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  1. Sleeping under a long-lasting insecticidal net (LLIN) is recommended for all pregnant women in sub-Saharan Africa, due to the high prevalence of malaria infection and its associated complications in the region...

    Authors: Ahmed Dahiru Balami, Salmiah Md Said, Nor Afiah Mohd Zulkefli, Norsa’adah Bachok and Emmanuel Luke Balami

    Citation: BMC Medical Research Methodology 2019 19:157

    Content type: Research article

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  2. Pragmatic randomized, controlled trials (PCTs) test the effectiveness of interventions implemented in routine clinical practice. Because PCT findings are generalizable, this approach is gaining momentum among ...

    Authors: Rosa R. Baier, Eric Jutkowitz, Susan L. Mitchell, Ellen McCreedy and Vincent Mor

    Citation: BMC Medical Research Methodology 2019 19:156

    Content type: Research article

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  3. The identification of sections in narrative content of Electronic Health Records (EHR) has demonstrated to improve the performance of clinical extraction tasks; however, there is not yet a shared understanding...

    Authors: Alexandra Pomares-Quimbaya, Markus Kreuzthaler and Stefan Schulz

    Citation: BMC Medical Research Methodology 2019 19:155

    Content type: Research article

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  4. In low-income countries, studies demonstrate greater access and utilization of maternal and neonatal health services, yet mortality rates remain high with poor quality increasingly scrutinized as a potential p...

    Authors: Danielle Wilhelm, Julia Lohmann, Manuela De Allegri, Jobiba Chinkhumba, Adamson S. Muula and Stephan Brenner

    Citation: BMC Medical Research Methodology 2019 19:154

    Content type: Research article

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  5. The purpose of this paper is to systematically review the literature on the relationship between socioeconomic status (SES) and influenza immunization and to examine how certain measures of SES may influence i...

    Authors: Kelsey Lucyk, Kimberley A. Simmonds, Diane L. Lorenzetti, Steven J. Drews, Lawrence W. Svenson and Margaret L. Russell

    Citation: BMC Medical Research Methodology 2019 19:153

    Content type: Research article

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  6. In recent years, the availability of publicly available data related to public health has significantly increased. These data have substantial potential to develop public health policy; however, this requires ...

    Authors: Paul van Schaik, Yonghong Peng, Adedokun Ojelabi and Jonathan Ling

    Citation: BMC Medical Research Methodology 2019 19:152

    Content type: Research article

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  7. Improving response rates in epidemiologic studies is important for the generalizability of the outcome. The aim of this study was to examine whether it can be advantageous for participation to target different...

    Authors: Anne Illemann Christensen, Peter Lynn and Janne Schurmann Tolstrup

    Citation: BMC Medical Research Methodology 2019 19:151

    Content type: Research article

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  8. Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design as...

    Authors: Dorothea Weber, Lorenz Uhlmann, Silvia Schönenberger and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2019 19:150

    Content type: Research article

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  9. In the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field. Most preve...

    Authors: Abdoulaye Guindo, Issaka Sagara, Boukary Ouedraogo, Kankoe Sallah, Mahamadoun Hamady Assadou, Sara Healy, Patrick Duffy, Ogobara K. Doumbo, Alassane Dicko, Roch Giorgi and Jean Gaudart

    Citation: BMC Medical Research Methodology 2019 19:149

    Content type: Technical advance

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  10. There is an increasing number of published systematic reviews (SR) of dose-response meta-analyses (DRMAs) over the past decades. However, the quality of abstract reporting of these SR-DRMAs remains to be under...

    Authors: Peng-Li Jia, Bin Xu, Jing-Min Cheng, Xi-Hao Huang, Joey S. W. Kwong, Yu Liu, Chao Zhang, Ying Han and Chang Xu

    Citation: BMC Medical Research Methodology 2019 19:148

    Content type: Research article

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  11. The attendance to cervical cancer screening is low among immigrants in many high-income countries. Although several interventions have been experimentally tested,implementation remains a challenge. Several fac...

    Authors: Samera A. Qureshi, Abdi Gele, Prabhjot Kour, Kathy A. Møen, Bernadette Kumar and Esperanza Diaz

    Citation: BMC Medical Research Methodology 2019 19:147

    Content type: Research article

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  12. To reliably evaluate the acceptance and use of computer-based prostate cancer decision aids (CBDAs) for African-American men, culturally relevant measures are needed. This study describes the development and i...

    Authors: Otis L. Owens, Nikki R. Wooten and Abbas S. Tavakoli

    Citation: BMC Medical Research Methodology 2019 19:146

    Content type: Research article

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  13. The life expectancy of cancer patients, and the loss in expectation of life as compared to the life expectancy without cancer, is a useful measure of cancer patient survival and complement the more commonly re...

    Authors: Therese M.-L. Andersson, Mark J. Rutherford and Paul C. Lambert

    Citation: BMC Medical Research Methodology 2019 19:145

    Content type: Research article

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  14. Postal surveys are widely used in scientific studies, including dietary surveys, but few studies about methods to increase participation in national dietary surveys are published. In the present study we compa...

    Authors: Jannicke Borch Myhre, Lene Frost Andersen, Kristin Holvik, Helene Astrup and Anne Lene Kristiansen

    Citation: BMC Medical Research Methodology 2019 19:144

    Content type: Research article

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  15. Sequence symmetry analysis (SSA) is a signal detection method that can be used to assist with adverse drug event detection. It provides both a risk estimate and a data visualisation. Published methods provide ...

    Authors: Adrian Kym Preiss, Elizabeth Ellen Roughead and Nicole Leanne Pratt

    Citation: BMC Medical Research Methodology 2019 19:143

    Content type: Research article

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  16. Incidence rates of advanced cancer stages are important, e.g., for monitoring cancer screening programs. However, information from cancer registries on tumor stage is often incomplete. Exemplified by colorecta...

    Authors: Katja Anita Oppelt, Sabine Luttmann, Klaus Kraywinkel and Ulrike Haug

    Citation: BMC Medical Research Methodology 2019 19:142

    Content type: Research article

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  17. In most cases, the total scores from different instruments assessing the same construct are not directly comparable, but must be equated. In this study we aimed to illustrate a novel test equating methodology ...

    Authors: Núria Duran Adroher, Svend Kreiner, Carolyn Young, Roger Mills and Alan Tennant

    Citation: BMC Medical Research Methodology 2019 19:141

    Content type: Research article

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  18. The multicriteria decision method (MCDM) aims to find conflicts among alternatives by comparing and evaluating them according to various criteria to reach the best compromise solution. The evaluation of a new ...

    Authors: Giovanni Improta, Antonietta Perrone, Mario Alessandro Russo and Maria Triassi

    Citation: BMC Medical Research Methodology 2019 19:140

    Content type: Research article

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  19. Information exchange between physician and patient is crucial to achieve patient involvement, shared decision making and treatment adherence. No reliable method exists for measuring how much information physic...

    Authors: J. M. Nordfalk, P. Gulbrandsen, J. Gerwing, M. Nylenna and J. Menichetti

    Citation: BMC Medical Research Methodology 2019 19:139

    Content type: Research article

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  20. Monetary incentive is often used to increase response rate in smokers’ survey, but such effect of prepaid and promised incentives in a follow-up survey is unknown. We compared the effect of different incentive...

    Authors: Yee Tak Derek Cheung, Xue Weng, Man Ping Wang, Sai Yin Ho, Antonio Cho Shing Kwong, Vienna Wai Yin Lai and Tai Hing Lam

    Citation: BMC Medical Research Methodology 2019 19:138

    Content type: Research article

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  21. Randomised controlled trials (RCTs) are considered the gold standard when evaluating the causal effects of healthcare interventions. When RCTs cannot be used (e.g. ethically difficult), the interrupted time se...

    Authors: Jemma Hudson, Shona Fielding and Craig R. Ramsay

    Citation: BMC Medical Research Methodology 2019 19:137

    Content type: Research article

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  22. In theory, efficient design of randomized controlled trials (RCTs) involves randomization algorithms that control baseline variable imbalance efficiently, and corresponding analysis involves pre-specified adju...

    Authors: Jody D. Ciolino, Hannah L. Palac, Amy Yang, Mireya Vaca and Hayley M. Belli

    Citation: BMC Medical Research Methodology 2019 19:136

    Content type: Research article

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  23. Participation in epidemiologic studies is steadily declining, which may result in selection bias. It is therefore an ongoing challenge to clarify the determinants of participation to judge possible selection e...

    Authors: Cornelia Enzenbach, Barbara Wicklein, Kerstin Wirkner and Markus Loeffler

    Citation: BMC Medical Research Methodology 2019 19:135

    Content type: Research article

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  24. Clinical guidelines produced in developed nations may not be appropriate in resource-constrained environments, due to differences in cultural, societal, economic and policy contexts. The purpose of this articl...

    Authors: D. V. Ernstzen, S. L. Hillier and Q. A. Louw

    Citation: BMC Medical Research Methodology 2019 19:134

    Content type: Research article

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  25. Stringent requirements exist regarding the transparency of the study selection process and the reliability of results. A 2-step selection process is generally recommended; this is conducted by 2 reviewers inde...

    Authors: Siw Waffenschmidt, Marco Knelangen, Wiebke Sieben, Stefanie Bühn and Dawid Pieper

    Citation: BMC Medical Research Methodology 2019 19:132

    Content type: Research article

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  26. Report cards on the health care system increasingly report provider-specific performance on indicators that measure the quality of health care delivered. A natural reaction to the publishing of hospital-specif...

    Authors: Peter C. Austin, Iris E. Ceyisakar, Ewout W. Steyerberg, Hester F. Lingsma and Perla J. Marang-van de Mheen

    Citation: BMC Medical Research Methodology 2019 19:131

    Content type: Research article

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  27. Tacrolimus (TAC) is an immunosuppressant drug given to kidney transplant recipients post-transplant to prevent antibody formation and kidney rejection. The optimal therapeutic dose for TAC is poorly defined an...

    Authors: Kristen R. Campbell, Elizabeth Juarez-Colunga, Gary K. Grunwald, James Cooper, Scott Davis and Jane Gralla

    Citation: BMC Medical Research Methodology 2019 19:130

    Content type: Research article

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  28. Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it’s important to control the family wise error rate (FWER). A popular approach to do this is...

    Authors: Victoria Vickerstaff, Rumana Z. Omar and Gareth Ambler

    Citation: BMC Medical Research Methodology 2019 19:129

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:158

  29. A large number of articles examined the preventability rate of readmissions, but comparison and interpretability of these preventability rates is complicated due to the large heterogeneity of methods that were...

    Authors: Eva-Linda Kneepkens, Corline Brouwers, Richelle Glory Singotani, Martine C. de Bruijne and Fatma Karapinar-Çarkit

    Citation: BMC Medical Research Methodology 2019 19:128

    Content type: Research article

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  30. The number of web-based E-epidemiologic studies using online recruitment methods is increasing. However, the optimal online recruitment method in terms of maximizing recruitment rates is still unknown. Our aim...

    Authors: Cauane Blumenberg, Ana Maria Baptista Menezes, Helen Gonçalves, Maria Cecília Formoso Assunção, Fernando César Wehrmeister and Aluísio J. D. Barros

    Citation: BMC Medical Research Methodology 2019 19:127

    Content type: Research article

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  31. The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multip...

    Authors: Charlotte L. Hall, Susan Brown, Marilyn James, Jennifer L. Martin, Nikki Brown, Kim Selby, Julie Clarke, Laura Williams, Kapil Sayal, Chris Hollis and Madeleine J. Groom

    Citation: BMC Medical Research Methodology 2019 19:126

    Content type: Research article

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  32. Use of big data is becoming increasingly popular in medical research. Since big data-based projects differ notably from classical research studies, both in terms of scope and quality, a debate is apt as to whe...

    Authors: Amke Caliebe, Friedhelm Leverkus, Gerd Antes and Michael Krawczak

    Citation: BMC Medical Research Methodology 2019 19:125

    Content type: Debate

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  33. Two randomized controlled trials (RCTs) were conducted to explore the utility of the Mechanical Turk (MTurk) crowdsourcing platform to conduct rapid trials evaluating online interventions for unhealthy alcohol...

    Authors: John A. Cunningham, Alexandra Godinho and Nicolas Bertholet

    Citation: BMC Medical Research Methodology 2019 19:124

    Content type: Research article

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  34. Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for cl...

    Authors: James Thomas Martin, Karla Hemming and Alan Girling

    Citation: BMC Medical Research Methodology 2019 19:123

    Content type: Research article

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  35. Accurate measurement of health literacy is essential to improve accessibility and effectiveness of health care and prevention. One measure frequently applied in international research is the Short Assessment o...

    Authors: A. J. Woudstra, C. S. Meppelink, H. Pander Maat, J. Oosterhaven, M. P. Fransen and A. L. Dima

    Citation: BMC Medical Research Methodology 2019 19:122

    Content type: Research article

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  36. Small group research in healthcare is important because it deals with interaction and decision-making processes that can help to identify and improve safer patient treatment and care. However, the number of st...

    Authors: Lisa Aufegger, Colin Bicknell, Emma Soane, Hutan Ashrafian and Ara Darzi

    Citation: BMC Medical Research Methodology 2019 19:121

    Content type: Research article

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  37. Health researchers often use survey studies to examine associations between risk factors at one time point and health outcomes later in life. Previous studies have shown that missing not at random (MNAR) may p...

    Authors: Kristin Gustavson, Espen Røysamb and Ingrid Borren

    Citation: BMC Medical Research Methodology 2019 19:120

    Content type: Research article

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  38. The Fred Hutchinson Cancer Research Center has engaged an External Stakeholder Advisory Group (ESAG) in the planning and implementation of the TrACER Study (S1415CD), a five-year pragmatic clinical trial asses...

    Authors: Sarah Barger, Sean D. Sullivan, Ari Bell-Brown, Brad Bott, Anne Marie Ciccarella, John Golenski, Mark Gorman, Judy Johnson, Karma Kreizenbeck, Florence Kurttila, Ginny Mason, Jamie Myers, Carole Seigel, James L. Wade III, Guneet Walia, Kate Watabayashi…

    Citation: BMC Medical Research Methodology 2019 19:119

    Content type: Research article

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  39. Clinical prediction models are not routinely validated. To facilitate validation procedures, the online Evidencio platform (https://​www.​evidencio.​com) ...

    Authors: Cornelia D. van Steenbeek, Marissa C. van Maaren, Sabine Siesling, Annemieke Witteveen, Xander A. A. M. Verbeek and Hendrik Koffijberg

    Citation: BMC Medical Research Methodology 2019 19:117

    Content type: Research article

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  40. We determined whether it is feasible to identify important changes in care management resulting from cardiovascular magnetic resonance (CMR) in patients who activate the primary percutaneous coronary intervent...

    Authors: Maria Pufulete, Jessica Harris, Stephen Dorman, Lynn Cook, Chiara Bucciarelli-Ducci, John P. Greenwood, Richard Anderson, Rachel Brierley and Barnaby C. Reeves

    Citation: BMC Medical Research Methodology 2019 19:116

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:190

  41. Comorbidity measures, such as the Charlson Comorbidity Index (CCI) and Elixhauser Method (EM), are frequently used for risk-adjustment by healthcare researchers. This study sought to create CCI and EM lists of...

    Authors: David Metcalfe, James Masters, Antonella Delmestri, Andrew Judge, Daniel Perry, Cheryl Zogg, Belinda Gabbe and Matthew Costa

    Citation: BMC Medical Research Methodology 2019 19:115

    Content type: Research article

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  42. Qualitative evidence synthesis is increasingly used alongside reviews of effectiveness to inform guidelines and other decisions. To support this use, the GRADE-CERQual approach was developed to assess and comm...

    Authors: Heather Menzies Munthe-Kaas, Claire Glenton, Andrew Booth, Jane Noyes and Simon Lewin

    Citation: BMC Medical Research Methodology 2019 19:113

    Content type: Research article

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  43. From 2005 to 2010, we conducted 2 randomized studies on a journal (Medicina Clínica), where we took manuscripts received for publication and randomly assigned them to either the standard editorial process or t...

    Authors: Marta Vilaró, Jordi Cortés, Albert Selva-O’Callaghan, Agustín Urrutia, Josep-Maria Ribera, Francesc Cardellach, Xavier Basagaña, Matthew Elmore, Miquel Vilardell, Douglas Altman, José-Antonio González and Erik Cobo

    Citation: BMC Medical Research Methodology 2019 19:112

    Content type: Research article

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  44. Length of stay evaluations are very common to determine the burden of nosocomial infections. However, there exist fundamentally different methods to quantify the prolonged length of stay associated with nosoco...

    Authors: Martin Wolkewitz, Martin Schumacher, Gerta Rücker, Stephan Harbarth and Jan Beyersmann

    Citation: BMC Medical Research Methodology 2019 19:111

    Content type: Research article

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  45. This study compares an algorithm to detect acute gastroenteritis (AG) episodes from drug dispensing data to the validated data reported in a primary care surveillance system in France.

    Authors: Ana-Maria Vilcu, Thierry Blanchon, Laure Sabatte, Cécile Souty, Milka Maravic, Thomas Hanslik and Olivier Steichen

    Citation: BMC Medical Research Methodology 2019 19:110

    Content type: Research article

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  46. Household surveys are a key epidemiological, medical, and social research method. In poor urban environments, such as slums, censuses can often be out-of-date or fail to record transient residents, maps may be...

    Authors:

    Citation: BMC Medical Research Methodology 2019 19:109

    Content type: Study protocol

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  47. The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way t...

    Authors: Andrew M. Smith, John P. Christodouleas and Wei-Ting Hwang

    Citation: BMC Medical Research Methodology 2019 19:108

    Content type: Research article

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