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  1. In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, an...

    Authors: Dina Voeltz, Annika Hoyer, Amelie Forkel, Anke Schwandt and Oliver Kuß
    Citation: BMC Medical Research Methodology 2024 24:48
  2. Successfully recruiting male participants to complete a healthcare related study is important for healthcare study completion and to advance our clinical knowledgebase. To date, most research studies have exam...

    Authors: Danielle J. Borg, Melina Haritopoulou-Sinanidou, Pam Gabrovska, Hsu-Wen Tseng, David Honeyman, Daniel Schweitzer and Kym M. Rae
    Citation: BMC Medical Research Methodology 2024 24:46
  3. Scoping reviews have emerged as a valuable method for synthesizing emerging evidence, providing a comprehensive contextual overview, and influencing policy and practice developments. The objective of this stud...

    Authors: Xinyu Xue, Xintong Tang, Shanshan Liu, Ting Yu, Zhonglan Chen, Ningsu Chen and Jiajie Yu
    Citation: BMC Medical Research Methodology 2024 24:45
  4. The residual life of a patient with human immunodeficiency virus (HIV) is of major interest to patients and their physicians. While existing analyses of HIV patient survival focus mostly on data collected at b...

    Authors: Soo Min Kim, Yunsu Choi, Sangwook Kang and Korea HIV/AIDS cohort study
    Citation: BMC Medical Research Methodology 2024 24:44
  5. People with dementia are routinely included as research participants in trials and other quantitative studies in which they are invited to respond to standardised measures. This paper reviews the reporting of ...

    Authors: Kate Gridley, Kate Baxter and Yvonne Birks
    Citation: BMC Medical Research Methodology 2024 24:43
  6. Group sequential designs are one of the most widely used methodologies for adaptive design in randomized clinical trials. In settings where early outcomes are available, they offer large gains in efficiency co...

    Authors: Nick R. Parsons, Joydeep Basu and Nigel Stallard
    Citation: BMC Medical Research Methodology 2024 24:42
  7. Missing data is frequently an inevitable issue in cohort studies and it can adversely affect the study's findings. We assess the effectiveness of eight frequently utilized statistical and machine learning (ML)...

    Authors: JiaHang Li, ShuXia Guo, RuLin Ma, Jia He, XiangHui Zhang, DongSheng Rui, YuSong Ding, Yu Li, LeYao Jian, Jing Cheng and Heng Guo
    Citation: BMC Medical Research Methodology 2024 24:41
  8. Data mining has been used to help discover Frequent patterns in health data. it is widely used to diagnose and prevent various diseases and to obtain the causes and factors affecting diseases. Therefore, the a...

    Authors: Zahra Kohzadi, Ali Mohammad Nickfarjam, Leila Shokrizadeh Arani, Zeinab Kohzadi and Mehrdad Mahdian
    Citation: BMC Medical Research Methodology 2024 24:40
  9. Surrogate endpoints, such as those of interest in chronic kidney disease (CKD), are often evaluated using Bayesian meta-regression. Trials used for the analysis can evaluate a variety of interventions for diff...

    Authors: Willem Collier, Benjamin Haaland, Lesley A. Inker, Hiddo J.L. Heerspink and Tom Greene
    Citation: BMC Medical Research Methodology 2024 24:39
  10. Several strategies for identifying biologically implausible values in longitudinal anthropometric data have recently been proposed, but the suitability of these strategies for large population datasets needs t...

    Authors: Juliana Freitas de Mello e Silva, Natanael de Jesus Silva, Thaís Rangel Bousquet Carrilho, Elizabete de Jesus Pinto, Aline Santos Rocha, Jéssica Pedroso, Sara Araújo Silva, Ana Maria Spaniol, Rafaella da Costa Santin de Andrade, Gisele Ane Bortolini, Enny Paixão, Gilberto Kac, Rita de Cássia Ribeiro-Silva and Maurício L. Barreto
    Citation: BMC Medical Research Methodology 2024 24:38
  11. Despite the fact that team manual handling is common in different working environments, the previous studies in this regard, particularly those with a physiological approach are quite limited. The present stud...

    Authors: Mohammad Hamed Hosseini, Rashid Heidarimoghaddam, Mehrdad Anbarian, Saeed Ilbeigi and Leili Tapak
    Citation: BMC Medical Research Methodology 2024 24:37
  12. Surveys have been used worldwide to provide information on the COVID-19 pandemic impact so as to prepare and deliver an effective Public Health response. Overlapping panel surveys allow longitudinal estimates ...

    Authors: Luis Castro, María del Mar Rueda, Carmen Sánchez-Cantalejo, Ramón Ferri and Andrés Cabrera-León
    Citation: BMC Medical Research Methodology 2024 24:36
  13. The importance of contextual effects and their roles in clinical care controversial. A Cochrane review published in 2010 concluded that placebo interventions lack important clinical effects overall, but that p...

    Authors: Tobias Saueressig, Hugo Pedder, Patrick J Owen and Daniel L Belavy
    Citation: BMC Medical Research Methodology 2024 24:35
  14. Mendelian randomization is a popular method for causal inference with observational data that uses genetic variants as instrumental variables. Similarly to a randomized trial, a standard Mendelian randomizatio...

    Authors: Haodong Tian, Brian D. M. Tom and Stephen Burgess
    Citation: BMC Medical Research Methodology 2024 24:34
  15. The purpose of this paper is to evaluate the impact of modifying the published scoring system to address identified potential weaknesses in the published scoring system for the Evaluation of Activity Surveys i...

    Authors: Julie Agel, Umesh Ghimire, Nicholas M. Edwards, Bradley Nelson and Todd Rockwood
    Citation: BMC Medical Research Methodology 2024 24:33
  16. When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient...

    Authors: Antonio Remiro-Azócar, Anna Heath and Gianluca Baio
    Citation: BMC Medical Research Methodology 2024 24:32
  17. The Interrupted Time Series (ITS) is a robust design for evaluating public health and policy interventions or exposures when randomisation may be infeasible. Several statistical methods are available for the a...

    Authors: Elizabeth Korevaar, Simon L. Turner, Andrew B. Forbes, Amalia Karahalios, Monica Taljaard and Joanne E. McKenzie
    Citation: BMC Medical Research Methodology 2024 24:31
  18. Rapidly developing tests for emerging diseases is critical for early disease monitoring. In the early stages of an epidemic, when low prevalences are expected, high specificity tests are desired to avoid numer...

    Authors: Sierra Pugh, Bailey K. Fosdick, Mary Nehring, Emily N. Gallichotte, Sue VandeWoude and Ander Wilson
    Citation: BMC Medical Research Methodology 2024 24:30
  19. Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage. We aimed to develop a com...

    Authors: Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan and Lotty Hooft
    Citation: BMC Medical Research Methodology 2024 24:29
  20. Selective reporting of results from only well-performing cut-offs leads to biased estimates of accuracy in primary studies of questionnaire-based screening tools and in meta-analyses that synthesize results. I...

    Authors: Zelalem F. Negeri, Brooke Levis, John P. A. Ioannidis, Brett D. Thombs and Andrea Benedetti
    Citation: BMC Medical Research Methodology 2024 24:28
  21. Standard pediatric growth curves cannot be used to impute missing height or weight measurements in individual children. The Michaelis–Menten equation, used for characterizing substrate-enzyme saturation curves...

    Authors: William A. Walters, Catherine Ley, Trevor Hastie, Ruth E. Ley and Julie Parsonnet
    Citation: BMC Medical Research Methodology 2024 24:27
  22. The rapidly growing burden of non-communicable diseases (NCDs) among people living with HIV in sub-Saharan Africa (SSA) has expanded the number of multidisease models predicting future care needs and health sy...

    Authors: Sharon Jepkorir Sawe, Richard Mugo, Marta Wilson-Barthes, Brianna Osetinsky, Stavroula A. Chrysanthopoulou, Faith Yego, Ann Mwangi and Omar Galárraga
    Citation: BMC Medical Research Methodology 2024 24:26
  23. We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86–101, 2018) by allowing for interval null causal hypotheses, where values of the causal effect parameter...

    Authors: Linyi Zou, Teresa Fazia, Hui Guo and Carlo Berzuini
    Citation: BMC Medical Research Methodology 2024 24:25
  24. When multiple influential covariates need to be balanced during a clinical trial, stratified blocked randomization and covariate-adaptive randomization procedures are frequently used in trials to prevent bias ...

    Authors: Guogen Shan, Yulin Li, Xinlin Lu, Yahui Zhang and Samuel S. Wu
    Citation: BMC Medical Research Methodology 2024 24:22
  25. The relationships between place (e.g., neighborhood) and HIV are commonly investigated. As measurements of place are multivariate, most studies apply some dimension reduction, resulting in one variable (or a s...

    Authors: Trang Quynh Nguyen, Laken C. Roberts Lavigne, Carly Lupton Brantner, Gregory D. Kirk, Shruti H. Mehta and Sabriya L. Linton
    Citation: BMC Medical Research Methodology 2024 24:21
  26. Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic meth...

    Authors: Alexandra Bannach-Brown, Torsten Rackoll, Nurcennet Kaynak, Natascha Drude, René Aquarius, Sofija Vojvodić, Mariana Abreu, Julia M. L. Menon and Kimberley E. Wever
    Citation: BMC Medical Research Methodology 2024 24:20
  27. The global research response to the COVID-19 pandemic was impressive, but also led to an infodemic and considerable research waste. Registered, but unpublished trials added to this noise. We aimed to determine...

    Authors: Lisa Fincham, Ameer Hohlfeld, Mike Clarke, Tamara Kredo and Michael McCaul
    Citation: BMC Medical Research Methodology 2024 24:19
  28. An inability to successfully recruit participants into clinical research has consequences that negatively affect the conduct and reliability of research studies. Understanding facilitators of research particip...

    Authors: Charles Start, Meagan McBride, Guohao Zhu, Sana Shaikh and Jennifer Pierce
    Citation: BMC Medical Research Methodology 2024 24:18
  29. Treatment switching in randomised controlled trials (RCTs) is a problem for health technology assessment when substantial proportions of patients switch onto effective treatments that would not be available in...

    Authors: Nicholas R Latimer, Alice Dewdney and Marco Campioni
    Citation: BMC Medical Research Methodology 2024 24:17
  30. Lung cancer is a leading cause of cancer deaths and imposes an enormous economic burden on patients. It is important to develop an accurate risk assessment model to determine the appropriate treatment for pati...

    Authors: Lu Zhong, Fan Yang, Shanshan Sun, Lijie Wang, Hong Yu, Xiushan Nie, Ailing Liu, Ning Xu, Lanfang Zhang, Mingjuan Zhang, Yue Qi, Huaijun Ji, Guiyuan Liu, Huan Zhao, Yinan Jiang, Jingyi Li…
    Citation: BMC Medical Research Methodology 2024 24:16
  31. Sample size calculation is a central aspect in planning of clinical trials. The sample size is calculated based on parameter assumptions, like the treatment effect and the endpoint’s variance. A fundamental pr...

    Authors: Björn Bokelmann, Geraldine Rauch, Jan Meis, Meinhard Kieser and Carolin Herrmann
    Citation: BMC Medical Research Methodology 2024 24:15
  32. Dengue is a mosquito-borne disease that causes over 300 million infections worldwide each year with no specific treatment available. Effective surveillance systems are needed for outbreak detection and resourc...

    Authors: Chawarat Rotejanaprasert, Kawin Chinpong, Andrew B. Lawson, Peerut Chienwichai and Richard J. Maude
    Citation: BMC Medical Research Methodology 2024 24:14
  33. Community optometrists in Scotland have performed regular free-at-point-of-care eye examinations for all, for over 15 years. Eye examinations include retinal imaging but image storage is fragmented and they ar...

    Authors: Claire Tochel, Emma Pead, Alice McTrusty, Fiona Buckmaster, Tom MacGillivray, Andrew J. Tatham, Niall C. Strang, Baljean Dhillon and Miguel O. Bernabeu
    Citation: BMC Medical Research Methodology 2024 24:13
  34. Seamless phase 2/3 design has become increasingly popular in clinical trials with a single endpoint. Trials that define success based on the achievement of all co-primary endpoints (CPEs) encounter the challen...

    Authors: Jiaying Yang, Guochun Li, Dongqing Yang, Juan Wu, Junqin Wang, Xingsu Gao and Pei Liu
    Citation: BMC Medical Research Methodology 2024 24:12
  35. In this article we describe the methodology of the time-to-event continual reassessment method in the presence of partial orders (PO-TITE-CRM) and the process of implementing this trial design into a phase I t...

    Authors: Amit Patel, Kristian Brock, Daniel Slade, Claire Gaunt, Anthony Kong, Hisham Mehanna, Lucinda Billingham and Piers Gaunt
    Citation: BMC Medical Research Methodology 2024 24:11
  36. Dengue infection ranges from asymptomatic to severe and life-threatening, with no specific treatment available. Vector control is crucial for interrupting its transmission cycle. Accurate estimation of outbrea...

    Authors: Chawarat Rotejanaprasert, Darin Areechokchai and Richard J. Maude
    Citation: BMC Medical Research Methodology 2024 24:10
  37. Preprints are increasingly used to disseminate research results, providing multiple sources of information for the same study. We assessed the consistency in effect estimates between preprint and subsequent jo...

    Authors: Mauricia Davidson, Theodoros Evrenoglou, Carolina Graña, Anna Chaimani and Isabelle Boutron
    Citation: BMC Medical Research Methodology 2024 24:9
  38. Prescribing cascades occur when patients are prescribed medication to treat the adverse drug reaction of previously prescribed medication. Prescription sequence symmetry analysis (PSSA) can be used to assess t...

    Authors: Mandy R. S. Hendrix, Mustafa Yasar, Atiya K. Mohammad, Jacqueline G. Hugtenburg, Joost W. Vanhommerig, Ruveyda Gündoğan-Yilmaz, Patricia M. L. A. van den Bemt, Petra Denig and Fatma Karapinar-Carkıt
    Citation: BMC Medical Research Methodology 2024 24:8
  39. The validity of self-reported chronic conditions has been assessed by comparing them with medical records or register data in several studies. However, the reliability of self-reports of chronic diseases has l...

    Authors: Bernd Kowall, Carolin Girschik and Susanne Stolpe
    Citation: BMC Medical Research Methodology 2024 24:7
  40. Meta-analysis poses a challenge when original study results have been expressed in a non-uniform manner, such as when regression results from some original studies were based on a log-transformed key independe...

    Authors: Matthew W. Linakis, Cynthia Van Landingham, Alessandro Gasparini and Matthew P. Longnecker
    Citation: BMC Medical Research Methodology 2024 24:6
  41. In the last decades, medical research fields studying rare conditions such as spinal cord injury (SCI) have made extensive efforts to collect large-scale data. However, most analysis methods rely on complete d...

    Authors: Lucie Bourguignon, Louis P. Lukas, James D. Guest, Fred H. Geisler, Vanessa Noonan, Armin Curt, Sarah C. Brüningk and Catherine R. Jutzeler
    Citation: BMC Medical Research Methodology 2024 24:5
  42. Identification of difficult laryngoscopy is a frequent demand in cervical spondylosis clinical surgery. This work aims to develop a hybrid architecture for identifying difficult laryngoscopy based on new indexes.

    Authors: XiaoXiao Liu, Colin Flanagan, Gang Li, Yiming Lei, Liaoyuan Zeng, Jingchao Fang, Xiangyang Guo, Sean McGrath and Yongzheng Han
    Citation: BMC Medical Research Methodology 2024 24:4
  43. In any single-arm trial on novel treatments, assessment of toxicity plays an important role as occurrence of adverse events (AEs) is relevant for application in clinical practice. In the presence of a non-fata...

    Authors: Elena Tassistro, Davide Paolo Bernasconi, Maria Grazia Valsecchi and Laura Antolini
    Citation: BMC Medical Research Methodology 2024 24:3
  44. Estimation of mortality rates and mortality rate ratios (MRR) of diseased and non-diseased individuals is a core metric of disease impact used in chronic disease epidemiology. Estimation of mortality rates is ...

    Authors: Sabrina Voß, Annika Hoyer, Sandra Landwehr, Meda E. Pavkov, Edward Gregg and Ralph Brinks
    Citation: BMC Medical Research Methodology 2024 24:2
  45. Effective care coordination may increase clinical efficiency, but its measurement remains difficult. The established metric “care density” (CD) measures care coordination based on patient-sharing among physici...

    Authors: Alexander Engels, Claudia Konnopka, Espen Henken, Martin Härter and Hans-Helmut König
    Citation: BMC Medical Research Methodology 2024 24:1
  46. Implications for research (IfR) sections are an important part of systematic reviews (SRs) to inform health care researchers and policy makers. PRISMA 2020 recommends reporting IfR, while Cochrane Reviews requ...

    Authors: W. Siemens, G. Bantle, C. Ebner, A. Blümle, G. Becker, G. Schwarzer and J. J. Meerpohl
    Citation: BMC Medical Research Methodology 2023 23:302
  47. To demonstrate bioequivalence between two drug formulations, a pilot trial is often conducted prior to a pivotal trial to assess feasibility and gain preliminary information about the treatment effect. Due to ...

    Authors: Duo Lv, Michael J. Grayling, Xinyue Zhang, Qingwei Zhao and Haiyan Zheng
    Citation: BMC Medical Research Methodology 2023 23:301

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