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  1. Content type: Research article

    Noncommunicable diseases represents long term medical conditions, which often puts the patients under enormous demands when following treatment, exposing them to experiencing treatment burden. The Patient Expe...

    Authors: Anne Marie Lunde Husebø, Ingvild Margreta Morken, Kristina Sundt Eriksen and Oda Karin Nordfonn

    Citation: BMC Medical Research Methodology 2018 18:147

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  2. Content type: Research article

    Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effe...

    Authors: Leila Heckel, Kate M. Gunn and Patricia M. Livingston

    Citation: BMC Medical Research Methodology 2018 18:146

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  3. Content type: Research article

    The retinal vascular tortuosity can be a potential indicator of relevant vascular and non-vascular diseases. However, the lack of a precise and standard guide for the tortuosity evaluation hinders its use for ...

    Authors: Lucía Ramos, Jorge Novo, José Rouco, Stephanie Romeo, María D. Álvarez and Marcos Ortega

    Citation: BMC Medical Research Methodology 2018 18:144

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  4. Content type: Research article

    Prognostic tools for intracerebral hemorrhage (ICH) patients are potentially useful for ascertaining prognosis and recommended in guidelines to facilitate streamline assessment and communication between provid...

    Authors: Tiago Gregório, Sara Pipa, Pedro Cavaleiro, Gabriel Atanásio, Inês Albuquerque, Paulo Castro Chaves and Luís Azevedo

    Citation: BMC Medical Research Methodology 2018 18:145

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  5. Content type: Research article

    Indices of inter-evaluator reliability are used in many fields such as computational linguistics, psychology, and medical science; however, the interpretation of resulting values and determination of appropria...

    Authors: Dylan T. Beckler, Zachary C. Thumser, Jonathon S. Schofield and Paul D. Marasco

    Citation: BMC Medical Research Methodology 2018 18:141

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  6. Content type: Debate

    Scoping reviews are a relatively new approach to evidence synthesis and currently there exists little guidance regarding the decision to choose between a systematic review or scoping review approach when synth...

    Authors: Zachary Munn, Micah D. J. Peters, Cindy Stern, Catalin Tufanaru, Alexa McArthur and Edoardo Aromataris

    Citation: BMC Medical Research Methodology 2018 18:143

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  7. Content type: Research article

    When conducting a survival analysis, researchers might consider two broad classes of models: nonparametric models and parametric models. While nonparametric models are more flexible because they make few assum...

    Authors: Jacqueline E. Rudolph, Stephen R. Cole and Jessie K. Edwards

    Citation: BMC Medical Research Methodology 2018 18:142

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  8. Content type: Research article

    Electronic diaries are increasingly used in diverse disciplines to collect momentary data on experienced feelings, cognitions, behavior and social context in real life situations. Choices to be made for an eff...

    Authors: Karin A. M. Janssens, Elisabeth H. Bos, Judith G. M. Rosmalen, Marieke C. Wichers and Harriëtte Riese

    Citation: BMC Medical Research Methodology 2018 18:140

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  9. Content type: Research article

    While red blood cell transfusion rates have declined in most Australian medical specialties, obstetric transfusion rates have instead been increasing. Obstetric transfusions are mostly linked to postpartum hae...

    Authors: Edward Jegasothy, Jillian Patterson, Deborah Randall, Tanya A. Nippita, Judy M. Simpson, David O. Irving and Jane B. Ford

    Citation: BMC Medical Research Methodology 2018 18:139

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  10. Content type: Research article

    Increasingly, collaborative participatory methods requiring open and honest interaction between a range of stakeholders are being used to improve health service delivery. To be successful these methodologies m...

    Authors: Ian Litchfield, Louise Bentham, Ann Hill, Richard J. McManus, Richard Lilford and Sheila Greenfield

    Citation: BMC Medical Research Methodology 2018 18:136

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  11. Content type: Research article

    Joint modeling is appropriate when one wants to predict the time to an event with covariates that are measured longitudinally and are related to the event. An underlying random effects structure links the surv...

    Authors: Jeffrey D. Long and James A. Mills

    Citation: BMC Medical Research Methodology 2018 18:138

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  12. Content type: Debate

    Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The...

    Authors: Dimitrios Zikos and Nailya DeLellis

    Citation: BMC Medical Research Methodology 2018 18:137

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  13. Content type: Research article

    Successful implementation and embedding of new health care practices relies on co-ordinated, collective behaviour of individuals working within the constraints of health care settings. Normalization Process Th...

    Authors: Tracy L. Finch, Melissa Girling, Carl R. May, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Clare Cook, Christopher R. Vernazza, Nicola Mackintosh, Samridh Sharma, Gaery Barbery, Jimmy Steele and Tim Rapley

    Citation: BMC Medical Research Methodology 2018 18:135

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  14. Content type: Research article

    As increasing numbers of dengue vaccines and therapeutics are in clinical development, standardized consensus clinical endpoint definitions are urgently needed to assess the efficacy of different interventions...

    Authors: Thomas Jaenisch, Kim Hendrickx, Martin Erpicum, Liane Agulto, Kay M. Tomashek, Walla Dempsey, João Bosco Siqueira, Morgan A. Marks, Michael P. Fay, Catherine Laughlin, Maina L’Azou, Yee-Sin Leo, Federico Narvaez, Remy Teyssou, Stephen J. Thomas, Hasitha Tissera…

    Citation: BMC Medical Research Methodology 2018 18:134

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  15. Content type: Research article

    Understanding and measuring implementation processes is a key challenge for implementation researchers. This study draws on Normalization Process Theory (NPT) to develop an instrument that can be applied to as...

    Authors: Tim Rapley, Melissa Girling, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Carl R. May and Tracy L. Finch

    Citation: BMC Medical Research Methodology 2018 18:133

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  16. Content type: Research article

    Efforts to improve maternal health are increasingly focused on improving the quality of care provided to women at health facilities, including the promotion of respectful care and eliminating mistreatment of w...

    Authors: Meghan A. Bohren, Joshua P. Vogel, Bukola Fawole, Ernest T. Maya, Thae Maung Maung, Mamadou Diouldé Baldé, Agnes A. Oyeniran, Modupe Ogunlade, Kwame Adu-Bonsaffoh, Nwe Oo Mon, Boubacar Alpha Diallo, Abou Bangoura, Richard Adanu, Sihem Landoulsi, A. Metin Gülmezoglu and Özge Tunçalp

    Citation: BMC Medical Research Methodology 2018 18:132

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  17. Content type: Debate

    The dominant medical and health research paradigm continues to be quantitative. While the authors sense a sea-change in opinion about mixed-method research, underpinned by two decades of highly-cited publicati...

    Authors: Frances Rapport and Jeffrey Braithwaite

    Citation: BMC Medical Research Methodology 2018 18:131

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  18. Content type: Research article

    This study aimed to introduce recursively imputed survival trees into multistate survival models (MSRIST) to analyze these types of data and to identify the prognostic factors influencing the disease progressi...

    Authors: Leili Tapak, Michael R. Kosorok, Majid Sadeghifar and Omid Hamidi

    Citation: BMC Medical Research Methodology 2018 18:129

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  19. Content type: Debate

    Using internet search engines (such as Google search) in systematic literature reviews is increasingly becoming a ubiquitous part of search methodology. In order to integrate the vast quantity of available kno...

    Authors: Marko Ćurković and Andro Košec

    Citation: BMC Medical Research Methodology 2018 18:130

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  20. Content type: Technical advance

    Network meta-analysis is an extension of the classical pairwise meta-analysis and allows to compare multiple interventions based on both head-to-head comparisons within trials and indirect comparisons across t...

    Authors: Lorenz Uhlmann, Katrin Jensen and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2018 18:128

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  21. Content type: Research article

    Hypertension remains one of the most important preventable risk factors for diseases and death. Identifying clustered patterns of modifiable lifestyle risk factors for hypertension and demographics factors rel...

    Authors: Jalileh Ghanbari, Asghar Mohammadpoorasl, Leila Jahangiry, Mahdieh Abbasalizad Farhangi, Jamileh Amirzadeh and Koen Ponnet

    Citation: BMC Medical Research Methodology 2018 18:127

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  22. Content type: Research article

    With 1 in 4 Canadian preschoolers considered overweight or obese, identifying risk factors for excess weight gain and developing effective interventions aimed at promoting healthy weights and related behaviour...

    Authors: Kathryn Walton, Tory Ambrose, Angela Annis, David WL. Ma and Jess Haines

    Citation: BMC Medical Research Methodology 2018 18:126

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  23. Content type: Study protocol

    Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and...

    Authors: Macey L. Murray, Jade Meadows, Caroline J. Doré, Andrew J. Copas, Lewis J. Haddow, Charles Lacey, Mark Jit, Kate Soldan, Kate Bennett, Michelle Tetlow, Mayura Nathan and Richard Gilson

    Citation: BMC Medical Research Methodology 2018 18:125

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  24. Content type: Study protocol

    Recent regulatory changes in the system by which premises are licensed to sell alcohol, have given health representatives a formal role in the process in England and Scotland. The degree to which local public ...

    Authors: Niamh Fitzgerald, Matt Egan, Frank de Vocht, Colin Angus, James Nicholls, Niamh Shortt, Tim Nichols, Nason Maani Hessari, Cheryl McQuire, Richard Purves, Nathan Critchlow, Andrea Mohan, Laura Mahon, Colin Sumpter and Linda Bauld

    Citation: BMC Medical Research Methodology 2018 18:123

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  25. Content type: Research article

    Biomarker-based analyses are commonly reported in observational epidemiological studies; however currently there are no specific study quality assessment tools to assist evaluation of conducted research. Accou...

    Authors: Jan Wirsching, Sophie Graßmann, Fabian Eichelmann, Laura Malin Harms, Matthew Schenk, Eva Barth, Alide Berndzen, Moses Olalekan, Leen Sarmini, Hedwig Zuberer and Krasimira Aleksandrova

    Citation: BMC Medical Research Methodology 2018 18:122

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  26. Content type: Study protocol

    Considering the targeted general practitioner-centred healthcare in Germany, general practitioners (GPs) are in the best possible position to increase awareness of all sorts of dementia, an age-related syndrom...

    Authors: Judith Tillmann, Rieke Schnakenberg, Marie-Therese Puth, Klaus Weckbecker, Johannes Just and Eva Münster

    Citation: BMC Medical Research Methodology 2018 18:124

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  27. Content type: Research article

    Data-driven population segmentation analysis utilizes data analytics to divide a heterogeneous population into parsimonious and relatively homogenous groups with similar healthcare characteristics. It is a pro...

    Authors: Shi Yan, Yu Heng Kwan, Chuen Seng Tan, Julian Thumboo and Lian Leng Low

    Citation: BMC Medical Research Methodology 2018 18:121

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  28. Content type: Research article

    Mediation analysis tests whether the relationship between two variables is explained by a third intermediate variable. We sought to describe the usage and reporting of mediation analysis with time-to-event out...

    Authors: Lauren Lapointe-Shaw, Zachary Bouck, Nicholas A. Howell, Theis Lange, Ani Orchanian-Cheff, Peter C. Austin, Noah M. Ivers, Donald A. Redelmeier and Chaim M. Bell

    Citation: BMC Medical Research Methodology 2018 18:118

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  29. Content type: Research article

    The most commonly reported outcome measure in Dupuytren disease is the extension deficit in finger joints. This study aimed to investigate the examiners’ influence on the measured difference between active and...

    Authors: Jesper Nordenskjöld, Stina Brodén and Isam Atroshi

    Citation: BMC Medical Research Methodology 2018 18:120

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  30. Content type: Research article

    Dyadic data analysis (DDA) is increasingly being used to better understand, analyze and model intra- and inter-personal mechanisms of health in various types of dyads such as husband-wife, caregiver-patient, d...

    Authors: Saman Maroufizadeh, Mostafa Hosseini, Abbas Rahimi Foroushani, Reza Omani-Samani and Payam Amini

    Citation: BMC Medical Research Methodology 2018 18:117

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  31. Content type: Research article

    A number of conceptual frameworks for patient and public involvement (PPI) in research have been published in recent years. Although some are based on empirical research and/or existing theory, in many cases t...

    Authors: David Evans, Noreen Hopewell-Kelly, Michele Kok and Jo White

    Citation: BMC Medical Research Methodology 2018 18:116

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  32. Content type: Research article

    While enrolling dyads in research studies is not uncommon, there is limited literature on the utility of different recruitment strategies and the resulting selection biases. This paper examined two recruitment...

    Authors: Hope Seib McMaster, Valerie A. Stander, Christianna S. Williams, Kelly A. Woodall, Christopher A. O’Malley, Lauren M. Bauer and Evelyn P. Davila

    Citation: BMC Medical Research Methodology 2018 18:114

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  33. Content type: Research article

    To provide empirical evidence about prevalence, reporting and handling of missing outcome data in systematic reviews with network meta-analysis and acknowledgement of their impact on the conclusions.

    Authors: Loukia M. Spineli, Juan J. Yepes-Nuñez and Holger J. Schünemann

    Citation: BMC Medical Research Methodology 2018 18:115

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  34. Content type: Technical advance

    Value of information is now recognized as a reference method in the decision process underpinning cost-effectiveness evaluation. The expected value of perfect information (EVPI) is the expected value from comp...

    Authors: Clément Bader, Sébastien Cossin, Aline Maillard and Antoine Bénard

    Citation: BMC Medical Research Methodology 2018 18:113

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  35. Content type: Research article

    Sexual desire is one of the domains of sexual function with multiple dimensions, which commonly affects men and women around the world. Classically, its assessment has been applied through self-report tools; h...

    Authors: Denisse Cartagena-Ramos, Miguel Fuentealba-Torres, Flávio Rebustini, Ana Carolina Andrade Biaggi Leite, Willyane de Andrade Alvarenga, Ricardo Alexandre Arcêncio, Rosana Aparecida Spadoti Dantas and Lucila Castanheira Nascimento

    Citation: BMC Medical Research Methodology 2018 18:109

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  36. Content type: Research article

    Conducting a systematic review requires a comprehensive bibliographic search. Comparing different search strategies is essential for choosing those that cover all useful data sources. Our aim was to develop se...

    Authors: Boris Bikbov, Norberto Perico and Giuseppe Remuzzi

    Citation: BMC Medical Research Methodology 2018 18:110

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  37. Content type: Research article

    Men are usually excluded from surveys on reproductive health as some works have cast doubts on their ability to accurately report information on reproduction. Recent papers challenged this viewpoint, arguing t...

    Authors: Soraya Belgherbi and Elise de La Rochebrochard

    Citation: BMC Medical Research Methodology 2018 18:111

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  38. Content type: Correction

    Following publication of the original article [1], the authors reported that the following notation wasn’t used consistently.

    Authors: Ines Rombach, Alastair M Gray, Crispin Jenkinson, David W Murray and Oliver Rivero-Arias

    Citation: BMC Medical Research Methodology 2018 18:107

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    The original article was published in BMC Medical Research Methodology 2018 18:87

  39. Content type: Research article

    Health inequalities, worse health associated with social and economic disadvantage, are reported by a minority of research articles. Locating these studies when conducting an equity-focused systematic review i...

    Authors: Stephanie L Prady, Eleonora P Uphoff, Madeleine Power and Su Golder

    Citation: BMC Medical Research Methodology 2018 18:106

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  40. Content type: Research article

    In individually randomised trials we might expect interventions delivered in groups or by care providers to result in clustering of outcomes for participants treated in the same group or by the same care provi...

    Authors: Jane Candlish, M. Dawn Teare, Munyaradzi Dimairo, Laura Flight, Laura Mandefield and Stephen J. Walters

    Citation: BMC Medical Research Methodology 2018 18:105

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  41. Content type: Research article

    Survey researchers use monetary incentives as a strategy to motivate physicians’ survey participation. Experiments from general population surveys demonstrate that prepaid incentives increase response rates an...

    Authors: Kristine Wiant, Emily Geisen, Darryl Creel, Gordon Willis, Andrew Freedman, Janet de Moor and Carrie Klabunde

    Citation: BMC Medical Research Methodology 2018 18:104

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  42. Content type: Research article

    Research waste is estimated to be very common, but assessments of its prevalence and scope are rare. As an example, we assessed research waste in clinical research on calcium intake (assessing study design and...

    Authors: Mark J. Bolland, Alison Avenell and Andrew Grey

    Citation: BMC Medical Research Methodology 2018 18:103

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  43. Content type: Research article

    Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this ma...

    Authors: Paul M Bakaki, Jennifer Staley, Rujia Liu, Neal Dawson, Negar Golchin, Alexis Horace, Hannah Johnson, Jennifer Waldron, Almut Winterstein, Lawrence C Kleinman and Shari D Bolen

    Citation: BMC Medical Research Methodology 2018 18:102

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  44. Content type: Research article

    Research waste can occur when trials are conducted in the wrong populations. Vitamin D deficient populations are most likely to benefit from vitamin D supplementation. We investigated waste attributable to ran...

    Authors: Mark J. Bolland, Andrew Grey and Alison Avenell

    Citation: BMC Medical Research Methodology 2018 18:101

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  45. Content type: Research article

    The aim of this study was to quantify and compare the diagnostic value of The Western Electric (WE) statistical process control (SPC) chart rules and the Anhoej rules for detection of non-random variation in t...

    Authors: Jacob Anhøj and Tore Wentzel-Larsen

    Citation: BMC Medical Research Methodology 2018 18:100

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  46. Content type: Research article

    In the presence of an intermediate clinical event, the analysis of time-to-event survival data by conventional approaches, such as the log-rank test, can result in biased results due to the length-biased chara...

    Authors: Sohee Kim, Jinheum Kim and Chung Mo Nam

    Citation: BMC Medical Research Methodology 2018 18:98

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  47. Content type: Research article

    Consumers, clinicians, policymakers and researchers require high quality evidence to guide decision-making in child health. Though Cochrane systematic reviews (SRs) are a well-established source of evidence, l...

    Authors: Michelle Gates, Sarah A Elliott, Cydney Johnson, Denise Thomson, Katrina Williams, Ricardo M Fernandes and Lisa Hartling

    Citation: BMC Medical Research Methodology 2018 18:99

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