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  1. Report cards on the health care system increasingly report provider-specific performance on indicators that measure the quality of health care delivered. A natural reaction to the publishing of hospital-specif...

    Authors: Peter C. Austin, Iris E. Ceyisakar, Ewout W. Steyerberg, Hester F. Lingsma and Perla J. Marang-van de Mheen

    Citation: BMC Medical Research Methodology 2019 19:131

    Content type: Research article

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  2. Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it’s important to control the family wise error rate (FWER). A popular approach to do this is...

    Authors: Victoria Vickerstaff, Rumana Z. Omar and Gareth Ambler

    Citation: BMC Medical Research Methodology 2019 19:129

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:158

  3. A large number of articles examined the preventability rate of readmissions, but comparison and interpretability of these preventability rates is complicated due to the large heterogeneity of methods that were...

    Authors: Eva-Linda Kneepkens, Corline Brouwers, Richelle Glory Singotani, Martine C. de Bruijne and Fatma Karapinar-Çarkit

    Citation: BMC Medical Research Methodology 2019 19:128

    Content type: Research article

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  4. The number of web-based E-epidemiologic studies using online recruitment methods is increasing. However, the optimal online recruitment method in terms of maximizing recruitment rates is still unknown. Our aim...

    Authors: Cauane Blumenberg, Ana Maria Baptista Menezes, Helen Gonçalves, Maria Cecília Formoso Assunção, Fernando César Wehrmeister and Aluísio J. D. Barros

    Citation: BMC Medical Research Methodology 2019 19:127

    Content type: Research article

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  5. The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multip...

    Authors: Charlotte L. Hall, Susan Brown, Marilyn James, Jennifer L. Martin, Nikki Brown, Kim Selby, Julie Clarke, Laura Williams, Kapil Sayal, Chris Hollis and Madeleine J. Groom

    Citation: BMC Medical Research Methodology 2019 19:126

    Content type: Research article

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  6. Use of big data is becoming increasingly popular in medical research. Since big data-based projects differ notably from classical research studies, both in terms of scope and quality, a debate is apt as to whe...

    Authors: Amke Caliebe, Friedhelm Leverkus, Gerd Antes and Michael Krawczak

    Citation: BMC Medical Research Methodology 2019 19:125

    Content type: Debate

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  7. Two randomized controlled trials (RCTs) were conducted to explore the utility of the Mechanical Turk (MTurk) crowdsourcing platform to conduct rapid trials evaluating online interventions for unhealthy alcohol...

    Authors: John A. Cunningham, Alexandra Godinho and Nicolas Bertholet

    Citation: BMC Medical Research Methodology 2019 19:124

    Content type: Research article

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  8. Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for cl...

    Authors: James Thomas Martin, Karla Hemming and Alan Girling

    Citation: BMC Medical Research Methodology 2019 19:123

    Content type: Research article

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  9. Accurate measurement of health literacy is essential to improve accessibility and effectiveness of health care and prevention. One measure frequently applied in international research is the Short Assessment o...

    Authors: A. J. Woudstra, C. S. Meppelink, H. Pander Maat, J. Oosterhaven, M. P. Fransen and A. L. Dima

    Citation: BMC Medical Research Methodology 2019 19:122

    Content type: Research article

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  10. Small group research in healthcare is important because it deals with interaction and decision-making processes that can help to identify and improve safer patient treatment and care. However, the number of st...

    Authors: Lisa Aufegger, Colin Bicknell, Emma Soane, Hutan Ashrafian and Ara Darzi

    Citation: BMC Medical Research Methodology 2019 19:121

    Content type: Research article

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  11. Health researchers often use survey studies to examine associations between risk factors at one time point and health outcomes later in life. Previous studies have shown that missing not at random (MNAR) may p...

    Authors: Kristin Gustavson, Espen Røysamb and Ingrid Borren

    Citation: BMC Medical Research Methodology 2019 19:120

    Content type: Research article

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  12. The Fred Hutchinson Cancer Research Center has engaged an External Stakeholder Advisory Group (ESAG) in the planning and implementation of the TrACER Study (S1415CD), a five-year pragmatic clinical trial asses...

    Authors: Sarah Barger, Sean D. Sullivan, Ari Bell-Brown, Brad Bott, Anne Marie Ciccarella, John Golenski, Mark Gorman, Judy Johnson, Karma Kreizenbeck, Florence Kurttila, Ginny Mason, Jamie Myers, Carole Seigel, James L. Wade III, Guneet Walia, Kate Watabayashi…

    Citation: BMC Medical Research Methodology 2019 19:119

    Content type: Research article

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  14. Clinical prediction models are not routinely validated. To facilitate validation procedures, the online Evidencio platform (https://​www.​evidencio.​com) ...

    Authors: Cornelia D. van Steenbeek, Marissa C. van Maaren, Sabine Siesling, Annemieke Witteveen, Xander A. A. M. Verbeek and Hendrik Koffijberg

    Citation: BMC Medical Research Methodology 2019 19:117

    Content type: Research article

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  15. We determined whether it is feasible to identify important changes in care management resulting from cardiovascular magnetic resonance (CMR) in patients who activate the primary percutaneous coronary intervent...

    Authors: Maria Pufulete, Jessica Harris, Stephen Dorman, Lynn Cook, Chiara Bucciarelli-Ducci, John P. Greenwood, Richard Anderson, Rachel Brierley and Barnaby C. Reeves

    Citation: BMC Medical Research Methodology 2019 19:116

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:190

  16. Comorbidity measures, such as the Charlson Comorbidity Index (CCI) and Elixhauser Method (EM), are frequently used for risk-adjustment by healthcare researchers. This study sought to create CCI and EM lists of...

    Authors: David Metcalfe, James Masters, Antonella Delmestri, Andrew Judge, Daniel Perry, Cheryl Zogg, Belinda Gabbe and Matthew Costa

    Citation: BMC Medical Research Methodology 2019 19:115

    Content type: Research article

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  18. Qualitative evidence synthesis is increasingly used alongside reviews of effectiveness to inform guidelines and other decisions. To support this use, the GRADE-CERQual approach was developed to assess and comm...

    Authors: Heather Menzies Munthe-Kaas, Claire Glenton, Andrew Booth, Jane Noyes and Simon Lewin

    Citation: BMC Medical Research Methodology 2019 19:113

    Content type: Research article

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  19. From 2005 to 2010, we conducted 2 randomized studies on a journal (Medicina Clínica), where we took manuscripts received for publication and randomly assigned them to either the standard editorial process or t...

    Authors: Marta Vilaró, Jordi Cortés, Albert Selva-O’Callaghan, Agustín Urrutia, Josep-Maria Ribera, Francesc Cardellach, Xavier Basagaña, Matthew Elmore, Miquel Vilardell, Douglas Altman, José-Antonio González and Erik Cobo

    Citation: BMC Medical Research Methodology 2019 19:112

    Content type: Research article

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  20. Length of stay evaluations are very common to determine the burden of nosocomial infections. However, there exist fundamentally different methods to quantify the prolonged length of stay associated with nosoco...

    Authors: Martin Wolkewitz, Martin Schumacher, Gerta Rücker, Stephan Harbarth and Jan Beyersmann

    Citation: BMC Medical Research Methodology 2019 19:111

    Content type: Research article

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  21. This study compares an algorithm to detect acute gastroenteritis (AG) episodes from drug dispensing data to the validated data reported in a primary care surveillance system in France.

    Authors: Ana-Maria Vilcu, Thierry Blanchon, Laure Sabatte, Cécile Souty, Milka Maravic, Thomas Hanslik and Olivier Steichen

    Citation: BMC Medical Research Methodology 2019 19:110

    Content type: Research article

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  22. Household surveys are a key epidemiological, medical, and social research method. In poor urban environments, such as slums, censuses can often be out-of-date or fail to record transient residents, maps may be...

    Authors:

    Citation: BMC Medical Research Methodology 2019 19:109

    Content type: Study protocol

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  23. The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way t...

    Authors: Andrew M. Smith, John P. Christodouleas and Wei-Ting Hwang

    Citation: BMC Medical Research Methodology 2019 19:108

    Content type: Research article

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  24. Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primar...

    Authors: Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson and Kasia Stepniewska

    Citation: BMC Medical Research Methodology 2019 19:107

    Content type: Research article

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  26. In this paper we discuss the emergence of many different methods for doing a literature review. Referring back to the early days, when there were essentially two types of review; a Cochrane systematic review a...

    Authors: Helen Aveyard and Caroline Bradbury-Jones

    Citation: BMC Medical Research Methodology 2019 19:105

    Content type: Research article

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  27. Net survival, a measure of the survival where the patients would only die from the cancer under study, may be compared between treatment groups using either “cause-specific methods”, when the causes of death a...

    Authors: Juste Aristide Goungounga, Célia Touraine, Nathalie Grafféo and Roch Giorgi

    Citation: BMC Medical Research Methodology 2019 19:104

    Content type: Research article

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  28. Most clinical trials with time-to-event primary outcomes are designed assuming constant event rates and proportional hazards over time. Non-constant event rates and non-proportional hazards are seen increasing...

    Authors: Kim Jachno, Stephane Heritier and Rory Wolfe

    Citation: BMC Medical Research Methodology 2019 19:103

    Content type: Research article

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  29. Large and complex studies are now routine, and quality assurance and quality control (QC) procedures ensure reliable results and conclusions. Standard procedures may comprise manual verification and double ent...

    Authors: Kelly M. Sunderland, Derek Beaton, Julia Fraser, Donna Kwan, Paula M. McLaughlin, Manuel Montero-Odasso, Alicia J. Peltsch, Frederico Pieruccini-Faria, Demetrios J. Sahlas, Richard H. Swartz, Stephen C. Strother and Malcolm A. Binns

    Citation: BMC Medical Research Methodology 2019 19:102

    Content type: Research article

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  30. Q methodology is an evidenced approach to researching subjectivity, involving a combination of qualitative and quantitative techniques. The methodology has been used successfully in healthcare research to expl...

    Authors: Melissa Kirschbaum, Tony Barnett and Merylin Cross

    Citation: BMC Medical Research Methodology 2019 19:101

    Content type: Research article

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  31. Childhood acute lymphoblastic leukemia (cALL) is the most frequent pediatric cancer. Over the past decades, treatment of cALL has significantly improved, with cure rates close to 90%. However intensive chemoth...

    Authors: Miguel Caubet Fernandez, Simon Drouin, Mariia Samoilenko, Sophia Morel, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Emile Levy, Valérie Marcil and Geneviève Lefebvre

    Citation: BMC Medical Research Methodology 2019 19:100

    Content type: Research article

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  32. Bayesian adaptive designs can improve the efficiency of trials, and lead to trials that can produce high quality evidence more quickly, with fewer patients and lower costs than traditional methods. The aim of ...

    Authors: Elizabeth G. Ryan, Julie Bruce, Andrew J. Metcalfe, Nigel Stallard, Sarah E. Lamb, Kert Viele, Duncan Young and Simon Gates

    Citation: BMC Medical Research Methodology 2019 19:99

    Content type: Research article

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  33. A dataset is indispensable to answer the research questions of clinical research studies. Inaccurate data lead to ambiguous results, and the removal of errors results in increased cost. The aim of this Quality...

    Authors: Naila A. Shaheen, Bipin Manezhi, Abin Thomas and Mohammed AlKelya

    Citation: BMC Medical Research Methodology 2019 19:98

    Content type: Research article

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  34. Despite its popularity, issues concerning the estimation of power in multilevel logistic regression models are prevalent because of the complexity involved in its calculation (i.e., computer-simulation-based a...

    Authors: Oscar L. Olvera Astivia, Anne Gadermann and Martin Guhn

    Citation: BMC Medical Research Methodology 2019 19:97

    Content type: Research article

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  35. In clinical and epidemiological researches, continuous predictors are often discretized into categorical variables for classification of patients. When the relationship between a continuous predictor and log r...

    Authors: Yimin Chen, Jialing Huang, Xianying He, Yongxiang Gao, Gehendra Mahara, Zhuochen Lin and Jinxin Zhang

    Citation: BMC Medical Research Methodology 2019 19:96

    Content type: Technical advance

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  36. Poor medication adherence is a major factor in the secondary prevention of cardiovascular diseases (CVD) and contributes to increased morbidity, mortality, and costs. Interventions for improving medication adh...

    Authors: A. Sieben, S. J. H. Bredie, J. C. H. B. M. Luijten, C. J. H. M. van Laarhoven, S. van Dulmen and H. A. W. van Onzenoort

    Citation: BMC Medical Research Methodology 2019 19:95

    Content type: Research article

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  37. To study patient physiology throughout a period of acute hospitalization, we sought to create accessible, standardized nationwide data at the level of the individual patient-facility-day. This methodology pape...

    Authors: Xiao Qing Wang, Brenda M. Vincent, Wyndy L. Wiitala, Kaitlyn A. Luginbill, Elizabeth M. Viglianti, Hallie C. Prescott and Theodore J. Iwashyna

    Citation: BMC Medical Research Methodology 2019 19:94

    Content type: Database

    Published on:

  38. While it is widely acknowledged that family burden can be ameliorated with effective psycho-social interventions, how to measure family burden and define a valid cutoff to identify family caregivers in need of...

    Authors: Yu Yu, Zi-Wei Liu, Wei Zhou, Mei Zhao, Bing-Wei Tang and Shui-Yuan Xiao

    Citation: BMC Medical Research Methodology 2019 19:93

    Content type: Research article

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  39. Evaluation of complex interventions (CI) is challenging for health researchers and requires innovative approaches. The objective of this work is to present the main methods used to evaluate CI.

    Authors: Laetitia Minary, Justine Trompette, Joëlle Kivits, Linda Cambon, Cyril Tarquinio and François Alla

    Citation: BMC Medical Research Methodology 2019 19:92

    Content type: Research article

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  40. Reliable data from health surveys are essential to describe the status and trends in health indicators by means of information not available from official registers. In Denmark, nationally representative healt...

    Authors: Heidi Amalie Rosendahl Jensen, Ola Ekholm, Michael Davidsen and Anne Illemann Christensen

    Citation: BMC Medical Research Methodology 2019 19:91

    Content type: Research article

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  41. Radiologic assessments of baseline and post-treatment tumor burden are subject to measurement variability, but the impact of this variability on the objective response rate (ORR) and progression rate in specif...

    Authors: Jeong-Hwa Yoon, Soon Ho Yoon and Seokyung Hahn

    Citation: BMC Medical Research Methodology 2019 19:90

    Content type: Research article

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  42. Studies in both paediatric and psychiatric settings often experience problems in recruitment. This can compromise the ability of the study to recruit to target, meaning studies are potentially underpowered. It...

    Authors: Maria E. Loades, Lucie Smith, Nina Higson-Sweeney, Lucy Beasant, Paul Stallard, David Kessler and Esther Crawley

    Citation: BMC Medical Research Methodology 2019 19:89

    Content type: Research article

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  43. Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative pat...

    Authors: Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin…

    Citation: BMC Medical Research Methodology 2019 19:88

    Content type: Research article

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  44. This study examined the agreement between patient-reported chronic diseases and hospital administrative records in hip or knee arthroplasty patients in England.

    Authors: Bélène Podmore, Andrew Hutchings, Sujith Konan and Jan van der Meulen

    Citation: BMC Medical Research Methodology 2019 19:87

    Content type: Research article

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  46. Performing well-powered randomised controlled trials (RCTs) of new treatments for rare diseases is often infeasible. However, with the increasing availability of historical data, incorporating existing informa...

    Authors: Caroline Brard, Lisa V. Hampson, Nathalie Gaspar, Marie-Cécile Le Deley and Gwénaël Le Teuff

    Citation: BMC Medical Research Methodology 2019 19:85

    Content type: Research article

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  47. Measuring body mass index (BMI) has been proposed as a method of screening for preventive primary care and population surveillance of childhood obesity. However, the accuracy of routinely collected measurement...

    Authors: Sarah Carsley, Patricia C. Parkin, Karen Tu, Eleanor Pullenayegum, Nav Persaud, Jonathon L. Maguire and Catherine S. Birken

    Citation: BMC Medical Research Methodology 2019 19:84

    Content type: Research article

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  48. Maternal and child health are internationally considered to be among the best measures for assessing health-care quality. The study was carried out with the following aims: 1) to assess the quality of perinata...

    Authors: Claudia Pileggi, Lorena Squillace, Mariavalentina Giordano, Rosa Papadopoli, Aida Bianco and Maria Pavia

    Citation: BMC Medical Research Methodology 2019 19:83

    Content type: Research article

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  49. Multiple neonatal and pediatric disorders have been linked to older paternal ages. Combining these findings with the evidence that many men are having children at much later ages generates considerable public ...

    Authors: James A. Thompson

    Citation: BMC Medical Research Methodology 2019 19:82

    Content type: Research article

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  50. Recommended statistical methods for meta-analysis of diagnostic test accuracy studies require relatively complex bivariate statistical models which can be a barrier for non-statisticians. A further barrier exi...

    Authors: Suzanne C. Freeman, Clareece R. Kerby, Amit Patel, Nicola J. Cooper, Terry Quinn and Alex J. Sutton

    Citation: BMC Medical Research Methodology 2019 19:81

    Content type: Software

    Published on:

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