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  1. Research article

    Estimating correlation between multivariate longitudinal data in the presence of heterogeneity

    Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique oppor...

    Feng Gao, J. Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A. Beiser, Ling Chen and Mae O. Gordon

    BMC Medical Research Methodology 2017 17:124

    Published on: 17 August 2017

  2. Research article

    The impact of self-interviews on response patterns for sensitive topics: a randomized trial of electronic delivery methods for a sexual behaviour questionnaire in rural South Africa

    Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Compute...

    Guy Harling, Dumile Gumede, Tinofa Mutevedzi, Nuala McGrath, Janet Seeley, Deenan Pillay, Till W. Bärnighausen and Abraham J. Herbst

    BMC Medical Research Methodology 2017 17:125

    Published on: 17 August 2017

  3. Research article

    Applied Swarm-based medicine: collecting decision trees for patterns of algorithms analysis

    The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an ...

    Cédric M. Panje, Markus Glatzer, Joscha von Rappard, Christian Rothermundt, Thomas Hundsberger, Valentin Zumstein, Ludwig Plasswilm and Paul Martin Putora

    BMC Medical Research Methodology 2017 17:123

    Published on: 16 August 2017

  4. Research article

    The impact of the lookback period and definition of confirmatory events on the identification of incident cancer cases in administrative data

    This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...

    Jonas Czwikla, Kathrin Jobski and Tania Schink

    BMC Medical Research Methodology 2017 17:122

    Published on: 14 August 2017

  5. Research article

    Using classification and regression tree modelling to investigate response shift patterns in dentine hypersensitivity

    Dentine hypersensitivity (DH) affects people’s quality of life (QoL). However changes in the internal meaning of QoL, known as Response shift (RS) may undermine longitudinal assessment of QoL. This study aimed...

    Carolina Machuca, Mario V. Vettore, Marta Krasuska, Sarah R. Baker and Peter G. Robinson

    BMC Medical Research Methodology 2017 17:120

    Published on: 14 August 2017

  6. Research article

    Trading certainty for speed - how much uncertainty are decisionmakers and guideline developers willing to accept when using rapid reviews: an international survey

    Decisionmakers and guideline developers demand rapid syntheses of the evidence when time sensitive evidence-informed decisions are required. A potential trade-off of such rapid reviews is that their results ca...

    Gernot Wagner, Barbara Nussbaumer-Streit, Judith Greimel, Agustín Ciapponi and Gerald Gartlehner

    BMC Medical Research Methodology 2017 17:121

    Published on: 14 August 2017

  7. Research Article

    Choice of futility boundaries for group sequential designs with two endpoints

    In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources. This is especially important, if the pla...

    Svenja Schüler, Meinhard Kieser and Geraldine Rauch

    BMC Medical Research Methodology 2017 17:119

    Published on: 8 August 2017

  8. Research article

    Validity and reliability of a Malay version of the brief illness perception questionnaire for patients with type 2 diabetes mellitus

    Illness perceptions involve the personal beliefs that patients have about their illness and may influence health behaviours considerably. Since an instrument to measure these perceptions for Malay population i...

    Boon-How Chew, Rimke C. Vos, Monique Heijmans, Sazlina Shariff-Ghazali, Aaron Fernandez and Guy E. H. M. Rutten

    BMC Medical Research Methodology 2017 17:118

    Published on: 3 August 2017

  9. Research article

    Programme Reporting Standards (PRS) for improving the reporting of sexual, reproductive, maternal, newborn, child and adolescent health programmes

    Information about design, implementation, monitoring and evaluation is central to understand the impact of programmes within the field of sexual, reproductive, maternal, newborn, child and adolescent health (S...

    Anna E. Kågesten, Özge Tunçalp, Anayda Portela, Moazzam Ali, Nhan Tran and A. Metin Gülmezoglu

    BMC Medical Research Methodology 2017 17:117

    Published on: 3 August 2017

  10. Research Article

    A comparison of the conditional inference survival forest model to random survival forests based on a simulation study as well as on two applications with time-to-event data

    Random survival forest (RSF) models have been identified as alternative methods to the Cox proportional hazards model in analysing time-to-event data. These methods, however, have been criticised for the bias ...

    Justine B. Nasejje, Henry Mwambi, Keertan Dheda and Maia Lesosky

    BMC Medical Research Methodology 2017 17:115

    Published on: 28 July 2017

  11. Research article

    A comparison of multiple imputation methods for handling missing values in longitudinal data in the presence of a time-varying covariate with a non-linear association with time: a simulation study

    Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which involve multiple waves of data collection. Traditional multiple imputation (MI) methods (f...

    Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee and Julie Anne Simpson

    BMC Medical Research Methodology 2017 17:114

    Published on: 25 July 2017

  12. Research article

    Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy

    More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different typ...

    Joe Alexander, Roger A. Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky and Bruce Parsons

    BMC Medical Research Methodology 2017 17:113

    Published on: 20 July 2017

  13. Research Article

    Basic parametric analysis for a multi-state model in hospital epidemiology

    The extended illness-death model is a useful tool to study the risks and consequences of hospital-acquired infections (HAIs). The statistical quantities of interest are the transition-specific hazard rates and...

    Maja von Cube, Martin Schumacher and Martin Wolkewitz

    BMC Medical Research Methodology 2017 17:111

    Published on: 20 July 2017

  14. Research Article

    Binomial outcomes in dataset with some clusters of size two: can the dependence of twins be accounted for? A simulation study comparing the reliability of statistical methods based on a dataset of preterm infants

    The analysis of perinatal outcomes often involves datasets with some multiple births. These are datasets mostly formed of independent observations and a limited number of clusters of size two (twins) and maybe...

    Odile Sauzet and Janet L. Peacock

    BMC Medical Research Methodology 2017 17:110

    Published on: 20 July 2017

  15. Research Article

    Implementing the EffTox dose-finding design in the Matchpoint trial

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    BMC Medical Research Methodology 2017 17:112

    Published on: 20 July 2017

  16. Research Article

    A random effects meta-analysis model with Box-Cox transformation

    In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of ...

    Yusuke Yamaguchi, Kazushi Maruo, Christopher Partlett and Richard D. Riley

    BMC Medical Research Methodology 2017 17:109

    Published on: 19 July 2017

  17. Research article

    A literature review of applied adaptive design methodology within the field of oncology in randomised controlled trials and a proposed extension to the CONSORT guidelines

    The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs...

    Pankaj Mistry, Janet A Dunn and Andrea Marshall

    BMC Medical Research Methodology 2017 17:108

    Published on: 18 July 2017

  18. Research Article

    Nonlinear joint models for individual dynamic prediction of risk of death using Hamiltonian Monte Carlo: application to metastatic prostate cancer

    Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to cal...

    Solène Desmée, France Mentré, Christine Veyrat-Follet, Bernard Sébastien and Jérémie Guedj

    BMC Medical Research Methodology 2017 17:105

    Published on: 17 July 2017

  19. Debate

    Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study

    The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in t...

    F. Lauzier, N. K. Adhikari, A. Seely, K. K. Y. Koo, E. P. Belley-Côté, K. E. A. Burns, D. J. Cook, F. D’Aragon, B. Rochwerg, M. E. Kho, S. J. W. Oczkowksi, E. H. Duan, M. O. Meade, A. G. Day and F. Lamontagne

    BMC Medical Research Methodology 2017 17:106

    Published on: 17 July 2017

  20. Research article

    Using structural equation modeling for network meta-analysis

    Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...

    Yu-Kang Tu and Yun-Chun Wu

    BMC Medical Research Methodology 2017 17:104

    Published on: 14 July 2017

  21. Research article

    Accounting for treatment use when validating a prognostic model: a simulation study

    Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...

    Romin Pajouheshnia, Linda M. Peelen, Karel G. M. Moons, Johannes B. Reitsma and Rolf H. H. Groenwold

    BMC Medical Research Methodology 2017 17:103

    Published on: 14 July 2017

  22. Research article

    Cost and yield considerations when expanding recruitment for genetic studies: the primary open-angle African American glaucoma genetics study

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    BMC Medical Research Methodology 2017 17:101

    Published on: 14 July 2017

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