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BMC Medical Research Methodology

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  1. Content type: Debate

    When discussing results medical research articles often tear substantive and statistical (methodical) contributions apart, just as if both were independent. Consequently, reasoning on bias tends to be vague, u...

    Authors: Michael Höfler, John Venz, Sebastian Trautmann and Robert Miller

    Citation: BMC Medical Research Methodology 2018 18:34

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  2. Content type: Correction

    Following publication of the original article [1] the authors reported that reference 15 (Cella et al.) had been incorrectly replaced with a duplicate of Brombin et al. during publication.

    Authors: Maria Sudell, Ruwanthi Kolamunnage-Dona and Catrin Tudur-Smith

    Citation: BMC Medical Research Methodology 2018 18:33

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    The original article was published in BMC Medical Research Methodology 2016 16:168

  3. Content type: Research article

    Sample size planning for longitudinal data is crucial when designing mediation studies because sufficient statistical power is not only required in grant applications and peer-reviewed publications, but is ess...

    Authors: Haitao Pan, Suyu Liu, Danmin Miao and Ying Yuan

    Citation: BMC Medical Research Methodology 2018 18:32

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  4. Content type: Research article

    Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear...

    Authors: Roelof B. Toonen, Klaas J. Wardenaar, Elisabeth H. Bos, Sonja L. van Ockenburg and Peter de Jonge

    Citation: BMC Medical Research Methodology 2018 18:31

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  5. Content type: Research article

    Increasing numbers of systematic reviews (SRs) on total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been published in recent years, but their quality has been unclear. The purpose of this stu...

    Authors: Xinyu Wu, Huan Sun, Xiaoqin Zhou, Ji Wang and Jing Li

    Citation: BMC Medical Research Methodology 2018 18:30

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  6. Content type: Research article

    Measures of mental well-being and positive mental health (PMH) have been largely developed and used in Western populations, however, data on representative Asian communities are lacking. Using data from a popu...

    Authors: Janhavi Ajit Vaingankar, Mythily Subramaniam, Linda Wei Lin Tan, Edimansyah Abdin, Wei Yen Lim, Hwee Lin Wee, Siow Ann Chong and Rob Martinus van Dam

    Citation: BMC Medical Research Methodology 2018 18:29

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  7. Content type: Study protocol

    Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues.

    Authors: James H. Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine and Tapan Mehta

    Citation: BMC Medical Research Methodology 2018 18:28

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  8. Content type: Research article

    Restricted mean survival time (RMST) is an underutilized estimand in time-to-event analyses. Herein, we highlight its strengths by comparing time to (1) all-cause mortality and (2) initiation of antiretroviral...

    Authors: Keri L. Calkins, Chelsea E. Canan, Richard D. Moore, Catherine R. Lesko and Bryan Lau

    Citation: BMC Medical Research Methodology 2018 18:27

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  9. Content type: Research article

    Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary...

    Authors: Christopher J. Weir, Isabella Butcher, Valentina Assi, Stephanie C. Lewis, Gordon D. Murray, Peter Langhorne and Marian C. Brady

    Citation: BMC Medical Research Methodology 2018 18:25

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  10. Content type: Research article

    We use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the dem...

    Authors: Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley and Gail Davey

    Citation: BMC Medical Research Methodology 2018 18:26

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  11. Content type: Research article

    Medical practitioners use survival models to explore and understand the relationships between patients’ covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Stand...

    Authors: Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang and Yuval Kluger

    Citation: BMC Medical Research Methodology 2018 18:24

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  12. Content type: Research article

    Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data w...

    Authors: G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann and L. C. de Wreede

    Citation: BMC Medical Research Methodology 2018 18:23

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  13. Content type: Research article

    Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation i...

    Authors: Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley and Stuart R Dalziel

    Citation: BMC Medical Research Methodology 2018 18:22

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  14. Content type: Correction

    Following publication of the original article [1], a member of the writing group reported that his name is misspelt. The paper should appear in Pubmed under “Ter Riet G”, bot as “Riet GT”.

    Authors: Sarah R. Haile, Beniamino Guerra, Joan B. Soriano and Milo A. Puhan

    Citation: BMC Medical Research Methodology 2018 18:21

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    The original article was published in BMC Medical Research Methodology 2017 17:172

  15. Content type: Research article

    Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided...

    Authors: Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar and Nigel Stallard

    Citation: BMC Medical Research Methodology 2018 18:20

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  16. Content type: Research article

    Demands placed on individuals in occupational and social settings, as well as imbalances in personal traits and resources, can lead to chronic stress. The Trier Inventory for Chronic Stress (TICS) measures chr...

    Authors: Katja Petrowski, Sören Kliem, Michael Sadler, Alicia E. Meuret, Thomas Ritz and Elmar Brähler

    Citation: BMC Medical Research Methodology 2018 18:18

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  17. Content type: Research article

    Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling...

    Authors: Alex G. Karanevich, Jeffrey M. Statland, Byron J. Gajewski and Jianghua He

    Citation: BMC Medical Research Methodology 2018 18:19

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  18. Content type: Correction

    Following publication of the original article [1], the authors reported that the following four references in Table 2 are incorrect:

    Authors: Geneviève Lefebvre and Mariia Samoilenko

    Citation: BMC Medical Research Methodology 2018 18:17

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    The original article was published in BMC Medical Research Methodology 2017 17:165

  19. Content type: Research article

    Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent vari...

    Authors: Thomas Forkmann, Tobias Teismann, Jana-Sophie Stenzel, Heide Glaesmer and Derek de Beurs

    Citation: BMC Medical Research Methodology 2018 18:16

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  20. Content type: Research article

    Video vignettes are used to test the effects of physicians’ communication on patient outcomes. Methodological choices in video-vignette development may have far-stretching consequences for participants’ engage...

    Authors: Leonie N. C. Visser, Nadine Bol, Marij A. Hillen, Mathilde G. E. Verdam, Hanneke C. J. M. de Haes, Julia C. M. van Weert and Ellen M. A. Smets

    Citation: BMC Medical Research Methodology 2018 18:15

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  21. Content type: Technical advance

    Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor ...

    Authors: Ulrike Pötschger, Harald Heinzl, Maria Grazia Valsecchi and Martina Mittlböck

    Citation: BMC Medical Research Methodology 2018 18:14

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  22. Content type: Research article

    While full disclosure of information on placebo control in participant information leaflets (PILs) in a clinical trial is ethically required during informed consent, there have been concerning voices such comp...

    Authors: Soyeon Cheon, Hi-Joon Park, Younbyoung Chae and Hyangsook Lee

    Citation: BMC Medical Research Methodology 2018 18:13

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  23. Content type: Debate

    The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is n...

    Authors: Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson and Michael Spence

    Citation: BMC Medical Research Methodology 2018 18:12

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  24. Content type: Research article

    The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electr...

    Authors: Dale J. Cooper, Brigitte E. Scammell, Mark E. Batt and Debbie Palmer

    Citation: BMC Medical Research Methodology 2018 18:11

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  25. Content type: Research article

    This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis.

    Authors: Meryl Dahan, Caroline Scemama, Raphael Porcher and David J. Biau

    Citation: BMC Medical Research Methodology 2018 18:10

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BMC Medical Research Methodology

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