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  1. Attrition due to death and non-attendance are common sources of bias in studies of age-related diseases. A simulation study is presented to compare two methods for estimating the survivor average causal effect...

    Authors: Myra B. McGuinness, Jessica Kasza, Amalia Karahalios, Robyn H. Guymer, Robert P. Finger and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2019 19:223

    Content type: Research article

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    The Correction to this article has been published in BMC Medical Research Methodology 2020 20:40

  2. The recent progress in medical research generates an increasing interest in the use of longitudinal biomarkers for characterizing the occurrence of an outcome. The present work is motivated by a study, where t...

    Authors: Maeregu W. Arisido, Laura Antolini, Davide P. Bernasconi, Maria G. Valsecchi and Paola Rebora

    Citation: BMC Medical Research Methodology 2019 19:222

    Content type: Research Article

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  3. To assess cross-cultural validity between Dutch and English versions of the FVQ_CYP, a patient-reported outcome measure developed in the United Kingdom (UK) for children and adolescents with (severe) visual im...

    Authors: Ellen B. M. Elsman, Valerija Tadić, Carel F. W. Peeters, Ger H. M. B. van Rens, Jugnoo S. Rahi and Ruth M. A. van Nispen

    Citation: BMC Medical Research Methodology 2019 19:221

    Content type: Research article

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  4. Exercise is an effective therapeutic intervention for cancer survivors. Concerns about the completeness of reporting of exercise interventions have been raised in the literature, but without any formal analysi...

    Authors: Jose Francisco Meneses-Echavez, Indira Rodriguez-Prieto, Mark Elkins, Javier Martínez-Torres, Lien Nguyen and Julia Bidonde

    Citation: BMC Medical Research Methodology 2019 19:220

    Content type: Research article

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  5. Within qualitative research in-person interviews have the reputation for being the highest standard of interviewer-participant encounter. However, there are other approaches to interviewing such as telephone a...

    Authors: Matthew Krouwel, Kate Jolly and Sheila Greenfield

    Citation: BMC Medical Research Methodology 2019 19:219

    Content type: Research article

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  6. Until recently a typical rule that has often been used for the endorsement of new medications by the Food and Drug Administration has been the existence of at least two statistically significant clinical trial...

    Authors: Don van Ravenzwaaij and John P. A. Ioannidis

    Citation: BMC Medical Research Methodology 2019 19:218

    Content type: Technical advance

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  7. Continuous monitoring of surgical outcomes after joint replacement is needed to detect which brands’ components have a higher than expected failure rate and are therefore no longer recommended to be used in su...

    Authors: Alexander Begun, Elena Kulinskaya and Alexander J MacGregor

    Citation: BMC Medical Research Methodology 2019 19:217

    Content type: Research Article

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  8. Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcri...

    Authors: Jong Soo Lee, Elijah Paintsil, Vivek Gopalakrishnan and Musie Ghebremichael

    Citation: BMC Medical Research Methodology 2019 19:216

    Content type: Research article

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  9. Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either ...

    Authors: Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2019 19:215

    Content type: Research article

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  10. Due to an error introduced during copyediting of this article [1], following corrections need to be made.

    Authors: R. G. Singotani, F. Karapinar, C. Brouwers, C. Wagner and M. C. de Bruijne

    Citation: BMC Medical Research Methodology 2019 19:214

    Content type: Correction

    Published on:

    The original article was published in BMC Medical Research Methodology 2019 19:189

  11. We recently introduced a system of partial differential equations (PDEs) to model the prevalence of chronic diseases with a possibly prolonged state of asymptomatic, undiagnosed disease preceding a diagnosis. ...

    Authors: Ralph Brinks, Sophie Kaufmann, Annika Hoyer, Edward W Gregg and Jürgen Saal

    Citation: BMC Medical Research Methodology 2019 19:213

    Content type: Research Article

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  12. Many population health surveys consist of a mixed-mode design that includes a face-to-face (F2F) interview followed by a paper-and-pencil (P&P) self-administered questionnaire (SAQ) for the sensitive topics. I...

    Authors: Elise Braekman, Sabine Drieskens, Rana Charafeddine, Stefaan Demarest, Finaba Berete, Lydia Gisle, Jean Tafforeau, Johan Van der Heyden and Guido Van Hal

    Citation: BMC Medical Research Methodology 2019 19:212

    Content type: Research article

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  13. Engaging those who influence, administer and/or who are active users (“knowledge users”) of health care systems, as co-producers of health research, can help to ensure that research products will better addres...

    Authors: Janet E. Jull, Laurie Davidson, Rachel Dungan, Tram Nguyen, Krista P. Woodward and Ian D. Graham

    Citation: BMC Medical Research Methodology 2019 19:211

    Content type: Research article

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  14. Large and complex population-based cancer data are becoming broadly available, thanks to purposeful linkage between cancer registry data and health electronic records. Aiming at understanding the explanatory p...

    Authors: Camille Maringe, Aurélien Belot, Francisco Javier Rubio and Bernard Rachet

    Citation: BMC Medical Research Methodology 2019 19:210

    Content type: Research article

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  15. The analysis of twin data presents a unique challenge. Second-born twins on average weigh less than first-born twins and have an elevated risk of perinatal mortality. It is not clear whether the risk differenc...

    Authors: Muhammad Abu Shadeque Mullah, James A. Hanley and Andrea Benedetti

    Citation: BMC Medical Research Methodology 2019 19:209

    Content type: Research article

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  16. Central cancer registries are often used to survey population-based samples of cancer survivors. These surveys are typically administered via paper or telephone. In most populations, web surveys obtain much lo...

    Authors: Morgan M. Millar, Joanne W. Elena, Lisa Gallicchio, Sandra L. Edwards, Marjorie E. Carter, Kimberly A. Herget and Carol Sweeney

    Citation: BMC Medical Research Methodology 2019 19:208

    Content type: Research article

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  17. Recently, there has been a heightened interest in developing and evaluating different methods for analysing observational data. This has been driven by the increased availability of large data resources such a...

    Authors: E. R. John, K. R. Abrams, C. E. Brightling and N. A. Sheehan

    Citation: BMC Medical Research Methodology 2019 19:207

    Content type: Research article

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  18. Clinical quality registries and other systems that conduct routine post-discharge surveillance of patient outcomes following surgery may have difficulty surveying patients who have limited proficiency in the l...

    Authors: Daniel Xue, Timothy Churches, Elizabeth Armstrong, Rajat Mittal, Justine Maree Naylor and Ian Andrew Harris

    Citation: BMC Medical Research Methodology 2019 19:206

    Content type: Research article

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  19. Increasing rates of long-term sickness absence are a worldwide problem. Belgium is the first country in Europe that aims to screen its entire population of sick leavers (sick leave > 6 weeks) for the risk of l...

    Authors: Kaat Goorts, Charlotte Vanovenberghe, Charlotte Lambreghts, Eline Bruneel, Dorina Rusu, Marc Du Bois, Sofie Vandenbroeck and Lode Godderis

    Citation: BMC Medical Research Methodology 2019 19:205

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:224

  20. Clinical study reports (CSRs) have been increasingly utilised within academic research in recent years. European Medicines Agency (EMA) Policy 0070 ‘Phase 1,’ which came into effect in January 2015, requires t...

    Authors: Jean-Marc Ferran and Sarah J. Nevitt

    Citation: BMC Medical Research Methodology 2019 19:204

    Content type: Research article

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  21. A standard or consensus definition of a systematic review does not exist. Therefore, if there is no definition about a systematic review in secondary studies that analyse them or the definition is too broad, i...

    Authors: Marina Krnic Martinic, Dawid Pieper, Angelina Glatt and Livia Puljak

    Citation: BMC Medical Research Methodology 2019 19:203

    Content type: Research article

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  22. It is unclear whether weighted or unweighted regression is preferred in the analysis of data derived from respondent driven sampling. Our objective was to evaluate the validity of various regression models, wi...

    Authors: Lisa Avery, Nooshin Rotondi, Constance McKnight, Michelle Firestone, Janet Smylie and Michael Rotondi

    Citation: BMC Medical Research Methodology 2019 19:202

    Content type: Research article

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  23. Longitudinal research has demonstrated that experiences of abuse and adversity are not consistently reported over time; however, there is a paucity of available evidence regarding the consistency of reporting ...

    Authors: Deborah Loxton, Jennifer Powers, Natalie Townsend, Melissa L. Harris and Peta Forder

    Citation: BMC Medical Research Methodology 2019 19:201

    Content type: Research article

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  24. New emerging diseases are public health concerns in which policy makers have to make decisions in the presence of enormous uncertainty. This is an important challenge in terms of emergency preparation requirin...

    Authors: Chawarat Rotejanaprasert, Andrew B. Lawson and Sopon Iamsirithaworn

    Citation: BMC Medical Research Methodology 2019 19:200

    Content type: Research article

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  25. The incorporation of repeated measurements into multivariable prediction research may greatly enhance predictive performance. However, the methodological possibilities vary widely and a structured overview of ...

    Authors: Joost D. J. Plate, Rutger R. van de Leur, Luke P. H. Leenen, Falco Hietbrink, Linda M. Peelen and M. J. C. Eijkemans

    Citation: BMC Medical Research Methodology 2019 19:199

    Content type: Research article

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  26. When investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interact...

    Authors: Bruno R. da Costa and Alex J. Sutton

    Citation: BMC Medical Research Methodology 2019 19:198

    Content type: Research article

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  27. In the early years of life, the benefits of parental engagement in children’s learning are well documented. Early childhood educators are a potentially effective source of support, having opportunity to engage...

    Authors: Zvezdana Petrovic, Olivia Clayton, Jan Matthews, Catherine Wade, Lina Tan, Denny Meyer, Antony Gates, Alex Almendingen and Warren Cann

    Citation: BMC Medical Research Methodology 2019 19:197

    Content type: Study protocol

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  28. Several reviews have noted shortcomings regarding the quality and reporting of network meta-analyses (NMAs). We suspect that this issue may be partially attributable to limitations in current NMA software whic...

    Authors: Audrey Béliveau, Devon J. Boyne, Justin Slater, Darren Brenner and Paul Arora

    Citation: BMC Medical Research Methodology 2019 19:196

    Content type: Software

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  29. Recruitment to health research remains a major challenge. Innovation is required to meet policy commitments to help patients take part in health research. One innovation that may help meet those policy goals i...

    Authors: Katherine Grady, Martin Gibson and Peter Bower

    Citation: BMC Medical Research Methodology 2019 19:195

    Content type: Debate

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  30. Validation studies on an ICD-10-based algorithm to identify major bleeding events are scarce, and mostly focused on positive predictive values.

    Authors: Emmanuel Oger, Marie-Anne Botrel, Catherine Juchault and Jacques Bouget

    Citation: BMC Medical Research Methodology 2019 19:194

    Content type: Research article

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  31. The importance of adjusting for cross-study heterogeneity in control group response rates when conducting network meta-analyses (NMA) was demonstrated using a case study involving a comparison of biologics for...

    Authors: Chris Cameron, Abhishek Varu, Arthur Lau, Mahdi Gharaibeh, Marcelo Paulino and Raina Rogoza

    Citation: BMC Medical Research Methodology 2019 19:193

    Content type: Research article

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  32. Locally produced generic drugs offer a cost–effective alternative to imported drugs to treat patients in Ethiopia. However, due to a lack of bioequivalence testing, additional assurance tests are needed to bui...

    Authors: Chalachew Alemayehu, Geoff Mitchell, Jane Nikles, Abraham Aseffa and Alexandra Clavarino

    Citation: BMC Medical Research Methodology 2019 19:192

    Content type: Research article

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  33. Online clinical risk prediction tools built on data from multiple cohorts are increasingly being utilized for contemporary doctor-patient decision-making and validation. This report outlines a comprehensive da...

    Authors: Johanna Tolksdorf, Michael W. Kattan, Stephen A. Boorjian, Stephen J. Freedland, Karim Saba, Cedric Poyet, Lourdes Guerrios, Amanda De Hoedt, Michael A. Liss, Robin J. Leach, Javier Hernandez, Emily Vertosick, Andrew J. Vickers and Donna P. Ankerst

    Citation: BMC Medical Research Methodology 2019 19:191

    Content type: Research article

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  34. In the original publication of this article [1], the author noted two corrections after publication.

    Authors: Maria Pufulete, Jessica Harris, Stephen Dorman, Lynn Cook, Chiara Bucciarelli-Ducci, John P. Greenwood, Richard Anderson, Rachel Brierley and Barnaby C. Reeves

    Citation: BMC Medical Research Methodology 2019 19:190

    Content type: Correction

    Published on:

    The original article was published in BMC Medical Research Methodology 2019 19:116

  35. Several literature reviews have been published focusing on the prevalence and/or preventability of hospital readmissions. To our knowledge, none focused on the different causes which have been used to evaluate...

    Authors: R. G. Singotani, F. Karapinar, C. Brouwers, C. Wagner and M. C. de Bruijne

    Citation: BMC Medical Research Methodology 2019 19:189

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Medical Research Methodology 2019 19:214

  36. The Pain Medication Questionnaire (PMQ) assesses the risk of opioid abuse in people with non-oncological chronic pain.

    Authors: Sheila Raposo Galindo, Manoel Henrique da Nóbrega Marinho, Robert J. Gatchel, Tatiana de Paula Santana da Silva, Eduardo Henrique Soares Viana, Selene Cordeiro Vasconcelos and Murilo Duarte da Costa Lima

    Citation: BMC Medical Research Methodology 2019 19:188

    Content type: Research article

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  37. When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have be...

    Authors: Camille Aupiais, Corinne Alberti, Thomas Schmitz, Olivier Baud, Moreno Ursino and Sarah Zohar

    Citation: BMC Medical Research Methodology 2019 19:187

    Content type: Research Article

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  38. Population attributable fractions (PAF) measure the proportion of disease prevalence that would be avoided in a hypothetical population, similar to the population of interest, but where a particular risk facto...

    Authors: John Ferguson, Neil O’Leary, Fabrizio Maturo, Salim Yusuf and Martin O’Donnell

    Citation: BMC Medical Research Methodology 2019 19:186

    Content type: Research article

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  39. An overarching objective in research comparing different sample groups is to ensure that the reported differences in outcomes are not affected by differences between groups in the functioning of the measuremen...

    Authors: Curt Hagquist

    Citation: BMC Medical Research Methodology 2019 19:185

    Content type: Research article

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  40. This article describes a bibliometric review of the scientific production, geographical distribution, collaboration, impact, and subject area focus of pneumonia research indexed on the Web of Science over a 15...

    Authors: José M. Ramos-Rincón, Héctor Pinargote-Celorio, Isabel Belinchón-Romero and Gregorio González-Alcaide

    Citation: BMC Medical Research Methodology 2019 19:184

    Content type: Research article

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  41. Individual participant data meta-analysis (IPD-MA) is considered the gold standard for investigating subgroup effects. Frequently used regression-based approaches to detect subgroups in IPD-MA are: meta-regres...

    Authors: Michail Belias, Maroeska M. Rovers, Johannes B. Reitsma, Thomas P. A. Debray and Joanna IntHout

    Citation: BMC Medical Research Methodology 2019 19:183

    Content type: Research article

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  42. Long-term clinical outcomes are necessary to assess the cost-effectiveness of new treatments over a lifetime horizon. Without long-term clinical trial data, current practice to extrapolate survival beyond the ...

    Authors: Shannon Cope, Dieter Ayers, Jie Zhang, Katharine Batt and Jeroen P. Jansen

    Citation: BMC Medical Research Methodology 2019 19:182

    Content type: Research article

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  43. Loneliness and social isolation are major determinants of mental wellbeing, especially among older adults. The effectiveness of interventions to address loneliness and social isolation among older adults has b...

    Authors: Janet Ige, Lynn Gibbons, Issy Bray and Selena Gray

    Citation: BMC Medical Research Methodology 2019 19:181

    Content type: Research article

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  44. The use of systematic review methods are widely recognized to be essential in the development of recommendations in clinical practice guidelines to prove their trustworthiness. The objective of this study was ...

    Authors: Chiara Trevisiol, Michela Cinquini, Aline S. C. Fabricio, Massimo Gion and Anne W. S. Rutjes

    Citation: BMC Medical Research Methodology 2019 19:180

    Content type: Research article

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  45. Health services have not provided adequate support for young people with long term health conditions to transfer from child to adult services. National Institute of Health and Care (NICE) guidance on transitio...

    Authors: Helen Eke, Astrid Janssens, Johnny Downs, Richard M. Lynn, Cornelius Ani and Tamsin Ford

    Citation: BMC Medical Research Methodology 2019 19:179

    Content type: Research article

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  46. Current methods for assessing strength of evidence prioritize the contributions of randomized controlled trials (RCTs). The objective of this study was to characterize strength of evidence (SOE) tools in recen...

    Authors: D. L. Katz, M. C. Karlsen, M. Chung, M. M. Shams-White, L. W. Green, J. Fielding, A. Saito and W. Willett

    Citation: BMC Medical Research Methodology 2019 19:178

    Content type: Research article

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  47. The use of real-world data to generate evidence requires careful assessment and validation of critical variables before drawing clinical conclusions. Prospective clinical trial data suggest that anatomic origi...

    Authors: Patricia Luhn, Deborah Kuk, Gillis Carrigan, Nathan Nussbaum, Rachael Sorg, Rebecca Rohrer, Melisa G. Tucker, Brandon Arnieri, Michael D. Taylor and Neal J. Meropol

    Citation: BMC Medical Research Methodology 2019 19:177

    Content type: Research article

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  50. Muscular dystrophies (MDs) are a group of inherited conditions characterized by progressive muscle degeneration and weakness. The rarity and heterogeneity of the population with MD have hindered therapeutic de...

    Authors: Xiaoxue Chen, Abiy Agiro, Ann S. Martin, Ann M. Lucas and Kevin Haynes

    Citation: BMC Medical Research Methodology 2019 19:174

    Content type: Research article

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