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BMC Medical Research Methodology

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  1. Content type: Research article

    It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug be...

    Authors: Feng Liu, Stephen J. Walters and Steven A. Julious

    Citation: BMC Medical Research Methodology 2017 17:149

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  2. Content type: Research Article

    The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance,...

    Authors: Antoine Barbieri, Jean Peyhardi, Thierry Conroy, Sophie Gourgou, Christian Lavergne and Caroline Mollevi

    Citation: BMC Medical Research Methodology 2017 17:148

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  3. Content type: Research article

    It is challenging for current statistical models to predict clinical progression of Parkinson’s disease (PD) because of the involvement of multi-domains and longitudinal data.

    Authors: Ming Wang, Zheng Li, Eun Young Lee, Mechelle M. Lewis, Lijun Zhang, Nicholas W. Sterling, Daymond Wagner, Paul Eslinger, Guangwei Du and Xuemei Huang

    Citation: BMC Medical Research Methodology 2017 17:147

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  4. Content type: Research article

    Several statistical approaches have been proposed to assess and correct for exposure measurement error. We aimed to provide a critical overview of the most common approaches used in nutritional epidemiology.

    Authors: Derrick A. Bennett, Denise Landry, Julian Little and Cosetta Minelli

    Citation: BMC Medical Research Methodology 2017 17:146

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  5. Content type: Research article

    The reproducibility of research is essential to rigorous science, yet significant concerns of the reliability and verifiability of biomedical research have been recently highlighted. Ongoing efforts across sev...

    Authors: Leslie D. McIntosh, Anthony Juehne, Cynthia R. H. Vitale, Xiaoyan Liu, Rosalia Alcoser, J. Christian Lukas and Bradley Evanoff

    Citation: BMC Medical Research Methodology 2017 17:143

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  6. Content type: Research article

    The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that ...

    Authors: Kevin P. Weinfurt, Adrian F. Hernandez, Gloria D. Coronado, Lynn L. DeBar, Laura M. Dember, Beverly B. Green, Patrick J. Heagerty, Susan S. Huang, Kathryn T. James, Jeffrey G. Jarvik, Eric B. Larson, Vincent Mor, Richard Platt, Gary E. Rosenthal, Edward J. Septimus, Gregory E. Simon…

    Citation: BMC Medical Research Methodology 2017 17:144

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  7. Content type: Research article

    The requirement to obtain written informed consent may undermine the potential of pragmatic randomized clinical trials (pRCTs) to improve evidence-based care. This requirement could compromise trials statistic...

    Authors: Rafael Dal-Ré, Antonio J. Carcas, Xavier Carné and David Wendler

    Citation: BMC Medical Research Methodology 2017 17:145

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  8. Content type: Research article

    We sought to understand the main ethical considerations when conducting clinical trials in the prehospital ambulance based setting.

    Authors: Stephanie Armstrong, Adele Langlois, Despina Laparidou, Mark Dixon, Jason P. Appleton, Philip M. Bath, Helen Snooks and A. Niroshan Siriwardena

    Citation: BMC Medical Research Methodology 2017 17:142

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  9. Content type: Research article

    The ACE-III, a gold standard for screening cognitive impairment, is restricted by language and culture, with no uniform set of guidelines for its adaptation. To develop guidelines a compilation of all the adap...

    Authors: Nadine Mirza, Maria Panagioti, Muhammad Wali Waheed and Waquas Waheed

    Citation: BMC Medical Research Methodology 2017 17:141

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  10. Content type: Correspondence

    Focused ethnography is an applied and pragmatic form of ethnography that explores a specific social phenomenon as it occurs in everyday life. Based on the literature a problem-focused research question is form...

    Authors: A.P. Bikker, H. Atherton, H. Brant, T. Porqueddu, J.L. Campbell, A. Gibson, B. McKinstry, C. Salisbury and S. Ziebland

    Citation: BMC Medical Research Methodology 2017 17:139

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  11. Content type: Research article

    Although there has been growing research on the burden of treatment, the current state of evidence on measuring this concept is unknown. This scoping review aimed to provide an overview of the current state of...

    Authors: Adem Sav, Asiyeh Salehi, Frances S. Mair and Sara S. McMillan

    Citation: BMC Medical Research Methodology 2017 17:140

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  12. Content type: Debate

    The goal of medical research is to develop interventions that are in some sense superior, with respect to patient outcome, to interventions currently in use. Similarly, the goal of research in methodological c...

    Authors: Anne-Laure Boulesteix, Rory Wilson and Alexander Hapfelmeier

    Citation: BMC Medical Research Methodology 2017 17:138

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  13. Content type: Research article

    Rich literature has reported that there exists a nonlinear association between temperature and mortality. One important feature in the temperature-mortality association is the minimum mortality temperature (MM...

    Authors: Whanhee Lee, Ho Kim, Sunghee Hwang, Antonella Zanobetti, Joel D. Schwartz and Yeonseung Chung

    Citation: BMC Medical Research Methodology 2017 17:137

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  14. Content type: Research article

    Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this resea...

    Authors: Mónica Ballesteros, Nadia Montero, Antonio López-Pousa, Gerard Urrútia, Ivan Solà, Gabriel Rada, Hector Pardo-Hernandez and Xavier Bonfill

    Citation: BMC Medical Research Methodology 2017 17:135

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  15. Content type: Research article

    Data confidentiality and shared use of research data are two desirable but sometimes conflicting goals in research with multi-center studies and distributed data. While ideal for straightforward analysis, conf...

    Authors: P. Saha-Chaudhuri and C.R. Weinberg

    Citation: BMC Medical Research Methodology 2017 17:136

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  16. Content type: Research article

    Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available b...

    Authors: Delaram Farzanfar, Asmaa Abumuamar, Jayoon Kim, Emily Sirotich, Yue Wang and Eleanor Pullenayegum

    Citation: BMC Medical Research Methodology 2017 17:133

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  17. Content type: Research article

    Multiple imputation is a popular approach to handling missing data in medical research, yet little is known about its applicability for estimating the relative risk. Standard methods for imputing incomplete bi...

    Authors: Thomas R. Sullivan, Katherine J. Lee, Philip Ryan and Amy B. Salter

    Citation: BMC Medical Research Methodology 2017 17:134

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  18. Content type: Research article

    Knowing about predictors of attrition in a panel is important to initiate early measures against loss of participants. We investigated attrition in both early and late phase of an online panel with special foc...

    Authors: Nicole Rübsamen, Manas K. Akmatov, Stefanie Castell, André Karch and Rafael T. Mikolajczyk

    Citation: BMC Medical Research Methodology 2017 17:132

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  19. Content type: Research article

    The Barthel Index (BI) is a measure of independence in activities of daily living (ADL). In the modified Barthel Index (MBI), a five-point system replaced the original two or three or four point rating system....

    Authors: Tomoko Ohura, Kimitaka Hase, Yoshie Nakajima and Takeo Nakayama

    Citation: BMC Medical Research Methodology 2017 17:131

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  20. Content type: Research article

    There is a great need for high quality clinical research for children. The European Pediatric Regulation aimed to improve the quality of clinical trials in order to increase the availability of treatments for ...

    Authors: Isabelle Gautier, Perrine Janiaud, Nelly Rollet, Nicolas André, Michel Tsimaratos, Catherine Cornu, Salma Malik, Stéphanie Gentile and Behrouz Kassaï

    Citation: BMC Medical Research Methodology 2017 17:130

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  21. Content type: Research article

    The common frequentist approach is limited in providing investigators with appropriate measures for conducting a new trial. To answer such important questions and one has to look at Bayesian statistics.

    Authors: David J. Biau, Samuel Boulezaz, Laurent Casabianca, Moussa Hamadouche, Philippe Anract and Sylvie Chevret

    Citation: BMC Medical Research Methodology 2017 17:128

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  22. Content type: Technical advance

    Multiple imputation is a recommended method to handle missing data. For significance testing after multiple imputation, Rubin’s Rules (RR) are easily applied to pool parameter estimates. In a logistic regressi...

    Authors: Iris Eekhout, Mark A. van de Wiel and Martijn W. Heymans

    Citation: BMC Medical Research Methodology 2017 17:129

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  23. Content type: Research article

    Aspirin has been considered to be beneficial in preventing cardiovascular diseases and cancer. Several pharmaco-epidemiology cohort studies have shown protective effects of aspirin on diseases using various st...

    Authors: In Sung Cho, Ye Rin Chae, Ji Hyeon Kim, Hae Rin Yoo, Suk Yong Jang, Gyu Ri Kim and Chung Mo Nam

    Citation: BMC Medical Research Methodology 2017 17:126

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  24. Content type: Research article

    Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Compute...

    Authors: Guy Harling, Dumile Gumede, Tinofa Mutevedzi, Nuala McGrath, Janet Seeley, Deenan Pillay, Till W. Bärnighausen and Abraham J. Herbst

    Citation: BMC Medical Research Methodology 2017 17:125

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