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  1. Content type: Software

    Recommended statistical methods for meta-analysis of diagnostic test accuracy studies require relatively complex bivariate statistical models which can be a barrier for non-statisticians. A further barrier exi...

    Authors: Suzanne C. Freeman, Clareece R. Kerby, Amit Patel, Nicola J. Cooper, Terry Quinn and Alex J. Sutton

    Citation: BMC Medical Research Methodology 2019 19:81

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  2. Content type: Research article

    There have been calls for greater consideration of applicability and transferability in systematic reviews, to improve their usefulness in informing policy and practice. Understanding how evidence is, or is no...

    Authors: Susan Baxter, Maxine Johnson, Duncan Chambers, Anthea Sutton, Elizabeth Goyder and Andrew Booth

    Citation: BMC Medical Research Methodology 2019 19:80

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  3. Content type: Software

    In medical research, explanatory continuous variables are frequently transformed or converted into categorical variables. If the coding is unknown, many tests can be used to identify the “optimal” transformati...

    Authors: Benoit Liquet and Jérémie Riou

    Citation: BMC Medical Research Methodology 2019 19:79

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  4. Content type: Research article

    To investigate the prevalence of protocol registration (or development) among published dose-response meta-analyses (DRMAs), and whether DRMAs with a protocol are better than those not.

    Authors: Chang Xu, Liang-Liang Cheng, Yu Liu, Peng-Li Jia, Ming-Yue Gao and Chao Zhang

    Citation: BMC Medical Research Methodology 2019 19:78

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  5. Content type: Research article

    Clinical decisions are made based on Cochrane reviews, but the implementation of results of evidence syntheses such as Cochrane reviews is problematic if the evidence is not prepared consistently. All systemat...

    Authors: Andrija Babic, Andela Pijuk, Lucie Brázdilová, Yuliyana Georgieva, Marco António Raposo Pereira, Tina Poklepovic Pericic and Livia Puljak

    Citation: BMC Medical Research Methodology 2019 19:77

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  6. Content type: Research article

    An important part of the systematic review methodology is appraisal of the risk of bias in included studies. Cochrane systematic reviews are considered golden standard regarding systematic review methodology, ...

    Authors: Andrija Babic, Ruzica Tokalic, João Amílcar Silva Cunha, Ivana Novak, Jelena Suto, Marin Vidak, Ivana Miosic, Ivana Vuka, Tina Poklepovic Pericic and Livia Puljak

    Citation: BMC Medical Research Methodology 2019 19:76

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  7. Content type: Research article

    Although subjective expressions and linguistic fluency have been shown as important factors in processing and interpreting textual facts, analyses of these traits in textual health information for different au...

    Authors: Jasna Karačić, Pierpaolo Dondio, Ivan Buljan, Darko Hren and Ana Marušić

    Citation: BMC Medical Research Methodology 2019 19:75

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  9. Content type: Research article

    There is evidence that the physician response rate is declining. In response to this, methods for increasing the physician response rate are currently being explored. This paper examines the response rate and ...

    Authors: Lesley Weaver, Timothy J. Beebe and Todd Rockwood

    Citation: BMC Medical Research Methodology 2019 19:73

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  10. Content type: Research article

    Accelerometers are widely used to measure sedentary time and daily physical activity (PA). However, data collection and processing criteria, such as non-wear time rules might affect the assessment of total PA ...

    Authors: Jérémy Vanhelst, Florian Vidal, Elodie Drumez, Laurent Béghin, Jean-Benoît Baudelet, Stéphanie Coopman and Frédéric Gottrand

    Citation: BMC Medical Research Methodology 2019 19:72

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  11. Content type: Technical advance

    In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control. Typically, evidence in each of these paradigm...

    Authors: Don van Ravenzwaaij, Rei Monden, Jorge N. Tendeiro and John P. A. Ioannidis

    Citation: BMC Medical Research Methodology 2019 19:71

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  12. Content type: Research article

    Chronic respiratory symptoms involving bronchitis, cough and phlegm in children are underappreciated but pose a significant public health burden. Efforts for prevention and management could be supported by an ...

    Authors: Huiyu Deng, Robert Urman, Frank D. Gilliland and Sandrah P. Eckel

    Citation: BMC Medical Research Methodology 2019 19:70

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  13. Content type: Research article

    Treatment switching is common in randomised trials of oncology treatments, with control group patients switching onto the experimental treatment during follow-up. This distorts an intention-to-treat comparison...

    Authors: N. R. Latimer, K. R. Abrams and U. Siebert

    Citation: BMC Medical Research Methodology 2019 19:69

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  14. Content type: Research article

    Crowding in the emergency department (ED) is associated with increased mortality, increased treatment cost, and reduced quality of care. Crowding arises when demand exceed resources in the ED and a first sign ...

    Authors: Andreas Halgreen Eiset, Hans Kirkegaard and Mogens Erlandsen

    Citation: BMC Medical Research Methodology 2019 19:68

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  15. Content type: Research article

    Rare diseases are a global public health priority. Though each disease is rare, when taken together the thousands of known rare diseases cause significant morbidity and mortality, impact quality of life, and c...

    Authors: Menaka Pai, Cindy H. T. Yeung, Elie A. Akl, Andrea Darzi, Christopher Hillis, Kimberly Legault, Joerg J. Meerpohl, Nancy Santesso, Domenica Taruscio, Madeleine Verhovsek, Holger J. Schünemann and Alfonso Iorio

    Citation: BMC Medical Research Methodology 2019 19:67

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  16. Content type: Research article

    Navigating the world of qualitative thematic analysis can be challenging. This is compounded by the fact that detailed descriptions of methods are often omitted from qualitative discussions. While qualitative ...

    Authors: Kate Roberts, Anthony Dowell and Jing-Bao Nie

    Citation: BMC Medical Research Methodology 2019 19:66

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  17. Content type: Research article

    Surveys are established methods for collecting population data that are unavailable from other sources; however, response rates to surveys are declining. A number of methods have been identified to increase su...

    Authors: Siân Harrison, Jane Henderson, Fiona Alderdice and Maria A. Quigley

    Citation: BMC Medical Research Methodology 2019 19:65

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  18. Content type: Research article

    Following visible successes on a wide range of predictive tasks, machine learning techniques are attracting substantial interest from medical researchers and clinicians. We address the need for capacity develo...

    Authors: Jenni A. M. Sidey-Gibbons and Chris J. Sidey-Gibbons

    Citation: BMC Medical Research Methodology 2019 19:64

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  19. Content type: Research article

    The Scaling Integrated Care in Context (SCIROCCO) tool has been developed to facilitate knowledge transfer and learning about the implementation and scaling-up of integrated care in European regions. To adequa...

    Authors: Liset Grooten, Hubertus Johannes Maria Vrijhoef, Stefano Calciolari, Laura Guadalupe González Ortiz, Marcela Janečková, Mirella M. N. Minkman and Dirk Devroey

    Citation: BMC Medical Research Methodology 2019 19:63

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  20. Content type: Research article

    Continuity of cardiac care after hospital discharge is a priority, especially as healthcare systems become increasingly complex and fragmented. There are few available instruments to measure continuity of card...

    Authors: Irene Valaker, Bengt Fridlund, Tore Wentzel-Larsen, Heather Hadjistavropoulos, Jan Erik Nordrehaug, Svein Rotevatn, Maj-Britt Råholm and Tone M. Norekvål

    Citation: BMC Medical Research Methodology 2019 19:62

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  21. Content type: Research article

    Meta-analysis is a useful tool for combining evidence from multiple studies to estimate a pooled treatment effect. An extension of meta-analysis, network meta-analysis, is becoming more commonly used as a way ...

    Authors: Martin Law, Navid Alam, Areti Angeliki Veroniki, Yi Yu and Dan Jackson

    Citation: BMC Medical Research Methodology 2019 19:61

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  22. Content type: Research article

    Interviewers can substantially affect self-reported data. This may be due to random variation in interviewers’ ability to put respondents at ease or in how they frame questions. It may also be due to systemati...

    Authors: Guy Harling, Michael M. Chanda, Katrina F. Ortblad, Magdalene Mwale, Steven Chongo, Catherine Kanchele, Nyambe Kamungoma, Leah G. Barresi, Till Bärnighausen and Catherine E. Oldenburg

    Citation: BMC Medical Research Methodology 2019 19:60

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  23. Content type: Research article

    Evaluation of complex interventions should include a process evaluation to give evaluators, researchers, and policy makers greater confidence in the outcomes reported from RCTs. Implementation fidelity can be ...

    Authors: Line Kildal Bragstad, Berit Arnesveen Bronken, Unni Sveen, Ellen Gabrielsen Hjelle, Gabriele Kitzmüller, Randi Martinsen, Kari J. Kvigne, Margrete Mangset and Marit Kirkevold

    Citation: BMC Medical Research Methodology 2019 19:59

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  25. Content type: Research article

    An a priori design is essential to reduce the risk of bias in systematic reviews (SRs). To this end, authors can register their SR with PROSPERO, and/or publish a SR protocol in an academic journal. The latter...

    Authors: Tanja Rombey, Katharina Allers, Tim Mathes, Falk Hoffmann and Dawid Pieper

    Citation: BMC Medical Research Methodology 2019 19:57

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  26. Content type: Technical advance

    Family health history (FHH) inherently involves collecting proxy reports of health statuses of related family members. Traditionally, such information has been collected from a single informant. More recently,...

    Authors: Jielu Lin, Melanie F. Myers, Laura M. Koehly and Christopher Steven Marcum

    Citation: BMC Medical Research Methodology 2019 19:56

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  29. Content type: Research article

    The availability of clinical and therapeutic data drawn from medical records and administrative databases has entailed new opportunities for clinical and epidemiologic research. However, these databases presen...

    Authors: Guillermo Prada-Ramallal, Bahi Takkouche and Adolfo Figueiras

    Citation: BMC Medical Research Methodology 2019 19:53

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  30. Content type: Research article

    The Global Activity Limitation Indicator (GALI) is a single-item measure of functional decline, it is widely used in Europe but it has never been validated in an Asian population. The aim of this study was to ...

    Authors: Ru-Ling Hsiao, Chih-Hsun Wu, Che-Wei Hsu, Yasuhiko Saito and Yu-Hsuan Lin

    Citation: BMC Medical Research Methodology 2019 19:52

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  31. Content type: Research article

    Our work was motivated by the need to, given serum availability and/or financial resources, decide on which samples to test in a serum bank for different pathogens. Simulation-based sample size calculations we...

    Authors: Stéphanie Blaizot, Sereina A. Herzog, Steven Abrams, Heidi Theeten, Amber Litzroth and Niel Hens

    Citation: BMC Medical Research Methodology 2019 19:51

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  32. Content type: Research article

    Choosing the most performing method in terms of outcome prediction or variables selection is a recurring problem in prognosis studies, leading to many publications on methods comparison. But some aspects have ...

    Authors: Simon Bussy, Raphaël Veil, Vincent Looten, Anita Burgun, Stéphane Gaïffas, Agathe Guilloux, Brigitte Ranque and Anne-Sophie Jannot

    Citation: BMC Medical Research Methodology 2019 19:50

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  33. Content type: Research article

    In clinical trials and survival analysis, participants may be excluded from the study due to withdrawal, which is often referred to as lost-to-follow-up (LTF). It is natural to argue that a disease would be ce...

    Authors: Jinheum Kim, Jayoun Kim and Seong W. Kim

    Citation: BMC Medical Research Methodology 2019 19:49

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  34. Content type: Research article

    A strong need exists for a validated tool that clearly defines peer review report quality in biomedical research, as it will allow evaluating interventions aimed at improving the peer review process in well-pe...

    Authors: Cecilia Superchi, José Antonio González, Ivan Solà, Erik Cobo, Darko Hren and Isabelle Boutron

    Citation: BMC Medical Research Methodology 2019 19:48

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  35. Content type: Research article

    The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the liter...

    Authors: Andrea Callegaro and Fabian Tibaldi

    Citation: BMC Medical Research Methodology 2019 19:47

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  36. Content type: Review

    With progress on both the theoretical and the computational fronts the use of spline modelling has become an established tool in statistical regression analysis. An important issue in spline modelling is the a...

    Authors: Aris Perperoglou, Willi Sauerbrei, Michal Abrahamowicz and Matthias Schmid

    Citation: BMC Medical Research Methodology 2019 19:46

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  37. Content type: Research article

    Studies find that identifying additional study data is possible by contacting study authors or experts. What is less certain is the time taken, costs involved and value found by using this supplementary search...

    Authors: Chris Cooper, Juan Talens Bou and Jo Varley-Campbell

    Citation: BMC Medical Research Methodology 2019 19:45

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  38. Content type: Research article

    Quality of life (QoL) is an established outcome measure of substance use disorder treatment. The WHOQOL-BREF is the gold standard tool, but its appropriateness for particularly vulnerable patient populations m...

    Authors: Ashley Elizabeth Muller, Svetlana Skurtveit and Thomas Clausen

    Citation: BMC Medical Research Methodology 2019 19:44

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  39. Content type: Research article

    This systematic review examined the methodological quality of studies and assessed the psychometric qualities of interview-administered Past-week and Usual-week Physical Activity Questionnaires (PAQs). Pubmed ...

    Authors: Kenji Doma, Renée Speyer, Lauren Alese Parsons and Reinie Cordier

    Citation: BMC Medical Research Methodology 2019 19:43

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  40. Content type: Research article

    EHR phenotyping offers the ability to rapidly assemble a precisely defined cohort of patients prescreened for eligibility to participate in health-related research. Even so, stakeholders in the process must st...

    Authors: Laura M. Beskow, Kathleen M. Brelsford and Catherine M. Hammack

    Citation: BMC Medical Research Methodology 2019 19:42

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  41. Content type: Research article

    Precarious status migrants are a group of persons who are vulnerable, heterogeneous, and often suspicious of research teams. They are underrepresented in population-based research projects, and strategies to r...

    Authors: Margaux Fête, Josephine Aho, Magalie Benoit, Patrick Cloos and Valéry Ridde

    Citation: BMC Medical Research Methodology 2019 19:41

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  42. Content type: Research article

    The use of guidelines has shown to improve clinical practice process and structure of health care, but health care providers don’t always use and keep up-to-date with the new clinical practice guidelines. Nurs...

    Authors: Wen Yan, Qian Chen, Xuemei Zhang, Marko Elovainio and Yan Huang

    Citation: BMC Medical Research Methodology 2019 19:40

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  43. Content type: Research article

    Recruitment and retention are two significant barriers in research, particularly for historically underrepresented groups, including racial and ethnic minorities, patients who are low-income, or people with su...

    Authors: Beatrice Huang, Denise De Vore, Chris Chirinos, Jessica Wolf, Devon Low, Rachel Willard-Grace, Stephanie Tsao, Chris Garvey, Doranne Donesky, George Su and David H. Thom

    Citation: BMC Medical Research Methodology 2019 19:39

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  44. Content type: Research article

    Looked after children and care leavers have an increased risk of drug and alcohol use compared to their non-LAC peers. Despite high prevalence rates within this population, looked after children are reported t...

    Authors: Hayley Alderson, Rebecca Brown, Alex Copello, Eileen Kaner, Gillian Tober, Raghu Lingam and Ruth McGovern

    Citation: BMC Medical Research Methodology 2019 19:38

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  45. Content type: Research article

    The aim of the Hellenic National Nutrition and Health Survey was to assess nutritional intake, health status and various behaviors in a representative sample of the Greek population.

    Authors: Emmanuella Magriplis, Ioannis Dimakopoulos, Dimitra Karageorgou, Anastasia-Vasiliki Mitsopoulou, Ioanna Bakogianni, Renata Micha, George Michas, Triantafyllia Ntouroupi, Sophia-Maria Tsaniklidou, Kostantina Argyri, George Danezis, Constantinos Georgiou, Demosthenes B. Panagiotakos and Antonis Zampelas

    Citation: BMC Medical Research Methodology 2019 19:37

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  46. Content type: Technical advance

    Patient-reported outcome measures developed using Classical Test Theory are commonly comprised of ordinal level items on a Likert response scale are problematic as they do not permit the results to be compared...

    Authors: Michael Robinson, Andrew M. Johnson, David M. Walton and Joy C. MacDermid

    Citation: BMC Medical Research Methodology 2019 19:36

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  47. Content type: Research article

    Decision making in health and social care requires robust syntheses of both quantitative and qualitative evidence. Meta-ethnography is a seven-phase methodology for synthesising qualitative studies. Developed ...

    Authors: Emma F. France, Isabelle Uny, Nicola Ring, Ruth L. Turley, Margaret Maxwell, Edward A. S. Duncan, Ruth G. Jepson, Rachel J. Roberts and Jane Noyes

    Citation: BMC Medical Research Methodology 2019 19:35

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  48. Content type: Research article

    Public and patient involvement is a routine element of health services research methods to produce better designed and reported studies. Although co-production is recommended when involving people in research,...

    Authors: Bridie Angela Evans, Alison Porter, Helen Snooks and Vanessa Burholt

    Citation: BMC Medical Research Methodology 2019 19:34

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  49. Content type: Research article

    Reporting quality of systematic reviews’ (SRs) abstracts is important because this is often the only information about a study that readers have. The aim of this study was to assess adherence of SR abstracts i...

    Authors: Katarina Maticic, Marina Krnic Martinic and Livia Puljak

    Citation: BMC Medical Research Methodology 2019 19:32

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  50. Content type: Research article

    In some clinical situations, patients experience repeated events of the same type. Among these, cancer recurrences can result in terminal events such as death. Therefore, here we dynamically predicted the risk...

    Authors: Isao Yokota and Yutaka Matsuyama

    Citation: BMC Medical Research Methodology 2019 19:31

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