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  1. Content type: Research article

    Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design as...

    Authors: Dorothea Weber, Lorenz Uhlmann, Silvia Schönenberger and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2019 19:150

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  2. Content type: Technical advance

    In the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field. Most preve...

    Authors: Abdoulaye Guindo, Issaka Sagara, Boukary Ouedraogo, Kankoe Sallah, Mahamadoun Hamady Assadou, Sara Healy, Patrick Duffy, Ogobara K. Doumbo, Alassane Dicko, Roch Giorgi and Jean Gaudart

    Citation: BMC Medical Research Methodology 2019 19:149

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  3. Content type: Research article

    There is an increasing number of published systematic reviews (SR) of dose-response meta-analyses (DRMAs) over the past decades. However, the quality of abstract reporting of these SR-DRMAs remains to be under...

    Authors: Peng-Li Jia, Bin Xu, Jing-Min Cheng, Xi-Hao Huang, Joey S. W. Kwong, Yu Liu, Chao Zhang, Ying Han and Chang Xu

    Citation: BMC Medical Research Methodology 2019 19:148

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  4. Content type: Research article

    The attendance to cervical cancer screening is low among immigrants in many high-income countries. Although several interventions have been experimentally tested,implementation remains a challenge. Several fac...

    Authors: Samera A. Qureshi, Abdi Gele, Prabhjot Kour, Kathy A. Møen, Bernadette Kumar and Esperanza Diaz

    Citation: BMC Medical Research Methodology 2019 19:147

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  5. Content type: Research article

    To reliably evaluate the acceptance and use of computer-based prostate cancer decision aids (CBDAs) for African-American men, culturally relevant measures are needed. This study describes the development and i...

    Authors: Otis L. Owens, Nikki R. Wooten and Abbas S. Tavakoli

    Citation: BMC Medical Research Methodology 2019 19:146

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  6. Content type: Research article

    The life expectancy of cancer patients, and the loss in expectation of life as compared to the life expectancy without cancer, is a useful measure of cancer patient survival and complement the more commonly re...

    Authors: Therese M.-L. Andersson, Mark J. Rutherford and Paul C. Lambert

    Citation: BMC Medical Research Methodology 2019 19:145

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  7. Content type: Research article

    Postal surveys are widely used in scientific studies, including dietary surveys, but few studies about methods to increase participation in national dietary surveys are published. In the present study we compa...

    Authors: Jannicke Borch Myhre, Lene Frost Andersen, Kristin Holvik, Helene Astrup and Anne Lene Kristiansen

    Citation: BMC Medical Research Methodology 2019 19:144

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  8. Content type: Research article

    Sequence symmetry analysis (SSA) is a signal detection method that can be used to assist with adverse drug event detection. It provides both a risk estimate and a data visualisation. Published methods provide ...

    Authors: Adrian Kym Preiss, Elizabeth Ellen Roughead and Nicole Leanne Pratt

    Citation: BMC Medical Research Methodology 2019 19:143

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  9. Content type: Research article

    Incidence rates of advanced cancer stages are important, e.g., for monitoring cancer screening programs. However, information from cancer registries on tumor stage is often incomplete. Exemplified by colorecta...

    Authors: Katja Anita Oppelt, Sabine Luttmann, Klaus Kraywinkel and Ulrike Haug

    Citation: BMC Medical Research Methodology 2019 19:142

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  10. Content type: Research article

    In most cases, the total scores from different instruments assessing the same construct are not directly comparable, but must be equated. In this study we aimed to illustrate a novel test equating methodology ...

    Authors: Núria Duran Adroher, Svend Kreiner, Carolyn Young, Roger Mills and Alan Tennant

    Citation: BMC Medical Research Methodology 2019 19:141

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  11. Content type: Research article

    The multicriteria decision method (MCDM) aims to find conflicts among alternatives by comparing and evaluating them according to various criteria to reach the best compromise solution. The evaluation of a new ...

    Authors: Giovanni Improta, Antonietta Perrone, Mario Alessandro Russo and Maria Triassi

    Citation: BMC Medical Research Methodology 2019 19:140

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  12. Content type: Research article

    Information exchange between physician and patient is crucial to achieve patient involvement, shared decision making and treatment adherence. No reliable method exists for measuring how much information physic...

    Authors: J. M. Nordfalk, P. Gulbrandsen, J. Gerwing, M. Nylenna and J. Menichetti

    Citation: BMC Medical Research Methodology 2019 19:139

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  13. Content type: Research article

    Monetary incentive is often used to increase response rate in smokers’ survey, but such effect of prepaid and promised incentives in a follow-up survey is unknown. We compared the effect of different incentive...

    Authors: Yee Tak Derek Cheung, Xue Weng, Man Ping Wang, Sai Yin Ho, Antonio Cho Shing Kwong, Vienna Wai Yin Lai and Tai Hing Lam

    Citation: BMC Medical Research Methodology 2019 19:138

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  14. Content type: Research article

    Randomised controlled trials (RCTs) are considered the gold standard when evaluating the causal effects of healthcare interventions. When RCTs cannot be used (e.g. ethically difficult), the interrupted time se...

    Authors: Jemma Hudson, Shona Fielding and Craig R. Ramsay

    Citation: BMC Medical Research Methodology 2019 19:137

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  15. Content type: Research article

    In theory, efficient design of randomized controlled trials (RCTs) involves randomization algorithms that control baseline variable imbalance efficiently, and corresponding analysis involves pre-specified adju...

    Authors: Jody D. Ciolino, Hannah L. Palac, Amy Yang, Mireya Vaca and Hayley M. Belli

    Citation: BMC Medical Research Methodology 2019 19:136

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  16. Content type: Research article

    Participation in epidemiologic studies is steadily declining, which may result in selection bias. It is therefore an ongoing challenge to clarify the determinants of participation to judge possible selection e...

    Authors: Cornelia Enzenbach, Barbara Wicklein, Kerstin Wirkner and Markus Loeffler

    Citation: BMC Medical Research Methodology 2019 19:135

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  17. Content type: Research article

    Clinical guidelines produced in developed nations may not be appropriate in resource-constrained environments, due to differences in cultural, societal, economic and policy contexts. The purpose of this articl...

    Authors: D. V. Ernstzen, S. L. Hillier and Q. A. Louw

    Citation: BMC Medical Research Methodology 2019 19:134

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  19. Content type: Research article

    Stringent requirements exist regarding the transparency of the study selection process and the reliability of results. A 2-step selection process is generally recommended; this is conducted by 2 reviewers inde...

    Authors: Siw Waffenschmidt, Marco Knelangen, Wiebke Sieben, Stefanie Bühn and Dawid Pieper

    Citation: BMC Medical Research Methodology 2019 19:132

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  20. Content type: Research article

    Report cards on the health care system increasingly report provider-specific performance on indicators that measure the quality of health care delivered. A natural reaction to the publishing of hospital-specif...

    Authors: Peter C. Austin, Iris E. Ceyisakar, Ewout W. Steyerberg, Hester F. Lingsma and Perla J. Marang-van de Mheen

    Citation: BMC Medical Research Methodology 2019 19:131

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  21. Content type: Research article

    Tacrolimus (TAC) is an immunosuppressant drug given to kidney transplant recipients post-transplant to prevent antibody formation and kidney rejection. The optimal therapeutic dose for TAC is poorly defined an...

    Authors: Kristen R. Campbell, Elizabeth Juarez-Colunga, Gary K. Grunwald, James Cooper, Scott Davis and Jane Gralla

    Citation: BMC Medical Research Methodology 2019 19:130

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  22. Content type: Research article

    Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it’s important to control the family wise error rate (FWER). A popular approach to do this is...

    Authors: Victoria Vickerstaff, Rumana Z. Omar and Gareth Ambler

    Citation: BMC Medical Research Methodology 2019 19:129

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  23. Content type: Research article

    A large number of articles examined the preventability rate of readmissions, but comparison and interpretability of these preventability rates is complicated due to the large heterogeneity of methods that were...

    Authors: Eva-Linda Kneepkens, Corline Brouwers, Richelle Glory Singotani, Martine C. de Bruijne and Fatma Karapinar-Çarkit

    Citation: BMC Medical Research Methodology 2019 19:128

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  24. Content type: Research article

    The number of web-based E-epidemiologic studies using online recruitment methods is increasing. However, the optimal online recruitment method in terms of maximizing recruitment rates is still unknown. Our aim...

    Authors: Cauane Blumenberg, Ana Maria Baptista Menezes, Helen Gonçalves, Maria Cecília Formoso Assunção, Fernando César Wehrmeister and Aluísio J. D. Barros

    Citation: BMC Medical Research Methodology 2019 19:127

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  25. Content type: Research article

    The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multip...

    Authors: Charlotte L. Hall, Susan Brown, Marilyn James, Jennifer L. Martin, Nikki Brown, Kim Selby, Julie Clarke, Laura Williams, Kapil Sayal, Chris Hollis and Madeleine J. Groom

    Citation: BMC Medical Research Methodology 2019 19:126

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  26. Content type: Debate

    Use of big data is becoming increasingly popular in medical research. Since big data-based projects differ notably from classical research studies, both in terms of scope and quality, a debate is apt as to whe...

    Authors: Amke Caliebe, Friedhelm Leverkus, Gerd Antes and Michael Krawczak

    Citation: BMC Medical Research Methodology 2019 19:125

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  27. Content type: Research article

    Two randomized controlled trials (RCTs) were conducted to explore the utility of the Mechanical Turk (MTurk) crowdsourcing platform to conduct rapid trials evaluating online interventions for unhealthy alcohol...

    Authors: John A. Cunningham, Alexandra Godinho and Nicolas Bertholet

    Citation: BMC Medical Research Methodology 2019 19:124

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  28. Content type: Research article

    Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for cl...

    Authors: James Thomas Martin, Karla Hemming and Alan Girling

    Citation: BMC Medical Research Methodology 2019 19:123

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  29. Content type: Research article

    Accurate measurement of health literacy is essential to improve accessibility and effectiveness of health care and prevention. One measure frequently applied in international research is the Short Assessment o...

    Authors: A. J. Woudstra, C. S. Meppelink, H. Pander Maat, J. Oosterhaven, M. P. Fransen and A. L. Dima

    Citation: BMC Medical Research Methodology 2019 19:122

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  30. Content type: Research article

    Small group research in healthcare is important because it deals with interaction and decision-making processes that can help to identify and improve safer patient treatment and care. However, the number of st...

    Authors: Lisa Aufegger, Colin Bicknell, Emma Soane, Hutan Ashrafian and Ara Darzi

    Citation: BMC Medical Research Methodology 2019 19:121

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  31. Content type: Research article

    Health researchers often use survey studies to examine associations between risk factors at one time point and health outcomes later in life. Previous studies have shown that missing not at random (MNAR) may p...

    Authors: Kristin Gustavson, Espen Røysamb and Ingrid Borren

    Citation: BMC Medical Research Methodology 2019 19:120

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  32. Content type: Research article

    The Fred Hutchinson Cancer Research Center has engaged an External Stakeholder Advisory Group (ESAG) in the planning and implementation of the TrACER Study (S1415CD), a five-year pragmatic clinical trial asses...

    Authors: Sarah Barger, Sean D. Sullivan, Ari Bell-Brown, Brad Bott, Anne Marie Ciccarella, John Golenski, Mark Gorman, Judy Johnson, Karma Kreizenbeck, Florence Kurttila, Ginny Mason, Jamie Myers, Carole Seigel, James L. Wade III, Guneet Walia, Kate Watabayashi…

    Citation: BMC Medical Research Methodology 2019 19:119

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  34. Content type: Research article

    Clinical prediction models are not routinely validated. To facilitate validation procedures, the online Evidencio platform (https://​www.​evidencio.​com) ...

    Authors: Cornelia D. van Steenbeek, Marissa C. van Maaren, Sabine Siesling, Annemieke Witteveen, Xander A. A. M. Verbeek and Hendrik Koffijberg

    Citation: BMC Medical Research Methodology 2019 19:117

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  35. Content type: Research article

    We determined whether it is feasible to identify important changes in care management resulting from cardiovascular magnetic resonance (CMR) in patients who activate the primary percutaneous coronary intervent...

    Authors: Maria Pufulete, Jessica Harris, Stephen Dorman, Lynn Cook, Chiara Bucciarelli-Ducci, John Greenwood, Richard Anderson, Rachel Brierley and Barnaby C. Reeves

    Citation: BMC Medical Research Methodology 2019 19:116

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  36. Content type: Research article

    Comorbidity measures, such as the Charlson Comorbidity Index (CCI) and Elixhauser Method (EM), are frequently used for risk-adjustment by healthcare researchers. This study sought to create CCI and EM lists of...

    Authors: David Metcalfe, James Masters, Antonella Delmestri, Andrew Judge, Daniel Perry, Cheryl Zogg, Belinda Gabbe and Matthew Costa

    Citation: BMC Medical Research Methodology 2019 19:115

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  38. Content type: Research article

    Qualitative evidence synthesis is increasingly used alongside reviews of effectiveness to inform guidelines and other decisions. To support this use, the GRADE-CERQual approach was developed to assess and comm...

    Authors: Heather Menzies Munthe-Kaas, Claire Glenton, Andrew Booth, Jane Noyes and Simon Lewin

    Citation: BMC Medical Research Methodology 2019 19:113

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  39. Content type: Research article

    From 2005 to 2010, we conducted 2 randomized studies on a journal (Medicina Clínica), where we took manuscripts received for publication and randomly assigned them to either the standard editorial process or t...

    Authors: Marta Vilaró, Jordi Cortés, Albert Selva-O’Callaghan, Agustín Urrutia, Josep-Maria Ribera, Francesc Cardellach, Xavier Basagaña, Matthew Elmore, Miquel Vilardell, Douglas Altman, José-Antonio González and Erik Cobo

    Citation: BMC Medical Research Methodology 2019 19:112

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  40. Content type: Research article

    Length of stay evaluations are very common to determine the burden of nosocomial infections. However, there exist fundamentally different methods to quantify the prolonged length of stay associated with nosoco...

    Authors: Martin Wolkewitz, Martin Schumacher, Gerta Rücker, Stephan Harbarth and Jan Beyersmann

    Citation: BMC Medical Research Methodology 2019 19:111

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  41. Content type: Research article

    This study compares an algorithm to detect acute gastroenteritis (AG) episodes from drug dispensing data to the validated data reported in a primary care surveillance system in France.

    Authors: Ana-Maria Vilcu, Thierry Blanchon, Laure Sabatte, Cécile Souty, Milka Maravic, Thomas Hanslik and Olivier Steichen

    Citation: BMC Medical Research Methodology 2019 19:110

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  42. Content type: Study protocol

    Household surveys are a key epidemiological, medical, and social research method. In poor urban environments, such as slums, censuses can often be out-of-date or fail to record transient residents, maps may be...

    Authors:

    Citation: BMC Medical Research Methodology 2019 19:109

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  43. Content type: Research article

    The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way t...

    Authors: Andrew M. Smith, John P. Christodouleas and Wei-Ting Hwang

    Citation: BMC Medical Research Methodology 2019 19:108

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  44. Content type: Research article

    Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primar...

    Authors: Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson and Kasia Stepniewska

    Citation: BMC Medical Research Methodology 2019 19:107

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  46. Content type: Research article

    In this paper we discuss the emergence of many different methods for doing a literature review. Referring back to the early days, when there were essentially two types of review; a Cochrane systematic review a...

    Authors: Helen Aveyard and Caroline Bradbury-Jones

    Citation: BMC Medical Research Methodology 2019 19:105

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  47. Content type: Research article

    Net survival, a measure of the survival where the patients would only die from the cancer under study, may be compared between treatment groups using either “cause-specific methods”, when the causes of death a...

    Authors: Juste Aristide Goungounga, Célia Touraine, Nathalie Grafféo and Roch Giorgi

    Citation: BMC Medical Research Methodology 2019 19:104

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  48. Content type: Research article

    Most clinical trials with time-to-event primary outcomes are designed assuming constant event rates and proportional hazards over time. Non-constant event rates and non-proportional hazards are seen increasing...

    Authors: Kim Jachno, Stephane Heritier and Rory Wolfe

    Citation: BMC Medical Research Methodology 2019 19:103

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  49. Content type: Research article

    Large and complex studies are now routine, and quality assurance and quality control (QC) procedures ensure reliable results and conclusions. Standard procedures may comprise manual verification and double ent...

    Authors: Kelly M. Sunderland, Derek Beaton, Julia Fraser, Donna Kwan, Paula M. McLaughlin, Manuel Montero-Odasso, Alicia J. Peltsch, Frederico Pieruccini-Faria, Demetrios J. Sahlas, Richard H. Swartz, Stephen C. Strother and Malcolm A. Binns

    Citation: BMC Medical Research Methodology 2019 19:102

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  50. Content type: Research article

    Bayesian adaptive designs can improve the efficiency of trials, and lead to trials that can produce high quality evidence more quickly, with fewer patients and lower costs than traditional methods. The aim of ...

    Authors: Elizabeth G. Ryan, Julie Bruce, Andrew J. Metcalfe, Nigel Stallard, Sarah E. Lamb, Kert Viele, Duncan Young and Simon Gates

    Citation: BMC Medical Research Methodology 2019 19:99

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