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  1. The mortality risk among cancer patients measured from the time of diagnosis is often elevated in comparison to the general population. However, for some cancer types, the patient mortality risk will over time...

    Authors: Lasse H. Jakobsen, Therese M.-L. Andersson, Jorne L. Biccler, Laurids Ø. Poulsen, Marianne T. Severinsen, Tarec C. El-Galaly and Martin Bøgsted

    Citation: BMC Medical Research Methodology 2020 20:71

    Content type: Research Article

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  2. It is important to estimate the treatment effect of interest accurately and precisely within the analysis of randomised controlled trials. One way to increase precision in the estimate and thus improve the pow...

    Authors: Hanaya Raad, Victoria Cornelius, Susan Chan, Elizabeth Williamson and Suzie Cro

    Citation: BMC Medical Research Methodology 2020 20:70

    Content type: Research article

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  3. With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-e...

    Authors: Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy and Philippe Broët

    Citation: BMC Medical Research Methodology 2020 20:69

    Content type: Research Article

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  4. Rates of non-communicable diseases (NCDs) are rapidly rising in the Eastern Mediterranean Region (EMR). Systematic reviews satisfy the demand from practitioners and policy makers for prompt comprehensive evide...

    Authors: Alaa Akkawi, Joanne Khabsa, Aya Noubani, Sarah Jamali, Abla M. Sibai and Tamara Lotfi

    Citation: BMC Medical Research Methodology 2020 20:68

    Content type: Research article

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  5. Clinical trials are essential to improve knowledge of anesthesia and perioperative medicine. Unfortunately, many studies face participant-recruitment issues and fail to include the planned number of participan...

    Authors: Caroline Noirmain, Béatrice Gil-Wey, Isabelle Pichon, Pauline Brindel and Guy Haller

    Citation: BMC Medical Research Methodology 2020 20:67

    Content type: Research article

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  6. Missing data are an inevitable challenge in Randomised Controlled Trials (RCTs), particularly those with Patient Reported Outcome Measures. Methodological guidance suggests that to avoid incorrect conclusions,...

    Authors: Alexina J. Mason, Richard D. Grieve, Alvin Richards-Belle, Paul R. Mouncey, David A. Harrison and James R. Carpenter

    Citation: BMC Medical Research Methodology 2020 20:66

    Content type: Technical Advance

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  7. One of the frequently used methods for assessing research trends and the impact of published scientific literature in a particular discipline is citation analysis. Journals may strive to improve their metrics ...

    Authors: Antonia Jelicic Kadic, Tanja Kovacevic, Edita Runjic, Ana Simicic Majce, Josko Markic, Branka Polic, Julije Mestrovic and Livia Puljak

    Citation: BMC Medical Research Methodology 2020 20:60

    Content type: Research article

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  8. Sero- prevalence studies often have a problem of missing data. Few studies report the proportion of missing data and even fewer describe the methods used to adjust the results for missing data. The objective o...

    Authors: Neema R. Mosha, Omololu S. Aluko, Jim Todd, Rhoderick Machekano and Taryn Young

    Citation: BMC Medical Research Methodology 2020 20:65

    Content type: Research article

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  9. Among different investigators studying the same exposures and outcomes, there may be a lack of consensus about potential confounders that should be considered as matching, adjustment, or stratification variabl...

    Authors: Joshua D. Wallach, Stylianos Serghiou, Lingzhi Chu, Alexander C. Egilman, Vasilis Vasiliou, Joseph S. Ross and John P. A. Ioannidis

    Citation: BMC Medical Research Methodology 2020 20:64

    Content type: Research article

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  10. Non-participation and attrition are rarely studied despite being important methodological issues when performing post-disaster studies. A longitudinal survey of civilians exposed to the January 2015 terrorist ...

    Authors: Cécile Vuillermoz, Lise Eilin Stene, Lydéric Aubert, Yvon Motreff, Philippe Pirard, Thierry Baubet, Sophie Lesieur, Pierre Chauvin and Stéphanie Vandentorren

    Citation: BMC Medical Research Methodology 2020 20:63

    Content type: Research article

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  11. Cox proportional hazards regression models are used to evaluate associations between exposures of interest and time-to-event outcomes in observational data. When exposures are measured on only a sample of part...

    Authors: Colleen M. Sitlani, Thomas Lumley, Barbara McKnight, Kenneth M. Rice, Nels C. Olson, Margaret F. Doyle, Sally A. Huber, Russell P. Tracy, Bruce M. Psaty and Joseph A. C. Delaney

    Citation: BMC Medical Research Methodology 2020 20:62

    Content type: Research Article

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  12. In the data pipeline from the data collection process to the planned statistical analyses, initial data analysis (IDA) typically takes place between the end of the data collection and do not touch the research...

    Authors: Marianne Huebner, Werner Vach, Saskia le Cessie, Carsten Oliver Schmidt and Lara Lusa

    Citation: BMC Medical Research Methodology 2020 20:61

    Content type: Research article

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  13. Participant recruitment for clinical research studies remains a significant challenge for researchers. Novel approaches to recruitment are necessary to ensure that populations are easier to reach. In the conte...

    Authors: Janelle Applequist, Cristina Burroughs, Artemio Ramirez Jr, Peter A. Merkel, Marc E. Rothenberg, Bruce Trapnell, Robert J. Desnick, Mustafa Sahin and Jeffrey P. Krischer

    Citation: BMC Medical Research Methodology 2020 20:58

    Content type: Research article

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  14. The aims of this study were to assess whether the previous registration of a systematic review (SR) is associated with the improvement of the quality of the report of SRs and whether SR registration reduced ou...

    Authors: Mateus Bertolini Fernandes dos Santos, Bernardo Antônio Agostini, Rafaela Bassani, Gabriel Kalil Rocha Pereira and Rafael Sarkis-Onofre

    Citation: BMC Medical Research Methodology 2020 20:57

    Content type: Research article

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  15. Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood mental health disorders. Stimulant drugs as the most commonly used treatment and first-line therapy for ADHD have side effect...

    Authors: Hoda Shirafkan, Javad Mahmoudi-Gharaei, Akbar Fotouhi, Seyyed Ali Mozaffarpur, Mehdi Yaseri and Mostafa Hoseini

    Citation: BMC Medical Research Methodology 2020 20:56

    Content type: Research article

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  16. Single time-point assessments of psychological distress are often used to indicate chronic mental health problems, but the validity of this approach is unclear. The aims of this study were to investigate how a...

    Authors: J. Welsh, R. J. Korda, E. Banks, L. Strazdins, G. Joshy and P. Butterworth

    Citation: BMC Medical Research Methodology 2020 20:55

    Content type: Research article

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  17. Claims-based algorithms are commonly used to identify sepsis in health services research because the laboratory features required to define clinical criteria may not be available in administrative data.

    Authors: John P. Donnelly, Yuling Dai, Lisandro D. Colantonio, Hong Zhao, Monika M. Safford, John W. Baddley, Paul Muntner and Henry E. Wang

    Citation: BMC Medical Research Methodology 2020 20:54

    Content type: Research article

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  18. Studies examining incident heart failure (HF) have been limited to select populations. To examine incident HF with broader generalizability, there is need to assemble a HF-free cohort using a geographically-di...

    Authors: Parag Goyal, Matthew T. Mefford, Ligong Chen, Madeline R. Sterling, Raegan W. Durant, Monika M. Safford and Emily B. Levitan

    Citation: BMC Medical Research Methodology 2020 20:53

    Content type: Research article

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  19. In composing multi-thematic questionnaires for the Lolland-Falster Health Study (LOFUS), we faced a range of challenges, for which we found limited guidance in the literature. LOFUS is a household-based popula...

    Authors: Cecilie Lindström Egholm, Aake Packness, Jakob Stokholm, Knud Rasmussen, Christina Ellervik, Erik Simonsen, Anne Illemann Christensen and Randi Jepsen

    Citation: BMC Medical Research Methodology 2020 20:52

    Content type: Commentary

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  20. The health regulatory focus is an application of Higgins’ regulatory focus theory to a health-specific context. It explains individual differences in health motivation, strategies, and behavior. Previous resea...

    Authors: Bjarne Schmalbach, Markus Zenger, Elmar Brähler and Katja Petrowski

    Citation: BMC Medical Research Methodology 2020 20:51

    Content type: Research article

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  21. Longitudinal randomized controlled trials (RCTs) often aim to test and measure the effect of treatment between arms at a single time point. A two-sample χ2 test is a common statistical approach when outcome data ...

    Authors: Mary L. Miller, Denise J. Roe, Chengcheng Hu and Melanie L. Bell

    Citation: BMC Medical Research Methodology 2020 20:50

    Content type: Research article

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  22. Missing participant outcome data (MOD) are ubiquitous in systematic reviews with network meta-analysis (NMA) as they invade from the inclusion of clinical trials with reported participant losses. There are ava...

    Authors: Loukia M. Spineli and Chrysostomos Kalyvas

    Citation: BMC Medical Research Methodology 2020 20:48

    Content type: Research article

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  23. Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention. This is a particular risk in rehabilitation studies where it is ea...

    Authors: K. Robinson, F. Allen, J. Darby, C. Fox, A. L. Gordon, J. C. Horne, P. Leighton, E. Sims and P. A. Logan

    Citation: BMC Medical Research Methodology 2020 20:46

    Content type: Debate

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  24. Biosocial survey data are in high demand, yet little is known about the measurement quality of health measures collected by nurses in respondents’ homes. Our objective was to analyze the degree to which nurses...

    Authors: Alexandru Cernat and Joseph W. Sakshaug

    Citation: BMC Medical Research Methodology 2020 20:45

    Content type: Research article

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  25. Incomplete data are of particular important influence in mental measurement questionnaires. Most experts, however, mostly focus on clinical trials and cohort studies and generally pay less attention to this de...

    Authors: Xueying Xu, Leizhen Xia, Qimeng Zhang, Shaoning Wu, Mingcheng Wu and Hongbo Liu

    Citation: BMC Medical Research Methodology 2020 20:42

    Content type: Research article

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  26. A Core Outcomes Set (COS) is an agreed minimum set of outcomes that should be reported in all clinical studies related to a specific condition. Using prostate cancer as a case study, we identified, summarized,...

    Authors: Michela Meregaglia, Oriana Ciani, Helen Banks, Maximilian Salcher-Konrad, Caroline Carney, Sahan Jayawardana, Paula Williamson and Giovanni Fattore

    Citation: BMC Medical Research Methodology 2020 20:41

    Content type: Research article

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  27. In the original publication of this article [1], the incorrect causal diagram was submitted as Fig. 1.

    Authors: Myra B. McGuinness, Jessica Kasza, Amalia Karahalios, Robyn H. Guymer, Robert P. Finger and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2020 20:40

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2019 19:223

  28. The main goal of this study is to explore the use of features representing patient-level electronic health record (EHR) data, generated by the unsupervised deep learning algorithm autoencoder, in predictive mo...

    Authors: Lei Wang, Liping Tong, Darcy Davis, Tim Arnold and Tina Esposito

    Citation: BMC Medical Research Methodology 2020 20:37

    Content type: Research article

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  29. Network meta-analysis (NMA) is becoming increasingly popular in systematic reviews and health technology assessments. However, there is still ambiguity concerning the properties of the estimation approaches as...

    Authors: Corinna Kiefer, Sibylle Sturtz and Ralf Bender

    Citation: BMC Medical Research Methodology 2020 20:36

    Content type: Research Article

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  30. Validated algorithms to classify type 1 and 2 diabetes (T1D, T2D) are mostly limited to white pediatric populations. We conducted a large study in Hong Kong among children and adults with diabetes to develop a...

    Authors: Calvin Ke, Thérèse A. Stukel, Andrea Luk, Baiju R. Shah, Prabhat Jha, Eric Lau, Ronald C. W. Ma, Wing-Yee So, Alice P. Kong, Elaine Chow and Juliana C. N. Chan

    Citation: BMC Medical Research Methodology 2020 20:35

    Content type: Research article

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  31. The mechanisms and pathways to impacts from public health research in the UK have not been widely studied. Through the lens of one funder (NIHR), our aims are to map the diversity of public health research, in...

    Authors: Harriet Boulding, Adam Kamenetzky, Ioana Ghiga, Becky Ioppolo, Facundo Herrera, Sarah Parks, Catriona Manville, Susan Guthrie and Saba Hinrichs-Krapels

    Citation: BMC Medical Research Methodology 2020 20:34

    Content type: Research article

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  32. This article describes the design and baseline sample of a single-site trial comparing Individual Placement and Support (IPS) supported employment delivered within a Veterans Health Administration (VHA) primar...

    Authors: Lori L. Davis, Catherine M. Blansett, Mercy N. Mumba, David MacVicar, Richard Toscano, Patricia Pilkinton, Whitney Gay and Al Bartolucci

    Citation: BMC Medical Research Methodology 2020 20:33

    Content type: Research article

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  33. Outcomes in observational studies may not best estimate those expected in the HIV vaccine efficacy trials. We compared retention in Simulated HIV Vaccine Efficacy Trials (SiVETs) and observational cohorts draw...

    Authors: Andrew Abaasa, Jim Todd, Stephen Nash, Yunia Mayanja, Pontiano Kaleebu, Patricia E. Fast and Matt Price

    Citation: BMC Medical Research Methodology 2020 20:32

    Content type: Research article

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  34. There is broad recognition of the importance of evidence in informing clinical decisions. When information from all studies included in a systematic review (“review”) does not contribute to a meta-analysis, de...

    Authors: Ian J. Saldanha, Kristina B. Lindsley, Sarah Money, Hannah J. Kimmel, Bryant T. Smith and Kay Dickersin

    Citation: BMC Medical Research Methodology 2020 20:30

    Content type: Research article

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  35. Patient and public involvement (PPI) has become enshrined as an important pillar of health services empirical research, including PPI roles during stages of research development and analysis and co-design appr...

    Authors: S. Park, N. Khan, F. Stevenson and A. Malpass

    Citation: BMC Medical Research Methodology 2020 20:29

    Content type: Technical advance

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  36. Consensus-orientated Delphi studies are increasingly used in various areas of medical research using a variety of different rating scales and criteria for reaching consensus. We explored the influence of using...

    Authors: Toni Lange, Christian Kopkow, Jörg Lützner, Klaus-Peter Günther, Sascha Gravius, Hanns-Peter Scharf, Johannes Stöve, Richard Wagner and Jochen Schmitt

    Citation: BMC Medical Research Methodology 2020 20:28

    Content type: Research article

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  37. In the original publication of this article [1], the author should be only the collaboration group “STARSurg Collaborative”.

    Authors:

    Citation: BMC Medical Research Methodology 2020 20:27

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2019 19:237

  38. Data-visualization methods are essential to explore and communicate meta-analytic data and results. With a large number of novel graphs proposed quite recently, a comprehensive, up-to-date overview of availabl...

    Authors: Michael Kossmeier, Ulrich S. Tran and Martin Voracek

    Citation: BMC Medical Research Methodology 2020 20:26

    Content type: Research article

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  39. We recently developed CoCites, a citation-based search method that is designed to be more efficient than traditional keyword-based methods. The method begins with identification of one or more highly relevant ...

    Authors: A. Cecile J. W. Janssens, Marta Gwinn, J. Elaine Brockman, Kimberley Powell and Michael Goodman

    Citation: BMC Medical Research Methodology 2020 20:25

    Content type: Research article

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  40. Personalized healthcare promises to successfully advance the treatment of heterogeneous neurological disorders such as relapsing remitting multiple sclerosis by addressing the caveats of traditional healthcare...

    Authors: E. Stühler, S. Braune, F. Lionetto, Y. Heer, E. Jules, C. Westermann, A. Bergmann and P. van Hövell

    Citation: BMC Medical Research Methodology 2020 20:24

    Content type: Research article

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  41. The quality of medical research importantly depends, among other aspects, on a valid statistical planning of the study, analysis of the data, and reporting of the results, which is usually guaranteed by a bios...

    Authors: Antonia Zapf, Geraldine Rauch and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2020 20:23

    Content type: Debate

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  42. Clinical prediction models are widely used to guide medical advice and therapeutic interventions. Asthma is one of the most common chronic diseases globally and is characterised by acute deteriorations. These ...

    Authors: Joshua Bridge, John D. Blakey and Laura J. Bonnett

    Citation: BMC Medical Research Methodology 2020 20:22

    Content type: Research article

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  43. Identifying and assessing degree and type of frailty among older persons is a major challenge when targeting high risk populations to identify preventive interventions. The Vulnerable Elders Survey-(VES-13) is...

    Authors: Joël Belmin, Lyamna Khellaf, Sylvie Pariel, Witold Jarzebowski, Lucie Valembois, John Zeisel and Carmelo Lafuente-Lafuente

    Citation: BMC Medical Research Methodology 2020 20:21

    Content type: Research article

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  44. Cohen’s κ coefficient is often used as an index to measure the agreement of inter-rater determinations. However, κ varies greatly depending on the marginal distribution of the target population and overestimates ...

    Authors: Chikara Honda and Tetsuji Ohyama

    Citation: BMC Medical Research Methodology 2020 20:20

    Content type: Research article

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  45. There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and ...

    Authors: Aidan G. Cashin, James H. McAuley, Sarah E. Lamb, Sally Hopewell, Steven J. Kamper, Christopher M. Williams, Nicholas Henschke and Hopin Lee

    Citation: BMC Medical Research Methodology 2020 20:19

    Content type: Research article

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  46. With the increased empirical interest in the positive significance of improving nurses’ sense of professional benefits, there is a requirement for measures of nurses’ perceived professional benefit (NPPB). Our...

    Authors: Yanli Hu, Jing Hu, Liping Li, Bin Zhao, Xiaohong Liu and Fan Li

    Citation: BMC Medical Research Methodology 2020 20:18

    Content type: Research article

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  47. Patients infected with the Human Immunodeficiency Virus (HIV) are susceptible to many diseases. In these patients, the occurrence of one disease alters the chance of contracting another. Under such circumstanc...

    Authors: Sahar Nouri, Mahmood Mahmoudi, Kazem Mohammad, Mohammad Ali Mansournia, Mahdi Yaseri and Noori Akhtar-Danesh

    Citation: BMC Medical Research Methodology 2020 20:17

    Content type: Research article

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  48. Use of generalized linear models with continuous, non-linear functions for age, period and cohort makes it possible to estimate these effects so they are interpretable, reliable and easily displayed graphicall...

    Authors: Annette Dobson, Richard Hockey, Hsiu-Wen Chan and Gita Mishra

    Citation: BMC Medical Research Methodology 2020 20:16

    Content type: Research article

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  49. Regression analyses of time series of disease counts on environmental determinants are a prominent component of environmental epidemiology. For planning such studies, it can be useful to predict the precision ...

    Authors: Ben G. Armstrong, Antonio Gasparrini, Aurelio Tobias and Francesco Sera

    Citation: BMC Medical Research Methodology 2020 20:15

    Content type: Research article

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