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  1. Bayesian adaptive methods are increasingly being used to design clinical trials and offer several advantages over traditional approaches. Decisions at analysis points are usually based on the posterior distrib...

    Authors: Elizabeth G. Ryan, Kristian Brock, Simon Gates and Daniel Slade

    Citation: BMC Medical Research Methodology 2020 20:150

    Content type: Research article

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  2. Evidence on the effectiveness of postal recruitment methods for Indigenous peoples is lacking. Mayi Kuwayu, the National Study of Aboriginal and Torres Strait Islander Wellbeing, uses multi-staged sampling. We...

    Authors: Alyson Wright, Katherine Ann Thurber, Mandy Yap, Wei Du, Emily Banks, Jennie Walker, Faye Irwin, Will Sanders and Raymond Lovett

    Citation: BMC Medical Research Methodology 2020 20:149

    Content type: Research article

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  3. Missing data is a common problem in epidemiological studies, while it becomes more critical, when the missing data concern a multi-item instrument, since lack of information in even one of its items, leads to the...

    Authors: Thomas Tsiampalis and Demosthenes B. Panagiotakos

    Citation: BMC Medical Research Methodology 2020 20:148

    Content type: Research article

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  4. Stratification analyses have been widely utilized in molecular association meta-analyses to estimate the interaction between genetic and environmental factors or to control for the confounding variables linked...

    Authors: Shuhuang Lin, Yukun Ma and Zunnan Huang

    Citation: BMC Medical Research Methodology 2020 20:147

    Content type: Technical advance

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  5. Despite widespread use, the accuracy of the diagnostic test for SARS-CoV-2 infection is poorly understood. The aim of our work was to better quantify misclassification errors in identification of true cases of...

    Authors: Igor Burstyn, Neal D. Goldstein and Paul Gustafson

    Citation: BMC Medical Research Methodology 2020 20:146

    Content type: Research article

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  6. The change in two measurements of a continuous outcome can be modelled directly with a linear regression model, or indirectly with a random effects model (REM) of the individual measurements. These methods are...

    Authors: Yilin Ning, Nathalie C. Støer, Peh Joo Ho, Shih Ling Kao, Kee Yuan Ngiam, Eric Yin Hao Khoo, Soo Chin Lee, E-Shyong Tai, Mikael Hartman, Marie Reilly and Chuen Seng Tan

    Citation: BMC Medical Research Methodology 2020 20:145

    Content type: Research article

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  7. Person-environment fit, which examines the individual’s perceptions of if, and in what way, he or she is compatible with aspects of the work context, offers a promising conceptual model for understanding emplo...

    Authors: J. Herkes, L. A. Ellis, K. Churruca and J. Braithwaite

    Citation: BMC Medical Research Methodology 2020 20:144

    Content type: Research article

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  9. Although null hypothesis significance testing (NHST) is the agreed gold standard in medical decision making and the most widespread inferential framework used in medical research, it has several drawbacks. Bay...

    Authors: Riko Kelter

    Citation: BMC Medical Research Methodology 2020 20:142

    Content type: Software

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  11. There is a growing trend in using the “statistically significant” term in the scientific literature. However, harsh criticism of this concept motivated the recommendation to withdraw its use of scientific publ...

    Authors: Fredi Alexander Diaz-Quijano, Fernando Morelli Calixto and José Mário Nunes da Silva

    Citation: BMC Medical Research Methodology 2020 20:140

    Content type: Research article

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  12. We investigated the feasibility of using a machine learning tool’s relevance predictions to expedite title and abstract screening.

    Authors: Allison Gates, Michelle Gates, Meghan Sebastianski, Samantha Guitard, Sarah A. Elliott and Lisa Hartling

    Citation: BMC Medical Research Methodology 2020 20:139

    Content type: Research article

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  13. When conducting an Overviews of Reviews on health-related topics, it is unclear which combination of bibliographic databases authors should use for searching for SRs. Our goal was to determine which databases ...

    Authors: Käthe Goossen, Simone Hess, Carole Lunny and Dawid Pieper

    Citation: BMC Medical Research Methodology 2020 20:138

    Content type: Research article

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  14. Publication and related biases (including publication bias, time-lag bias, outcome reporting bias and p-hacking) have been well documented in clinical research, but relatively little is known about their prese...

    Authors: Abimbola A. Ayorinde, Iestyn Williams, Russell Mannion, Fujian Song, Magdalena Skrybant, Richard J. Lilford and Yen-Fu Chen

    Citation: BMC Medical Research Methodology 2020 20:137

    Content type: Research article

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  15. Continuous reference intervals (RIs) allow for more precise consideration of the dynamic changes of physiological development, which can provide new strategies for the presentation of laboratory test results. ...

    Authors: Kun Li, Lixin Hu, Yaguang Peng, Ruohua Yan, Qiliang Li, Xiaoxia Peng, Wenqi Song and Xin Ni

    Citation: BMC Medical Research Methodology 2020 20:136

    Content type: Research article

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  16. Observational longitudinal data often feature irregular, informative visit times. We propose descriptive measures to quantify the extent of irregularity to select an appropriate analytic outcome approach.

    Authors: Armend Lokku, Lily S. Lim, Catherine S. Birken and Eleanor M. Pullenayegum

    Citation: BMC Medical Research Methodology 2020 20:135

    Content type: Research article

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  17. Missing data in covariates can result in biased estimates and loss of power to detect associations. It can also lead to other challenges in time-to-event analyses including the handling of time-varying effects...

    Authors: Orlagh U. Carroll, Tim P. Morris and Ruth H. Keogh

    Citation: BMC Medical Research Methodology 2020 20:134

    Content type: Research Article

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  18. Too often, studies of evidence-based interventions (EBIs) in preventive, community, and health care are not sufficiently useful to end users (typically practitioners, patients, policymakers, or other researche...

    Authors: Henna Hasson, Laura Leviton and Ulrica von Thiele Schwarz

    Citation: BMC Medical Research Methodology 2020 20:133

    Content type: Debate

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  19. Propensity scores are widely used to deal with confounding bias in medical research. An incorrectly specified propensity score model may lead to residual confounding bias; therefore it is essential to use diag...

    Authors: Emily Granger, Tim Watkins, Jamie C. Sergeant and Mark Lunt

    Citation: BMC Medical Research Methodology 2020 20:132

    Content type: Research article

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  21. Cross-cultural research with patient-reported outcomes measures (PROMs) assumes that the PROM in the target language will measure the same construct in the same way as the PROM in the source language. Yet tran...

    Authors: Melanie Hawkins, Christina Cheng, Gerald R. Elsworth and Richard H. Osborne

    Citation: BMC Medical Research Methodology 2020 20:130

    Content type: Research article

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  22. Evidence-based health care is informed by results of randomized clinical trials (RCTs) and their syntheses in meta-analyses. When the trial outcomes measured are not clearly described in trial publications, kn...

    Authors: Andrea Monsour, Emma J. Mew, Sagar Patel, Alyssandra Chee-a-tow, Leena Saeed, Lucia Santos, Darren B. Courtney, Priya N. Watson, Suneeta Monga, Peter Szatmari, Martin Offringa and Nancy J. Butcher

    Citation: BMC Medical Research Methodology 2020 20:129

    Content type: Research article

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  23. Elderly population’s health is a major concern for most industrial nations. National health surveys provide a measure of the state of elderly health. One such survey is the Chinese Longitudinal Healthy Longevi...

    Authors: Elsa Vazquez-Arreola, Dan Xue and Jeffrey R. Wilson

    Citation: BMC Medical Research Methodology 2020 20:128

    Content type: Research article

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  24. Recent changes in communication technologies, including increased reliance on mobile phones and the internet, may present challenges and/or opportunities to re-engaging inactive study cohorts. We evaluate our ...

    Authors: Gareth Lingham, David A. Mackey, Nicola Seed, Lisa Ryan, Elizabeth Milne, Robyn M. Lucas, Maria Franchina, Samantha Sze-Yee Lee and Seyhan Yazar

    Citation: BMC Medical Research Methodology 2020 20:127

    Content type: Research article

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  26. Effective health care requires services that are responsive to local needs and contexts. Achieving this in indigenous settings implies communication between traditional and conventional medicine perspectives. ...

    Authors: Ivan Sarmiento, Sergio Paredes-Solís, David Loutfi, Anna Dion, Anne Cockcroft and Neil Andersson

    Citation: BMC Medical Research Methodology 2020 20:125

    Content type: Research article

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  27. As technology is advancing, so are the possibilities for new data collection methods in research, potentially improving data quality and validity of the results. In Sweden, a system using frequent repeated dat...

    Authors: I. Axén, I. Jensen, E. Butler Forslund, B. Grahn, V. Jørgensen, C. H. Opava and L. Bodin

    Citation: BMC Medical Research Methodology 2020 20:124

    Content type: Research article

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  28. Patient participation in cancer clinical trials is suboptimal. A challenge to capturing physicians’ insights about trials has been low response to surveys. We conducted a study using varying combinations of ma...

    Authors: Caitlin C. Murphy, Simon J. Craddock Lee, Ann M. Geiger, John V. Cox, Chul Ahn, Rasmi Nair, David E. Gerber, Ethan A. Halm, Katharine McCallister and Celette Sugg Skinner

    Citation: BMC Medical Research Methodology 2020 20:123

    Content type: Research article

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  29. Peer review is at the heart of the scientific process. With the advent of digitisation, journals started to offer electronic articles or publishing online only. A new philosophy regarding the peer review proce...

    Authors: Oliver Rudolf HERBER, Caroline BRADBURY-JONES, Susanna BÖLING, Sarah COMBES, Julian HIRT, Yvonne KOOP, Ragnhild NYHAGEN, Jessica D. VELDHUIZEN and Julie TAYLOR

    Citation: BMC Medical Research Methodology 2020 20:122

    Content type: Research article

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  30. A crucial element in the systematic review (SR) methodology is the appraisal of included primary studies, using tools for assessment of methodological quality or risk of bias (RoB). SR authors can conduct sens...

    Authors: Marija Franka Marušić, Mahir Fidahić, Cristina Mihaela Cepeha, Loredana Gabriela Farcaș, Alexandra Tseke and Livia Puljak

    Citation: BMC Medical Research Methodology 2020 20:121

    Content type: Research article

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  31. Cancer patients have to undergo a difficult medical therapy and are also confronted with various psychological, social and economic problems. Support is available from many providers, but patients often gain n...

    Authors: Nico Schneider, Anna Bäcker, Katja Brenk-Franz, Christian Keinki, Jutta Hübner, Florian Brandt, Geraldine von der Winkel, Lutz Hager, Bernhard Strauss and Uwe Altmann

    Citation: BMC Medical Research Methodology 2020 20:120

    Content type: Study protocol

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  32. Efforts to improve informed consent have led to calls for providing information a reasonable person would want to have, in a way that facilitates understanding of the reasons why one might or might not want to...

    Authors: Laura M. Beskow, Catherine M. Hammack-Aviran and Kathleen M. Brelsford

    Citation: BMC Medical Research Methodology 2020 20:119

    Content type: Research article

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  33. Health-related quality of life (HRQoL) is often measured using EQ-5D-3L by the elicitation methods of visual analogue scale (VAS) and time trade-off (TTO). Although many countries have constructed both nationa...

    Authors: Xiuying Wang, Lin Zhuo, Yifei Ma, Ting Cai, Aviva Must, Ling Xu and Lang Zhuo

    Citation: BMC Medical Research Methodology 2020 20:118

    Content type: Research article

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  34. A nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and ...

    Authors: Christopher Partlett, Nigel J. Hall, Alison Leaf, Edmund Juszczak and Louise Linsell

    Citation: BMC Medical Research Methodology 2020 20:117

    Content type: Research article

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  35. The COVID-19 pandemic has evolved into one of the most impactful health crises in modern history, compelling researchers to explore innovative ways to efficiently collect public health data in a timely manner....

    Authors: Shahmir H. Ali, Joshua Foreman, Ariadna Capasso, Abbey M. Jones, Yesim Tozan and Ralph J. DiClemente

    Citation: BMC Medical Research Methodology 2020 20:116

    Content type: Research article

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  36. Rapid reviews (RRs) have emerged as an efficient alternative to time-consuming systematic reviews—they can help meet the demand for accelerated evidence synthesis to inform decision-making in healthcare. The s...

    Authors: Ingrid Arevalo-Rodriguez, Karen R. Steingart, Andrea C. Tricco, Barbara Nussbaumer-Streit, David Kaunelis, Pablo Alonso-Coello, Susan Baxter, Patrick M. Bossuyt, José Ignacio Emparanza and Javier Zamora

    Citation: BMC Medical Research Methodology 2020 20:115

    Content type: Research article

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  37. Enrolment in a research study requires the participant’s informed consent. In the case of minors, informed consent of the respective legal guardian is obtained in conjunction with informed assent of the undera...

    Authors: Dominik Soll, Maria Magdalena Guraiib, Nigel Campbell Rollins and Andreas Alois Reis

    Citation: BMC Medical Research Methodology 2020 20:114

    Content type: Research article

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  38. Shifts in data sharing policy have increased researchers’ access to individual participant data (IPD) from clinical studies. Simultaneously the number of IPD meta-analyses (IPDMAs) is increasing. However, rate...

    Authors: Matthew Ventresca, Holger J. Schünemann, Fergus Macbeth, Mike Clarke, Lehana Thabane, Gareth Griffiths, Simon Noble, David Garcia, Maura Marcucci, Alfonso Iorio, Qi Zhou, Mark Crowther, Elie A. Akl, Gary H. Lyman, Viktoria Gloy, Marcello DiNisio…

    Citation: BMC Medical Research Methodology 2020 20:113

    Content type: Research article

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  39. While randomised controlled trials (RCTs) provide high-quality evidence to guide practice, much routine care is not based upon available RCTs. This disconnect between evidence and practice is not sufficiently ...

    Authors: Ben E. Byrne, Leila Rooshenas, Helen S. Lambert and Jane M. Blazeby

    Citation: BMC Medical Research Methodology 2020 20:112

    Content type: Research article

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  40. Alcohol use disorder (AUD) is highly prevalent and presents a large treatment gap. Self-help internet interventions are an attractive approach to lowering thresholds for seeking help and disseminating evidence...

    Authors: Philip Lindner, Magnus Johansson, Mikael Gajecki and Anne H. Berman

    Citation: BMC Medical Research Methodology 2020 20:111

    Content type: Research article

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  41. Health experts including planners and policy-makers face complex decisions in diverse and constantly changing healthcare systems. Visual analytics may play a critical role in supporting analysis of complex hea...

    Authors: Erin I. Walsh, Younjin Chung, Nicolas Cherbuin and Luis Salvador-Carulla

    Citation: BMC Medical Research Methodology 2020 20:110

    Content type: Research article

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  43. Machine learning (ML) has made a significant impact in medicine and cancer research; however, its impact in these areas has been undeniably slower and more limited than in other application domains. A major re...

    Authors: Andre Goncalves, Priyadip Ray, Braden Soper, Jennifer Stevens, Linda Coyle and Ana Paula Sales

    Citation: BMC Medical Research Methodology 2020 20:108

    Content type: Research Article

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  44. Most structured clinical data, such as diagnosis codes, are not sufficient to obtain precise phenotypes and assess disease burden. Text mining of clinical notes could provide a basis for detailed profiles of p...

    Authors: Freja Karuna Hemmingsen Sørup, Søren Brunak and Robert Eriksson

    Citation: BMC Medical Research Methodology 2020 20:107

    Content type: Research article

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  45. Synthesis of psychometric properties of substance use measures to identify patterns of use and substance use disorders remains limited. To address this gap, we sought to systematically evaluate the psychometri...

    Authors: Glenn-Milo Santos, Steffanie A. Strathdee, Nabila El-Bassel, Poonam Patel, Divya Subramanian, Danielle Horyniak, Ryan R. Cook, Charlotte McCullagh, Phillip Marotta, Foram Choksi, Brian Kang, Isabel Allen and Steven Shoptaw

    Citation: BMC Medical Research Methodology 2020 20:106

    Content type: Research article

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  46. The objective of this study was to assess the overall quality of study-level meta-analyses in high-ranking journals using commonly employed guidelines and standards for systematic reviews and meta-analyses.

    Authors: Irbaz Hameed, Michelle Demetres, Derrick Y. Tam, Mohamed Rahouma, Faiza M. Khan, Drew N. Wright, Keith Mages, Antonio P. DeRosa, Becky Baltich Nelson, Kevin Pain, Diana Delgado, Leonard N. Girardi, Stephen E. Fremes and Mario Gaudino

    Citation: BMC Medical Research Methodology 2020 20:105

    Content type: Research article

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  47. Sum scores of ordinal outcomes are common in randomized clinical trials. The approaches routinely employed for assessing treatment effects, such as t-tests or Wilcoxon tests, are not particularly powerful in dete...

    Authors: Muriel Buri, Armin Curt, John Steeves and Torsten Hothorn

    Citation: BMC Medical Research Methodology 2020 20:104

    Content type: Research Article

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  48. Due to limited duration of follow up in clinical trials of cancer treatments, estimates of lifetime survival benefits are typically derived using statistical extrapolation methods. To justify the method used, ...

    Authors: Ash Bullement, Anna Willis, Amerah Amin, Michael Schlichting, Anthony James Hatswell and Murtuza Bharmal

    Citation: BMC Medical Research Methodology 2020 20:103

    Content type: Research article

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  49. To demonstrate how the Observational Healthcare Data Science and Informatics (OHDSI) collaborative network and standardization can be utilized to scale-up external validation of patient-level prediction models...

    Authors: Jenna M. Reps, Ross D. Williams, Seng Chan You, Thomas Falconer, Evan Minty, Alison Callahan, Patrick B. Ryan, Rae Woong Park, Hong-Seok Lim and Peter Rijnbeek

    Citation: BMC Medical Research Methodology 2020 20:102

    Content type: Research article

    Published on:

  50. The co-occurrence of two or more medical conditions in the same individual is not uncommon. If disability-adjusted life year (DALY) calculations are carried out for each condition separately, multimorbidity ma...

    Authors: Scott A. McDonald, Juanita A. Haagsma, Alessandro Cassini and Brecht Devleesschauwer

    Citation: BMC Medical Research Methodology 2020 20:100

    Content type: Research article

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