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BMC Medical Research Methodology

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  1. Content type: Study protocol

    Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues.

    Authors: James H. Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine and Tapan Mehta

    Citation: BMC Medical Research Methodology 2018 18:28

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  2. Content type: Research article

    Restricted mean survival time (RMST) is an underutilized estimand in time-to-event analyses. Herein, we highlight its strengths by comparing time to (1) all-cause mortality and (2) initiation of antiretroviral...

    Authors: Keri L. Calkins, Chelsea E. Canan, Richard D. Moore, Catherine R. Lesko and Bryan Lau

    Citation: BMC Medical Research Methodology 2018 18:27

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  3. Content type: Research article

    Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary...

    Authors: Christopher J. Weir, Isabella Butcher, Valentina Assi, Stephanie C. Lewis, Gordon D. Murray, Peter Langhorne and Marian C. Brady

    Citation: BMC Medical Research Methodology 2018 18:25

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  4. Content type: Research article

    We use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the dem...

    Authors: Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley and Gail Davey

    Citation: BMC Medical Research Methodology 2018 18:26

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  5. Content type: Research article

    Medical practitioners use survival models to explore and understand the relationships between patients’ covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Stand...

    Authors: Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang and Yuval Kluger

    Citation: BMC Medical Research Methodology 2018 18:24

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  6. Content type: Research article

    Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data w...

    Authors: G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann and L. C. de Wreede

    Citation: BMC Medical Research Methodology 2018 18:23

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  7. Content type: Research article

    Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation i...

    Authors: Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley and Stuart R Dalziel

    Citation: BMC Medical Research Methodology 2018 18:22

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  8. Content type: Correction

    Following publication of the original article [1], a member of the writing group reported that his name is misspelt. The paper should appear in Pubmed under “Ter Riet G”, bot as “Riet GT”.

    Authors: Sarah R. Haile, Beniamino Guerra, Joan B. Soriano and Milo A. Puhan

    Citation: BMC Medical Research Methodology 2018 18:21

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    The original article was published in BMC Medical Research Methodology 2017 17:172

  9. Content type: Research article

    Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided...

    Authors: Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar and Nigel Stallard

    Citation: BMC Medical Research Methodology 2018 18:20

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  10. Content type: Research article

    Demands placed on individuals in occupational and social settings, as well as imbalances in personal traits and resources, can lead to chronic stress. The Trier Inventory for Chronic Stress (TICS) measures chr...

    Authors: Katja Petrowski, Sören Kliem, Michael Sadler, Alicia E. Meuret, Thomas Ritz and Elmar Brähler

    Citation: BMC Medical Research Methodology 2018 18:18

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  11. Content type: Research article

    Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling...

    Authors: Alex G. Karanevich, Jeffrey M. Statland, Byron J. Gajewski and Jianghua He

    Citation: BMC Medical Research Methodology 2018 18:19

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported that the following four references in Table 2 are incorrect:

    Authors: Geneviève Lefebvre and Mariia Samoilenko

    Citation: BMC Medical Research Methodology 2018 18:17

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    The original article was published in BMC Medical Research Methodology 2017 17:165

  13. Content type: Research article

    Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent vari...

    Authors: Thomas Forkmann, Tobias Teismann, Jana-Sophie Stenzel, Heide Glaesmer and Derek de Beurs

    Citation: BMC Medical Research Methodology 2018 18:16

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  14. Content type: Research article

    Video vignettes are used to test the effects of physicians’ communication on patient outcomes. Methodological choices in video-vignette development may have far-stretching consequences for participants’ engage...

    Authors: Leonie N. C. Visser, Nadine Bol, Marij A. Hillen, Mathilde G. E. Verdam, Hanneke C. J. M. de Haes, Julia C. M. van Weert and Ellen M. A. Smets

    Citation: BMC Medical Research Methodology 2018 18:15

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  15. Content type: Technical advance

    Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor ...

    Authors: Ulrike Pötschger, Harald Heinzl, Maria Grazia Valsecchi and Martina Mittlböck

    Citation: BMC Medical Research Methodology 2018 18:14

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  16. Content type: Research article

    While full disclosure of information on placebo control in participant information leaflets (PILs) in a clinical trial is ethically required during informed consent, there have been concerning voices such comp...

    Authors: Soyeon Cheon, Hi-Joon Park, Younbyoung Chae and Hyangsook Lee

    Citation: BMC Medical Research Methodology 2018 18:13

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  17. Content type: Debate

    The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is n...

    Authors: Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson and Michael Spence

    Citation: BMC Medical Research Methodology 2018 18:12

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  18. Content type: Research article

    The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electr...

    Authors: Dale J. Cooper, Brigitte E. Scammell, Mark E. Batt and Debbie Palmer

    Citation: BMC Medical Research Methodology 2018 18:11

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  19. Content type: Research article

    This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis.

    Authors: Meryl Dahan, Caroline Scemama, Raphael Porcher and David J. Biau

    Citation: BMC Medical Research Methodology 2018 18:10

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  20. Content type: Research article

    In patient-based studies, biomarker data are often subject to left censoring due to the detection limits, or to incomplete sample or data collection. In the context of longitudinal regression analysis, inappro...

    Authors: MinJae Lee, Mohammad H. Rahbar, Matthew Brown, Lianne Gensler, Michael Weisman, Laura Diekman and John D. Reveille

    Citation: BMC Medical Research Methodology 2018 18:8

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  21. Content type: Research article

    Prospective study protocols and registrations can play a significant role in reducing incomplete or selective reporting of primary biomedical research, because they are pre-specified blueprints which are avail...

    Authors: Guowei Li, Luciana P. F. Abbade, Ikunna Nwosu, Yanling Jin, Alvin Leenus, Muhammad Maaz, Mei Wang, Meha Bhatt, Laura Zielinski, Nitika Sanger, Bianca Bantoto, Candice Luo, Ieta Shams, Hamnah Shahid, Yaping Chang, Guangwen Sun…

    Citation: BMC Medical Research Methodology 2018 18:9

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  22. Content type: Research article

    The reporting of randomised controlled trial (RCT) abstracts is of vital importance. The primary objective of this study was to investigate the association between structure format and RCT abstracts’ quality o...

    Authors: Fang Hua, Tanya Walsh, Anne-Marie Glenny and Helen Worthington

    Citation: BMC Medical Research Methodology 2018 18:6

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  23. Content type: Correspondence

    Systematic reviews have been considered as the pillar on which evidence-based healthcare rests. Systematic review methodology has evolved and been modified over the years to accommodate the range of questions ...

    Authors: Zachary Munn, Cindy Stern, Edoardo Aromataris, Craig Lockwood and Zoe Jordan

    Citation: BMC Medical Research Methodology 2018 18:5

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  24. Content type: Research article

    We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former.

    Authors: Ben Vandermeer, Ingeborg van der Tweel, Marijke C. Jansen-van der Weide, Stephanie S. Weinreich, Despina G. Contopoulos-Ioannidis, Dirk Bassler, Ricardo M. Fernandes, Lisa Askie, Haroon Saloojee, Paola Baiardi, Susan S. Ellenberg and Johanna H. van der Lee

    Citation: BMC Medical Research Methodology 2018 18:7

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  25. Content type: Research article

    Despite the frequent use of self-controlled methods in pharmacoepidemiological studies, the factors that may bias the estimates from these methods have not been adequately compared in real-world settings. Here...

    Authors: Yoshinori Takeuchi, Tomohiro Shinozaki and Yutaka Matsuyama

    Citation: BMC Medical Research Methodology 2018 18:4

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BMC Medical Research Methodology

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