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  1. Combination therapies directed at multiple targets have potentially improved treatment effects for cancer patients. Compared to monotherapy, targeted combination therapy leads to an increasing number of subgro...

    Authors: Xin Chen, Jingyi Zhang, Liyun Jiang and Fangrong Yan
    Citation: BMC Medical Research Methodology 2023 23:66
  2. Overweight and obesity are severe public health problems worldwide. Obesity can lead to chronic diseases such as type 2 diabetes mellitus. Environmental factors may affect lifestyle aspects and are therefore e...

    Authors: Maximilian Präger, Christoph Kurz, Rolf Holle, Werner Maier and Michael Laxy
    Citation: BMC Medical Research Methodology 2023 23:65
  3. The effectiveness of malaria vector control interventions is often evaluated using cluster randomized trials (CRT) with outcomes assessed using repeated cross-sectional surveys. A key requirement for appropria...

    Authors: Yongdong Ouyang, Manisha A. Kulkarni, Natacha Protopopoff, Fan Li and Monica Taljaard
    Citation: BMC Medical Research Methodology 2023 23:64
  4. ‘A Measurement Tool to Assess Systematic Reviews, version 2’ (AMSTAR 2) is a validated 16-item scale designed to appraise systematic reviews (SRs) of healthcare interventions and to rate the overall confidence...

    Authors: Karina Karolina De Santis, Dawid Pieper, Robert C. Lorenz, Uta Wegewitz, Waldemar Siemens and Katja Matthias
    Citation: BMC Medical Research Methodology 2023 23:63
  5. To control emerging diseases, governments often have to make decisions based on limited evidence. The effective or temporal reproductive number is used to estimate the expected number of new cases caused by an...

    Authors: Chawarat Rotejanaprasert, Andrew B. Lawson and Richard J. Maude
    Citation: BMC Medical Research Methodology 2023 23:62
  6. In evidence synthesis practice, dealing with studies with no cases in both arms has been a tough problem, for which there is no consensus in the research community. In this study, we propose a method to measur...

    Authors: Chang Xu, Luis Furuya-Kanamori, Lifeng Lin, Liliane Zorzela, Tianqi Yu and Sunita Vohra
    Citation: BMC Medical Research Methodology 2023 23:61
  7. Latent class models are increasingly used to estimate the sensitivity and specificity of diagnostic tests in the absence of a gold standard, and are commonly fitted using Bayesian methods. These models allow u...

    Authors: Suzanne H. Keddie, Oliver Baerenbold, Ruth H. Keogh and John Bradley
    Citation: BMC Medical Research Methodology 2023 23:58
  8. Combinations of drugs are becoming increasingly common in oncology treatment. In some cases, patients can benefit from the interaction between two drugs, although there is usually a higher risk of developing t...

    Authors: Zhaohang Li, Ze Xu, Aijun Zhang, Guanpeng Qi and Zuojing Li
    Citation: BMC Medical Research Methodology 2023 23:57
  9. Science is becoming increasingly data intensive as digital innovations bring new capacity for continuous data generation and storage. This progress also brings challenges, as many scientific initiatives are ch...

    Authors: Mingkai Peng, Danielle A. Southern, Wrechelle Ocampo, Jaime Kaufman, David B. Hogan, John Conly, Barry W. Baylis, Henry T. Stelfox, Chester Ho and William A. Ghali
    Citation: BMC Medical Research Methodology 2023 23:56
  10. Safe and effective vaccines are crucial for the control of Covid-19 and to protect individuals at higher risk of severe disease. The test-negative design is a popular option for evaluating the effectiveness of...

    Authors: Paolo Eusebi, Niko Speybroeck, Sonja Hartnack, Jacob Stærk-Østergaard, Matthew J. Denwood and Polychronis Kostoulas
    Citation: BMC Medical Research Methodology 2023 23:55
  11. Longitudinal studies are critical to informing evolving responses to COVID-19 but can be hampered by attrition bias, which undermines their reliability for guiding policy and practice. We describe recruitment ...

    Authors: Thi Nguyen, Alexander J. Thomas, Phoebe Kerr, Ashleigh C. Stewart, Anna Lee Wilkinson, Long Nguyen, Aimée Altermatt, Kathryn Young, Katherine Heath, Anna Bowring, Stephanie Fletcher-Lartey, Dean Lusher, Sophie Hill, Alisa Pedrana, Mark Stoové, Katherine Gibney…
    Citation: BMC Medical Research Methodology 2023 23:54
  12. The study aimed to explore reporting characteristics of scoping reviews in dental public health and the impact of some factors on the reporting quality.

    Authors: Lara Dotto, Mateus Bertolini Fernandes dos Santos and Rafael Sarkis-Onofre
    Citation: BMC Medical Research Methodology 2023 23:53
  13. In health research, several chronic diseases are susceptible to competing risks (CRs). Initially, statistical models (SM) were developed to estimate the cumulative incidence of an event in the presence of CRs....

    Authors: Georgios Kantidakis, Hein Putter, Saskia Litière and Marta Fiocco
    Citation: BMC Medical Research Methodology 2023 23:51
  14. Commercial activity trackers are increasingly used in research and compared with research-based accelerometers are often less intrusive, cheaper, with improved storage and battery capacity, although typically ...

    Authors: Emilia Kristiansson, Jonatan Fridolfsson, Daniel Arvidsson, Agneta Holmäng, Mats Börjesson and Ulrika Andersson-Hall
    Citation: BMC Medical Research Methodology 2023 23:50
  15. Treatment switching, also called crossover, is common in clinical trials because of ethical concerns or other reasons. When it occurs and the primary objective is to identify treatment effects, the most widely...

    Authors: Lejun Deng, Chih-Yuan Hsu and Yu Shyr
    Citation: BMC Medical Research Methodology 2023 23:49
  16. Limited information is available about neonates’ critical conditions data quality. The study aim was to measure the agreement regarding presence of neonatal critical conditions between Medicaid Analytic eXtrac...

    Authors: Yasser Albogami, Yanmin Zhu, Xi Wang and Almut G Winterstein
    Citation: BMC Medical Research Methodology 2023 23:47
  17. Multi-institution electronic health records (EHR) are a rich source of real world data (RWD) for generating real world evidence (RWE) regarding the utilization, benefits and harms of medical interventions. The...

    Authors: Hythem Sidky, Jessica C. Young, Andrew T. Girvin, Eileen Lee, Yu Raymond Shao, Nathan Hotaling, Sam Michael, Kenneth J. Wilkins, Soko Setoguchi and Michele Jonsson Funk
    Citation: BMC Medical Research Methodology 2023 23:46
  18. Systematic reviews of studies of clinical prediction models are becoming increasingly abundant in the literature. Data extraction and risk of bias assessment are critical steps in any systematic review. CHARMS...

    Authors: Borja M. Fernandez-Felix, Jesus López-Alcalde, Marta Roqué, Alfonso Muriel and Javier Zamora
    Citation: BMC Medical Research Methodology 2023 23:44
  19. Researchers are cautioned against misinterpreting the conventional P value, especially while implementing the popular t test. Therefore, this study evaluated the agreement between the P value and Bayes factor (BF

    Authors: Natchalee Srimaneekarn, Pattamon Leelachaikul, Sasipa Thiradilok and Somchai Manopatanakul
    Citation: BMC Medical Research Methodology 2023 23:43
  20. Despite recent advances in causal inference methods, outcome regression remains the most widely used approach for estimating causal effects in epidemiological studies with a single-point exposure and outcome. ...

    Authors: Jiaxin Zhang, S Ghazaleh Dashti, John B. Carlin, Katherine J. Lee and Margarita Moreno-Betancur
    Citation: BMC Medical Research Methodology 2023 23:42
  21. Propensity score analysis is increasingly used to control for confounding factors in observational studies. Unfortunately, unavoidable missing values make estimating propensity scores extremely challenging. We...

    Authors: Shu Yang, Peipei Du, Xixi Feng, Daihai He, Yaolong Chen, Linda L. D. Zhong, Xiaodong Yan and Jiawei Luo
    Citation: BMC Medical Research Methodology 2023 23:41
  22. Multi-state models are complex stochastic models which focus on pathways defined by the temporal and sequential occurrence of numerous events of interest. In particular, the so-called illness-death models are ...

    Authors: Fran Llopis-Cardona, Carmen Armero and Gabriel Sanfélix-Gimeno
    Citation: BMC Medical Research Methodology 2023 23:40
  23. Incidence is one of the most important epidemiologic indices in surveillance. However, determining incidence is complex and requires time-consuming cohort studies or registries with date of diagnosis. Estimati...

    Authors: Annika Hoyer, Ralph Brinks, Thaddäus Tönnies, Sharon H. Saydah, Ralph B. D’Agostino Jr., Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan and Giuseppina Imperatore
    Citation: BMC Medical Research Methodology 2023 23:39
  24. Patient-reported outcomes such as health-related quality of life (HRQoL) are increasingly used as endpoints in randomized cancer clinical trials. However, the patients often drop out so that observation of the...

    Authors: Célia Touraine, Benjamin Cuer, Thierry Conroy, Beata Juzyna, Sophie Gourgou and Caroline Mollevi
    Citation: BMC Medical Research Methodology 2023 23:36
  25. Composite endpoints for estimating treatment efficacy are routinely used in several therapeutic areas and have become complex in the number and types of component outcomes included. It is assumed that its comp...

    Authors: Majid Nabipoor, Cynthia M. Westerhout, Sarah Rathwell and Jeffrey A. Bakal
    Citation: BMC Medical Research Methodology 2023 23:35
  26. This analysis addresses the characteristics of two emergency department (ED) patient populations defined by three model diseases (hip fractures, respiratory, and cardiac symptoms) making use of survey (primary...

    Authors: Anna Schneider, Andreas Wagenknecht, Hanna Sydow, Dorothee Riedlinger, Felix Holzinger, Andrea Figura, Johannes Deutschbein, Thomas Reinhold, Mareen Pigorsch, Ulrike Stasun, Liane Schenk and Martin Möckel
    Citation: BMC Medical Research Methodology 2023 23:34
  27. There is increasing interest in clinical prediction models for rare outcomes such as suicide, psychiatric hospitalizations, and opioid overdose. Accurate model validation is needed to guide model selection and...

    Authors: R Yates Coley, Qinqing Liao, Noah Simon and Susan M. Shortreed
    Citation: BMC Medical Research Methodology 2023 23:33
  28. Authors: Gloria A. Aguayo, Lu Zhang, Michel Vaillant, Moses Ngari, Magali Perquin, Valerie Moran, Laetitia Huiart, Rejko Krüger, Francisco Azuaje, Cyril Ferdynus and Guy Fagherazzi
    Citation: BMC Medical Research Methodology 2023 23:32

    The original article was published in BMC Medical Research Methodology 2023 23:8

  29. A previously developed decision model to prioritize surgical procedures in times of scarce surgical capacity used quality of life (QoL) primarily derived from experts in one center. These estimates are key inp...

    Authors: Benjamin Y. Gravesteijn, Kira S. van Hof, Eline Krijkamp, Franck Asselman, C. René Leemans, Anouk M.I.A. van Alphen, Henriëtte van der Horst, Guy Widdershoven, Leonie Baatenburg de Jong, Hester Lingsma, Jan Busschbach and Rob Baatenburg de Jong
    Citation: BMC Medical Research Methodology 2023 23:31
  30. Diagnostic tests are important in clinical medicine. To determine the test performance indices — test sensitivity, specificity, likelihood ratio, predictive values, etc. — the test results should be compared a...

    Authors: Farrokh Habibzadeh and Hooman Roozbehi
    Citation: BMC Medical Research Methodology 2023 23:30
  31. The registration of clinical trials is required by law in Switzerland. We investigated (1) the proportion of registered and prospectively registered clinical trials, (2) the availability of results for ethical...

    Authors: Katharina Klatte, Constantin Sluka, Viktoria Gloy, Ala Taji Heravi, Christof Schönenberger, Nienke Jones, Elena Brunnschweiler, Christiane Pauli-Magnus and Matthias Briel
    Citation: BMC Medical Research Methodology 2023 23:27
  32. Authors: R. K. Ismail, F. M. N. H. Schramel, M. van Dartel, A. M. G. Pasmooij, C. M. Cramer-van der Welle, D. L. Hilarius, A. de Boer, M. W. J. M. Wouters and E. M. W. van de Garde
    Citation: BMC Medical Research Methodology 2023 23:26

    The original article was published in BMC Medical Research Methodology 2023 23:1

  33. Numerous clinical trials have been initiated to find effective treatments for COVID-19. These trials have often been initiated in regions where the pandemic has already peaked. Consequently, achieving full enr...

    Authors: Danni Wu, Keith S. Goldfeld and Eva Petkova
    Citation: BMC Medical Research Methodology 2023 23:25
  34. One of the main challenges of the COVID-19 pandemic is to make sense of available, but often heterogeneous and noisy data. This contribution presents a data-driven methodology that allows exploring the hospita...

    Authors: Alberto Aleta, Juan Luis Blas-Laína, Gabriel Tirado Anglés and Yamir Moreno
    Citation: BMC Medical Research Methodology 2023 23:24
  35. Multivariate longitudinal data are under-utilized for survival analysis compared to cross-sectional data (CS - data collected once across cohort). Particularly in cardiovascular risk prediction, despite availa...

    Authors: Hieu T. Nguyen, Henrique D. Vasconcellos, Kimberley Keck, Jared P. Reis, Cora E. Lewis, Steven Sidney, Donald M. Lloyd-Jones, Pamela J. Schreiner, Eliseo Guallar, Colin O. Wu, João A.C. Lima and Bharath Ambale-Venkatesh
    Citation: BMC Medical Research Methodology 2023 23:23
  36. The Pooled Cohort Equations (PCEs) are race- and sex-specific Cox proportional hazards (PH)-based models used for 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction with acceptable discrimi...

    Authors: Yu Deng, Lei Liu, Hongmei Jiang, Yifan Peng, Yishu Wei, Zhiyang Zhou, Yizhen Zhong, Yun Zhao, Xiaoyun Yang, Jingzhi Yu, Zhiyong Lu, Abel Kho, Hongyan Ning, Norrina B. Allen, John T. Wilkins, Kiang Liu…
    Citation: BMC Medical Research Methodology 2023 23:22
  37. Patient-reported physical function (PF) is a key endpoint in cancer clinical trials. Using complex statistical methods, common metrics have been developed to compare scores from different patient-reported outc...

    Authors: T Schurr, F Loth, E Lidington, C Piccinin, JI Arraras, M Groenvold, B Holzner, M van Leeuwen, MA Petersen, H Schmidt, T Young and JM Giesinger
    Citation: BMC Medical Research Methodology 2023 23:21
  38. Reporting quality is a critical issue in health sciences. Adopting the reporting guidelines has been approved to be an effective way of enhancing the reporting quality and transparency of clinical research. In...

    Authors: Yuting Duan, Lingyun Zhao, Yanfang Ma, Jingyuan Luo, Juexuan Chen, Jiangxia Miao, Xuan Zhang, David Moher and Zhaoxiang Bian
    Citation: BMC Medical Research Methodology 2023 23:20
  39. Advantages of meta-analysis depend on the assumptions underlying the statistical procedures used being met. One of the main assumptions that is usually taken for granted is the normality underlying the populat...

    Authors: Desirée Blázquez-Rincón, Julio Sánchez-Meca, Juan Botella and Manuel Suero
    Citation: BMC Medical Research Methodology 2023 23:19
  40. To have confidence in one's interpretation of treatment effects assessed by comparing trial results to external controls, minimizing bias is a critical step. We sought to investigate different methods for caus...

    Authors: Jinma Ren, Paul Cislo, Joseph C. Cappelleri, Patrick Hlavacek and Marco DiBonaventura
    Citation: BMC Medical Research Methodology 2023 23:18
  41. Surveys are common research tools, and questionnaires revisions are a common occurrence in longitudinal studies. Revisions can, at times, introduce systematic shifts in measures of interest. We formulate that ...

    Authors: Chung-Han Liang, Da-Wei Wang and Mei-Lien Pan
    Citation: BMC Medical Research Methodology 2023 23:15

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