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  1. Oral cancer is the most common cancer among Indian men, and has strong tendency of metastatic spread to neck lymph node which strongly influences prognosis especially 5 year survival-rate and also guides the r...

    Authors: Vishwajeet Singh, Sada Nand Dwivedi and S. V. S. Deo

    Citation: BMC Medical Research Methodology 2020 20:95

    Content type: Research article

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  2. In clinical research, there is an increasing interest in joint modelling of longitudinal and time-to-event data, since it reduces bias in parameter estimation and increases the efficiency of statistical infere...

    Authors: Maha Alsefri, Maria Sudell, Marta García-Fiñana and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2020 20:94

    Content type: Research article

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  3. The prevalence of oral HPV infection and HPV-related oropharyngeal squamous cell carcinoma (OPSCC) among Indigenous Australians is unknown. This paper outlines the engagement, consultation and recruitment stra...

    Authors: Joanne Hedges, Gail Garvey, Zell Dodd, Warren Miller, Terry Dunbar, Cathy Leane, Amanda Mitchell, Isaac Hill and Lisa Jamieson

    Citation: BMC Medical Research Methodology 2020 20:92

    Content type: Research article

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  4. Mobile applications for health, also known as ‘mHealth apps’, have experienced increasing popularity over the past ten years. However, most publicly available mHealth apps are not clinically validated, and man...

    Authors: Adrian B. R. Shatte and Samantha J. Teague

    Citation: BMC Medical Research Methodology 2020 20:91

    Content type: Software

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  5. Visual displays such as charts and tables may significantly moderate the effects of audit and feedback interventions, but the systematic study of these intervention components will likely remain limited withou...

    Authors: Dahee Lee, Veena Panicker, Colin Gross, Jessica Zhang and Zach Landis-Lewis

    Citation: BMC Medical Research Methodology 2020 20:90

    Content type: Research article

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  6. State Trait Anxiety Inventory (STAI) scale was developed in the 1980’s and has been widely used both in clinical settings and in research. However the Danish version of STAI has not been validated. The aim of ...

    Authors: L. W. Gustafson, P. Gabel, A. Hammer, H. H. Lauridsen, L. K. Petersen, B. Andersen, P. Bor and M. B. Larsen

    Citation: BMC Medical Research Methodology 2020 20:89

    Content type: Research article

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  7. The replication crisis hit the medical sciences about a decade ago, but today still most of the flaws inherent in null hypothesis significance testing (NHST) have not been solved. While the drawbacks of p-values ...

    Authors: Riko Kelter

    Citation: BMC Medical Research Methodology 2020 20:88

    Content type: Research Article

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  8. Occupational stress and specifically job anxiety are crucial factors in determining health outcomes, job satisfaction as well as performance. In order to assess this phenomenon, the Job Anxiety Scale is one of...

    Authors: Bjarne Schmalbach, Andreas Kalkbrenner, Markus Bassler, Andreas Hinz and Katja Petrowski

    Citation: BMC Medical Research Methodology 2020 20:87

    Content type: Research article

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    The Retraction Note to this article has been published in BMC Medical Research Methodology 2020 20:285

  9. Repeatability and reproducibility are essential for clinicians for several purposes. Although discouraged, use of the Coefficient of Variation (CV) for assessing repeatability and reproducibility, rather than ...

    Authors: Giovanna Cilluffo, Anna Maria Zicari, Giuliana Ferrante, Velia Malizia, Salvatore Fasola, Marzia Duse, Giovanna De Castro, Valentina De Vittori, Laura Schiavi, Giulia Brindisi, Paolo Petrelli and Stefania La Grutta

    Citation: BMC Medical Research Methodology 2020 20:86

    Content type: Research article

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  10. A pretest probability must be selected to calculate data to help clinicians, guideline boards and policy makers interpret diagnostic accuracy parameters. When multiple analyses for the same target condition ar...

    Authors: Michiel S. Oerbekke, Kevin Jenniskens, Rob J. P. M. Scholten and Lotty Hooft

    Citation: BMC Medical Research Methodology 2020 20:85

    Content type: Research article

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  11. Predictive models within epilepsy are frequently developed via Cox’s proportional hazards models. These models estimate risk of a specified event such as 12-month remission. They are relatively simple to produ...

    Authors: Laura J. Bonnett, Jane L. Hutton and Anthony G. Marson

    Citation: BMC Medical Research Methodology 2020 20:84

    Content type: Research article

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  12. In randomised controlled trials, the assumption of independence of individual observations is fundamental to the design, analysis and interpretation of studies. However, in individually randomised trials in pr...

    Authors: Beth Stuart, Taeko Becque, Michael Moore and Paul Little

    Citation: BMC Medical Research Methodology 2020 20:83

    Content type: Research article

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  13. In the original publication of this article [1], the number “− 0.49” in the below sentence in the Results section should be changed to “-3.23”, and this typo does not affect the wider conclusions.

    Authors: Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    Citation: BMC Medical Research Methodology 2020 20:82

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2017 17:29

  14. The Schedule for the Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW) is a prevalent face-to-face interview method for measuring quality of life by integrating respondent-generated dimensi...

    Authors: Marion Burckhardt, Steffen Fleischer and Almuth Berg

    Citation: BMC Medical Research Methodology 2020 20:80

    Content type: Research article

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  15. The lack of attention to Indigenous epistemologies and, more broadly, Indigenous values in primary research, is mirrored in the standardised critical appraisal tools used to guide evidence-based practice and s...

    Authors: Stephen Harfield, Odette Pearson, Kim Morey, Elaine Kite, Karla Canuto, Karen Glover, Judith Streak Gomersall, Drew Carter, Carol Davy, Edoardo Aromataris and Annette Braunack-Mayer

    Citation: BMC Medical Research Methodology 2020 20:79

    Content type: Research article

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  16. To monitor the adoption of climate change adaptive behaviors in the population, public health authorities have to conduct national surveys, which can help them target vulnerable subpopulations. To ensure relia...

    Authors: Grâce Ngambo Domche, Pierre Valois, Magalie Canuel, Denis Talbot, Maxime Tessier, Cécile Aenishaenslin, Catherine Bouchard and Sandie Briand

    Citation: BMC Medical Research Methodology 2020 20:78

    Content type: Research article

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  17. Electronic Health Records (EHR) has been increasingly used as a tool to monitor population health. However, subject-level errors in the records can yield biased estimates of health indicators. There is an urge...

    Authors: Ryung S. Kim and Viswanathan Shankar

    Citation: BMC Medical Research Methodology 2020 20:77

    Content type: Research article

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  18. Modeling studies to inform the design of complex health services interventions often involves elements that differ from the intervention’s ultimate real-world use. These “hypothetical” elements include pilot p...

    Authors: Tavis Hayes, Natasha Hudek, Ian D. Graham, Doug Coyle and Jamie C. Brehaut

    Citation: BMC Medical Research Methodology 2020 20:76

    Content type: Research article

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  19. Postoperative atrial fibrillation (POAF) is a frequent complication of cardiac surgery associated with important morbidity, mortality, and costs. To assess the effectiveness of preventive interventions, an imp...

    Authors: Jonathan Bourgon Labelle, Paul Farand, Christian Vincelette, Myriam Dumont, Mathilde Le Blanc and Christian M. Rochefort

    Citation: BMC Medical Research Methodology 2020 20:75

    Content type: Research article

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  20. Information on the associations between pre-diagnosis health behavior and post-diagnosis survival time in esophageal cancer could assist in planning health services but can be difficult to obtain using establi...

    Authors: Paul P. Fahey, Andrew Page, Glenn Stone and Thomas Astell-Burt

    Citation: BMC Medical Research Methodology 2020 20:74

    Content type: Research article

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  21. Exposure to unhealthy environments and inadequate child stimulation are main risk factors that affect children’s health and wellbeing in low- and middle-income countries. Interventions that simultaneously addr...

    Authors: Stella M. Hartinger, Nestor Nuño, Jan Hattendorf, Hector Verastegui, Walter Karlen, Mariela Ortiz and Daniel Mäusezahl

    Citation: BMC Medical Research Methodology 2020 20:73

    Content type: Research article

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  22. The mortality risk among cancer patients measured from the time of diagnosis is often elevated in comparison to the general population. However, for some cancer types, the patient mortality risk will over time...

    Authors: Lasse H. Jakobsen, Therese M.-L. Andersson, Jorne L. Biccler, Laurids Ø. Poulsen, Marianne T. Severinsen, Tarec C. El-Galaly and Martin Bøgsted

    Citation: BMC Medical Research Methodology 2020 20:71

    Content type: Research Article

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  23. It is important to estimate the treatment effect of interest accurately and precisely within the analysis of randomised controlled trials. One way to increase precision in the estimate and thus improve the pow...

    Authors: Hanaya Raad, Victoria Cornelius, Susan Chan, Elizabeth Williamson and Suzie Cro

    Citation: BMC Medical Research Methodology 2020 20:70

    Content type: Research article

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  24. With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-e...

    Authors: Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy and Philippe Broët

    Citation: BMC Medical Research Methodology 2020 20:69

    Content type: Research Article

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  25. Rates of non-communicable diseases (NCDs) are rapidly rising in the Eastern Mediterranean Region (EMR). Systematic reviews satisfy the demand from practitioners and policy makers for prompt comprehensive evide...

    Authors: Alaa Akkawi, Joanne Khabsa, Aya Noubani, Sarah Jamali, Abla M. Sibai and Tamara Lotfi

    Citation: BMC Medical Research Methodology 2020 20:68

    Content type: Research article

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  26. Clinical trials are essential to improve knowledge of anesthesia and perioperative medicine. Unfortunately, many studies face participant-recruitment issues and fail to include the planned number of participan...

    Authors: Caroline Noirmain, Béatrice Gil-Wey, Isabelle Pichon, Pauline Brindel and Guy Haller

    Citation: BMC Medical Research Methodology 2020 20:67

    Content type: Research article

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  27. Missing data are an inevitable challenge in Randomised Controlled Trials (RCTs), particularly those with Patient Reported Outcome Measures. Methodological guidance suggests that to avoid incorrect conclusions,...

    Authors: Alexina J. Mason, Richard D. Grieve, Alvin Richards-Belle, Paul R. Mouncey, David A. Harrison and James R. Carpenter

    Citation: BMC Medical Research Methodology 2020 20:66

    Content type: Technical Advance

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  28. One of the frequently used methods for assessing research trends and the impact of published scientific literature in a particular discipline is citation analysis. Journals may strive to improve their metrics ...

    Authors: Antonia Jelicic Kadic, Tanja Kovacevic, Edita Runjic, Ana Simicic Majce, Josko Markic, Branka Polic, Julije Mestrovic and Livia Puljak

    Citation: BMC Medical Research Methodology 2020 20:60

    Content type: Research article

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  29. Sero- prevalence studies often have a problem of missing data. Few studies report the proportion of missing data and even fewer describe the methods used to adjust the results for missing data. The objective o...

    Authors: Neema R. Mosha, Omololu S. Aluko, Jim Todd, Rhoderick Machekano and Taryn Young

    Citation: BMC Medical Research Methodology 2020 20:65

    Content type: Research article

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  30. Among different investigators studying the same exposures and outcomes, there may be a lack of consensus about potential confounders that should be considered as matching, adjustment, or stratification variabl...

    Authors: Joshua D. Wallach, Stylianos Serghiou, Lingzhi Chu, Alexander C. Egilman, Vasilis Vasiliou, Joseph S. Ross and John P. A. Ioannidis

    Citation: BMC Medical Research Methodology 2020 20:64

    Content type: Research article

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  31. Non-participation and attrition are rarely studied despite being important methodological issues when performing post-disaster studies. A longitudinal survey of civilians exposed to the January 2015 terrorist ...

    Authors: Cécile Vuillermoz, Lise Eilin Stene, Lydéric Aubert, Yvon Motreff, Philippe Pirard, Thierry Baubet, Sophie Lesieur, Pierre Chauvin and Stéphanie Vandentorren

    Citation: BMC Medical Research Methodology 2020 20:63

    Content type: Research article

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  32. Cox proportional hazards regression models are used to evaluate associations between exposures of interest and time-to-event outcomes in observational data. When exposures are measured on only a sample of part...

    Authors: Colleen M. Sitlani, Thomas Lumley, Barbara McKnight, Kenneth M. Rice, Nels C. Olson, Margaret F. Doyle, Sally A. Huber, Russell P. Tracy, Bruce M. Psaty and Joseph A. C. Delaney

    Citation: BMC Medical Research Methodology 2020 20:62

    Content type: Research Article

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  33. In the data pipeline from the data collection process to the planned statistical analyses, initial data analysis (IDA) typically takes place between the end of the data collection and do not touch the research...

    Authors: Marianne Huebner, Werner Vach, Saskia le Cessie, Carsten Oliver Schmidt and Lara Lusa

    Citation: BMC Medical Research Methodology 2020 20:61

    Content type: Research article

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  34. Participant recruitment for clinical research studies remains a significant challenge for researchers. Novel approaches to recruitment are necessary to ensure that populations are easier to reach. In the conte...

    Authors: Janelle Applequist, Cristina Burroughs, Artemio Ramirez Jr, Peter A. Merkel, Marc E. Rothenberg, Bruce Trapnell, Robert J. Desnick, Mustafa Sahin and Jeffrey P. Krischer

    Citation: BMC Medical Research Methodology 2020 20:58

    Content type: Research article

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  35. The aims of this study were to assess whether the previous registration of a systematic review (SR) is associated with the improvement of the quality of the report of SRs and whether SR registration reduced ou...

    Authors: Mateus Bertolini Fernandes dos Santos, Bernardo Antônio Agostini, Rafaela Bassani, Gabriel Kalil Rocha Pereira and Rafael Sarkis-Onofre

    Citation: BMC Medical Research Methodology 2020 20:57

    Content type: Research article

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  36. Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood mental health disorders. Stimulant drugs as the most commonly used treatment and first-line therapy for ADHD have side effect...

    Authors: Hoda Shirafkan, Javad Mahmoudi-Gharaei, Akbar Fotouhi, Seyyed Ali Mozaffarpur, Mehdi Yaseri and Mostafa Hoseini

    Citation: BMC Medical Research Methodology 2020 20:56

    Content type: Research article

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  37. Single time-point assessments of psychological distress are often used to indicate chronic mental health problems, but the validity of this approach is unclear. The aims of this study were to investigate how a...

    Authors: J. Welsh, R. J. Korda, E. Banks, L. Strazdins, G. Joshy and P. Butterworth

    Citation: BMC Medical Research Methodology 2020 20:55

    Content type: Research article

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  38. Claims-based algorithms are commonly used to identify sepsis in health services research because the laboratory features required to define clinical criteria may not be available in administrative data.

    Authors: John P. Donnelly, Yuling Dai, Lisandro D. Colantonio, Hong Zhao, Monika M. Safford, John W. Baddley, Paul Muntner and Henry E. Wang

    Citation: BMC Medical Research Methodology 2020 20:54

    Content type: Research article

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  39. Studies examining incident heart failure (HF) have been limited to select populations. To examine incident HF with broader generalizability, there is need to assemble a HF-free cohort using a geographically-di...

    Authors: Parag Goyal, Matthew T. Mefford, Ligong Chen, Madeline R. Sterling, Raegan W. Durant, Monika M. Safford and Emily B. Levitan

    Citation: BMC Medical Research Methodology 2020 20:53

    Content type: Research article

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  40. In composing multi-thematic questionnaires for the Lolland-Falster Health Study (LOFUS), we faced a range of challenges, for which we found limited guidance in the literature. LOFUS is a household-based popula...

    Authors: Cecilie Lindström Egholm, Aake Packness, Jakob Stokholm, Knud Rasmussen, Christina Ellervik, Erik Simonsen, Anne Illemann Christensen and Randi Jepsen

    Citation: BMC Medical Research Methodology 2020 20:52

    Content type: Commentary

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  41. The health regulatory focus is an application of Higgins’ regulatory focus theory to a health-specific context. It explains individual differences in health motivation, strategies, and behavior. Previous resea...

    Authors: Bjarne Schmalbach, Markus Zenger, Elmar Brähler and Katja Petrowski

    Citation: BMC Medical Research Methodology 2020 20:51

    Content type: Research article

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  42. Longitudinal randomized controlled trials (RCTs) often aim to test and measure the effect of treatment between arms at a single time point. A two-sample χ2 test is a common statistical approach when outcome data ...

    Authors: Mary L. Miller, Denise J. Roe, Chengcheng Hu and Melanie L. Bell

    Citation: BMC Medical Research Methodology 2020 20:50

    Content type: Research article

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  43. Missing participant outcome data (MOD) are ubiquitous in systematic reviews with network meta-analysis (NMA) as they invade from the inclusion of clinical trials with reported participant losses. There are ava...

    Authors: Loukia M. Spineli and Chrysostomos Kalyvas

    Citation: BMC Medical Research Methodology 2020 20:48

    Content type: Research article

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  44. Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention. This is a particular risk in rehabilitation studies where it is ea...

    Authors: K. Robinson, F. Allen, J. Darby, C. Fox, A. L. Gordon, J. C. Horne, P. Leighton, E. Sims and P. A. Logan

    Citation: BMC Medical Research Methodology 2020 20:46

    Content type: Debate

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  45. Biosocial survey data are in high demand, yet little is known about the measurement quality of health measures collected by nurses in respondents’ homes. Our objective was to analyze the degree to which nurses...

    Authors: Alexandru Cernat and Joseph W. Sakshaug

    Citation: BMC Medical Research Methodology 2020 20:45

    Content type: Research article

    Published on:

  46. Incomplete data are of particular important influence in mental measurement questionnaires. Most experts, however, mostly focus on clinical trials and cohort studies and generally pay less attention to this de...

    Authors: Xueying Xu, Leizhen Xia, Qimeng Zhang, Shaoning Wu, Mingcheng Wu and Hongbo Liu

    Citation: BMC Medical Research Methodology 2020 20:42

    Content type: Research article

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  47. In the original publication of this article [1], the incorrect causal diagram was submitted as Fig. 1.

    Authors: Myra B. McGuinness, Jessica Kasza, Amalia Karahalios, Robyn H. Guymer, Robert P. Finger and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2020 20:40

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2019 19:223

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