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  1. Dropout is a common problem in longitudinal clinical trials and cohort studies, and is of particular concern when dropout occurs for reasons that may be related to the outcome of interest. This paper reviews c...

    Authors: Camille M. Moore, Samantha MaWhinney, Nichole E. Carlson and Sarah Kreidler

    Citation: BMC Medical Research Methodology 2020 20:250

    Content type: Research article

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  2. Men, particularly those living in disadvantaged areas, are less likely to participate in weight management programmes than women despite similar levels of excess weight. Little is known about how best to recru...

    Authors: Matthew D. McDonald, Stephan U. Dombrowski, Rebecca Skinner, Eileen Calveley, Paula Carroll, Andrew Elders, Cindy M. Gray, Mark Grindle, Fiona M. Harris, Claire Jones and Pat Hoddinott

    Citation: BMC Medical Research Methodology 2020 20:249

    Content type: Research article

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  3. Classic epidemic curves – counts of daily events or cumulative events over time –emphasise temporal changes in the growth or size of epidemic outbreaks. Like any graph, these curves have limitations: they are ...

    Authors: Thomas Perneger, Antoine Kevorkian, Thierry Grenet, Hubert Gallée and Angèle Gayet-Ageron

    Citation: BMC Medical Research Methodology 2020 20:248

    Content type: Technical advance

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    The Correction to this article has been published in BMC Medical Research Methodology 2020 20:265

  4. Acute Care Surgery (ACS) was developed as a structured, team-based approach to providing round-the-clock emergency general surgery (EGS) care for adult patients needing treatment for diseases such as cholecyst...

    Authors: Heena P. Santry, Scott A. Strassels, Angela M. Ingraham, Wendelyn M. Oslock, Kevin B. Ricci, Anghela Z. Paredes, Victor K. Heh, Holly E. Baselice, Amy P. Rushing, Adrian Diaz, Vijaya T. Daniel, M. Didem Ayturk and Catarina I. Kiefe

    Citation: BMC Medical Research Methodology 2020 20:247

    Content type: Research article

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  5. The German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) initiated large research programs to foster high quality clinical research in the academic area. These investigato...

    Authors: E. Nury, K. Bischoff, K. Wollmann, K. Nitschke, S. Lohner, M. Schumacher, G. Rücker and A. Blümle

    Citation: BMC Medical Research Methodology 2020 20:246

    Content type: Research article

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  6. Guidelines on public health and health system interventions often involve considerations beyond effectiveness and safety to account for the impact that these interventions have on the wider systems in which th...

    Authors: A. Movsisyan, E. Rehfuess and S. L. Norris

    Citation: BMC Medical Research Methodology 2020 20:245

    Content type: Review

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  7. Researchers often misinterpret and misrepresent statistical outputs. This abuse has led to a large literature on modification or replacement of testing thresholds and P-values with confidence intervals, Bayes fac...

    Authors: Zad Rafi and Sander Greenland

    Citation: BMC Medical Research Methodology 2020 20:244

    Content type: Technical advance

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  8. The early warning model of infectious diseases plays a key role in prevention and control. This study aims to using seasonal autoregressive fractionally integrated moving average (SARFIMA) model to predict the...

    Authors: Chang Qi, Dandan Zhang, Yuchen Zhu, Lili Liu, Chunyu Li, Zhiqiang Wang and Xiujun Li

    Citation: BMC Medical Research Methodology 2020 20:243

    Content type: Research article

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  9. There is consensus that health services commissioning and clinical practice should be driven by scientific evidence. However, workload pressures, accessibility of peer reviewed publications and skills to find,...

    Authors: Joanna K. Anderson, Emma Howarth, Maris Vainre, Ayla Humphrey, Peter B. Jones and Tamsin J. Ford

    Citation: BMC Medical Research Methodology 2020 20:242

    Content type: Research article

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  10. The objectives of the present study were to evaluate the performance of a time-to-event data reconstruction method, to assess the bias and efficiency of unanchored matching-adjusted indirect comparison (MAIC) ...

    Authors: Yawen Jiang and Weiyi Ni

    Citation: BMC Medical Research Methodology 2020 20:241

    Content type: Research article

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  11. Bias in randomized controlled trials (RCTs) can lead to underestimation or overestimation of the true effects of interventions. Surgical RCTs may suffer from the risk of bias (RoB) that is avoidable in trials ...

    Authors: Ognjen Barcot, Matija Boric, Svjetlana Dosenovic, Marija Cavar, Antonia Jelicic Kadic, Tina Poklepovic Pericic, Ivana Vukicevic, Ivana Vuka and Livia Puljak

    Citation: BMC Medical Research Methodology 2020 20:240

    Content type: Research article

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  12. A very large body of research documents relationships between self-reported Adverse Childhood Experiences (srACEs) and adult health outcomes. Despite multiple assessment tools that use the same or similar ques...

    Authors: Marianna D. LaNoue, Brandon J. George, Deborah L. Helitzer and Scott W. Keith

    Citation: BMC Medical Research Methodology 2020 20:239

    Content type: Research article

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  13. Very large cohorts that span an entire population raise new prospects for the conduct of multiple trials that speed up advances in prevention or treatment while reducing participant, financial and regulatory b...

    Authors: Melissa Wake, Yanhong Jessika Hu, Hayley Warren, Margie Danchin, Michael Fahey, Francesca Orsini, Maurizio Pacilli, Kirsten P. Perrett, Richard Saffery and Andrew Davidson

    Citation: BMC Medical Research Methodology 2020 20:238

    Content type: Technical advance

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  14. Evidence based medicine aims to integrate scientific evidence, clinical experience, and patient values and preferences. Individual health care professionals need to appraise the evidence from randomized trials...

    Authors: Hendrika J. Luijendijk, Matthew J. Page, Huibert Burger and Xander Koolman

    Citation: BMC Medical Research Methodology 2020 20:237

    Content type: Technical advance

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  15. The population attributable fraction (PAF) is the fraction of disease cases in a sample that can be attributed to an exposure. Estimating the PAF often involves the estimation of the probability of having the ...

    Authors: Wei Wang, Dylan S. Small and Michael O. Harhay

    Citation: BMC Medical Research Methodology 2020 20:236

    Content type: Technical advance

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  17. Usability testing of medical devices are mandatory for market access. The testings’ goal is to identify usability problems that could cause harm to the user or limit the device’s effectiveness. In practice, hu...

    Authors: Vincent Vandewalle, Alexandre Caron, Coralie Delettrez, Renaud Périchon, Sylvia Pelayo, Alain Duhamel and Benoit Dervaux

    Citation: BMC Medical Research Methodology 2020 20:234

    Content type: Technical advance

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  18. Contact tracing data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is used to estimate basic epidemiological parameters. Contact tracing data could also be potentially used for assessin...

    Authors: Karikalan Nagarajan, Malaisamy Muniyandi, Bharathidasan Palani and Senthil Sellappan

    Citation: BMC Medical Research Methodology 2020 20:233

    Content type: Research article

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  19. Psychiatric disorders may occur as a single episode or be persistent and relapsing, sometimes leading to suicidal behaviours. The exact causes of psychiatric disorders are hard to determine but easy access to ...

    Authors: Sharmin Sharker, Lloyd Balbuena, Gene Marcoux and Cindy Xin Feng

    Citation: BMC Medical Research Methodology 2020 20:232

    Content type: Research article

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  20. Emergency Departments (EDs) are a first point-of-contact for many youth with mental health and suicidality concerns and can serve as an effective recruitment source for randomized controlled trials (RCTs) of m...

    Authors: Matthew Tracey, Yaron Finkelstein, Reva Schachter, Kristin Cleverley, Suneeta Monga, Melanie Barwick, Peter Szatmari, Myla E. Moretti, Andrew Willan, Joanna Henderson and Daphne J. Korczak

    Citation: BMC Medical Research Methodology 2020 20:231

    Content type: Research article

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  21. Master of public health (MPH) plays an important role in Chinese medical education, and the dissertations is an important part of MPH education. In MPH dissertations, most are observational studies. Compared w...

    Authors: Shuangyang Dai, Xiaobin Zhou, Hong Xu, Beibei Li and Jingao Zhang

    Citation: BMC Medical Research Methodology 2020 20:230

    Content type: Research article

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  22. Defining incident cases has always been a challenging issue for researchers working with routine data. Lookback periods should enable researchers to identify and exclude recurrent cases and increase the accura...

    Authors: Jelena Epping, Siegfried Geyer and Juliane Tetzlaff

    Citation: BMC Medical Research Methodology 2020 20:229

    Content type: Research article

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  23. COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clin...

    Authors: Rosiane Lima, Elizabeth F. Gootkind, Denis De la Flor, Laura J. Yockey, Evan A. Bordt, Paolo D’Avino, Shen Ning, Katerina Heath, Katherine Harding, Jaclyn Zois, Grace Park, Margot Hardcastle, Kathleen A. Grinke, Sheila Grimmel, Susan P. Davidson, Pamela J. Forde…

    Citation: BMC Medical Research Methodology 2020 20:228

    Content type: Research article

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  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junhao Liu, Jo Wick, Renee’ H. Martin, Caitlyn Meinzer, Dooti Roy and Byron Gajewski

    Citation: BMC Medical Research Methodology 2020 20:227

    Content type: Correction

    Published on:

    The original article was published in BMC Medical Research Methodology 2020 20:211

  25. Methodological studies – studies that evaluate the design, analysis or reporting of other research-related reports – play an important role in health research. They help to highlight issues in the conduct of r...

    Authors: Lawrence Mbuagbaw, Daeria O. Lawson, Livia Puljak, David B. Allison and Lehana Thabane

    Citation: BMC Medical Research Methodology 2020 20:226

    Content type: Commentary

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  26. Claims databases are generally considered inadequate for obesity research due to suboptimal capture of body mass index (BMI) measurements. This might not be true for bariatric surgery because of reimbursement ...

    Authors: Xiaojuan Li, Kristina H. Lewis, Katherine Callaway, J. Frank Wharam and Sengwee Toh

    Citation: BMC Medical Research Methodology 2020 20:225

    Content type: Research article

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  27. Clinical Trials (CTs) help in testing and validating the safety and efficacy of newly discovered drugs on specific patient population cohorts. However, these trials usually experience many challenges, such as ...

    Authors: Ilhaam A. Omar, Raja Jayaraman, Khaled Salah, Mecit Can Emre Simsekler, Ibrar Yaqoob and Samer Ellahham

    Citation: BMC Medical Research Methodology 2020 20:224

    Content type: Technical advance

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  28. Health-related quality of life (HRQoL) has become a major endpoint to assess the clinical benefit of new therapeutic strategies in oncology clinical trials. Typically, HRQoL outcomes are analyzed using linear ...

    Authors: B. Cuer, C. Mollevi, A. Anota, E. Charton, B. Juzyna, T. Conroy and C. Touraine

    Citation: BMC Medical Research Methodology 2020 20:223

    Content type: Research article

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  29. Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study...

    Authors: Eric D. Schoen and Suzan Wopereis

    Citation: BMC Medical Research Methodology 2020 20:222

    Content type: Technical advance

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  30. Event-related potentials (ERP) data are widely used in brain studies that measure brain responses to specific stimuli using electroencephalogram (EEG) with multiple electrodes. Previous ERP data analyses haven...

    Authors: Ye Lin, Jianhui Zhou, Swapna Kumar, Wanze Xie, Sarah K. G. Jensen, Rashidul Haque, Charles A. Nelson, William A. Petri Jr and Jennie Z. Ma

    Citation: BMC Medical Research Methodology 2020 20:221

    Content type: Research article

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  31. Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patients. We propose two independent clinical...

    Authors: Shesh N. Rai, Chen Qian, Jianmin Pan, Anand Seth, Deo Kumar Srivastava and Aruni Bhatnagar

    Citation: BMC Medical Research Methodology 2020 20:220

    Content type: Research article

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  32. Evaluating a candidate marker or developing a model for predicting risk of future conditions is one of the major goals in medicine. However, model development and assessment for a time-to-event outcome may be ...

    Authors: Rajib Dey, Giada Sebastiani and Paramita Saha-Chaudhuri

    Citation: BMC Medical Research Methodology 2020 20:219

    Content type: Technical advance

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  33. The data from immuno-oncology (IO) therapy trials often show delayed effects, cure rate, crossing hazards, or some mixture of these phenomena. Thus, the proportional hazards (PH) assumption is often violated s...

    Authors: Jason J. Z. Liao, G. Frank Liu and Wen-Chi Wu

    Citation: BMC Medical Research Methodology 2020 20:218

    Content type: Technical advance

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  34. Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the...

    Authors: Susanne Coleman, Judy M. Wright, Jane Nixon, Lisette Schoonhoven, Maureen Twiddy and Joanne Greenhalgh

    Citation: BMC Medical Research Methodology 2020 20:217

    Content type: Research article

    Published on:

  35. This paper reports the construction and use of a specific method for qualitative medical research: The Inductive Process to Analyze the Structure of lived Experience (IPSE), an inductive and phenomenological appr...

    Authors: Jordan Sibeoni, Laurence Verneuil, Emilie Manolios and Anne Révah-Levy

    Citation: BMC Medical Research Methodology 2020 20:216

    Content type: Technical advance

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  36. Collection of biospecimens is a critical first step to understanding the impact of COVID-19 on pregnant women and newborns - vulnerable populations that are challenging to enroll and at risk of exclusion from ...

    Authors: Lydia L. Shook, Jessica E. Shui, Adeline A. Boatin, Samantha Devane, Natalie Croul, Lael M. Yonker, Juan D. Matute, Rosiane S. Lima, Muriel Schwinn, Dana Cvrk, Laurel Gardner, Robin Azevedo, Suzanne Stanton, Evan A. Bordt, Laura J. Yockey, Alessio Fasano…

    Citation: BMC Medical Research Methodology 2020 20:215

    Content type: Research article

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  37. Clinical uncertainty and equipoise are vague notions that play important roles in contemporary problems of medical care and research, including the design and conduct of pragmatic trials. Our goal was to show ...

    Authors: Robert Fahed, Tim E. Darsaut, Behzad Farzin, Miguel Chagnon and Jean Raymond

    Citation: BMC Medical Research Methodology 2020 20:214

    Content type: Research article

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  38. Although protocol registration of systematic reviews/meta-analysis (SR/MA) is still not mandatory, it is highly recommended that authors publish their SR/MA protocols prior to submitting their manuscripts for ...

    Authors: Gehad Mohamed Tawfik, Hoang Thi Nam Giang, Sherief Ghozy, Ahmed M. Altibi, Hend Kandil, Huu-Hoai Le, Peter Samuel Eid, Ibrahim Radwan, Omar Mohamed Makram, Tong Thi Thu Hien, Mahmoud Sherif, As-Saba Hossain, Tai Luu Lam Thang, Livia Puljak, Hosni Salem, Tarek Numair…

    Citation: BMC Medical Research Methodology 2020 20:213

    Content type: Research article

    Published on:

  39. Monitoring and reporting of drug safety during a clinical trial is essential to its success. More recent attention to drug safety has encouraged statistical methods development for monitoring and detecting pot...

    Authors: Junhao Liu, Jo Wick, Renee’ H. Martin, Caitlyn Meinzer, Dooti Roy and Byron Gajewski

    Citation: BMC Medical Research Methodology 2020 20:211

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2020 20:227

  40. Evidence is needed regarding effective incentive strategies to increase clinician survey response rates. Cash cards are increasingly used as survey incentives; they are appealing because of their convenience a...

    Authors: Lydia E. Pace, Yeonsoo S. Lee, Nadine Tung, Jada G. Hamilton, Camila Gabriel, Sahitya C. Raja, Colby Jenkins, Anthony Braswell, Susan M. Domchek, Heather Symecko, Kelsey Spielman, Beth Y. Karlan, Jenny Lester, Daniella Kamara, Jeffrey Levin, Kelly Morgan…

    Citation: BMC Medical Research Methodology 2020 20:210

    Content type: Research article

    Published on:

  41. Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical featu...

    Authors: J. Mark FitzGerald, Trung N. Tran, Marianna Alacqua, Alan Altraja, Vibeke Backer, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Guy Brusselle, Lakmini Bulathsinhala, John Busby, Giorgio W. Canonica, Victoria Carter, Isha Chaudhry, You Sook Cho, George Christoff…

    Citation: BMC Medical Research Methodology 2020 20:212

    Content type: Research article

    Published on:

  42. As the whole world is experiencing the cascading effect of a new pandemic, almost every aspect of modern life has been disrupted. Because of health emergencies during this period, widespread fear has resulted ...

    Authors: Atanu Bhattacharjee, Gajendra K. Vishwakarma, Souvik Banerjee and Sharvari Shukla

    Citation: BMC Medical Research Methodology 2020 20:209

    Content type: Research article

    Published on:

  43. The coronavirus pandemic (Covid-19) presents a variety of challenges for ongoing clinical trials, including an inevitably higher rate of missing outcome data, with new and non-standard reasons for missingness....

    Authors: Suzie Cro, Tim P. Morris, Brennan C. Kahan, Victoria R. Cornelius and James R. Carpenter

    Citation: BMC Medical Research Methodology 2020 20:208

    Content type: Research article

    Published on:

  44. Three-level data arising from repeated measures on individuals who are clustered within larger units are common in health research studies. Missing data are prominent in such longitudinal studies and multiple ...

    Authors: Rushani Wijesuriya, Margarita Moreno-Betancur, John B. Carlin and Katherine J. Lee

    Citation: BMC Medical Research Methodology 2020 20:207

    Content type: Research article

    Published on:

  45. The clinical progress of patients hospitalized due to COVID-19 is often associated with severe pneumonia which may require intensive care, invasive ventilation, or extracorporeal membrane oxygenation (ECMO). T...

    Authors: Derek Hazard, Klaus Kaier, Maja von Cube, Marlon Grodd, Lars Bugiera, Jerome Lambert and Martin Wolkewitz

    Citation: BMC Medical Research Methodology 2020 20:206

    Content type: Research article

    Published on:

  46. Recruitment of adolescents to intervention studies is a known challenge. For randomized controlled trials (RCT) to be generalizable, reach must be assessed, which means ascertaining how many of the intended po...

    Authors: Markus Saarijärvi, Lars Wallin, Philip Moons, Hanna Gyllensten and Ewa-Lena Bratt

    Citation: BMC Medical Research Methodology 2020 20:205

    Content type: Research article

    Published on:

  47. In the presence of dependent censoring even after stratification of baseline covariates, the Kaplan–Meier estimator provides an inconsistent estimate of risk. To account for dependent censoring, time-varying c...

    Authors: Takuya Kawahara, Tomohiro Shinozaki and Yutaka Matsuyama

    Citation: BMC Medical Research Methodology 2020 20:204

    Content type: Research article

    Published on:

  48. Psychological safety is a dynamic team-level phenomenon which exists when team members believe that it is safe to take interpersonal risks. In healthcare teams, the presence of psychological safety is critical...

    Authors: Róisín O’Donovan, Desirée Van Dun and Eilish McAuliffe

    Citation: BMC Medical Research Methodology 2020 20:203

    Content type: Research article

    Published on:

  49. Longitudinal cohort studies have made significant contributions to medical discoveries and provide the impetus for health interventions which reduce the risk of disease. Establishing and maintaining these coho...

    Authors: Leesa Costello, Julie Dare, Manon Dontje and Leon Straker

    Citation: BMC Medical Research Methodology 2020 20:202

    Content type: Research article

    Published on:

  50. Social media has changed the way surgeons communicate worldwide, particularly in dissemination of trial results. However, it is unclear if social media could be used in recruitment to surgical trials. This stu...

    Authors: Carly Nichola Bisset, Ben Carter, Jennifer Law, Jonathan Hewitt, Kat Parmar and Susan Joan Moug

    Citation: BMC Medical Research Methodology 2020 20:201

    Content type: Research article

    Published on:

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