun, Xiaoqin Zhou, Ji Wang and Jing Li

    Citation: BMC Medical Research Methodology 2018 18:30

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  29. Content type: Research article

    Measures of mental well-being and positive mental health (PMH) have been largely developed and used in Western populations, however, data on representative Asian communities are lacking. Using data from a popu...

    Authors: Janhavi Ajit Vaingankar, Mythily Subramaniam, Linda Wei Lin Tan, Edimansyah Abdin, Wei Yen Lim, Hwee Lin Wee, Siow Ann Chong and Rob Martinus van Dam

    Citation: BMC Medical Research Methodology 2018 18:29

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  30. Content type: Study protocol

    Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues.

    Authors: James H. Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine and Tapan Mehta

    Citation: BMC Medical Research Methodology 2018 18:28

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  31. Content type: Research article

    Restricted mean survival time (RMST) is an underutilized estimand in time-to-event analyses. Herein, we highlight its strengths by comparing time to (1) all-cause mortality and (2) initiation of antiretroviral...

    Authors: Keri L. Calkins, Chelsea E. Canan, Richard D. Moore, Catherine R. Lesko and Bryan Lau

    Citation: BMC Medical Research Methodology 2018 18:27

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  32. Content type: Research article

    Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary...

    Authors: Christopher J. Weir, Isabella Butcher, Valentina Assi, Stephanie C. Lewis, Gordon D. Murray, Peter Langhorne and Marian C. Brady

    Citation: BMC Medical Research Methodology 2018 18:25

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  33. Content type: Research article

    We use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the dem...

    Authors: Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley and Gail Davey

    Citation: BMC Medical Research Methodology 2018 18:26

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  34. Content type: Research article

    Medical practitioners use survival models to explore and understand the relationships between patients’ covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Stand...

    Authors: Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang and Yuval Kluger

    Citation: BMC Medical Research Methodology 2018 18:24

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  35. Content type: Research article

    Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data w...

    Authors: G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann and L. C. de Wreede

    Citation: BMC Medical Research Methodology 2018 18:23

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  36. Content type: Research article

    Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation i...

    Authors: Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley and Stuart R Dalziel

    Citation: BMC Medical Research Methodology 2018 18:22

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  37. Content type: Correction

    Following publication of the original article [1], a member of the writing group reported that his name is misspelt. The paper should appear in Pubmed under “Ter Riet G”, bot as “Riet GT”.

    Authors: Sarah R. Haile, Beniamino Guerra, Joan B. Soriano and Milo A. Puhan

    Citation: BMC Medical Research Methodology 2018 18:21

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    The original article was published in BMC Medical Research Methodology 2017 17:172

  38. Content type: Research article

    Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided...

    Authors: Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar and Nigel Stallard

    Citation: BMC Medical Research Methodology 2018 18:20

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  39. Content type: Research article

    Demands placed on individuals in occupational and social settings, as well as imbalances in personal traits and resources, can lead to chronic stress. The Trier Inventory for Chronic Stress (TICS) measures chr...

    Authors: Katja Petrowski, Sören Kliem, Michael Sadler, Alicia E. Meuret, Thomas Ritz and Elmar Brähler

    Citation: BMC Medical Research Methodology 2018 18:18

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  40. Content type: Research article

    Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling...

    Authors: Alex G. Karanevich, Jeffrey M. Statland, Byron J. Gajewski and Jianghua He

    Citation: BMC Medical Research Methodology 2018 18:19

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  41. Content type: Correction

    Following publication of the original article [1], the authors reported that the following four references in Table 2 are incorrect:

    Authors: Geneviève Lefebvre and Mariia Samoilenko

    Citation: BMC Medical Research Methodology 2018 18:17

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    The original article was published in BMC Medical Research Methodology 2017 17:165

  42. Content type: Research article

    Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent vari...

    Authors: Thomas Forkmann, Tobias Teismann, Jana-Sophie Stenzel, Heide Glaesmer and Derek de Beurs

    Citation: BMC Medical Research Methodology 2018 18:16

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  43. Content type: Research article

    Video vignettes are used to test the effects of physicians’ communication on patient outcomes. Methodological choices in video-vignette development may have far-stretching consequences for participants’ engage...

    Authors: Leonie N. C. Visser, Nadine Bol, Marij A. Hillen, Mathilde G. E. Verdam, Hanneke C. J. M. de Haes, Julia C. M. van Weert and Ellen M. A. Smets

    Citation: BMC Medical Research Methodology 2018 18:15

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  44. Content type: Technical advance

    Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor ...

    Authors: Ulrike Pötschger, Harald Heinzl, Maria Grazia Valsecchi and Martina Mittlböck

    Citation: BMC Medical Research Methodology 2018 18:14

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  45. Content type: Research article

    While full disclosure of information on placebo control in participant information leaflets (PILs) in a clinical trial is ethically required during informed consent, there have been concerning voices such comp...

    Authors: Soyeon Cheon, Hi-Joon Park, Younbyoung Chae and Hyangsook Lee

    Citation: BMC Medical Research Methodology 2018 18:13

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  46. Content type: Debate

    The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is n...

    Authors: Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson and Michael Spence

    Citation: BMC Medical Research Methodology 2018 18:12

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