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  1. Content type: Research article

    Multiple imputation (MI) is now widely used to handle missing data in longitudinal studies. Several MI techniques have been proposed to impute incomplete longitudinal covariates, including standard fully condi...

    Authors: Md Hamidul Huque, John B. Carlin, Julie A. Simpson and Katherine J. Lee

    Citation: BMC Medical Research Methodology 2018 18:168

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  2. Content type: Research article

    Clinical trials are an essential part of evidence-based medicine. Hence, to ensure transparency and accountability in these clinical trials, policies for registration have been framed with emphasis on mandator...

    Authors: Victoria J. Serpas, Kanwal P. Raghav, Daniel M. Halperin, James Yao and Michael J. Overman

    Citation: BMC Medical Research Methodology 2018 18:169

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  3. Content type: Research article

    Workplace health interventions incorporating qualitative and quantitative components (mixed methods) within a Participatory Action Research approach can increase understanding of contextual issues ensuring rea...

    Authors: Marguerite C. Sendall, Laura K. McCosker, Alison Brodie, Melissa Hill and Phil Crane

    Citation: BMC Medical Research Methodology 2018 18:167

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  4. Content type: Research article

    Multidrug-resistant tuberculosis (MDR-TB) cohorts often lack long-term survival data, and are summarized instead by initial treatment outcomes. When using Cox proportional hazards models to analyze these cohor...

    Authors: Meredith B. Brooks, Salmaan Keshavjee, Irina Gelmanova, Nataliya A. Zemlyanaya, Carole D. Mitnick and Justin Manjourides

    Citation: BMC Medical Research Methodology 2018 18:166

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  5. Content type: Research article

    Studies based on high-quality linked data in developed countries show that even minor linkage errors, which occur when records of two different individuals are erroneously linked or when records belonging to t...

    Authors: Christopher T. Rentsch, Katie Harron, Mark Urassa, Jim Todd, Georges Reniers and Basia Zaba

    Citation: BMC Medical Research Methodology 2018 18:165

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  6. Content type: Research article

    The SCL-90 and the SCL-90-R are the most applied measures regarding psychological distress. To reduce and prevent an overload to of the individuals, the Brief Symptom Inventory with 18 items (BSI-18) was devel...

    Authors: Katja Petrowski, Bjarne Schmalbach, Melanie Jagla, Gabriele Helga Franke and Elmar Brähler

    Citation: BMC Medical Research Methodology 2018 18:164

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  7. Content type: Study protocol

    Recent systematic reviews and editorials suggest that many organizations that produce nutritional guideline recommendations do not adhere to internationally recognized standards set forth by the Institute of M...

    Authors: Bradley C. Johnston, Pablo Alonso-Coello, Malgorzata M. Bala, Dena Zeraatkar, Montserrat Rabassa, Claudia Valli, Catherine Marshall, Regina El Dib, Robin W. M. Vernooij, Per O. Vandvik and Gordon H. Guyatt

    Citation: BMC Medical Research Methodology 2018 18:162

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  8. Content type: Research article

    The demand in biobanking for the collection and maintenance of biological specimens and personal data from civilians to improve the prevention, diagnosis and treatment of diseases has increased notably. Despit...

    Authors: Latifah Amin, Hasrizul Hashim, Zurina Mahadi and Khaidzir Ismail

    Citation: BMC Medical Research Methodology 2018 18:163

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  9. Content type: Research article

    In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, ...

    Authors: Jessica Carlsson, Sabina Davidsson, Jonna Fridfeldt, Francesca Giunchi, Valentina Fiano, Chiara Grasso, Renata Zelic, Lorenzo Richiardi, Ove Andrén, Andreas Pettersson, Michelangelo Fiorentino and Olof Akre

    Citation: BMC Medical Research Methodology 2018 18:161

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  10. Content type: Research article

    There is a high degree of variability in assessing the preventability of adverse drug events, limiting the ability to compare rates of preventable adverse drug events across different studies. We compared thre...

    Authors: Stephanie A. Woo, Amber Cragg, Maeve E. Wickham, David Peddie, Ellen Balka, Frank Scheuermeyer, Diane Villanyi and Corinne M. Hohl

    Citation: BMC Medical Research Methodology 2018 18:160

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  11. Content type: Research article

    Biological assays for the quantification of markers may suffer from a lack of sensitivity and thus from an analytical detection limit. This is the case of human immunodeficiency virus (HIV) viral load. Below t...

    Authors: Perrine Soret, Marta Avalos, Linda Wittkop, Daniel Commenges and Rodolphe Thiébaut

    Citation: BMC Medical Research Methodology 2018 18:159

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  12. Content type: Study protocol

    Pelvic Girdle Pain (PGP) is an important cause of disability and economic cost worldwide. There is a need for effective preventative and management strategies. Emerging studies measure a variety of outcomes re...

    Authors: Francesca Wuytack, Annelie Gutke, Britt Stuge, Siv Mørkved, Christina Olsson, Hilde Stendal Robinson, Nina K. Vøllestad, Birgitta Öberg, Lena Nilsson Wikmar, Juan Jose Saldaña Mena and Valerie Smith

    Citation: BMC Medical Research Methodology 2018 18:158

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  13. Content type: Research article

    Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitmen...

    Authors: Markus Harden and Tim Friede

    Citation: BMC Medical Research Methodology 2018 18:156

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  14. Content type: Research article

    Dose-response meta-analysis (DRMA) is a useful tool to investigate potential dose-response relationship between certain exposure or intervention and the outcome of interest. A large number of DRMAs have been p...

    Authors: Chang Xu, Tong-Zu Liu, Peng-Li Jia, Yu Liu, Ling Li, Liang-Liang Cheng and Xin Sun

    Citation: BMC Medical Research Methodology 2018 18:157

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  15. Content type: Research article

    Declining participation rates are impeding health research. Little is known about factors influencing the decision to participate in low- and middle-income countries (LMIC). Therefore, this paper reports on th...

    Authors: Jennifer J. Ayoub, May Abiad, Michele R. Forman, Gladys Honein-AbouHaidar and Farah Naja

    Citation: BMC Medical Research Methodology 2018 18:155

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  16. Content type: Research article

    Systematic reviews (SRs) and meta-analyses (MAs) are distillation of current best available evidence, but are potentially prone to bias. The bias of SRs and MAs comes from sampling bias, selection bias and wit...

    Authors: Xiao Sun, Xiaobin Zhou, Yan Yu and Haihua Liu

    Citation: BMC Medical Research Methodology 2018 18:154

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  17. Content type: Research article

    Ethnography has been proposed as a valuable method for understanding how implementation occurs within dynamic healthcare contexts, yet this method can be time-intensive and challenging to operationalize in pra...

    Authors: Erin P. Finley, Alexis K. Huynh, Melissa M. Farmer, Bevanne Bean-Mayberry, Tannaz Moin, Sabine M. Oishi, Jessica L. Moreau, Karen E. Dyer, Holly Jordan Lanham, Luci Leykum and Alison B. Hamilton

    Citation: BMC Medical Research Methodology 2018 18:153

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  18. Content type: Research article

    Participant retention strategies that minimise attrition in longitudinal cohort studies have evolved considerably in recent years. This study aimed to assess, via systematic review and meta-analysis, the effec...

    Authors: Samantha Teague, George J. Youssef, Jacqui A. Macdonald, Emma Sciberras, Adrian Shatte, Matthew Fuller-Tyszkiewicz, Chris Greenwood, Jennifer McIntosh, Craig A. Olsson and Delyse Hutchinson

    Citation: BMC Medical Research Methodology 2018 18:151

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  19. Content type: Technical advance

    We demonstrate an application of Group-Based Trajectory Modeling (GBTM) based on the beta distribution. It is offered as an alternative to the normal distribution for modeling continuous longitudinal data that...

    Authors: Jonathan Elmer, Bobby L. Jones and Daniel S. Nagin

    Citation: BMC Medical Research Methodology 2018 18:152

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  20. Content type: Research article

    Bronchiolitis is a common respiratory disorder in children. Although there are specific ICD-9-CM diagnosis codes for bronchiolitis, the illness is often coded using broader diagnosis codes. This creates the po...

    Authors: Paul Walsh and Stephen J. Rothenberg

    Citation: BMC Medical Research Methodology 2018 18:149

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  21. Content type: Research article

    Integrated knowledge translation (IKT) is a research approach in which knowledge users (KUs) co-produce research. The rationale for IKT is that it leads to research that is more relevant and useful to KUs, the...

    Authors: Mary Ann O’Brien, Andrea Carson, Lisa Barbera, Melissa C. Brouwers, Craig C. Earle, Ian D. Graham, Nicole Mittmann and Eva Grunfeld

    Citation: BMC Medical Research Methodology 2018 18:150

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  22. Content type: Research article

    Noncommunicable diseases represents long term medical conditions, which often puts the patients under enormous demands when following treatment, exposing them to experiencing treatment burden. The Patient Expe...

    Authors: Anne Marie Lunde Husebø, Ingvild Margreta Morken, Kristina Sundt Eriksen and Oda Karin Nordfonn

    Citation: BMC Medical Research Methodology 2018 18:147

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  23. Content type: Research article

    Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effe...

    Authors: Leila Heckel, Kate M. Gunn and Patricia M. Livingston

    Citation: BMC Medical Research Methodology 2018 18:146

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  24. Content type: Research article

    Choosing a suitable sample size in qualitative research is an area of conceptual debate and practical uncertainty. That sample size principles, guidelines and tools have been developed to enable researchers to...

    Authors: Konstantina Vasileiou, Julie Barnett, Susan Thorpe and Terry Young

    Citation: BMC Medical Research Methodology 2018 18:148

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  25. Content type: Research article

    The retinal vascular tortuosity can be a potential indicator of relevant vascular and non-vascular diseases. However, the lack of a precise and standard guide for the tortuosity evaluation hinders its use for ...

    Authors: Lucía Ramos, Jorge Novo, José Rouco, Stephanie Romeo, María D. Álvarez and Marcos Ortega

    Citation: BMC Medical Research Methodology 2018 18:144

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  26. Content type: Research article

    Prognostic tools for intracerebral hemorrhage (ICH) patients are potentially useful for ascertaining prognosis and recommended in guidelines to facilitate streamline assessment and communication between provid...

    Authors: Tiago Gregório, Sara Pipa, Pedro Cavaleiro, Gabriel Atanásio, Inês Albuquerque, Paulo Castro Chaves and Luís Azevedo

    Citation: BMC Medical Research Methodology 2018 18:145

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  27. Content type: Research article

    Indices of inter-evaluator reliability are used in many fields such as computational linguistics, psychology, and medical science; however, the interpretation of resulting values and determination of appropria...

    Authors: Dylan T. Beckler, Zachary C. Thumser, Jonathon S. Schofield and Paul D. Marasco

    Citation: BMC Medical Research Methodology 2018 18:141

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  28. Content type: Debate

    Scoping reviews are a relatively new approach to evidence synthesis and currently there exists little guidance regarding the decision to choose between a systematic review or scoping review approach when synth...

    Authors: Zachary Munn, Micah D. J. Peters, Cindy Stern, Catalin Tufanaru, Alexa McArthur and Edoardo Aromataris

    Citation: BMC Medical Research Methodology 2018 18:143

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  29. Content type: Research article

    When conducting a survival analysis, researchers might consider two broad classes of models: nonparametric models and parametric models. While nonparametric models are more flexible because they make few assum...

    Authors: Jacqueline E. Rudolph, Stephen R. Cole and Jessie K. Edwards

    Citation: BMC Medical Research Methodology 2018 18:142

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  30. Content type: Research article

    Electronic diaries are increasingly used in diverse disciplines to collect momentary data on experienced feelings, cognitions, behavior and social context in real life situations. Choices to be made for an eff...

    Authors: Karin A. M. Janssens, Elisabeth H. Bos, Judith G. M. Rosmalen, Marieke C. Wichers and Harriëtte Riese

    Citation: BMC Medical Research Methodology 2018 18:140

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  31. Content type: Research article

    While red blood cell transfusion rates have declined in most Australian medical specialties, obstetric transfusion rates have instead been increasing. Obstetric transfusions are mostly linked to postpartum hae...

    Authors: Edward Jegasothy, Jillian Patterson, Deborah Randall, Tanya A. Nippita, Judy M. Simpson, David O. Irving and Jane B. Ford

    Citation: BMC Medical Research Methodology 2018 18:139

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  32. Content type: Research article

    Increasingly, collaborative participatory methods requiring open and honest interaction between a range of stakeholders are being used to improve health service delivery. To be successful these methodologies m...

    Authors: Ian Litchfield, Louise Bentham, Ann Hill, Richard J. McManus, Richard Lilford and Sheila Greenfield

    Citation: BMC Medical Research Methodology 2018 18:136

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  33. Content type: Research article

    Joint modeling is appropriate when one wants to predict the time to an event with covariates that are measured longitudinally and are related to the event. An underlying random effects structure links the surv...

    Authors: Jeffrey D. Long and James A. Mills

    Citation: BMC Medical Research Methodology 2018 18:138

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  34. Content type: Debate

    Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The...

    Authors: Dimitrios Zikos and Nailya DeLellis

    Citation: BMC Medical Research Methodology 2018 18:137

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  35. Content type: Research article

    Successful implementation and embedding of new health care practices relies on co-ordinated, collective behaviour of individuals working within the constraints of health care settings. Normalization Process Th...

    Authors: Tracy L. Finch, Melissa Girling, Carl R. May, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Clare Cook, Christopher R. Vernazza, Nicola Mackintosh, Samridh Sharma, Gaery Barbery, Jimmy Steele and Tim Rapley

    Citation: BMC Medical Research Methodology 2018 18:135

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  36. Content type: Research article

    As increasing numbers of dengue vaccines and therapeutics are in clinical development, standardized consensus clinical endpoint definitions are urgently needed to assess the efficacy of different interventions...

    Authors: Thomas Jaenisch, Kim Hendrickx, Martin Erpicum, Liane Agulto, Kay M. Tomashek, Walla Dempsey, João Bosco Siqueira, Morgan A. Marks, Michael P. Fay, Catherine Laughlin, Maina L’Azou, Yee-Sin Leo, Federico Narvaez, Remy Teyssou, Stephen J. Thomas, Hasitha Tissera…

    Citation: BMC Medical Research Methodology 2018 18:134

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  37. Content type: Research article

    Understanding and measuring implementation processes is a key challenge for implementation researchers. This study draws on Normalization Process Theory (NPT) to develop an instrument that can be applied to as...

    Authors: Tim Rapley, Melissa Girling, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Carl R. May and Tracy L. Finch

    Citation: BMC Medical Research Methodology 2018 18:133

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  38. Content type: Research article

    Efforts to improve maternal health are increasingly focused on improving the quality of care provided to women at health facilities, including the promotion of respectful care and eliminating mistreatment of w...

    Authors: Meghan A. Bohren, Joshua P. Vogel, Bukola Fawole, Ernest T. Maya, Thae Maung Maung, Mamadou Diouldé Baldé, Agnes A. Oyeniran, Modupe Ogunlade, Kwame Adu-Bonsaffoh, Nwe Oo Mon, Boubacar Alpha Diallo, Abou Bangoura, Richard Adanu, Sihem Landoulsi, A. Metin Gülmezoglu and Özge Tunçalp

    Citation: BMC Medical Research Methodology 2018 18:132

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  39. Content type: Debate

    The dominant medical and health research paradigm continues to be quantitative. While the authors sense a sea-change in opinion about mixed-method research, underpinned by two decades of highly-cited publicati...

    Authors: Frances Rapport and Jeffrey Braithwaite

    Citation: BMC Medical Research Methodology 2018 18:131

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  40. Content type: Research article

    This study aimed to introduce recursively imputed survival trees into multistate survival models (MSRIST) to analyze these types of data and to identify the prognostic factors influencing the disease progressi...

    Authors: Leili Tapak, Michael R. Kosorok, Majid Sadeghifar and Omid Hamidi

    Citation: BMC Medical Research Methodology 2018 18:129

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  41. Content type: Debate

    Using internet search engines (such as Google search) in systematic literature reviews is increasingly becoming a ubiquitous part of search methodology. In order to integrate the vast quantity of available kno...

    Authors: Marko Ćurković and Andro Košec

    Citation: BMC Medical Research Methodology 2018 18:130

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  42. Content type: Technical advance

    Network meta-analysis is an extension of the classical pairwise meta-analysis and allows to compare multiple interventions based on both head-to-head comparisons within trials and indirect comparisons across t...

    Authors: Lorenz Uhlmann, Katrin Jensen and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2018 18:128

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  43. Content type: Research article

    Hypertension remains one of the most important preventable risk factors for diseases and death. Identifying clustered patterns of modifiable lifestyle risk factors for hypertension and demographics factors rel...

    Authors: Jalileh Ghanbari, Asghar Mohammadpoorasl, Leila Jahangiry, Mahdieh Abbasalizad Farhangi, Jamileh Amirzadeh and Koen Ponnet

    Citation: BMC Medical Research Methodology 2018 18:127

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  44. Content type: Research article

    With 1 in 4 Canadian preschoolers considered overweight or obese, identifying risk factors for excess weight gain and developing effective interventions aimed at promoting healthy weights and related behaviour...

    Authors: Kathryn Walton, Tory Ambrose, Angela Annis, David WL. Ma and Jess Haines

    Citation: BMC Medical Research Methodology 2018 18:126

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  45. Content type: Study protocol

    Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and...

    Authors: Macey L. Murray, Jade Meadows, Caroline J. Doré, Andrew J. Copas, Lewis J. Haddow, Charles Lacey, Mark Jit, Kate Soldan, Kate Bennett, Michelle Tetlow, Mayura Nathan and Richard Gilson

    Citation: BMC Medical Research Methodology 2018 18:125

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  46. Content type: Study protocol

    Recent regulatory changes in the system by which premises are licensed to sell alcohol, have given health representatives a formal role in the process in England and Scotland. The degree to which local public ...

    Authors: Niamh Fitzgerald, Matt Egan, Frank de Vocht, Colin Angus, James Nicholls, Niamh Shortt, Tim Nichols, Nason Maani Hessari, Cheryl McQuire, Richard Purves, Nathan Critchlow, Andrea Mohan, Laura Mahon, Colin Sumpter and Linda Bauld

    Citation: BMC Medical Research Methodology 2018 18:123

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  47. Content type: Research article

    Biomarker-based analyses are commonly reported in observational epidemiological studies; however currently there are no specific study quality assessment tools to assist evaluation of conducted research. Accou...

    Authors: Jan Wirsching, Sophie Graßmann, Fabian Eichelmann, Laura Malin Harms, Matthew Schenk, Eva Barth, Alide Berndzen, Moses Olalekan, Leen Sarmini, Hedwig Zuberer and Krasimira Aleksandrova

    Citation: BMC Medical Research Methodology 2018 18:122

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  48. Content type: Study protocol

    Considering the targeted general practitioner-centred healthcare in Germany, general practitioners (GPs) are in the best possible position to increase awareness of all sorts of dementia, an age-related syndrom...

    Authors: Judith Tillmann, Rieke Schnakenberg, Marie-Therese Puth, Klaus Weckbecker, Johannes Just and Eva Münster

    Citation: BMC Medical Research Methodology 2018 18:124

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  49. Content type: Research article

    Data-driven population segmentation analysis utilizes data analytics to divide a heterogeneous population into parsimonious and relatively homogenous groups with similar healthcare characteristics. It is a pro...

    Authors: Shi Yan, Yu Heng Kwan, Chuen Seng Tan, Julian Thumboo and Lian Leng Low

    Citation: BMC Medical Research Methodology 2018 18:121

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  50. Content type: Research article

    The most commonly reported outcome measure in Dupuytren disease is the extension deficit in finger joints. This study aimed to investigate the examiners’ influence on the measured difference between active and...

    Authors: Jesper Nordenskjöld, Stina Brodén and Isam Atroshi

    Citation: BMC Medical Research Methodology 2018 18:120

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