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  1. Content type: Research article

    The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and ...

    Authors: Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Anders Helles Carlsen and Peter Vedsted

    Citation: BMC Medical Research Methodology 2017 17:74

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  2. Content type: Technical advance

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Authors: Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    Citation: BMC Medical Research Methodology 2017 17:76

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  3. Content type: Research article

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Authors: Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    Citation: BMC Medical Research Methodology 2017 17:73

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  4. Content type: Research article

    Evaluation of the potential effectiveness of a programme’s objectives (health or otherwise) is important in demonstrating how programmes work. However, evaluations are expensive and can focus on unrealistic ou...

    Authors: Melissa Belford, Tony Robertson and Ruth Jepson

    Citation: BMC Medical Research Methodology 2017 17:70

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  5. Content type: Research article

    In studies of recurrent events, it is common to consider a person who has suffered a disease episode and received curative treatment to be not at risk of suffering a new episode for a duration of time. It is a...

    Authors: Yin-Bun Cheung, Ying Xu, Matthew Cairns and Paul Milligan

    Citation: BMC Medical Research Methodology 2017 17:72

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  6. Content type: Research article

    Over the past decade, there have been substantial changes in landline and mobile phone ownership, with a substantial increase in the proportion of mobile-only households. Estimates of daily smoking rates for t...

    Authors: Joseph Hanna, Damien V. Cordery, David G. Steel, Walter Davis and Timothy C. Harrold

    Citation: BMC Medical Research Methodology 2017 17:65

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  7. Content type: Research article

    Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to i...

    Authors: Navjot Kaur, Ben Porter, Cynthia A. LeardMann, Laura E. Tobin, Hector Lemus and David D. Luxton

    Citation: BMC Medical Research Methodology 2017 17:69

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  8. Content type: Research article

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Authors: Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    Citation: BMC Medical Research Methodology 2017 17:66

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  9. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  10. Content type: Research article

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Authors: Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    Citation: BMC Medical Research Methodology 2017 17:68

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  11. Content type: Research article

    The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...

    Authors: Suman Kundu, Madhu Mazumdar and Bart Ferket

    Citation: BMC Medical Research Methodology 2017 17:63

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  12. Content type: Research article

    Systematic reviews (SRs) are an important source of information about healthcare interventions. A key component of a well-conducted SR is a comprehensive literature search. There is limited evidence on the con...

    Authors: Lisa Hartling, Robin Featherstone, Megan Nuspl, Kassi Shave, Donna M. Dryden and Ben Vandermeer

    Citation: BMC Medical Research Methodology 2017 17:64

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  13. Content type: Research article

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Authors: Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    Citation: BMC Medical Research Methodology 2017 17:62

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  14. Content type: Study protocol

    Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This wa...

    Authors: Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M. Gross, Soo Downe, Zarko Alfirevic and Declan Devane

    Citation: BMC Medical Research Methodology 2017 17:61

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  15. Content type: Research article

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    Authors: M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    Citation: BMC Medical Research Methodology 2017 17:60

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  16. Content type: Research article

    The collection of routine clinical data in the setting of research registries can serve an important role in understanding real world care. However, relatively little is known about the patient experience in r...

    Authors: Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Michelle Frits, Christine Iannaccone, Agnes Zak and Joshua R. Korzenik

    Citation: BMC Medical Research Methodology 2017 17:59

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  17. Content type: Research article

    Participant recruitment is an ongoing challenge in health research. Recruitment may be especially difficult for studies of access to health care because, even among those who are in care, people using services...

    Authors: Christopher J. Miller, James F. Burgess Jr., Ellen P. Fischer, Deborah J. Hodges, Lindsay K. Belanger, Jessica M. Lipschitz, Siena R. Easley, Christopher J. Koenig, Regina L. Stanley and Jeffrey M. Pyne

    Citation: BMC Medical Research Methodology 2017 17:57

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  18. Content type: Research article

    Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual’s absolute risk on stroke onset. However, several widely accepted risk factors for stroke were no...

    Authors: Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu and Jiayin Zheng

    Citation: BMC Medical Research Methodology 2017 17:58

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  19. Content type: Research article

    Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from vario...

    Authors: Bethany Shinkins, Yaling Yang, Lucy Abel and Thomas R. Fanshawe

    Citation: BMC Medical Research Methodology 2017 17:56

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  20. Content type: Research Article

    Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for...

    Authors: Ralph Brinks, Annika Hoyer, Deborah B. Rolka, Oliver Kuss and Edward W. Gregg

    Citation: BMC Medical Research Methodology 2017 17:54

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  21. Content type: Research article

    ROC (receiver operating characteristic) curve analysis is well established for assessing how well a marker is capable of discriminating between individuals who experience disease onset and individuals who do n...

    Authors: Adina Najwa Kamarudin, Trevor Cox and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2017 17:53

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  22. Content type: Correspondence

    Obesity and obesity-related conditions, such as type 2 diabetes, are a major issue for Veteran health. Veterans Health Administration (VA) researchers and health systems leaders have worked separately and toge...

    Authors: Mona AuYoung, Laura J. Damschroder, Linda Kinsinger, Tannaz Moin and Caroline R. Richardson

    Citation: BMC Medical Research Methodology 2017 17:50

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  23. Content type: Research article

    The effects of postal questionnaire burden on return rates and answers given are unclear following treatment on an intensive care unit (ICU). We aimed to establish the effects of different postal questionnaire...

    Authors: Robert Hatch, Duncan Young, Vicki Barber, David A Harrison and Peter Watkinson

    Citation: BMC Medical Research Methodology 2017 17:49

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  24. Content type: Research article

    Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making. It is recommended that authors assess and rep...

    Authors: Michelle Pollock, Ricardo M. Fernandes and Lisa Hartling

    Citation: BMC Medical Research Methodology 2017 17:48

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  25. Content type: Research article

    Vision influences functioning and disability of children with cerebral palsy, so there is a growing need for psychometrically robust tools to advance assessment of children’s vision abilities in clinical pract...

    Authors: Belinda Deramore Denver, Margareta Adolfsson, Elspeth Froude, Peter Rosenbaum and Christine Imms

    Citation: BMC Medical Research Methodology 2017 17:46

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  26. Content type: Research article

    Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent ...

    Authors: George J. Knafl, Kathleen A. Knafl, Margaret Grey, Jane Dixon, Janet A. Deatrick and Agatha M. Gallo

    Citation: BMC Medical Research Methodology 2017 17:45

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  27. Content type: Research article

    Meta-analysis is very useful to summarize the effect of a treatment or a risk factor for a given disease. Often studies report results based on log-transformed variables in order to achieve the principal assum...

    Authors: Miguel Rodríguez-Barranco, Aurelio Tobías, Daniel Redondo, Elena Molina-Portillo and María José Sánchez

    Citation: BMC Medical Research Methodology 2017 17:44

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:91

  28. Content type: Correspondence

    With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to h...

    Authors: Roy Eagleson, Luis Altamirano-Diaz, Alex McInnis, Eva Welisch, Stefanie De Jesus, Harry Prapavessis, Meghan Rombeek, Jamie A. Seabrook, Teresa Park and Kambiz Norozi

    Citation: BMC Medical Research Methodology 2017 17:43

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  29. Content type: Research article

    Propensity scores are typically applied in retrospective cohort studies. We describe the feasibility of matching on a propensity score derived from a retrospective cohort and subsequently applied in a prospect...

    Authors: Eric S. Johnson, John F. Dickerson, William M. Vollmer, Alee M. Rowley, Cheryl Ritenbaugh, Richard A. Deyo and Lynn DeBar

    Citation: BMC Medical Research Methodology 2017 17:42

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  30. Content type: Research article

    Reporting of adverse events in randomized clinical trials (RCTs) is encouraged by the authors of The Consolidated Standards of Reporting Trials (CONSORT) statement. With robust methodological design and adequa...

    Authors: Lindsay M. Gorrell, Roger M. Engel, Reidar P. Lystad and Benjamin T. Brown

    Citation: BMC Medical Research Methodology 2017 17:41

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  31. Content type: Research article

    Sample selection can substantially affect the solutions generated using exploratory factor analysis. Validation studies of the 12-item World Health Organization (WHO) Disability Assessment Schedule 2.0 (WHODAS...

    Authors: Cadeyrn J. Gaskin, Sylvie D. Lambert, Steven J. Bowe and Liliana Orellana

    Citation: BMC Medical Research Methodology 2017 17:40

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  32. Content type: Research article

    Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded...

    Authors: Jørn Wetterslev, Janus Christian Jakobsen and Christian Gluud

    Citation: BMC Medical Research Methodology 2017 17:39

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  33. Content type: Research article

    Proliferation of terms describing the science of effectively promoting and supporting the use of research evidence in healthcare policy and practice has hampered understanding and development of the field. To ...

    Authors: Peter Bragge, Jeremy M. Grimshaw, Cynthia Lokker and Heather Colquhoun

    Citation: BMC Medical Research Methodology 2017 17:38

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  34. Content type: Research article

    The aim was to review the literature to identify the most effective methods for creating a representative sample of refugee and asylum seeker groups living in the community to participate in health and mental ...

    Authors: Joanne C. Enticott, Frances Shawyer, Shiva Vasi, Kimberly Buck, I-Hao Cheng, Grant Russell, Ritsuko Kakuma, Harry Minas and Graham Meadows

    Citation: BMC Medical Research Methodology 2017 17:37

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  35. Content type: Research article

    The development of Electronic Health Records (EHRs) in hospitals offers the ability to reuse data from patient care activities for clinical research. EHR4CR is a European public-private partnership aiming to d...

    Authors: Yannick Girardeau, Justin Doods, Eric Zapletal, Gilles Chatellier, Christel Daniel, Anita Burgun, Martin Dugas and Bastien Rance

    Citation: BMC Medical Research Methodology 2017 17:36

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  36. Content type: Research article

    The most rigorous method for evaluating the effectiveness of diagnostic tests is through randomised trials that compare test-treatment interventions: complex interventions comprising episodes of testing, decis...

    Authors: Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Sian Taylor-Phillips, Clare Davenport, Chris Hyde and Jonathan J. Deeks

    Citation: BMC Medical Research Methodology 2017 17:32

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  37. Content type: Research article

    There is a growing recognition for the need to expand our evidence base for the clinical effectiveness of diagnostic tests. Many international bodies are calling for diagnostic randomized controlled trials to ...

    Authors: Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Alice J. Sitch, Chris Hyde and Jonathan J. Deeks

    Citation: BMC Medical Research Methodology 2017 17:35

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  38. Content type: Research Article

    When developing risk models for binary data with small or sparse data sets, the standard maximum likelihood estimation (MLE) based logistic regression faces several problems including biased or infinite estima...

    Authors: M. Shafiqur Rahman and Mahbuba Sultana

    Citation: BMC Medical Research Methodology 2017 17:33

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  39. Content type: Research article

    In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connectin...

    Authors: Ka Chun Chong, Benny Chung Ying Zee and Maggie Haitian Wang

    Citation: BMC Medical Research Methodology 2017 17:31

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  40. Content type: Research article

    There is a need for improving cohort retention in longitudinal studies. Our objective was to identify cohort retention strategies and implementation approaches used in studies with high retention rates.

    Authors: Martha Abshire, Victor D. Dinglas, Maan Isabella A. Cajita, Michelle N. Eakin, Dale M. Needham and Cheryl Dennison Himmelfarb

    Citation: BMC Medical Research Methodology 2017 17:30

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  41. Content type: Research article

    In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual ...

    Authors: Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    Citation: BMC Medical Research Methodology 2017 17:29

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  42. Content type: Research article

    Individual patient data meta-analyses (IPD-MA) are often performed using a one-stage approach-- a form of generalized linear mixed model (GLMM) for binary outcomes. We compare (i) one-stage to two-stage approa...

    Authors: Doneal Thomas, Robert Platt and Andrea Benedetti

    Citation: BMC Medical Research Methodology 2017 17:28

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  43. Content type: Research Article

    Information and theory beyond copula concepts are essential to understand the dependence relationship between several marginal covariates distributions. In a therapeutic trial data scheme, most of the time, ce...

    Authors: Charles Fontaine, Jean-Pierre Daurès and Paul Landais

    Citation: BMC Medical Research Methodology 2017 17:27

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  44. Content type: Research article

    In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness remains sparse. This mixed-methods study aimed to evalua...

    Authors: Belinda von Niederhäusern, Annette Orleth, Sabine Schädelin, Nawal Rawi, Martin Velkopolszky, Claudia Becherer, Pascal Benkert, Priya Satalkar, Matthias Briel and Christiane Pauli-Magnus

    Citation: BMC Medical Research Methodology 2017 17:26

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