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  1. Content type: Technical advance

    Phase III randomized controlled trials (RCT) typically exclude certain patient subgroups, thereby potentially jeopardizing estimation of a drug’s effects when prescribed to wider populations and under routine ...

    Authors: Helene Karcher, Shuai Fu, Jie Meng, Mikkel Zöllner Ankarfeldt, Orestis Efthimiou, Mark Belger, Josep Maria Haro, Lucien Abenhaim and Clementine Nordon

    Citation: BMC Medical Research Methodology 2018 18:75

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  2. Content type: Research article

    Multilevel models for non-normal outcomes are widely used in medical and health sciences research. While methods for interpreting fixed effects are well-developed, methods to quantify and interpret random clus...

    Authors: Thomas J. Glorioso, Gary K. Grunwald, P. Michael Ho and Thomas M. Maddox

    Citation: BMC Medical Research Methodology 2018 18:74

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  3. Content type: Research article

    Records pertaining to individuals whose identity cannot be verified with legal documentation may contain errors, or be incorrect by intention of the individual. Probabilistic data linkage, especially in vulner...

    Authors: Holly Tibble, Hsei Di Law, Matthew J. Spittal, Rosemary Karmel, Rohan Borschmann, Katie Hail-Jares, Laura A. Thomas and Stuart A. Kinner

    Citation: BMC Medical Research Methodology 2018 18:76

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  4. Content type: Research article

    Degenerative cervical myelopathy (DCM) is a common condition with many unmet clinical needs. Pooled analysis of studies is an important tool for advancing medical understanding. This process starts with a syst...

    Authors: Benjamin M. Davies, Samuel Goh, Keonwoo Yi, Isla Kuhn and Mark R. N. Kotter

    Citation: BMC Medical Research Methodology 2018 18:73

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  5. Content type: Research article

    There are an increasing number of geo-coded information streams available which could improve public health surveillance accuracy and efficiency when properly integrated. Specifically, for zoonotic diseases, k...

    Authors: C. Rotejanaprasert, A. Lawson, H. Rossow, J. Sane, O. Huitu, H. Henttonen and V. J. Del Rio Vilas

    Citation: BMC Medical Research Methodology 2018 18:72

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  6. Content type: Research article

    Limited translational success in critical care medicine is thought to be in part due to inadequate methodology, study design, and reporting in preclinical studies. The purpose of this study was to compare repo...

    Authors: Justin S. Merkow, Janine M. Hoerauf, Angela F. Moss, Jason Brainard, Lena M. Mayes, Ana Fernandez-Bustamante, Susan K. Mikulich-Gilbertson and Karsten Bartels

    Citation: BMC Medical Research Methodology 2018 18:71

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  7. Content type: Research article

    A thorough evaluation of the adequacy of clinical practice in a designated health care setting and temporal context is key for clinical care improvement. This study aimed to perform a clinical audit of primary...

    Authors: María Abad-Arranz, Ana Moran-Rodríguez, Enrique Mascarós Balaguer, Carmen Quintana Velasco, Laura Abad Polo, Sara Núñez Palomo, Jaime Gonzálvez Rey, Ana María Fernández Vargas, Antonio Hidalgo Requena, Jose Manuel Helguera Quevedo, Marina García Pardo and Jose Luis Lopez-Campos

    Citation: BMC Medical Research Methodology 2018 18:68

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  8. Content type: Research article

    Recently, the intervention calculus when the DAG is absent (IDA) method was developed to estimate lower bounds of causal effects from observational high-dimensional data. Originally it was introduced to assess...

    Authors: Vahé Asvatourian, Clélia Coutzac, Nathalie Chaput, Caroline Robert, Stefan Michiels and Emilie Lanoy

    Citation: BMC Medical Research Methodology 2018 18:67

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  9. Content type: Research article

    Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery. Our goal in this study was to evalu...

    Authors: Annie M. Racine, Yun Gou, Tamara G. Fong, Edward R. Marcantonio, Eva M. Schmitt, Thomas G. Travison, Sharon K. Inouye and Richard N. Jones

    Citation: BMC Medical Research Methodology 2018 18:69

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  10. Content type: Research article

    Network meta-analysis (NMA) allows for the estimation of comparative effectiveness of treatments that have not been studied in head-to-head trials; however, relative treatment effects for all interventions can...

    Authors: Susanne Schmitz, Áine Maguire, James Morris, Kai Ruggeri, Elisa Haller, Isla Kuhn, Joy Leahy, Natalia Homer, Ayesha Khan, Jack Bowden, Vanessa Buchanan, Michael O’Dwyer, Gordon Cook and Cathal Walsh

    Citation: BMC Medical Research Methodology 2018 18:66

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  11. Content type: Research article

    A new patient-reported health measurement model has been developed to quantify descriptions of health states. Known as the multi-attribute preference response (MAPR) model, it is based on item response theory....

    Authors: Catharina G. M. Groothuis-Oudshoorn, Edwin R. van den Heuvel and Paul F. M. Krabbe

    Citation: BMC Medical Research Methodology 2018 18:62

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  12. Content type: Research article

    In pharmacoepidemiology, the prescription preference-based instrumental variables (IV) are often used with linear models to solve the endogeneity due to unobserved confounders even when the outcome and the end...

    Authors: Babagnidé François Koladjo, Sylvie Escolano and Pascale Tubert-Bitter

    Citation: BMC Medical Research Methodology 2018 18:61

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  13. Content type: Research article

    Log-binomial and robust (modified) Poisson regression models are popular approaches to estimate risk ratios for binary response variables. Previous studies have shown that comparatively they produce similar po...

    Authors: Wansu Chen, Lei Qian, Jiaxiao Shi and Meredith Franklin

    Citation: BMC Medical Research Methodology 2018 18:63

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  14. Content type: Research article

    Attrition occurs when a participant fails to respond to one or more study waves. The accumulation of attrition over several waves can lower the sample size and power and create a final sample that could differ...

    Authors: Samantha Spiers, Evrim Oral, Elizabeth T. H. Fontham, Edward S. Peters, James L. Mohler, Jeannette T. Bensen and Christine S. Brennan

    Citation: BMC Medical Research Methodology 2018 18:60

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  15. Content type: Research article

    Web-based surveys have become increasingly popular but response rates are low and may be prone to selection bias. How people are invited to participate may impact response rates and needs further study as prev...

    Authors: Xiaochen Tai, Alanna M. Smith, Allison J. McGeer, Eve Dubé, Dorothy Linn Holness, Kevin Katz, Linda McGillis Hall, Shelly A. McNeil, Jeff Powis and Brenda L. Coleman

    Citation: BMC Medical Research Methodology 2018 18:59

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  16. Content type: Research article

    Realist approaches seek to answer questions such as ‘how?’, ‘why?’, ‘for whom?’, ‘in what circumstances?’ and ‘to what extent?’ interventions ‘work’ using context-mechanism-outcome (CMO) configurations. Quanti...

    Authors: John A. Ford, Andy Jones, Geoff Wong, Allan Clark, Tom Porter and Nick Steel

    Citation: BMC Medical Research Methodology 2018 18:57

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  17. Content type: Research article

    The assessment of multiple systematic reviews (AMSTAR) tool is widely used for investigating the methodological quality of systematic reviews (SR). Originally, AMSTAR was developed for SRs of randomized contro...

    Authors: Dawid Pieper, Nadja Koensgen, Jessica Breuing, Long Ge and Uta Wegewitz

    Citation: BMC Medical Research Methodology 2018 18:56

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  18. Content type: Research article

    When profiling multiple health care providers, adjustment for case-mix is essential to accurately classify the quality of providers. Unfortunately, misclassification of provider performance is not uncommon and...

    Authors: Timo B. Brakenhoff, Kit C. B. Roes, Karel G. M. Moons and Rolf H. H. Groenwold

    Citation: BMC Medical Research Methodology 2018 18:54

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  19. Content type: Research article

    To evaluate participant-related variables associated with missing assessment(s) at follow-up visits during a longitudinal research study.

    Authors: Sara E. Heins, Amy W. Wozniak, Elizabeth Colantuoni, Kristin A. Sepulveda, Pedro A. Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M. Needham and Victor D. Dinglas

    Citation: BMC Medical Research Methodology 2018 18:55

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