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  1. Content type: Research Article

    Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first eve...

    Authors: Antje Jahn-Eimermacher, Katharina Ingel, Stella Preussler, Antoni Bayes-Genis and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:92

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  2. Content type: Research Article

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Authors: Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:90

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  3. Content type: Research article

    Administrative data is a useful tool for research and quality improvement; however, validity of research findings based on these data depends on their reliability. Diagnoses assigned by physicians are subseque...

    Authors: Kristin Burles, Grant Innes, Kevin Senior, Eddy Lang and Andrew McRae

    Citation: BMC Medical Research Methodology 2017 17:89

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  4. Content type: Research article

    Bayesian hierarchical piecewise regression (BHPR) modeling has not been previously formulated to detect and characterise the mechanism of trajectory divergence between groups of participants that have longitud...

    Authors: Marie-jeanne Buscot, Simon S. Wotherspoon, Costan G. Magnussen, Markus Juonala, Matthew A. Sabin, David P. Burgner, Terho Lehtimäki, Jorma S. A. Viikari, Nina Hutri-Kähönen, Olli T. Raitakari and Russell J. Thomson

    Citation: BMC Medical Research Methodology 2017 17:86

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  5. Content type: Research article

    The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...

    Authors: Long H. Ngo, Sharon K. Inouye, Richard N. Jones, Thomas G. Travison, Towia A. Libermann, Simon T. Dillon, George A. Kuchel, Sarinnapha M. Vasunilashorn, David C. Alsop and Edward R. Marcantonio

    Citation: BMC Medical Research Methodology 2017 17:88

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  6. Content type: Research article

    Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, t...

    Authors: Lewis Cooney, Yoon K. Loke, Su Golder, Jamie Kirkham, Andrea Jorgensen, Ian Sinha and Daniel Hawcutt

    Citation: BMC Medical Research Methodology 2017 17:84

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  7. Content type: Research article

    Self-reported weight and height are commonly used in lieu of direct measurements of weight and height in large epidemiological surveys due to inevitable constraints such as budget and human resource. However, ...

    Authors: C. C. Kee, K. H. Lim, M. G. Sumarni, C. H. Teh, Y. Y. Chan, M. I. Nuur Hafizah, Y. K. Cheah, E. O. Tee, Y. Ahmad Faudzi and M. Amal Nasir

    Citation: BMC Medical Research Methodology 2017 17:85

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  8. Content type: Research article

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Authors: Nils Ternès, Federico Rotolo and Stefan Michiels

    Citation: BMC Medical Research Methodology 2017 17:83

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  9. Content type: Research article

    The relative scale has been used for decades in analysing binary data in epidemiology. In contrast, there has been a long tradition of carrying out meta-analyses of continuous outcomes on the absolute, origina...

    Authors: Harri Hemilä

    Citation: BMC Medical Research Methodology 2017 17:82

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  10. Content type: Research article

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Authors: Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    Citation: BMC Medical Research Methodology 2017 17:81

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  11. Content type: Research Article

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Authors: Klemen Pavlič and Maja Pohar Perme

    Citation: BMC Medical Research Methodology 2017 17:79

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  12. Content type: Research article

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Authors: Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    Citation: BMC Medical Research Methodology 2017 17:78

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  13. Content type: Research article

    The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and ...

    Authors: Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Anders Helles Carlsen and Peter Vedsted

    Citation: BMC Medical Research Methodology 2017 17:74

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  14. Content type: Technical advance

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Authors: Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    Citation: BMC Medical Research Methodology 2017 17:76

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  15. Content type: Research article

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Authors: Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    Citation: BMC Medical Research Methodology 2017 17:73

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  16. Content type: Research article

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Authors: Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    Citation: BMC Medical Research Methodology 2017 17:77

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  17. Content type: Research article

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Authors: Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    Citation: BMC Medical Research Methodology 2017 17:75

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  18. Content type: Research article

    Evaluation of the potential effectiveness of a programme’s objectives (health or otherwise) is important in demonstrating how programmes work. However, evaluations are expensive and can focus on unrealistic ou...

    Authors: Melissa Belford, Tony Robertson and Ruth Jepson

    Citation: BMC Medical Research Methodology 2017 17:70

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  19. Content type: Research article

    In studies of recurrent events, it is common to consider a person who has suffered a disease episode and received curative treatment to be not at risk of suffering a new episode for a duration of time. It is a...

    Authors: Yin-Bun Cheung, Ying Xu, Matthew Cairns and Paul Milligan

    Citation: BMC Medical Research Methodology 2017 17:72

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  20. Content type: Research article

    Over the past decade, there have been substantial changes in landline and mobile phone ownership, with a substantial increase in the proportion of mobile-only households. Estimates of daily smoking rates for t...

    Authors: Joseph Hanna, Damien V. Cordery, David G. Steel, Walter Davis and Timothy C. Harrold

    Citation: BMC Medical Research Methodology 2017 17:65

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  21. Content type: Research article

    Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to i...

    Authors: Navjot Kaur, Ben Porter, Cynthia A. LeardMann, Laura E. Tobin, Hector Lemus and David D. Luxton

    Citation: BMC Medical Research Methodology 2017 17:69

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  22. Content type: Research article

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Authors: Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    Citation: BMC Medical Research Methodology 2017 17:66

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  23. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  24. Content type: Research article

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Authors: Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    Citation: BMC Medical Research Methodology 2017 17:68

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  25. Content type: Research article

    The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...

    Authors: Suman Kundu, Madhu Mazumdar and Bart Ferket

    Citation: BMC Medical Research Methodology 2017 17:63

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  26. Content type: Research article

    Systematic reviews (SRs) are an important source of information about healthcare interventions. A key component of a well-conducted SR is a comprehensive literature search. There is limited evidence on the con...

    Authors: Lisa Hartling, Robin Featherstone, Megan Nuspl, Kassi Shave, Donna M. Dryden and Ben Vandermeer

    Citation: BMC Medical Research Methodology 2017 17:64

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  27. Content type: Research article

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Authors: Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    Citation: BMC Medical Research Methodology 2017 17:62

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  28. Content type: Study protocol

    Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This wa...

    Authors: Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M. Gross, Soo Downe, Zarko Alfirevic and Declan Devane

    Citation: BMC Medical Research Methodology 2017 17:61

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  29. Content type: Research article

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    Authors: M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    Citation: BMC Medical Research Methodology 2017 17:60

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  30. Content type: Research article

    The collection of routine clinical data in the setting of research registries can serve an important role in understanding real world care. However, relatively little is known about the patient experience in r...

    Authors: Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Michelle Frits, Christine Iannaccone, Agnes Zak and Joshua R. Korzenik

    Citation: BMC Medical Research Methodology 2017 17:59

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  31. Content type: Research article

    Participant recruitment is an ongoing challenge in health research. Recruitment may be especially difficult for studies of access to health care because, even among those who are in care, people using services...

    Authors: Christopher J. Miller, James F. Burgess Jr., Ellen P. Fischer, Deborah J. Hodges, Lindsay K. Belanger, Jessica M. Lipschitz, Siena R. Easley, Christopher J. Koenig, Regina L. Stanley and Jeffrey M. Pyne

    Citation: BMC Medical Research Methodology 2017 17:57

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  32. Content type: Research article

    Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual’s absolute risk on stroke onset. However, several widely accepted risk factors for stroke were no...

    Authors: Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu and Jiayin Zheng

    Citation: BMC Medical Research Methodology 2017 17:58

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  33. Content type: Research article

    Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from vario...

    Authors: Bethany Shinkins, Yaling Yang, Lucy Abel and Thomas R. Fanshawe

    Citation: BMC Medical Research Methodology 2017 17:56

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  34. Content type: Research Article

    Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for...

    Authors: Ralph Brinks, Annika Hoyer, Deborah B. Rolka, Oliver Kuss and Edward W. Gregg

    Citation: BMC Medical Research Methodology 2017 17:54

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  35. Content type: Research article

    ROC (receiver operating characteristic) curve analysis is well established for assessing how well a marker is capable of discriminating between individuals who experience disease onset and individuals who do n...

    Authors: Adina Najwa Kamarudin, Trevor Cox and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2017 17:53

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  36. Content type: Correspondence

    Obesity and obesity-related conditions, such as type 2 diabetes, are a major issue for Veteran health. Veterans Health Administration (VA) researchers and health systems leaders have worked separately and toge...

    Authors: Mona AuYoung, Laura J. Damschroder, Linda Kinsinger, Tannaz Moin and Caroline R. Richardson

    Citation: BMC Medical Research Methodology 2017 17:50

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  37. Content type: Research article

    The effects of postal questionnaire burden on return rates and answers given are unclear following treatment on an intensive care unit (ICU). We aimed to establish the effects of different postal questionnaire...

    Authors: Robert Hatch, Duncan Young, Vicki Barber, David A Harrison and Peter Watkinson

    Citation: BMC Medical Research Methodology 2017 17:49

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  38. Content type: Research article

    Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making. It is recommended that authors assess and rep...

    Authors: Michelle Pollock, Ricardo M. Fernandes and Lisa Hartling

    Citation: BMC Medical Research Methodology 2017 17:48

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  39. Content type: Research article

    Vision influences functioning and disability of children with cerebral palsy, so there is a growing need for psychometrically robust tools to advance assessment of children’s vision abilities in clinical pract...

    Authors: Belinda Deramore Denver, Margareta Adolfsson, Elspeth Froude, Peter Rosenbaum and Christine Imms

    Citation: BMC Medical Research Methodology 2017 17:46

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  40. Content type: Research article

    Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent ...

    Authors: George J. Knafl, Kathleen A. Knafl, Margaret Grey, Jane Dixon, Janet A. Deatrick and Agatha M. Gallo

    Citation: BMC Medical Research Methodology 2017 17:45

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  41. Content type: Research article

    Meta-analysis is very useful to summarize the effect of a treatment or a risk factor for a given disease. Often studies report results based on log-transformed variables in order to achieve the principal assum...

    Authors: Miguel Rodríguez-Barranco, Aurelio Tobías, Daniel Redondo, Elena Molina-Portillo and María José Sánchez

    Citation: BMC Medical Research Methodology 2017 17:44

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:91

  42. Content type: Correspondence

    With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to h...

    Authors: Roy Eagleson, Luis Altamirano-Diaz, Alex McInnis, Eva Welisch, Stefanie De Jesus, Harry Prapavessis, Meghan Rombeek, Jamie A. Seabrook, Teresa Park and Kambiz Norozi

    Citation: BMC Medical Research Methodology 2017 17:43

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