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BMC Medical Research Methodology

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  1. Content type: Research article

    Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique oppor...

    Authors: Feng Gao, J. Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A. Beiser, Ling Chen and Mae O. Gordon

    Citation: BMC Medical Research Methodology 2017 17:124

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  2. Content type: Research article

    The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an ...

    Authors: Cédric M. Panje, Markus Glatzer, Joscha von Rappard, Christian Rothermundt, Thomas Hundsberger, Valentin Zumstein, Ludwig Plasswilm and Paul Martin Putora

    Citation: BMC Medical Research Methodology 2017 17:123

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  3. Content type: Research article

    This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...

    Authors: Jonas Czwikla, Kathrin Jobski and Tania Schink

    Citation: BMC Medical Research Methodology 2017 17:122

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  4. Content type: Research article

    Dentine hypersensitivity (DH) affects people’s quality of life (QoL). However changes in the internal meaning of QoL, known as Response shift (RS) may undermine longitudinal assessment of QoL. This study aimed...

    Authors: Carolina Machuca, Mario V. Vettore, Marta Krasuska, Sarah R. Baker and Peter G. Robinson

    Citation: BMC Medical Research Methodology 2017 17:120

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  5. Content type: Research article

    Decisionmakers and guideline developers demand rapid syntheses of the evidence when time sensitive evidence-informed decisions are required. A potential trade-off of such rapid reviews is that their results ca...

    Authors: Gernot Wagner, Barbara Nussbaumer-Streit, Judith Greimel, Agustín Ciapponi and Gerald Gartlehner

    Citation: BMC Medical Research Methodology 2017 17:121

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  6. Content type: Research article

    Illness perceptions involve the personal beliefs that patients have about their illness and may influence health behaviours considerably. Since an instrument to measure these perceptions for Malay population i...

    Authors: Boon-How Chew, Rimke C. Vos, Monique Heijmans, Sazlina Shariff-Ghazali, Aaron Fernandez and Guy E. H. M. Rutten

    Citation: BMC Medical Research Methodology 2017 17:118

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  7. Content type: Research article

    Information about design, implementation, monitoring and evaluation is central to understand the impact of programmes within the field of sexual, reproductive, maternal, newborn, child and adolescent health (S...

    Authors: Anna E. Kågesten, Özge Tunçalp, Anayda Portela, Moazzam Ali, Nhan Tran and A. Metin Gülmezoglu

    Citation: BMC Medical Research Methodology 2017 17:117

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  8. Content type: Research article

    Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses...

    Authors: Fran Toye, Kate Seers, Erin Hannink and Karen Barker

    Citation: BMC Medical Research Methodology 2017 17:116

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  9. Content type: Research Article

    Random survival forest (RSF) models have been identified as alternative methods to the Cox proportional hazards model in analysing time-to-event data. These methods, however, have been criticised for the bias ...

    Authors: Justine B. Nasejje, Henry Mwambi, Keertan Dheda and Maia Lesosky

    Citation: BMC Medical Research Methodology 2017 17:115

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  10. Content type: Research article

    Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which involve multiple waves of data collection. Traditional multiple imputation (MI) methods (f...

    Authors: Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee and Julie Anne Simpson

    Citation: BMC Medical Research Methodology 2017 17:114

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  11. Content type: Research article

    More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different typ...

    Authors: Joe Alexander, Roger A. Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky and Bruce Parsons

    Citation: BMC Medical Research Methodology 2017 17:113

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  12. Content type: Research Article

    The analysis of perinatal outcomes often involves datasets with some multiple births. These are datasets mostly formed of independent observations and a limited number of clusters of size two (twins) and maybe...

    Authors: Odile Sauzet and Janet L. Peacock

    Citation: BMC Medical Research Methodology 2017 17:110

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  13. Content type: Research Article

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Authors: Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    Citation: BMC Medical Research Methodology 2017 17:112

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  14. Content type: Research Article

    In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of ...

    Authors: Yusuke Yamaguchi, Kazushi Maruo, Christopher Partlett and Richard D. Riley

    Citation: BMC Medical Research Methodology 2017 17:109

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  15. Content type: Research article

    The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs...

    Authors: Pankaj Mistry, Janet A Dunn and Andrea Marshall

    Citation: BMC Medical Research Methodology 2017 17:108

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  16. Content type: Research Article

    Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to cal...

    Authors: Solène Desmée, France Mentré, Christine Veyrat-Follet, Bernard Sébastien and Jérémie Guedj

    Citation: BMC Medical Research Methodology 2017 17:105

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  17. Content type: Debate

    The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in t...

    Authors: F. Lauzier, N. K. Adhikari, A. Seely, K. K. Y. Koo, E. P. Belley-Côté, K. E. A. Burns, D. J. Cook, F. D’Aragon, B. Rochwerg, M. E. Kho, S. J. W. Oczkowksi, E. H. Duan, M. O. Meade, A. G. Day and F. Lamontagne

    Citation: BMC Medical Research Methodology 2017 17:106

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  18. Content type: Technical advance

    The sample size required to power a study to a nominal level in a paired comparative diagnostic accuracy study, i.e. studies in which the diagnostic accuracy of two testing procedures is compared relative to a...

    Authors: Gareth P. J. McCray, Andrew C. Titman, Paula Ghaneh and Gillian A. Lancaster

    Citation: BMC Medical Research Methodology 2017 17:102

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  19. Content type: Research article

    Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...

    Authors: Yu-Kang Tu and Yun-Chun Wu

    Citation: BMC Medical Research Methodology 2017 17:104

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  20. Content type: Research article

    Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...

    Authors: Romin Pajouheshnia, Linda M. Peelen, Karel G. M. Moons, Johannes B. Reitsma and Rolf H. H. Groenwold

    Citation: BMC Medical Research Methodology 2017 17:103

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  21. Content type: Research article

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Authors: Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    Citation: BMC Medical Research Methodology 2017 17:101

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